Amino acid dipepetide frequency for Streptomyces sp. 62

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.838AlaAla: 21.838 ± 0.153	1.061AlaCys: 1.061 ± 0.02	8.249AlaAsp: 8.249 ± 0.053	9.048AlaGlu: 9.048 ± 0.086	3.652AlaPhe: 3.652 ± 0.04	13.33AlaGly: 13.33 ± 0.089	2.878AlaHis: 2.878 ± 0.035	3.331AlaIle: 3.331 ± 0.042	2.81AlaLys: 2.81 ± 0.044	14.988AlaLeu: 14.988 ± 0.115	2.472AlaMet: 2.472 ± 0.029	1.863AlaAsn: 1.863 ± 0.034	7.805AlaPro: 7.805 ± 0.086	3.465AlaGln: 3.465 ± 0.042	10.433AlaArg: 10.433 ± 0.085	6.014AlaSer: 6.014 ± 0.053	7.323AlaThr: 7.323 ± 0.06	12.483AlaVal: 12.483 ± 0.073	1.935AlaTrp: 1.935 ± 0.033	2.936AlaTyr: 2.936 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.021	0.094CysCys: 0.094 ± 0.007	0.451CysAsp: 0.451 ± 0.013	0.393CysGlu: 0.393 ± 0.013	0.222CysPhe: 0.222 ± 0.011	0.944CysGly: 0.944 ± 0.02	0.193CysHis: 0.193 ± 0.008	0.163CysIle: 0.163 ± 0.008	0.113CysLys: 0.113 ± 0.006	0.769CysLeu: 0.769 ± 0.018	0.119CysMet: 0.119 ± 0.007	0.13CysAsn: 0.13 ± 0.008	0.475CysPro: 0.475 ± 0.017	0.149CysGln: 0.149 ± 0.009	0.597CysArg: 0.597 ± 0.017	0.414CysSer: 0.414 ± 0.012	0.488CysThr: 0.488 ± 0.012	0.631CysVal: 0.631 ± 0.013	0.131CysTrp: 0.131 ± 0.007	0.153CysTyr: 0.153 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.65AspAla: 7.65 ± 0.057	0.458AspCys: 0.458 ± 0.015	3.372AspAsp: 3.372 ± 0.049	3.95AspGlu: 3.95 ± 0.042	1.612AspPhe: 1.612 ± 0.026	6.662AspGly: 6.662 ± 0.059	1.414AspHis: 1.414 ± 0.023	1.694AspIle: 1.694 ± 0.026	1.128AspLys: 1.128 ± 0.026	6.188AspLeu: 6.188 ± 0.049	0.783AspMet: 0.783 ± 0.019	0.921AspAsn: 0.921 ± 0.023	4.667AspPro: 4.667 ± 0.052	1.409AspGln: 1.409 ± 0.026	5.046AspArg: 5.046 ± 0.048	2.411AspSer: 2.411 ± 0.031	3.24AspThr: 3.24 ± 0.04	4.53AspVal: 4.53 ± 0.041	1.065AspTrp: 1.065 ± 0.02	1.064AspTyr: 1.064 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.797GluAla: 7.797 ± 0.077	0.357GluCys: 0.357 ± 0.012	2.877GluAsp: 2.877 ± 0.036	3.82GluGlu: 3.82 ± 0.047	1.449GluPhe: 1.449 ± 0.023	4.483GluGly: 4.483 ± 0.052	1.475GluHis: 1.475 ± 0.026	2.181GluIle: 2.181 ± 0.031	1.454GluLys: 1.454 ± 0.026	6.812GluLeu: 6.812 ± 0.065	0.828GluMet: 0.828 ± 0.019	1.046GluAsn: 1.046 ± 0.021	3.475GluPro: 3.475 ± 0.046	2.127GluGln: 2.127 ± 0.032	5.531GluArg: 5.531 ± 0.054	2.521GluSer: 2.521 ± 0.035	3.048GluThr: 3.048 ± 0.038	4.337GluVal: 4.337 ± 0.047	0.793GluTrp: 0.793 ± 0.019	1.117GluTyr: 1.117 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.709PheAla: 3.709 ± 0.043	0.254PheCys: 0.254 ± 0.011	1.916PheAsp: 1.916 ± 0.03	1.416PheGlu: 1.416 ± 0.022	0.843PhePhe: 0.843 ± 0.02	2.992PheGly: 2.992 ± 0.039	0.647PheHis: 0.647 ± 0.016	0.637PheIle: 0.637 ± 0.015	0.525PheLys: 0.525 ± 0.015	2.668PheLeu: 2.668 ± 0.037	0.388PheMet: 0.388 ± 0.011	0.534PheAsn: 0.534 ± 0.015	1.384PhePro: 1.384 ± 0.022	0.667PheGln: 0.667 ± 0.014	1.864PheArg: 1.864 ± 0.029	1.425PheSer: 1.425 ± 0.023	2.015PheThr: 2.015 ± 0.03	2.215PheVal: 2.215 ± 0.026	0.429PheTrp: 0.429 ± 0.012	0.548PheTyr: 0.548 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.457GlyAla: 11.457 ± 0.082	0.796GlyCys: 0.796 ± 0.02	5.194GlyAsp: 5.194 ± 0.052	5.148GlyGlu: 5.148 ± 0.043	2.899GlyPhe: 2.899 ± 0.036	9.021GlyGly: 9.021 ± 0.087	2.285GlyHis: 2.285 ± 0.036	3.417GlyIle: 3.417 ± 0.041	2.38GlyLys: 2.38 ± 0.033	9.667GlyLeu: 9.667 ± 0.076	1.884GlyMet: 1.884 ± 0.025	1.8GlyAsn: 1.8 ± 0.033	5.447GlyPro: 5.447 ± 0.058	2.55GlyGln: 2.55 ± 0.035	7.972GlyArg: 7.972 ± 0.07	5.325GlySer: 5.325 ± 0.044	6.83GlyThr: 6.83 ± 0.071	7.494GlyVal: 7.494 ± 0.071	1.782GlyTrp: 1.782 ± 0.031	2.295GlyTyr: 2.295 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.667HisAla: 2.667 ± 0.034	0.198HisCys: 0.198 ± 0.009	1.295HisAsp: 1.295 ± 0.024	1.242HisGlu: 1.242 ± 0.023	0.64HisPhe: 0.64 ± 0.015	2.373HisGly: 2.373 ± 0.031	0.685HisHis: 0.685 ± 0.017	0.588HisIle: 0.588 ± 0.014	0.343HisLys: 0.343 ± 0.012	2.407HisLeu: 2.407 ± 0.029	0.314HisMet: 0.314 ± 0.011	0.354HisAsn: 0.354 ± 0.012	1.826HisPro: 1.826 ± 0.032	0.646HisGln: 0.646 ± 0.016	2.085HisArg: 2.085 ± 0.032	0.969HisSer: 0.969 ± 0.017	1.288HisThr: 1.288 ± 0.023	1.709HisVal: 1.709 ± 0.024	0.383HisTrp: 0.383 ± 0.012	0.474HisTyr: 0.474 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.694IleAla: 4.694 ± 0.053	0.286IleCys: 0.286 ± 0.011	2.135IleAsp: 2.135 ± 0.026	1.868IleGlu: 1.868 ± 0.031	0.618IlePhe: 0.618 ± 0.017	3.499IleGly: 3.499 ± 0.041	0.586IleHis: 0.586 ± 0.015	0.75IleIle: 0.75 ± 0.019	0.686IleLys: 0.686 ± 0.017	2.303IleLeu: 2.303 ± 0.035	0.409IleMet: 0.409 ± 0.012	0.62IleAsn: 0.62 ± 0.017	1.719IlePro: 1.719 ± 0.028	0.692IleGln: 0.692 ± 0.016	2.196IleArg: 2.196 ± 0.031	1.504IleSer: 1.504 ± 0.029	2.156IleThr: 2.156 ± 0.03	2.686IleVal: 2.686 ± 0.037	0.357IleTrp: 0.357 ± 0.012	0.501IleTyr: 0.501 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.066LysAla: 3.066 ± 0.043	0.102LysCys: 0.102 ± 0.007	1.321LysAsp: 1.321 ± 0.028	1.197LysGlu: 1.197 ± 0.023	0.455LysPhe: 0.455 ± 0.015	1.846LysGly: 1.846 ± 0.034	0.42LysHis: 0.42 ± 0.013	0.887LysIle: 0.887 ± 0.02	0.834LysLys: 0.834 ± 0.025	1.954LysLeu: 1.954 ± 0.029	0.361LysMet: 0.361 ± 0.012	0.555LysAsn: 0.555 ± 0.015	1.394LysPro: 1.394 ± 0.031	0.669LysGln: 0.669 ± 0.018	1.409LysArg: 1.409 ± 0.024	1.049LysSer: 1.049 ± 0.022	1.341LysThr: 1.341 ± 0.03	1.848LysVal: 1.848 ± 0.034	0.258LysTrp: 0.258 ± 0.01	0.434LysTyr: 0.434 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.587LeuAla: 15.587 ± 0.119	0.813LeuCys: 0.813 ± 0.019	6.895LeuAsp: 6.895 ± 0.062	4.42LeuGlu: 4.42 ± 0.047	2.592LeuPhe: 2.592 ± 0.039	9.483LeuGly: 9.483 ± 0.065	2.31LeuHis: 2.31 ± 0.034	3.063LeuIle: 3.063 ± 0.039	2.064LeuLys: 2.064 ± 0.032	11.467LeuLeu: 11.467 ± 0.112	1.581LeuMet: 1.581 ± 0.024	1.642LeuAsn: 1.642 ± 0.028	6.619LeuPro: 6.619 ± 0.061	2.125LeuGln: 2.125 ± 0.033	8.637LeuArg: 8.637 ± 0.066	5.265LeuSer: 5.265 ± 0.05	6.966LeuThr: 6.966 ± 0.056	9.0LeuVal: 9.0 ± 0.081	1.376LeuTrp: 1.376 ± 0.027	1.869LeuTyr: 1.869 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.173MetAla: 2.173 ± 0.027	0.132MetCys: 0.132 ± 0.007	0.881MetAsp: 0.881 ± 0.019	0.726MetGlu: 0.726 ± 0.019	0.425MetPhe: 0.425 ± 0.013	1.268MetGly: 1.268 ± 0.023	0.328MetHis: 0.328 ± 0.011	0.62MetIle: 0.62 ± 0.016	0.443MetLys: 0.443 ± 0.012	1.57MetLeu: 1.57 ± 0.025	0.273MetMet: 0.273 ± 0.01	0.455MetAsn: 0.455 ± 0.013	1.082MetPro: 1.082 ± 0.023	0.411MetGln: 0.411 ± 0.013	1.38MetArg: 1.38 ± 0.023	1.267MetSer: 1.267 ± 0.023	1.566MetThr: 1.566 ± 0.021	1.21MetVal: 1.21 ± 0.024	0.194MetTrp: 0.194 ± 0.008	0.313MetTyr: 0.313 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.142AsnAla: 2.142 ± 0.028	0.164AsnCys: 0.164 ± 0.008	0.944AsnAsp: 0.944 ± 0.019	0.82AsnGlu: 0.82 ± 0.019	0.444AsnPhe: 0.444 ± 0.013	1.984AsnGly: 1.984 ± 0.035	0.383AsnHis: 0.383 ± 0.012	0.598AsnIle: 0.598 ± 0.018	0.418AsnLys: 0.418 ± 0.013	1.616AsnLeu: 1.616 ± 0.026	0.286AsnMet: 0.286 ± 0.011	0.422AsnAsn: 0.422 ± 0.013	1.359AsnPro: 1.359 ± 0.025	0.506AsnGln: 0.506 ± 0.014	1.283AsnArg: 1.283 ± 0.023	0.892AsnSer: 0.892 ± 0.02	1.125AsnThr: 1.125 ± 0.024	1.317AsnVal: 1.317 ± 0.025	0.28AsnTrp: 0.28 ± 0.011	0.372AsnTyr: 0.372 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.237ProAla: 9.237 ± 0.082	0.339ProCys: 0.339 ± 0.013	4.47ProAsp: 4.47 ± 0.048	4.73ProGlu: 4.73 ± 0.049	1.553ProPhe: 1.553 ± 0.023	6.885ProGly: 6.885 ± 0.065	1.342ProHis: 1.342 ± 0.024	1.224ProIle: 1.224 ± 0.021	1.257ProLys: 1.257 ± 0.03	5.514ProLeu: 5.514 ± 0.051	0.986ProMet: 0.986 ± 0.018	0.9ProAsn: 0.9 ± 0.018	3.627ProPro: 3.627 ± 0.061	1.67ProGln: 1.67 ± 0.033	4.039ProArg: 4.039 ± 0.044	3.252ProSer: 3.252 ± 0.039	3.443ProThr: 3.443 ± 0.049	5.806ProVal: 5.806 ± 0.052	0.939ProTrp: 0.939 ± 0.02	1.483ProTyr: 1.483 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.561GlnAla: 3.561 ± 0.044	0.171GlnCys: 0.171 ± 0.008	1.374GlnAsp: 1.374 ± 0.025	1.401GlnGlu: 1.401 ± 0.025	0.637GlnPhe: 0.637 ± 0.015	2.194GlnGly: 2.194 ± 0.034	0.595GlnHis: 0.595 ± 0.015	1.034GlnIle: 1.034 ± 0.019	0.602GlnLys: 0.602 ± 0.016	2.807GlnLeu: 2.807 ± 0.035	0.434GlnMet: 0.434 ± 0.012	0.492GlnAsn: 0.492 ± 0.015	1.618GlnPro: 1.618 ± 0.031	1.135GlnGln: 1.135 ± 0.033	2.146GlnArg: 2.146 ± 0.031	1.184GlnSer: 1.184 ± 0.019	1.331GlnThr: 1.331 ± 0.023	2.219GlnVal: 2.219 ± 0.031	0.433GlnTrp: 0.433 ± 0.013	0.613GlnTyr: 0.613 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.061ArgAla: 10.061 ± 0.079	0.603ArgCys: 0.603 ± 0.016	4.156ArgAsp: 4.156 ± 0.04	4.714ArgGlu: 4.714 ± 0.049	2.355ArgPhe: 2.355 ± 0.031	5.761ArgGly: 5.761 ± 0.052	2.085ArgHis: 2.085 ± 0.035	3.31ArgIle: 3.31 ± 0.036	1.626ArgLys: 1.626 ± 0.025	8.858ArgLeu: 8.858 ± 0.075	1.685ArgMet: 1.685 ± 0.021	1.339ArgAsn: 1.339 ± 0.023	5.16ArgPro: 5.16 ± 0.054	2.136ArgGln: 2.136 ± 0.032	7.715ArgArg: 7.715 ± 0.081	3.999ArgSer: 3.999 ± 0.041	5.614ArgThr: 5.614 ± 0.05	5.772ArgVal: 5.772 ± 0.046	1.401ArgTrp: 1.401 ± 0.022	1.811ArgTyr: 1.811 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.53SerAla: 6.53 ± 0.055	0.41SerCys: 0.41 ± 0.014	2.648SerAsp: 2.648 ± 0.033	2.323SerGlu: 2.323 ± 0.031	1.487SerPhe: 1.487 ± 0.026	5.783SerGly: 5.783 ± 0.054	0.978SerHis: 0.978 ± 0.019	1.412SerIle: 1.412 ± 0.025	0.979SerLys: 0.979 ± 0.024	4.858SerLeu: 4.858 ± 0.047	1.057SerMet: 1.057 ± 0.023	0.829SerAsn: 0.829 ± 0.018	3.202SerPro: 3.202 ± 0.036	1.128SerGln: 1.128 ± 0.025	3.605SerArg: 3.605 ± 0.041	2.796SerSer: 2.796 ± 0.042	3.178SerThr: 3.178 ± 0.037	4.25SerVal: 4.25 ± 0.048	0.944SerTrp: 0.944 ± 0.022	1.225SerTyr: 1.225 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.404ThrAla: 9.404 ± 0.074	0.425ThrCys: 0.425 ± 0.014	3.713ThrAsp: 3.713 ± 0.044	3.378ThrGlu: 3.378 ± 0.039	1.655ThrPhe: 1.655 ± 0.029	7.191ThrGly: 7.191 ± 0.069	1.195ThrHis: 1.195 ± 0.022	1.709ThrIle: 1.709 ± 0.03	1.142ThrLys: 1.142 ± 0.024	5.93ThrLeu: 5.93 ± 0.046	0.911ThrMet: 0.911 ± 0.019	0.971ThrAsn: 0.971 ± 0.02	4.486ThrPro: 4.486 ± 0.055	1.297ThrGln: 1.297 ± 0.023	3.942ThrArg: 3.942 ± 0.046	3.19ThrSer: 3.19 ± 0.037	4.282ThrThr: 4.282 ± 0.069	6.32ThrVal: 6.32 ± 0.067	0.957ThrTrp: 0.957 ± 0.021	1.42ThrTyr: 1.42 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.679ValAla: 10.679 ± 0.075	0.69ValCys: 0.69 ± 0.014	5.012ValAsp: 5.012 ± 0.045	4.779ValGlu: 4.779 ± 0.045	2.38ValPhe: 2.38 ± 0.03	6.441ValGly: 6.441 ± 0.057	1.954ValHis: 1.954 ± 0.027	2.63ValIle: 2.63 ± 0.033	1.788ValLys: 1.788 ± 0.03	9.666ValLeu: 9.666 ± 0.084	1.392ValMet: 1.392 ± 0.025	1.605ValAsn: 1.605 ± 0.028	5.504ValPro: 5.504 ± 0.052	2.001ValGln: 2.001 ± 0.03	7.124ValArg: 7.124 ± 0.065	4.216ValSer: 4.216 ± 0.042	5.881ValThr: 5.881 ± 0.067	7.804ValVal: 7.804 ± 0.068	1.167ValTrp: 1.167 ± 0.023	1.595ValTyr: 1.595 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.732TrpAla: 1.732 ± 0.028	0.156TrpCys: 0.156 ± 0.008	0.846TrpAsp: 0.846 ± 0.021	0.784TrpGlu: 0.784 ± 0.017	0.523TrpPhe: 0.523 ± 0.015	1.099TrpGly: 1.099 ± 0.023	0.364TrpHis: 0.364 ± 0.011	0.576TrpIle: 0.576 ± 0.017	0.395TrpLys: 0.395 ± 0.014	1.712TrpLeu: 1.712 ± 0.03	0.295TrpMet: 0.295 ± 0.01	0.448TrpAsn: 0.448 ± 0.014	0.794TrpPro: 0.794 ± 0.017	0.601TrpGln: 0.601 ± 0.016	1.315TrpArg: 1.315 ± 0.025	0.983TrpSer: 0.983 ± 0.021	1.161TrpThr: 1.161 ± 0.024	1.025TrpVal: 1.025 ± 0.02	0.365TrpTrp: 0.365 ± 0.012	0.371TrpTyr: 0.371 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.867TyrAla: 2.867 ± 0.034	0.181TyrCys: 0.181 ± 0.009	1.516TyrAsp: 1.516 ± 0.032	1.372TyrGlu: 1.372 ± 0.024	0.633TyrPhe: 0.633 ± 0.016	2.407TyrGly: 2.407 ± 0.032	0.369TyrHis: 0.369 ± 0.013	0.441TyrIle: 0.441 ± 0.014	0.415TyrLys: 0.415 ± 0.014	2.021TyrLeu: 2.021 ± 0.031	0.258TyrMet: 0.258 ± 0.01	0.427TyrAsn: 0.427 ± 0.016	1.054TyrPro: 1.054 ± 0.023	0.596TyrGln: 0.596 ± 0.015	1.84TyrArg: 1.84 ± 0.03	0.943TyrSer: 0.943 ± 0.018	1.242TyrThr: 1.242 ± 0.025	1.652TyrVal: 1.652 ± 0.027	0.358TyrTrp: 0.358 ± 0.012	0.468TyrTyr: 0.468 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8152 proteins (2701151 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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