Amino acid dipepetide frequency for Mycoplasma gallinaceum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.622AlaAla: 3.622 ± 0.228
0.28AlaCys: 0.28 ± 0.028
2.624AlaAsp: 2.624 ± 0.114
3.305AlaGlu: 3.305 ± 0.13
2.826AlaPhe: 2.826 ± 0.098
2.448AlaGly: 2.448 ± 0.123
0.867AlaHis: 0.867 ± 0.054
5.679AlaIle: 5.679 ± 0.165
6.422AlaLys: 6.422 ± 0.21
6.184AlaLeu: 6.184 ± 0.25
1.027AlaMet: 1.027 ± 0.064
4.384AlaAsn: 4.384 ± 0.208
1.454AlaPro: 1.454 ± 0.07
2.523AlaGln: 2.523 ± 0.125
1.874AlaArg: 1.874 ± 0.087
4.058AlaSer: 4.058 ± 0.127
3.319AlaThr: 3.319 ± 0.16
2.676AlaVal: 2.676 ± 0.135
0.398AlaTrp: 0.398 ± 0.041
2.119AlaTyr: 2.119 ± 0.103
0.0AlaXaa: 0.0 ± 0.0
Cys
0.28CysAla: 0.28 ± 0.032
0.042CysCys: 0.042 ± 0.012
0.244CysAsp: 0.244 ± 0.032
0.218CysGlu: 0.218 ± 0.026
0.339CysPhe: 0.339 ± 0.039
0.319CysGly: 0.319 ± 0.033
0.085CysHis: 0.085 ± 0.016
0.293CysIle: 0.293 ± 0.035
0.417CysLys: 0.417 ± 0.044
0.502CysLeu: 0.502 ± 0.044
0.062CysMet: 0.062 ± 0.013
0.29CysAsn: 0.29 ± 0.03
0.134CysPro: 0.134 ± 0.017
0.134CysGln: 0.134 ± 0.021
0.098CysArg: 0.098 ± 0.018
0.28CysSer: 0.28 ± 0.033
0.117CysThr: 0.117 ± 0.021
0.241CysVal: 0.241 ± 0.027
0.029CysTrp: 0.029 ± 0.01
0.196CysTyr: 0.196 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.599AspAla: 3.599 ± 0.229
0.189AspCys: 0.189 ± 0.027
2.562AspAsp: 2.562 ± 0.128
4.006AspGlu: 4.006 ± 0.15
3.56AspPhe: 3.56 ± 0.127
2.777AspGly: 2.777 ± 0.114
0.652AspHis: 0.652 ± 0.047
4.316AspIle: 4.316 ± 0.143
5.887AspLys: 5.887 ± 0.168
6.024AspLeu: 6.024 ± 0.167
0.743AspMet: 0.743 ± 0.051
4.221AspAsn: 4.221 ± 0.198
1.874AspPro: 1.874 ± 0.101
2.259AspGln: 2.259 ± 0.107
1.46AspArg: 1.46 ± 0.073
3.941AspSer: 3.941 ± 0.163
2.416AspThr: 2.416 ± 0.103
3.289AspVal: 3.289 ± 0.108
0.492AspTrp: 0.492 ± 0.039
2.579AspTyr: 2.579 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
4.45GluAla: 4.45 ± 0.171
0.225GluCys: 0.225 ± 0.028
3.068GluAsp: 3.068 ± 0.119
5.389GluGlu: 5.389 ± 0.169
3.71GluPhe: 3.71 ± 0.128
2.621GluGly: 2.621 ± 0.127
0.916GluHis: 0.916 ± 0.058
7.054GluIle: 7.054 ± 0.169
7.628GluLys: 7.628 ± 0.212
6.849GluLeu: 6.849 ± 0.171
1.108GluMet: 1.108 ± 0.071
6.256GluAsn: 6.256 ± 0.223
1.33GluPro: 1.33 ± 0.074
3.054GluGln: 3.054 ± 0.111
2.174GluArg: 2.174 ± 0.093
3.674GluSer: 3.674 ± 0.129
3.622GluThr: 3.622 ± 0.115
4.062GluVal: 4.062 ± 0.13
0.531GluTrp: 0.531 ± 0.038
2.937GluTyr: 2.937 ± 0.103
0.0GluXaa: 0.0 ± 0.0
Phe
3.159PheAla: 3.159 ± 0.131
0.313PheCys: 0.313 ± 0.032
3.612PheAsp: 3.612 ± 0.104
3.811PheGlu: 3.811 ± 0.147
2.856PhePhe: 2.856 ± 0.14
2.758PheGly: 2.758 ± 0.128
0.655PheHis: 0.655 ± 0.048
4.665PheIle: 4.665 ± 0.184
4.913PheLys: 4.913 ± 0.173
4.955PheLeu: 4.955 ± 0.175
0.89PheMet: 0.89 ± 0.063
3.964PheAsn: 3.964 ± 0.11
1.209PhePro: 1.209 ± 0.063
1.46PheGln: 1.46 ± 0.07
1.434PheArg: 1.434 ± 0.069
3.664PheSer: 3.664 ± 0.15
2.634PheThr: 2.634 ± 0.111
3.635PheVal: 3.635 ± 0.131
0.639PheTrp: 0.639 ± 0.047
2.279PheTyr: 2.279 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
2.64GlyAla: 2.64 ± 0.127
0.209GlyCys: 0.209 ± 0.025
2.5GlyAsp: 2.5 ± 0.109
2.96GlyGlu: 2.96 ± 0.106
3.015GlyPhe: 3.015 ± 0.111
2.595GlyGly: 2.595 ± 0.139
0.743GlyHis: 0.743 ± 0.055
4.43GlyIle: 4.43 ± 0.159
4.326GlyLys: 4.326 ± 0.182
4.039GlyLeu: 4.039 ± 0.135
0.968GlyMet: 0.968 ± 0.058
2.575GlyAsn: 2.575 ± 0.098
0.88GlyPro: 0.88 ± 0.069
1.519GlyGln: 1.519 ± 0.071
1.5GlyArg: 1.5 ± 0.087
2.989GlySer: 2.989 ± 0.12
2.777GlyThr: 2.777 ± 0.116
3.019GlyVal: 3.019 ± 0.146
0.421GlyTrp: 0.421 ± 0.037
2.314GlyTyr: 2.314 ± 0.098
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.05
0.055HisCys: 0.055 ± 0.012
0.642HisAsp: 0.642 ± 0.049
0.812HisGlu: 0.812 ± 0.055
0.932HisPhe: 0.932 ± 0.053
0.681HisGly: 0.681 ± 0.059
0.225HisHis: 0.225 ± 0.031
1.125HisIle: 1.125 ± 0.071
1.294HisLys: 1.294 ± 0.071
1.447HisLeu: 1.447 ± 0.069
0.222HisMet: 0.222 ± 0.026
0.975HisAsn: 0.975 ± 0.05
0.554HisPro: 0.554 ± 0.046
0.499HisGln: 0.499 ± 0.046
0.359HisArg: 0.359 ± 0.032
0.962HisSer: 0.962 ± 0.059
0.606HisThr: 0.606 ± 0.046
0.658HisVal: 0.658 ± 0.05
0.095HisTrp: 0.095 ± 0.018
0.574HisTyr: 0.574 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.356IleAla: 5.356 ± 0.139
0.629IleCys: 0.629 ± 0.049
5.995IleAsp: 5.995 ± 0.171
5.972IleGlu: 5.972 ± 0.175
4.74IlePhe: 4.74 ± 0.204
4.179IleGly: 4.179 ± 0.184
1.226IleHis: 1.226 ± 0.067
7.074IleIle: 7.074 ± 0.196
8.218IleLys: 8.218 ± 0.197
7.677IleLeu: 7.677 ± 0.244
1.206IleMet: 1.206 ± 0.068
7.23IleAsn: 7.23 ± 0.224
2.354IlePro: 2.354 ± 0.113
2.878IleGln: 2.878 ± 0.098
2.305IleArg: 2.305 ± 0.094
6.679IleSer: 6.679 ± 0.187
4.668IleThr: 4.668 ± 0.14
5.141IleVal: 5.141 ± 0.13
0.724IleTrp: 0.724 ± 0.047
3.416IleTyr: 3.416 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
5.943LysAla: 5.943 ± 0.224
0.293LysCys: 0.293 ± 0.033
5.78LysAsp: 5.78 ± 0.174
8.775LysGlu: 8.775 ± 0.222
4.068LysPhe: 4.068 ± 0.14
3.896LysGly: 3.896 ± 0.158
1.35LysHis: 1.35 ± 0.075
8.707LysIle: 8.707 ± 0.202
8.577LysLys: 8.577 ± 0.225
9.095LysLeu: 9.095 ± 0.197
2.5LysMet: 2.5 ± 0.118
8.335LysAsn: 8.335 ± 0.241
2.272LysPro: 2.272 ± 0.099
3.628LysGln: 3.628 ± 0.129
2.986LysArg: 2.986 ± 0.123
5.447LysSer: 5.447 ± 0.155
5.45LysThr: 5.45 ± 0.177
5.93LysVal: 5.93 ± 0.153
1.004LysTrp: 1.004 ± 0.047
4.616LysTyr: 4.616 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
5.519LeuAla: 5.519 ± 0.138
0.518LeuCys: 0.518 ± 0.05
6.099LeuAsp: 6.099 ± 0.161
7.022LeuGlu: 7.022 ± 0.191
4.834LeuPhe: 4.834 ± 0.221
4.231LeuGly: 4.231 ± 0.164
1.138LeuHis: 1.138 ± 0.063
8.616LeuIle: 8.616 ± 0.218
9.366LeuLys: 9.366 ± 0.222
7.706LeuLeu: 7.706 ± 0.219
1.467LeuMet: 1.467 ± 0.078
8.12LeuAsn: 8.12 ± 0.261
2.722LeuPro: 2.722 ± 0.105
2.647LeuGln: 2.647 ± 0.095
2.601LeuArg: 2.601 ± 0.104
7.273LeuSer: 7.273 ± 0.146
5.3LeuThr: 5.3 ± 0.182
5.578LeuVal: 5.578 ± 0.152
0.717LeuTrp: 0.717 ± 0.047
2.97LeuTyr: 2.97 ± 0.122
0.0LeuXaa: 0.0 ± 0.0
Met
1.089MetAla: 1.089 ± 0.08
0.108MetCys: 0.108 ± 0.017
0.861MetAsp: 0.861 ± 0.058
0.87MetGlu: 0.87 ± 0.063
0.848MetPhe: 0.848 ± 0.063
0.73MetGly: 0.73 ± 0.055
0.293MetHis: 0.293 ± 0.03
1.464MetIle: 1.464 ± 0.09
1.852MetLys: 1.852 ± 0.073
1.571MetLeu: 1.571 ± 0.089
0.319MetMet: 0.319 ± 0.033
1.161MetAsn: 1.161 ± 0.066
0.681MetPro: 0.681 ± 0.053
0.681MetGln: 0.681 ± 0.047
0.584MetArg: 0.584 ± 0.043
1.239MetSer: 1.239 ± 0.069
0.805MetThr: 0.805 ± 0.056
0.906MetVal: 0.906 ± 0.067
0.114MetTrp: 0.114 ± 0.017
0.561MetTyr: 0.561 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
4.557AsnAla: 4.557 ± 0.25
0.215AsnCys: 0.215 ± 0.026
4.714AsnAsp: 4.714 ± 0.21
5.662AsnGlu: 5.662 ± 0.163
4.013AsnPhe: 4.013 ± 0.129
3.931AsnGly: 3.931 ± 0.133
0.978AsnHis: 0.978 ± 0.057
6.109AsnIle: 6.109 ± 0.174
8.042AsnLys: 8.042 ± 0.214
8.332AsnLeu: 8.332 ± 0.247
1.105AsnMet: 1.105 ± 0.065
6.771AsnAsn: 6.771 ± 0.391
2.732AsnPro: 2.732 ± 0.114
3.208AsnGln: 3.208 ± 0.188
2.047AsnArg: 2.047 ± 0.092
5.555AsnSer: 5.555 ± 0.222
3.586AsnThr: 3.586 ± 0.158
4.192AsnVal: 4.192 ± 0.136
0.88AsnTrp: 0.88 ± 0.053
3.322AsnTyr: 3.322 ± 0.12
0.0AsnXaa: 0.0 ± 0.0
Pro
1.415ProAla: 1.415 ± 0.074
0.055ProCys: 0.055 ± 0.015
1.395ProAsp: 1.395 ± 0.071
2.207ProGlu: 2.207 ± 0.09
1.447ProPhe: 1.447 ± 0.084
1.353ProGly: 1.353 ± 0.075
0.372ProHis: 0.372 ± 0.035
2.318ProIle: 2.318 ± 0.099
2.337ProLys: 2.337 ± 0.088
2.119ProLeu: 2.119 ± 0.082
0.424ProMet: 0.424 ± 0.042
2.22ProAsn: 2.22 ± 0.093
0.329ProPro: 0.329 ± 0.037
0.75ProGln: 0.75 ± 0.048
0.756ProArg: 0.756 ± 0.052
2.145ProSer: 2.145 ± 0.094
1.503ProThr: 1.503 ± 0.085
1.526ProVal: 1.526 ± 0.084
0.254ProTrp: 0.254 ± 0.026
1.154ProTyr: 1.154 ± 0.072
0.0ProXaa: 0.0 ± 0.0
Gln
2.067GlnAla: 2.067 ± 0.121
0.072GlnCys: 0.072 ± 0.014
1.816GlnAsp: 1.816 ± 0.086
2.667GlnGlu: 2.667 ± 0.111
1.522GlnPhe: 1.522 ± 0.077
1.379GlnGly: 1.379 ± 0.07
0.316GlnHis: 0.316 ± 0.032
3.944GlnIle: 3.944 ± 0.135
4.267GlnLys: 4.267 ± 0.127
3.068GlnLeu: 3.068 ± 0.107
0.724GlnMet: 0.724 ± 0.075
3.543GlnAsn: 3.543 ± 0.164
0.672GlnPro: 0.672 ± 0.046
1.024GlnGln: 1.024 ± 0.071
1.252GlnArg: 1.252 ± 0.076
2.041GlnSer: 2.041 ± 0.084
1.623GlnThr: 1.623 ± 0.093
1.819GlnVal: 1.819 ± 0.087
0.391GlnTrp: 0.391 ± 0.036
1.346GlnTyr: 1.346 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
1.451ArgAla: 1.451 ± 0.078
0.091ArgCys: 0.091 ± 0.015
1.659ArgAsp: 1.659 ± 0.081
2.331ArgGlu: 2.331 ± 0.104
1.535ArgPhe: 1.535 ± 0.083
1.363ArgGly: 1.363 ± 0.083
0.359ArgHis: 0.359 ± 0.038
2.592ArgIle: 2.592 ± 0.108
2.963ArgLys: 2.963 ± 0.124
2.644ArgLeu: 2.644 ± 0.099
0.665ArgMet: 0.665 ± 0.053
2.233ArgAsn: 2.233 ± 0.091
0.76ArgPro: 0.76 ± 0.053
1.046ArgGln: 1.046 ± 0.058
1.05ArgArg: 1.05 ± 0.062
1.711ArgSer: 1.711 ± 0.083
1.509ArgThr: 1.509 ± 0.075
1.669ArgVal: 1.669 ± 0.083
0.235ArgTrp: 0.235 ± 0.029
1.366ArgTyr: 1.366 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
3.273SerAla: 3.273 ± 0.112
0.326SerCys: 0.326 ± 0.031
3.886SerAsp: 3.886 ± 0.155
4.486SerGlu: 4.486 ± 0.154
4.173SerPhe: 4.173 ± 0.144
3.563SerGly: 3.563 ± 0.12
0.998SerHis: 0.998 ± 0.055
5.545SerIle: 5.545 ± 0.162
6.842SerLys: 6.842 ± 0.161
6.797SerLeu: 6.797 ± 0.161
1.011SerMet: 1.011 ± 0.059
5.242SerAsn: 5.242 ± 0.209
1.617SerPro: 1.617 ± 0.068
2.582SerGln: 2.582 ± 0.118
1.861SerArg: 1.861 ± 0.074
5.287SerSer: 5.287 ± 0.163
3.42SerThr: 3.42 ± 0.176
3.853SerVal: 3.853 ± 0.131
0.688SerTrp: 0.688 ± 0.054
3.045SerTyr: 3.045 ± 0.096
0.0SerXaa: 0.0 ± 0.0
Thr
2.393ThrAla: 2.393 ± 0.109
0.166ThrCys: 0.166 ± 0.024
2.732ThrAsp: 2.732 ± 0.136
3.058ThrGlu: 3.058 ± 0.14
2.921ThrPhe: 2.921 ± 0.106
2.644ThrGly: 2.644 ± 0.144
0.747ThrHis: 0.747 ± 0.054
4.955ThrIle: 4.955 ± 0.143
5.023ThrLys: 5.023 ± 0.148
5.079ThrLeu: 5.079 ± 0.129
0.691ThrMet: 0.691 ± 0.049
4.417ThrAsn: 4.417 ± 0.25
1.659ThrPro: 1.659 ± 0.089
1.809ThrGln: 1.809 ± 0.094
1.601ThrArg: 1.601 ± 0.076
3.592ThrSer: 3.592 ± 0.118
3.035ThrThr: 3.035 ± 0.127
2.797ThrVal: 2.797 ± 0.126
0.482ThrTrp: 0.482 ± 0.042
2.106ThrTyr: 2.106 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
4.107ValAla: 4.107 ± 0.122
0.277ValCys: 0.277 ± 0.036
3.576ValAsp: 3.576 ± 0.122
3.674ValGlu: 3.674 ± 0.132
3.335ValPhe: 3.335 ± 0.139
2.579ValGly: 2.579 ± 0.132
0.74ValHis: 0.74 ± 0.051
4.952ValIle: 4.952 ± 0.139
5.111ValLys: 5.111 ± 0.162
5.268ValLeu: 5.268 ± 0.169
0.795ValMet: 0.795 ± 0.063
4.15ValAsn: 4.15 ± 0.133
1.561ValPro: 1.561 ± 0.088
1.839ValGln: 1.839 ± 0.094
1.568ValArg: 1.568 ± 0.077
4.44ValSer: 4.44 ± 0.123
2.944ValThr: 2.944 ± 0.112
3.918ValVal: 3.918 ± 0.143
0.398ValTrp: 0.398 ± 0.039
2.308ValTyr: 2.308 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.482TrpAla: 0.482 ± 0.043
0.072TrpCys: 0.072 ± 0.017
0.551TrpAsp: 0.551 ± 0.042
0.694TrpGlu: 0.694 ± 0.048
0.489TrpPhe: 0.489 ± 0.047
0.424TrpGly: 0.424 ± 0.043
0.091TrpHis: 0.091 ± 0.019
0.861TrpIle: 0.861 ± 0.061
0.861TrpLys: 0.861 ± 0.058
0.773TrpLeu: 0.773 ± 0.049
0.186TrpMet: 0.186 ± 0.024
0.733TrpAsn: 0.733 ± 0.055
0.16TrpPro: 0.16 ± 0.025
0.274TrpGln: 0.274 ± 0.031
0.222TrpArg: 0.222 ± 0.028
0.58TrpSer: 0.58 ± 0.047
0.61TrpThr: 0.61 ± 0.05
0.499TrpVal: 0.499 ± 0.041
0.117TrpTrp: 0.117 ± 0.02
0.421TrpTyr: 0.421 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.008TyrAla: 2.008 ± 0.077
0.186TyrCys: 0.186 ± 0.026
2.533TyrAsp: 2.533 ± 0.102
2.738TyrGlu: 2.738 ± 0.088
2.341TyrPhe: 2.341 ± 0.109
1.949TyrGly: 1.949 ± 0.096
0.649TyrHis: 0.649 ± 0.048
2.97TyrIle: 2.97 ± 0.102
4.306TyrLys: 4.306 ± 0.146
4.316TyrLeu: 4.316 ± 0.134
0.619TyrMet: 0.619 ± 0.056
3.133TyrAsn: 3.133 ± 0.113
1.125TyrPro: 1.125 ± 0.061
1.737TyrGln: 1.737 ± 0.082
1.5TyrArg: 1.5 ± 0.067
2.934TyrSer: 2.934 ± 0.11
1.962TyrThr: 1.962 ± 0.119
2.132TyrVal: 2.132 ± 0.088
0.489TyrTrp: 0.489 ± 0.041
1.786TyrTyr: 1.786 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 768 proteins (306765 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski