Amino acid dipepetide frequency for Bovine papillomavirus type 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.207AlaAla: 4.207 ± 0.942
2.294AlaCys: 2.294 ± 0.625
2.677AlaAsp: 2.677 ± 0.779
6.501AlaGlu: 6.501 ± 1.064
1.912AlaPhe: 1.912 ± 0.612
10.707AlaGly: 10.707 ± 2.333
0.382AlaHis: 0.382 ± 0.476
1.912AlaIle: 1.912 ± 0.829
3.824AlaLys: 3.824 ± 1.302
6.501AlaLeu: 6.501 ± 1.755
0.765AlaMet: 0.765 ± 0.633
4.207AlaAsn: 4.207 ± 0.727
2.677AlaPro: 2.677 ± 1.04
3.824AlaGln: 3.824 ± 1.159
4.971AlaArg: 4.971 ± 1.386
7.266AlaSer: 7.266 ± 1.005
4.207AlaThr: 4.207 ± 1.512
5.354AlaVal: 5.354 ± 1.335
0.382AlaTrp: 0.382 ± 0.323
1.912AlaTyr: 1.912 ± 0.928
0.0AlaXaa: 0.0 ± 0.0
Cys
1.912CysAla: 1.912 ± 1.043
1.147CysCys: 1.147 ± 1.045
0.0CysAsp: 0.0 ± 0.0
1.147CysGlu: 1.147 ± 0.605
1.53CysPhe: 1.53 ± 0.675
1.912CysGly: 1.912 ± 1.16
0.382CysHis: 0.382 ± 0.493
0.382CysIle: 0.382 ± 0.467
1.147CysLys: 1.147 ± 0.526
2.294CysLeu: 2.294 ± 1.394
0.382CysMet: 0.382 ± 0.467
0.382CysAsn: 0.382 ± 0.293
1.147CysPro: 1.147 ± 0.477
0.382CysGln: 0.382 ± 0.332
1.53CysArg: 1.53 ± 1.361
3.442CysSer: 3.442 ± 1.219
2.677CysThr: 2.677 ± 0.772
0.382CysVal: 0.382 ± 0.323
0.382CysTrp: 0.382 ± 0.293
1.53CysTyr: 1.53 ± 0.998
0.0CysXaa: 0.0 ± 0.0
Asp
3.824AspAla: 3.824 ± 1.085
1.147AspCys: 1.147 ± 0.906
1.912AspAsp: 1.912 ± 0.536
2.294AspGlu: 2.294 ± 0.908
4.207AspPhe: 4.207 ± 0.874
5.354AspGly: 5.354 ± 1.77
1.147AspHis: 1.147 ± 0.587
1.147AspIle: 1.147 ± 0.343
2.294AspLys: 2.294 ± 0.819
4.589AspLeu: 4.589 ± 1.068
0.765AspMet: 0.765 ± 0.351
1.912AspAsn: 1.912 ± 0.545
2.294AspPro: 2.294 ± 0.722
0.765AspGln: 0.765 ± 0.4
4.589AspArg: 4.589 ± 0.741
4.971AspSer: 4.971 ± 1.088
4.207AspThr: 4.207 ± 1.798
1.147AspVal: 1.147 ± 0.583
0.382AspTrp: 0.382 ± 0.293
0.382AspTyr: 0.382 ± 0.323
0.0AspXaa: 0.0 ± 0.0
Glu
4.589GluAla: 4.589 ± 0.851
1.147GluCys: 1.147 ± 0.69
4.971GluAsp: 4.971 ± 1.206
8.413GluGlu: 8.413 ± 2.11
1.147GluPhe: 1.147 ± 0.679
4.589GluGly: 4.589 ± 0.827
0.382GluHis: 0.382 ± 0.493
2.677GluIle: 2.677 ± 1.601
2.677GluLys: 2.677 ± 0.762
4.589GluLeu: 4.589 ± 0.815
0.382GluMet: 0.382 ± 0.332
4.589GluAsn: 4.589 ± 0.729
4.207GluPro: 4.207 ± 1.465
3.442GluGln: 3.442 ± 0.828
3.059GluArg: 3.059 ± 1.08
3.059GluSer: 3.059 ± 1.468
4.589GluThr: 4.589 ± 0.841
2.294GluVal: 2.294 ± 0.686
0.382GluTrp: 0.382 ± 0.293
1.53GluTyr: 1.53 ± 0.918
0.0GluXaa: 0.0 ± 0.0
Phe
3.442PheAla: 3.442 ± 0.485
0.382PheCys: 0.382 ± 0.467
1.147PheAsp: 1.147 ± 0.6
2.294PheGlu: 2.294 ± 1.052
2.294PhePhe: 2.294 ± 0.9
4.207PheGly: 4.207 ± 0.638
1.53PheHis: 1.53 ± 0.544
1.147PheIle: 1.147 ± 0.572
3.059PheLys: 3.059 ± 1.158
5.354PheLeu: 5.354 ± 2.164
0.765PheMet: 0.765 ± 0.708
2.677PheAsn: 2.677 ± 1.115
1.147PhePro: 1.147 ± 0.485
0.765PheGln: 0.765 ± 0.587
2.677PheArg: 2.677 ± 0.719
2.677PheSer: 2.677 ± 1.193
1.912PheThr: 1.912 ± 0.877
1.53PheVal: 1.53 ± 0.718
1.147PheTrp: 1.147 ± 0.572
0.765PheTyr: 0.765 ± 0.646
0.0PheXaa: 0.0 ± 0.0
Gly
6.501GlyAla: 6.501 ± 1.067
1.53GlyCys: 1.53 ± 0.758
3.824GlyAsp: 3.824 ± 0.902
3.059GlyGlu: 3.059 ± 1.291
3.059GlyPhe: 3.059 ± 0.94
5.736GlyGly: 5.736 ± 1.121
2.294GlyHis: 2.294 ± 0.827
2.294GlyIle: 2.294 ± 0.76
3.059GlyLys: 3.059 ± 1.706
7.648GlyLeu: 7.648 ± 1.678
1.147GlyMet: 1.147 ± 0.485
1.53GlyAsn: 1.53 ± 0.524
5.354GlyPro: 5.354 ± 2.289
1.53GlyGln: 1.53 ± 0.67
3.824GlyArg: 3.824 ± 0.976
10.707GlySer: 10.707 ± 1.755
6.883GlyThr: 6.883 ± 1.147
4.207GlyVal: 4.207 ± 0.919
1.147GlyTrp: 1.147 ± 0.73
0.765GlyTyr: 0.765 ± 0.513
0.0GlyXaa: 0.0 ± 0.0
His
1.53HisAla: 1.53 ± 0.524
0.382HisCys: 0.382 ± 0.332
0.382HisAsp: 0.382 ± 0.293
1.147HisGlu: 1.147 ± 0.583
1.912HisPhe: 1.912 ± 0.852
1.912HisGly: 1.912 ± 1.151
0.382HisHis: 0.382 ± 0.476
1.147HisIle: 1.147 ± 0.647
1.147HisLys: 1.147 ± 0.88
2.677HisLeu: 2.677 ± 0.778
0.382HisMet: 0.382 ± 0.323
0.382HisAsn: 0.382 ± 0.323
2.294HisPro: 2.294 ± 0.734
0.765HisGln: 0.765 ± 0.495
3.442HisArg: 3.442 ± 1.129
0.765HisSer: 0.765 ± 0.386
0.382HisThr: 0.382 ± 0.291
2.677HisVal: 2.677 ± 0.96
0.0HisTrp: 0.0 ± 0.0
0.765HisTyr: 0.765 ± 0.386
0.0HisXaa: 0.0 ± 0.0
Ile
2.677IleAla: 2.677 ± 1.004
1.147IleCys: 1.147 ± 0.549
2.294IleAsp: 2.294 ± 0.821
2.677IleGlu: 2.677 ± 0.645
1.53IlePhe: 1.53 ± 0.74
3.824IleGly: 3.824 ± 1.577
0.765IleHis: 0.765 ± 0.359
1.53IleIle: 1.53 ± 0.988
1.147IleLys: 1.147 ± 0.687
4.971IleLeu: 4.971 ± 0.726
0.0IleMet: 0.0 ± 0.0
0.765IleAsn: 0.765 ± 0.36
2.677IlePro: 2.677 ± 1.063
0.765IleGln: 0.765 ± 0.646
2.677IleArg: 2.677 ± 1.316
2.677IleSer: 2.677 ± 0.819
2.677IleThr: 2.677 ± 0.599
0.382IleVal: 0.382 ± 0.291
0.382IleTrp: 0.382 ± 0.323
0.765IleTyr: 0.765 ± 0.403
0.0IleXaa: 0.0 ± 0.0
Lys
3.442LysAla: 3.442 ± 1.308
1.147LysCys: 1.147 ± 0.485
1.147LysAsp: 1.147 ± 0.639
4.589LysGlu: 4.589 ± 1.933
1.53LysPhe: 1.53 ± 0.562
2.294LysGly: 2.294 ± 0.592
3.059LysHis: 3.059 ± 0.582
1.912LysIle: 1.912 ± 0.64
4.971LysLys: 4.971 ± 0.958
3.824LysLeu: 3.824 ± 0.855
0.765LysMet: 0.765 ± 0.628
3.059LysAsn: 3.059 ± 0.717
1.53LysPro: 1.53 ± 0.726
1.912LysGln: 1.912 ± 0.486
4.971LysArg: 4.971 ± 1.393
4.971LysSer: 4.971 ± 2.331
2.677LysThr: 2.677 ± 1.022
1.912LysVal: 1.912 ± 0.85
0.0LysTrp: 0.0 ± 0.0
0.765LysTyr: 0.765 ± 0.485
0.0LysXaa: 0.0 ± 0.0
Leu
6.883LeuAla: 6.883 ± 1.519
3.059LeuCys: 3.059 ± 1.262
6.883LeuAsp: 6.883 ± 1.242
4.589LeuGlu: 4.589 ± 1.568
4.589LeuPhe: 4.589 ± 1.741
7.266LeuGly: 7.266 ± 0.763
3.059LeuHis: 3.059 ± 0.832
4.589LeuIle: 4.589 ± 1.248
6.883LeuLys: 6.883 ± 0.979
11.472LeuLeu: 11.472 ± 4.435
1.147LeuMet: 1.147 ± 0.572
2.294LeuAsn: 2.294 ± 1.191
5.354LeuPro: 5.354 ± 1.206
4.971LeuGln: 4.971 ± 1.246
3.059LeuArg: 3.059 ± 1.037
5.354LeuSer: 5.354 ± 1.348
4.971LeuThr: 4.971 ± 1.249
3.059LeuVal: 3.059 ± 1.124
2.294LeuTrp: 2.294 ± 1.008
3.824LeuTyr: 3.824 ± 1.199
0.0LeuXaa: 0.0 ± 0.0
Met
2.294MetAla: 2.294 ± 0.731
0.0MetCys: 0.0 ± 0.0
0.382MetAsp: 0.382 ± 0.467
1.147MetGlu: 1.147 ± 0.647
0.382MetPhe: 0.382 ± 0.323
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.382MetLys: 0.382 ± 0.382
0.765MetLeu: 0.765 ± 0.587
0.382MetMet: 0.382 ± 0.323
1.147MetAsn: 1.147 ± 0.485
1.147MetPro: 1.147 ± 0.553
1.53MetGln: 1.53 ± 0.783
0.765MetArg: 0.765 ± 0.386
0.765MetSer: 0.765 ± 0.403
0.0MetThr: 0.0 ± 0.0
1.53MetVal: 1.53 ± 0.794
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.824AsnAla: 3.824 ± 1.481
1.912AsnCys: 1.912 ± 0.718
1.912AsnAsp: 1.912 ± 0.672
2.677AsnGlu: 2.677 ± 1.266
1.147AsnPhe: 1.147 ± 0.485
1.53AsnGly: 1.53 ± 0.67
1.53AsnHis: 1.53 ± 0.584
3.442AsnIle: 3.442 ± 0.622
0.765AsnLys: 0.765 ± 0.646
2.677AsnLeu: 2.677 ± 0.825
0.0AsnMet: 0.0 ± 0.0
1.147AsnAsn: 1.147 ± 0.969
1.147AsnPro: 1.147 ± 0.611
2.294AsnGln: 2.294 ± 0.812
1.147AsnArg: 1.147 ± 0.618
1.912AsnSer: 1.912 ± 0.907
3.824AsnThr: 3.824 ± 0.95
1.53AsnVal: 1.53 ± 0.918
1.53AsnTrp: 1.53 ± 0.305
0.765AsnTyr: 0.765 ± 0.359
0.0AsnXaa: 0.0 ± 0.0
Pro
8.031ProAla: 8.031 ± 1.326
1.53ProCys: 1.53 ± 0.957
5.354ProAsp: 5.354 ± 1.457
2.677ProGlu: 2.677 ± 1.135
1.912ProPhe: 1.912 ± 1.407
1.912ProGly: 1.912 ± 0.616
0.382ProHis: 0.382 ± 0.332
1.147ProIle: 1.147 ± 0.538
2.294ProLys: 2.294 ± 0.861
6.883ProLeu: 6.883 ± 1.419
0.382ProMet: 0.382 ± 0.446
1.53ProAsn: 1.53 ± 0.788
4.971ProPro: 4.971 ± 1.926
0.765ProGln: 0.765 ± 0.581
3.824ProArg: 3.824 ± 1.532
5.354ProSer: 5.354 ± 1.817
4.589ProThr: 4.589 ± 1.696
5.736ProVal: 5.736 ± 1.463
0.382ProTrp: 0.382 ± 0.332
2.294ProTyr: 2.294 ± 0.877
0.0ProXaa: 0.0 ± 0.0
Gln
4.589GlnAla: 4.589 ± 1.329
0.382GlnCys: 0.382 ± 0.293
1.912GlnAsp: 1.912 ± 0.965
3.059GlnGlu: 3.059 ± 1.271
0.765GlnPhe: 0.765 ± 0.646
4.971GlnGly: 4.971 ± 0.899
0.0GlnHis: 0.0 ± 0.0
2.294GlnIle: 2.294 ± 0.564
1.147GlnLys: 1.147 ± 0.618
3.059GlnLeu: 3.059 ± 0.967
1.147GlnMet: 1.147 ± 0.5
1.53GlnAsn: 1.53 ± 0.523
3.442GlnPro: 3.442 ± 0.57
1.912GlnGln: 1.912 ± 1.23
1.147GlnArg: 1.147 ± 0.485
1.53GlnSer: 1.53 ± 0.72
3.059GlnThr: 3.059 ± 0.982
3.059GlnVal: 3.059 ± 0.73
0.765GlnTrp: 0.765 ± 0.587
0.382GlnTyr: 0.382 ± 0.323
0.0GlnXaa: 0.0 ± 0.0
Arg
4.589ArgAla: 4.589 ± 0.666
2.294ArgCys: 2.294 ± 1.366
1.912ArgAsp: 1.912 ± 1.189
1.912ArgGlu: 1.912 ± 1.065
2.294ArgPhe: 2.294 ± 0.876
3.824ArgGly: 3.824 ± 1.697
3.059ArgHis: 3.059 ± 1.031
0.765ArgIle: 0.765 ± 0.4
5.354ArgLys: 5.354 ± 1.145
4.971ArgLeu: 4.971 ± 1.13
0.382ArgMet: 0.382 ± 0.468
1.53ArgAsn: 1.53 ± 0.99
3.824ArgPro: 3.824 ± 1.203
2.677ArgGln: 2.677 ± 1.341
3.824ArgArg: 3.824 ± 0.631
3.824ArgSer: 3.824 ± 1.148
4.589ArgThr: 4.589 ± 1.126
4.589ArgVal: 4.589 ± 1.107
0.0ArgTrp: 0.0 ± 0.0
4.207ArgTyr: 4.207 ± 0.735
0.0ArgXaa: 0.0 ± 0.0
Ser
3.824SerAla: 3.824 ± 1.339
1.147SerCys: 1.147 ± 0.767
3.442SerAsp: 3.442 ± 0.98
3.824SerGlu: 3.824 ± 0.578
1.912SerPhe: 1.912 ± 1.467
7.266SerGly: 7.266 ± 1.506
2.677SerHis: 2.677 ± 0.732
4.589SerIle: 4.589 ± 1.173
4.207SerLys: 4.207 ± 1.328
8.031SerLeu: 8.031 ± 1.159
1.53SerMet: 1.53 ± 0.835
3.059SerAsn: 3.059 ± 0.769
7.266SerPro: 7.266 ± 2.153
3.442SerGln: 3.442 ± 0.579
4.207SerArg: 4.207 ± 0.73
9.178SerSer: 9.178 ± 1.85
6.119SerThr: 6.119 ± 2.025
4.207SerVal: 4.207 ± 1.209
0.765SerTrp: 0.765 ± 0.386
0.382SerTyr: 0.382 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
4.207ThrAla: 4.207 ± 1.176
1.53ThrCys: 1.53 ± 0.718
3.059ThrAsp: 3.059 ± 1.123
5.736ThrGlu: 5.736 ± 1.049
3.442ThrPhe: 3.442 ± 0.887
4.971ThrGly: 4.971 ± 0.772
1.147ThrHis: 1.147 ± 0.539
2.294ThrIle: 2.294 ± 0.94
0.765ThrLys: 0.765 ± 0.587
5.736ThrLeu: 5.736 ± 1.327
1.147ThrMet: 1.147 ± 0.6
3.059ThrAsn: 3.059 ± 0.701
5.736ThrPro: 5.736 ± 1.076
2.294ThrGln: 2.294 ± 0.716
3.824ThrArg: 3.824 ± 0.993
4.971ThrSer: 4.971 ± 1.227
6.883ThrThr: 6.883 ± 1.194
7.648ThrVal: 7.648 ± 1.394
1.53ThrTrp: 1.53 ± 0.72
2.294ThrTyr: 2.294 ± 0.831
0.0ThrXaa: 0.0 ± 0.0
Val
3.442ValAla: 3.442 ± 1.319
0.765ValCys: 0.765 ± 0.583
3.059ValAsp: 3.059 ± 0.807
2.677ValGlu: 2.677 ± 0.633
3.059ValPhe: 3.059 ± 1.241
2.294ValGly: 2.294 ± 1.095
1.147ValHis: 1.147 ± 0.627
1.912ValIle: 1.912 ± 0.893
3.824ValLys: 3.824 ± 0.968
4.589ValLeu: 4.589 ± 0.821
0.0ValMet: 0.0 ± 0.0
0.382ValAsn: 0.382 ± 0.323
4.207ValPro: 4.207 ± 1.289
4.207ValGln: 4.207 ± 1.213
4.589ValArg: 4.589 ± 0.843
4.207ValSer: 4.207 ± 1.608
4.971ValThr: 4.971 ± 0.913
1.53ValVal: 1.53 ± 0.729
1.147ValTrp: 1.147 ± 0.485
3.442ValTyr: 3.442 ± 0.797
0.0ValXaa: 0.0 ± 0.0
Trp
0.765TrpAla: 0.765 ± 0.36
0.382TrpCys: 0.382 ± 0.467
1.147TrpAsp: 1.147 ± 0.587
0.382TrpGlu: 0.382 ± 0.323
1.912TrpPhe: 1.912 ± 0.718
0.382TrpGly: 0.382 ± 0.293
0.0TrpHis: 0.0 ± 0.0
0.382TrpIle: 0.382 ± 0.293
0.765TrpLys: 0.765 ± 0.587
1.147TrpLeu: 1.147 ± 0.572
0.0TrpMet: 0.0 ± 0.0
0.765TrpAsn: 0.765 ± 0.646
0.0TrpPro: 0.0 ± 0.0
1.53TrpGln: 1.53 ± 0.568
0.382TrpArg: 0.382 ± 0.293
0.765TrpSer: 0.765 ± 0.403
1.147TrpThr: 1.147 ± 0.647
1.912TrpVal: 1.912 ± 0.877
0.0TrpTrp: 0.0 ± 0.0
0.382TrpTyr: 0.382 ± 0.332
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.912TyrAla: 1.912 ± 0.684
0.765TyrCys: 0.765 ± 0.505
1.912TyrAsp: 1.912 ± 0.612
1.912TyrGlu: 1.912 ± 0.637
0.765TyrPhe: 0.765 ± 0.359
1.147TyrGly: 1.147 ± 0.677
1.147TyrHis: 1.147 ± 0.627
0.765TyrIle: 0.765 ± 0.36
0.765TyrLys: 0.765 ± 0.367
3.824TyrLeu: 3.824 ± 1.616
0.765TyrMet: 0.765 ± 0.664
0.765TyrAsn: 0.765 ± 0.479
1.53TyrPro: 1.53 ± 0.758
0.382TyrGln: 0.382 ± 0.293
1.912TyrArg: 1.912 ± 0.633
2.677TyrSer: 2.677 ± 1.208
1.912TyrThr: 1.912 ± 1.155
0.765TyrVal: 0.765 ± 0.646
1.53TyrTrp: 1.53 ± 0.79
1.53TyrTyr: 1.53 ± 0.634
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski