Amino acid dipepetide frequency for Bifidobacterium indicum LMG 11587 = DSM 20214

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.551AlaAla: 10.551 ± 0.196
0.934AlaCys: 0.934 ± 0.044
6.5AlaAsp: 6.5 ± 0.111
5.089AlaGlu: 5.089 ± 0.122
3.109AlaPhe: 3.109 ± 0.084
9.018AlaGly: 9.018 ± 0.172
1.789AlaHis: 1.789 ± 0.06
5.038AlaIle: 5.038 ± 0.113
4.006AlaLys: 4.006 ± 0.096
10.003AlaLeu: 10.003 ± 0.178
2.806AlaMet: 2.806 ± 0.078
2.577AlaAsn: 2.577 ± 0.079
4.0AlaPro: 4.0 ± 0.112
4.191AlaGln: 4.191 ± 0.106
6.303AlaArg: 6.303 ± 0.13
6.183AlaSer: 6.183 ± 0.126
5.097AlaThr: 5.097 ± 0.107
7.288AlaVal: 7.288 ± 0.13
1.486AlaTrp: 1.486 ± 0.064
2.429AlaTyr: 2.429 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.853CysAla: 0.853 ± 0.05
0.083CysCys: 0.083 ± 0.013
0.445CysAsp: 0.445 ± 0.032
0.363CysGlu: 0.363 ± 0.031
0.246CysPhe: 0.246 ± 0.021
0.932CysGly: 0.932 ± 0.044
0.179CysHis: 0.179 ± 0.02
0.431CysIle: 0.431 ± 0.027
0.219CysLys: 0.219 ± 0.019
0.932CysLeu: 0.932 ± 0.056
0.234CysMet: 0.234 ± 0.02
0.189CysAsn: 0.189 ± 0.019
0.473CysPro: 0.473 ± 0.03
0.329CysGln: 0.329 ± 0.026
0.585CysArg: 0.585 ± 0.037
0.589CysSer: 0.589 ± 0.041
0.483CysThr: 0.483 ± 0.036
0.556CysVal: 0.556 ± 0.036
0.099CysTrp: 0.099 ± 0.014
0.191CysTyr: 0.191 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.82AspAla: 5.82 ± 0.107
0.52AspCys: 0.52 ± 0.034
4.345AspAsp: 4.345 ± 0.118
4.24AspGlu: 4.24 ± 0.112
2.268AspPhe: 2.268 ± 0.066
5.982AspGly: 5.982 ± 0.171
1.503AspHis: 1.503 ± 0.055
2.993AspIle: 2.993 ± 0.082
2.488AspLys: 2.488 ± 0.076
6.778AspLeu: 6.778 ± 0.129
1.85AspMet: 1.85 ± 0.059
1.482AspAsn: 1.482 ± 0.068
3.911AspPro: 3.911 ± 0.092
3.708AspGln: 3.708 ± 0.098
4.815AspArg: 4.815 ± 0.121
3.891AspSer: 3.891 ± 0.092
3.578AspThr: 3.578 ± 0.117
4.201AspVal: 4.201 ± 0.092
1.003AspTrp: 1.003 ± 0.048
1.89AspTyr: 1.89 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.986GluAla: 5.986 ± 0.13
0.37GluCys: 0.37 ± 0.027
3.74GluAsp: 3.74 ± 0.117
4.09GluGlu: 4.09 ± 0.113
1.574GluPhe: 1.574 ± 0.059
4.739GluGly: 4.739 ± 0.112
1.413GluHis: 1.413 ± 0.055
2.364GluIle: 2.364 ± 0.073
2.027GluLys: 2.027 ± 0.074
4.707GluLeu: 4.707 ± 0.104
1.432GluMet: 1.432 ± 0.059
1.598GluAsn: 1.598 ± 0.057
2.585GluPro: 2.585 ± 0.078
2.461GluGln: 2.461 ± 0.081
3.834GluArg: 3.834 ± 0.122
3.558GluSer: 3.558 ± 0.097
3.064GluThr: 3.064 ± 0.085
3.844GluVal: 3.844 ± 0.111
0.577GluTrp: 0.577 ± 0.038
1.397GluTyr: 1.397 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.018PheAla: 3.018 ± 0.076
0.311PheCys: 0.311 ± 0.026
2.455PheAsp: 2.455 ± 0.076
1.657PheGlu: 1.657 ± 0.062
1.178PhePhe: 1.178 ± 0.055
3.011PheGly: 3.011 ± 0.086
0.656PheHis: 0.656 ± 0.039
1.736PheIle: 1.736 ± 0.062
1.082PheLys: 1.082 ± 0.047
2.883PheLeu: 2.883 ± 0.085
0.865PheMet: 0.865 ± 0.045
1.135PheAsn: 1.135 ± 0.052
1.369PhePro: 1.369 ± 0.058
1.125PheGln: 1.125 ± 0.044
1.718PheArg: 1.718 ± 0.065
2.169PheSer: 2.169 ± 0.072
2.161PheThr: 2.161 ± 0.076
2.146PheVal: 2.146 ± 0.064
0.467PheTrp: 0.467 ± 0.03
0.808PheTyr: 0.808 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.245GlyAla: 7.245 ± 0.152
0.796GlyCys: 0.796 ± 0.043
5.141GlyAsp: 5.141 ± 0.136
4.248GlyGlu: 4.248 ± 0.115
3.212GlyPhe: 3.212 ± 0.081
6.593GlyGly: 6.593 ± 0.135
2.077GlyHis: 2.077 ± 0.069
5.036GlyIle: 5.036 ± 0.11
3.895GlyLys: 3.895 ± 0.099
8.35GlyLeu: 8.35 ± 0.119
2.453GlyMet: 2.453 ± 0.071
2.883GlyAsn: 2.883 ± 0.087
3.436GlyPro: 3.436 ± 0.088
3.954GlyGln: 3.954 ± 0.101
6.199GlyArg: 6.199 ± 0.14
6.281GlySer: 6.281 ± 0.134
5.318GlyThr: 5.318 ± 0.146
5.812GlyVal: 5.812 ± 0.118
1.387GlyTrp: 1.387 ± 0.063
2.51GlyTyr: 2.51 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.712HisAla: 1.712 ± 0.061
0.171HisCys: 0.171 ± 0.02
1.466HisAsp: 1.466 ± 0.058
1.066HisGlu: 1.066 ± 0.049
0.65HisPhe: 0.65 ± 0.039
1.921HisGly: 1.921 ± 0.067
0.556HisHis: 0.556 ± 0.039
1.058HisIle: 1.058 ± 0.043
0.629HisLys: 0.629 ± 0.032
1.882HisLeu: 1.882 ± 0.062
0.516HisMet: 0.516 ± 0.035
0.585HisAsn: 0.585 ± 0.033
1.454HisPro: 1.454 ± 0.061
0.881HisGln: 0.881 ± 0.042
1.527HisArg: 1.527 ± 0.053
1.22HisSer: 1.22 ± 0.045
1.261HisThr: 1.261 ± 0.058
1.45HisVal: 1.45 ± 0.05
0.333HisTrp: 0.333 ± 0.029
0.597HisTyr: 0.597 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
4.928IleAla: 4.928 ± 0.103
0.619IleCys: 0.619 ± 0.04
3.816IleAsp: 3.816 ± 0.091
2.78IleGlu: 2.78 ± 0.086
1.738IlePhe: 1.738 ± 0.072
4.345IleGly: 4.345 ± 0.096
1.109IleHis: 1.109 ± 0.047
2.705IleIle: 2.705 ± 0.089
1.714IleLys: 1.714 ± 0.064
4.876IleLeu: 4.876 ± 0.099
1.233IleMet: 1.233 ± 0.052
1.763IleAsn: 1.763 ± 0.06
2.81IlePro: 2.81 ± 0.074
1.687IleGln: 1.687 ± 0.058
3.292IleArg: 3.292 ± 0.088
3.592IleSer: 3.592 ± 0.089
2.827IleThr: 2.827 ± 0.071
3.915IleVal: 3.915 ± 0.089
0.737IleTrp: 0.737 ± 0.043
1.196IleTyr: 1.196 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.713LysAla: 4.713 ± 0.122
0.144LysCys: 0.144 ± 0.018
2.628LysAsp: 2.628 ± 0.084
2.443LysGlu: 2.443 ± 0.074
0.697LysPhe: 0.697 ± 0.04
3.184LysGly: 3.184 ± 0.09
0.674LysHis: 0.674 ± 0.035
1.604LysIle: 1.604 ± 0.061
1.551LysLys: 1.551 ± 0.078
2.508LysLeu: 2.508 ± 0.081
0.8LysMet: 0.8 ± 0.038
1.135LysAsn: 1.135 ± 0.051
2.179LysPro: 2.179 ± 0.063
1.375LysGln: 1.375 ± 0.054
2.201LysArg: 2.201 ± 0.066
2.341LysSer: 2.341 ± 0.085
2.416LysThr: 2.416 ± 0.081
3.05LysVal: 3.05 ± 0.089
0.4LysTrp: 0.4 ± 0.029
0.829LysTyr: 0.829 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.24LeuAla: 10.24 ± 0.162
0.833LeuCys: 0.833 ± 0.045
6.725LeuAsp: 6.725 ± 0.144
4.735LeuGlu: 4.735 ± 0.113
2.847LeuPhe: 2.847 ± 0.091
8.133LeuGly: 8.133 ± 0.166
1.826LeuHis: 1.826 ± 0.065
4.959LeuIle: 4.959 ± 0.121
3.296LeuLys: 3.296 ± 0.094
8.252LeuLeu: 8.252 ± 0.182
2.254LeuMet: 2.254 ± 0.072
2.8LeuAsn: 2.8 ± 0.067
4.863LeuPro: 4.863 ± 0.103
2.601LeuGln: 2.601 ± 0.083
5.186LeuArg: 5.186 ± 0.121
6.189LeuSer: 6.189 ± 0.12
5.964LeuThr: 5.964 ± 0.108
7.995LeuVal: 7.995 ± 0.188
0.92LeuTrp: 0.92 ± 0.043
2.006LeuTyr: 2.006 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
3.147MetAla: 3.147 ± 0.077
0.183MetCys: 0.183 ± 0.023
1.759MetAsp: 1.759 ± 0.063
1.391MetGlu: 1.391 ± 0.058
0.656MetPhe: 0.656 ± 0.035
2.175MetGly: 2.175 ± 0.063
0.51MetHis: 0.51 ± 0.033
1.283MetIle: 1.283 ± 0.052
0.969MetLys: 0.969 ± 0.041
2.087MetLeu: 2.087 ± 0.071
0.642MetMet: 0.642 ± 0.041
0.851MetAsn: 0.851 ± 0.037
1.474MetPro: 1.474 ± 0.05
0.812MetGln: 0.812 ± 0.041
1.525MetArg: 1.525 ± 0.055
1.88MetSer: 1.88 ± 0.061
1.958MetThr: 1.958 ± 0.07
2.124MetVal: 2.124 ± 0.072
0.191MetTrp: 0.191 ± 0.017
0.441MetTyr: 0.441 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.589AsnAla: 2.589 ± 0.071
0.232AsnCys: 0.232 ± 0.022
1.789AsnAsp: 1.789 ± 0.057
1.458AsnGlu: 1.458 ± 0.056
0.826AsnPhe: 0.826 ± 0.048
2.753AsnGly: 2.753 ± 0.086
0.696AsnHis: 0.696 ± 0.041
1.36AsnIle: 1.36 ± 0.049
1.117AsnLys: 1.117 ± 0.05
2.969AsnLeu: 2.969 ± 0.084
0.703AsnMet: 0.703 ± 0.037
0.816AsnAsn: 0.816 ± 0.046
2.431AsnPro: 2.431 ± 0.071
1.444AsnGln: 1.444 ± 0.053
2.142AsnArg: 2.142 ± 0.069
1.61AsnSer: 1.61 ± 0.071
1.754AsnThr: 1.754 ± 0.07
1.667AsnVal: 1.667 ± 0.06
0.42AsnTrp: 0.42 ± 0.029
0.707AsnTyr: 0.707 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.788ProAla: 4.788 ± 0.12
0.335ProCys: 0.335 ± 0.027
4.258ProAsp: 4.258 ± 0.089
3.604ProGlu: 3.604 ± 0.083
1.43ProPhe: 1.43 ± 0.056
4.575ProGly: 4.575 ± 0.11
0.975ProHis: 0.975 ± 0.046
2.402ProIle: 2.402 ± 0.066
1.694ProLys: 1.694 ± 0.062
4.238ProLeu: 4.238 ± 0.101
1.135ProMet: 1.135 ± 0.052
1.354ProAsn: 1.354 ± 0.057
1.492ProPro: 1.492 ± 0.063
1.951ProGln: 1.951 ± 0.07
2.577ProArg: 2.577 ± 0.072
3.401ProSer: 3.401 ± 0.085
3.072ProThr: 3.072 ± 0.104
4.228ProVal: 4.228 ± 0.113
0.686ProTrp: 0.686 ± 0.037
1.354ProTyr: 1.354 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
5.17GlnAla: 5.17 ± 0.136
0.201GlnCys: 0.201 ± 0.019
2.658GlnAsp: 2.658 ± 0.078
2.743GlnGlu: 2.743 ± 0.091
0.94GlnPhe: 0.94 ± 0.047
3.716GlnGly: 3.716 ± 0.092
0.674GlnHis: 0.674 ± 0.037
2.033GlnIle: 2.033 ± 0.061
1.107GlnLys: 1.107 ± 0.053
3.198GlnLeu: 3.198 ± 0.087
0.967GlnMet: 0.967 ± 0.045
1.111GlnAsn: 1.111 ± 0.052
1.87GlnPro: 1.87 ± 0.079
1.56GlnGln: 1.56 ± 0.064
2.199GlnArg: 2.199 ± 0.068
2.291GlnSer: 2.291 ± 0.074
2.286GlnThr: 2.286 ± 0.072
3.913GlnVal: 3.913 ± 0.089
0.522GlnTrp: 0.522 ± 0.035
0.983GlnTyr: 0.983 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
5.133ArgAla: 5.133 ± 0.105
0.455ArgCys: 0.455 ± 0.03
3.673ArgAsp: 3.673 ± 0.095
3.541ArgGlu: 3.541 ± 0.092
2.404ArgPhe: 2.404 ± 0.083
4.205ArgGly: 4.205 ± 0.108
1.622ArgHis: 1.622 ± 0.059
3.982ArgIle: 3.982 ± 0.087
2.634ArgLys: 2.634 ± 0.074
5.988ArgLeu: 5.988 ± 0.113
1.913ArgMet: 1.913 ± 0.056
2.055ArgAsn: 2.055 ± 0.064
3.127ArgPro: 3.127 ± 0.1
3.182ArgGln: 3.182 ± 0.093
4.902ArgArg: 4.902 ± 0.161
4.159ArgSer: 4.159 ± 0.111
3.876ArgThr: 3.876 ± 0.091
4.65ArgVal: 4.65 ± 0.107
0.916ArgTrp: 0.916 ± 0.039
1.933ArgTyr: 1.933 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.982SerAla: 5.982 ± 0.099
0.502SerCys: 0.502 ± 0.035
4.199SerAsp: 4.199 ± 0.098
3.145SerGlu: 3.145 ± 0.08
2.183SerPhe: 2.183 ± 0.066
6.352SerGly: 6.352 ± 0.13
1.293SerHis: 1.293 ± 0.053
3.403SerIle: 3.403 ± 0.096
2.534SerLys: 2.534 ± 0.078
6.36SerLeu: 6.36 ± 0.13
1.85SerMet: 1.85 ± 0.062
1.951SerAsn: 1.951 ± 0.067
3.099SerPro: 3.099 ± 0.086
2.802SerGln: 2.802 ± 0.091
4.317SerArg: 4.317 ± 0.108
4.583SerSer: 4.583 ± 0.148
3.866SerThr: 3.866 ± 0.11
4.705SerVal: 4.705 ± 0.103
0.932SerTrp: 0.932 ± 0.049
1.649SerTyr: 1.649 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
5.552ThrAla: 5.552 ± 0.145
0.475ThrCys: 0.475 ± 0.035
3.848ThrAsp: 3.848 ± 0.094
2.691ThrGlu: 2.691 ± 0.08
1.886ThrPhe: 1.886 ± 0.072
5.68ThrGly: 5.68 ± 0.134
1.178ThrHis: 1.178 ± 0.045
3.332ThrIle: 3.332 ± 0.091
2.067ThrLys: 2.067 ± 0.075
5.495ThrLeu: 5.495 ± 0.107
1.497ThrMet: 1.497 ± 0.053
1.752ThrAsn: 1.752 ± 0.072
3.554ThrPro: 3.554 ± 0.136
2.002ThrGln: 2.002 ± 0.068
3.46ThrArg: 3.46 ± 0.078
3.943ThrSer: 3.943 ± 0.103
3.746ThrThr: 3.746 ± 0.125
4.999ThrVal: 4.999 ± 0.107
0.983ThrTrp: 0.983 ± 0.07
1.622ThrTyr: 1.622 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
7.355ValAla: 7.355 ± 0.131
0.849ValCys: 0.849 ± 0.047
5.371ValAsp: 5.371 ± 0.131
4.138ValGlu: 4.138 ± 0.101
2.668ValPhe: 2.668 ± 0.078
5.824ValGly: 5.824 ± 0.125
1.377ValHis: 1.377 ± 0.064
4.142ValIle: 4.142 ± 0.086
2.52ValLys: 2.52 ± 0.068
7.322ValLeu: 7.322 ± 0.138
1.919ValMet: 1.919 ± 0.076
2.193ValAsn: 2.193 ± 0.066
3.724ValPro: 3.724 ± 0.097
2.345ValGln: 2.345 ± 0.071
4.743ValArg: 4.743 ± 0.093
5.34ValSer: 5.34 ± 0.1
4.64ValThr: 4.64 ± 0.115
6.376ValVal: 6.376 ± 0.127
0.958ValTrp: 0.958 ± 0.052
1.758ValTyr: 1.758 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
1.086TrpAla: 1.086 ± 0.043
0.144TrpCys: 0.144 ± 0.016
0.745TrpAsp: 0.745 ± 0.042
0.581TrpGlu: 0.581 ± 0.035
0.54TrpPhe: 0.54 ± 0.036
1.271TrpGly: 1.271 ± 0.106
0.329TrpHis: 0.329 ± 0.029
0.739TrpIle: 0.739 ± 0.041
0.528TrpLys: 0.528 ± 0.035
1.316TrpLeu: 1.316 ± 0.051
0.406TrpMet: 0.406 ± 0.028
0.516TrpAsn: 0.516 ± 0.035
0.502TrpPro: 0.502 ± 0.033
0.603TrpGln: 0.603 ± 0.037
0.906TrpArg: 0.906 ± 0.045
0.918TrpSer: 0.918 ± 0.043
0.932TrpThr: 0.932 ± 0.069
0.924TrpVal: 0.924 ± 0.045
0.254TrpTrp: 0.254 ± 0.026
0.404TrpTyr: 0.404 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.07
0.252TyrCys: 0.252 ± 0.02
1.706TyrAsp: 1.706 ± 0.067
1.361TyrGlu: 1.361 ± 0.061
0.898TyrPhe: 0.898 ± 0.045
2.418TyrGly: 2.418 ± 0.077
0.498TyrHis: 0.498 ± 0.032
1.084TyrIle: 1.084 ± 0.053
0.794TyrLys: 0.794 ± 0.049
2.481TyrLeu: 2.481 ± 0.077
0.579TyrMet: 0.579 ± 0.036
0.737TyrAsn: 0.737 ± 0.043
1.194TyrPro: 1.194 ± 0.055
1.131TyrGln: 1.131 ± 0.049
1.917TyrArg: 1.917 ± 0.072
1.568TyrSer: 1.568 ± 0.051
1.464TyrThr: 1.464 ± 0.059
1.716TyrVal: 1.716 ± 0.061
0.374TyrTrp: 0.374 ± 0.025
0.725TyrTyr: 0.725 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1350 proteins (507539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski