Amino acid dipepetide frequency for Rubella virus (strain Therien) (RUBV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.453AlaAla: 20.453 ± 3.229
4.72AlaCys: 4.72 ± 0.952
5.035AlaAsp: 5.035 ± 1.127
5.349AlaGlu: 5.349 ± 1.287
4.405AlaPhe: 4.405 ± 0.327
12.901AlaGly: 12.901 ± 2.258
3.461AlaHis: 3.461 ± 0.634
3.461AlaIle: 3.461 ± 0.805
1.573AlaLys: 1.573 ± 0.322
15.733AlaLeu: 15.733 ± 2.263
1.573AlaMet: 1.573 ± 0.322
3.147AlaAsn: 3.147 ± 0.644
10.699AlaPro: 10.699 ± 3.182
5.349AlaGln: 5.349 ± 0.808
11.328AlaArg: 11.328 ± 1.936
5.979AlaSer: 5.979 ± 0.311
8.811AlaThr: 8.811 ± 0.786
7.552AlaVal: 7.552 ± 0.491
2.832AlaTrp: 2.832 ± 0.964
4.405AlaTyr: 4.405 ± 0.806
0.0AlaXaa: 0.0 ± 0.0
Cys
6.923CysAla: 6.923 ± 0.65
0.315CysCys: 0.315 ± 0.319
0.629CysAsp: 0.629 ± 0.321
2.203CysGlu: 2.203 ± 0.316
0.315CysPhe: 0.315 ± 0.319
5.035CysGly: 5.035 ± 1.272
2.203CysHis: 2.203 ± 0.796
0.629CysIle: 0.629 ± 0.159
0.629CysLys: 0.629 ± 0.321
0.944CysLeu: 0.944 ± 0.001
0.315CysMet: 0.315 ± 0.16
0.944CysAsn: 0.944 ± 0.478
2.517CysPro: 2.517 ± 0.803
0.629CysGln: 0.629 ± 0.159
3.461CysArg: 3.461 ± 0.325
0.944CysSer: 0.944 ± 0.478
2.203CysThr: 2.203 ± 0.163
1.573CysVal: 1.573 ± 0.158
0.944CysTrp: 0.944 ± 0.001
0.629CysTyr: 0.629 ± 0.639
0.0CysXaa: 0.0 ± 0.0
Asp
5.979AspAla: 5.979 ± 2.088
1.573AspCys: 1.573 ± 0.322
2.517AspAsp: 2.517 ± 0.324
1.888AspGlu: 1.888 ± 0.483
1.573AspPhe: 1.573 ± 0.158
4.72AspGly: 4.72 ± 0.007
1.888AspHis: 1.888 ± 0.483
1.573AspIle: 1.573 ± 0.802
0.0AspLys: 0.0 ± 0.0
4.72AspLeu: 4.72 ± 0.007
1.259AspMet: 1.259 ± 0.271
0.0AspAsn: 0.0 ± 0.0
5.979AspPro: 5.979 ± 0.169
0.315AspGln: 0.315 ± 0.16
4.72AspArg: 4.72 ± 1.446
2.203AspSer: 2.203 ± 1.276
2.832AspThr: 2.832 ± 0.004
4.091AspVal: 4.091 ± 0.646
1.259AspTrp: 1.259 ± 0.798
1.259AspTyr: 1.259 ± 0.642
0.0AspXaa: 0.0 ± 0.0
Glu
5.664GluAla: 5.664 ± 0.488
0.0GluCys: 0.0 ± 0.0
4.405GluAsp: 4.405 ± 0.327
2.517GluGlu: 2.517 ± 0.324
0.315GluPhe: 0.315 ± 0.16
4.091GluGly: 4.091 ± 0.166
1.259GluHis: 1.259 ± 0.318
2.203GluIle: 2.203 ± 0.643
0.315GluLys: 0.315 ± 0.16
5.035GluLeu: 5.035 ± 0.647
0.629GluMet: 0.629 ± 0.159
0.0GluAsn: 0.0 ± 0.0
3.147GluPro: 3.147 ± 0.644
1.259GluGln: 1.259 ± 0.162
6.923GluArg: 6.923 ± 1.61
1.259GluSer: 1.259 ± 0.318
2.517GluThr: 2.517 ± 0.636
5.979GluVal: 5.979 ± 1.608
2.203GluTrp: 2.203 ± 0.163
0.629GluTyr: 0.629 ± 0.159
0.0GluXaa: 0.0 ± 0.0
Phe
2.517PheAla: 2.517 ± 0.324
0.944PheCys: 0.944 ± 0.001
1.259PheAsp: 1.259 ± 0.642
0.629PheGlu: 0.629 ± 0.159
0.315PhePhe: 0.315 ± 0.16
1.573PheGly: 1.573 ± 0.637
0.944PheHis: 0.944 ± 0.001
0.0PheIle: 0.0 ± 0.0
0.944PheLys: 0.944 ± 0.001
2.517PheLeu: 2.517 ± 0.156
0.315PheMet: 0.315 ± 0.319
0.315PheAsn: 0.315 ± 0.319
0.944PhePro: 0.944 ± 0.001
0.944PheGln: 0.944 ± 0.001
1.573PheArg: 1.573 ± 0.322
0.629PheSer: 0.629 ± 0.321
2.203PheThr: 2.203 ± 0.316
1.573PheVal: 1.573 ± 0.158
0.629PheTrp: 0.629 ± 0.639
0.629PheTyr: 0.629 ± 0.159
0.0PheXaa: 0.0 ± 0.0
Gly
9.44GlyAla: 9.44 ± 0.945
4.72GlyCys: 4.72 ± 0.473
4.405GlyAsp: 4.405 ± 0.327
5.035GlyGlu: 5.035 ± 0.312
0.944GlyPhe: 0.944 ± 0.478
7.867GlyGly: 7.867 ± 1.747
3.776GlyHis: 3.776 ± 0.954
1.888GlyIle: 1.888 ± 0.962
1.259GlyLys: 1.259 ± 0.318
7.867GlyLeu: 7.867 ± 2.227
1.259GlyMet: 1.259 ± 0.642
1.573GlyAsn: 1.573 ± 0.637
8.181GlyPro: 8.181 ± 0.332
1.888GlyGln: 1.888 ± 0.957
5.035GlyArg: 5.035 ± 0.312
4.091GlySer: 4.091 ± 0.166
5.349GlyThr: 5.349 ± 1.111
4.091GlyVal: 4.091 ± 0.314
1.888GlyTrp: 1.888 ± 0.003
1.259GlyTyr: 1.259 ± 0.318
0.0GlyXaa: 0.0 ± 0.0
His
3.776HisAla: 3.776 ± 0.006
0.629HisCys: 0.629 ± 0.321
1.888HisAsp: 1.888 ± 0.477
1.573HisGlu: 1.573 ± 0.802
1.573HisPhe: 1.573 ± 0.322
2.832HisGly: 2.832 ± 0.955
1.573HisHis: 1.573 ± 1.117
1.259HisIle: 1.259 ± 0.162
0.315HisLys: 0.315 ± 0.319
3.461HisLeu: 3.461 ± 1.285
0.629HisMet: 0.629 ± 0.159
0.315HisAsn: 0.315 ± 0.16
4.405HisPro: 4.405 ± 0.633
1.259HisGln: 1.259 ± 0.318
0.944HisArg: 0.944 ± 0.001
1.259HisSer: 1.259 ± 0.318
2.517HisThr: 2.517 ± 1.116
2.832HisVal: 2.832 ± 0.484
0.944HisTrp: 0.944 ± 0.478
1.888HisTyr: 1.888 ± 0.003
0.0HisXaa: 0.0 ± 0.0
Ile
1.259IleAla: 1.259 ± 0.162
1.573IleCys: 1.573 ± 0.637
2.203IleAsp: 2.203 ± 0.643
1.259IleGlu: 1.259 ± 0.162
1.573IlePhe: 1.573 ± 0.322
0.629IleGly: 0.629 ± 0.159
0.944IleHis: 0.944 ± 0.001
0.629IleIle: 0.629 ± 0.321
0.944IleLys: 0.944 ± 0.481
0.315IleLeu: 0.315 ± 0.16
1.259IleMet: 1.259 ± 0.162
0.0IleAsn: 0.0 ± 0.0
2.517IlePro: 2.517 ± 0.803
0.944IleGln: 0.944 ± 0.481
1.888IleArg: 1.888 ± 0.003
0.944IleSer: 0.944 ± 0.481
0.629IleThr: 0.629 ± 0.159
2.517IleVal: 2.517 ± 0.803
0.629IleTrp: 0.629 ± 0.159
0.629IleTyr: 0.629 ± 0.321
0.0IleXaa: 0.0 ± 0.0
Lys
0.944LysAla: 0.944 ± 0.001
1.259LysCys: 1.259 ± 0.318
0.0LysAsp: 0.0 ± 0.0
0.944LysGlu: 0.944 ± 0.481
1.573LysPhe: 1.573 ± 0.637
1.573LysGly: 1.573 ± 0.322
0.629LysHis: 0.629 ± 0.159
0.629LysIle: 0.629 ± 0.159
0.0LysLys: 0.0 ± 0.0
0.944LysLeu: 0.944 ± 0.481
0.0LysMet: 0.0 ± 0.0
0.944LysAsn: 0.944 ± 0.481
0.944LysPro: 0.944 ± 0.001
0.315LysGln: 0.315 ± 0.319
0.944LysArg: 0.944 ± 0.481
0.315LysSer: 0.315 ± 0.16
1.259LysThr: 1.259 ± 0.318
0.629LysVal: 0.629 ± 0.321
0.315LysTrp: 0.315 ± 0.16
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
13.216LeuAla: 13.216 ± 0.98
2.517LeuCys: 2.517 ± 0.803
4.405LeuAsp: 4.405 ± 0.806
5.035LeuGlu: 5.035 ± 1.127
0.944LeuPhe: 0.944 ± 0.481
5.979LeuGly: 5.979 ± 0.79
4.405LeuHis: 4.405 ± 0.806
1.573LeuIle: 1.573 ± 0.158
1.888LeuLys: 1.888 ± 0.483
6.608LeuLeu: 6.608 ± 0.01
0.944LeuMet: 0.944 ± 0.001
1.573LeuAsn: 1.573 ± 0.158
5.349LeuPro: 5.349 ± 0.632
2.203LeuGln: 2.203 ± 0.796
8.181LeuArg: 8.181 ± 0.332
5.035LeuSer: 5.035 ± 0.168
4.405LeuThr: 4.405 ± 0.153
4.405LeuVal: 4.405 ± 1.113
2.203LeuTrp: 2.203 ± 0.163
1.888LeuTyr: 1.888 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
1.573MetAla: 1.573 ± 0.158
1.573MetCys: 1.573 ± 0.802
0.629MetAsp: 0.629 ± 0.159
1.259MetGlu: 1.259 ± 0.162
0.0MetPhe: 0.0 ± 0.0
0.629MetGly: 0.629 ± 0.159
0.629MetHis: 0.629 ± 0.321
0.0MetIle: 0.0 ± 0.0
0.315MetLys: 0.315 ± 0.16
0.315MetLeu: 0.315 ± 0.16
0.0MetMet: 0.0 ± 0.0
0.629MetAsn: 0.629 ± 0.159
1.259MetPro: 1.259 ± 0.318
0.944MetGln: 0.944 ± 0.001
2.203MetArg: 2.203 ± 0.163
0.944MetSer: 0.944 ± 0.001
0.315MetThr: 0.315 ± 0.16
0.944MetVal: 0.944 ± 0.001
0.315MetTrp: 0.315 ± 0.16
0.315MetTyr: 0.315 ± 0.319
0.0MetXaa: 0.0 ± 0.0
Asn
4.091AsnAla: 4.091 ± 0.646
1.259AsnCys: 1.259 ± 0.318
0.629AsnAsp: 0.629 ± 0.159
0.315AsnGlu: 0.315 ± 0.16
0.0AsnPhe: 0.0 ± 0.0
0.944AsnGly: 0.944 ± 0.478
0.629AsnHis: 0.629 ± 0.321
0.315AsnIle: 0.315 ± 0.16
0.315AsnLys: 0.315 ± 0.16
1.888AsnLeu: 1.888 ± 0.003
0.315AsnMet: 0.315 ± 0.16
0.315AsnAsn: 0.315 ± 0.16
1.573AsnPro: 1.573 ± 1.117
0.944AsnGln: 0.944 ± 0.478
0.629AsnArg: 0.629 ± 0.159
0.315AsnSer: 0.315 ± 0.319
1.259AsnThr: 1.259 ± 0.318
1.259AsnVal: 1.259 ± 0.318
0.0AsnTrp: 0.0 ± 0.0
0.315AsnTyr: 0.315 ± 0.319
0.0AsnXaa: 0.0 ± 0.0
Pro
12.272ProAla: 12.272 ± 0.461
2.203ProCys: 2.203 ± 0.796
5.035ProAsp: 5.035 ± 0.647
5.979ProGlu: 5.979 ± 0.311
1.888ProPhe: 1.888 ± 0.477
6.608ProGly: 6.608 ± 1.429
2.517ProHis: 2.517 ± 0.156
0.944ProIle: 0.944 ± 0.001
1.573ProLys: 1.573 ± 0.322
6.293ProLeu: 6.293 ± 0.15
0.944ProMet: 0.944 ± 0.478
0.944ProAsn: 0.944 ± 0.001
18.25ProPro: 18.25 ± 2.211
2.203ProGln: 2.203 ± 0.796
9.755ProArg: 9.755 ± 0.175
2.832ProSer: 2.832 ± 0.964
5.349ProThr: 5.349 ± 1.111
4.405ProVal: 4.405 ± 0.633
2.832ProTrp: 2.832 ± 0.955
1.888ProTyr: 1.888 ± 0.003
0.0ProXaa: 0.0 ± 0.0
Gln
4.091GlnAla: 4.091 ± 0.166
0.629GlnCys: 0.629 ± 0.159
0.944GlnAsp: 0.944 ± 0.001
0.944GlnGlu: 0.944 ± 0.001
0.315GlnPhe: 0.315 ± 0.16
2.517GlnGly: 2.517 ± 0.156
1.573GlnHis: 1.573 ± 0.637
0.315GlnIle: 0.315 ± 0.16
0.944GlnLys: 0.944 ± 0.001
1.888GlnLeu: 1.888 ± 1.436
0.944GlnMet: 0.944 ± 0.481
0.0GlnAsn: 0.0 ± 0.0
2.832GlnPro: 2.832 ± 0.955
1.259GlnGln: 1.259 ± 0.318
3.147GlnArg: 3.147 ± 0.315
2.203GlnSer: 2.203 ± 0.796
1.888GlnThr: 1.888 ± 0.477
2.517GlnVal: 2.517 ± 0.324
0.0GlnTrp: 0.0 ± 0.0
0.629GlnTyr: 0.629 ± 0.639
0.0GlnXaa: 0.0 ± 0.0
Arg
15.733ArgAla: 15.733 ± 2.263
3.147ArgCys: 3.147 ± 0.644
5.664ArgAsp: 5.664 ± 1.448
3.461ArgGlu: 3.461 ± 1.764
1.888ArgPhe: 1.888 ± 0.477
8.181ArgGly: 8.181 ± 0.627
3.776ArgHis: 3.776 ± 0.485
2.832ArgIle: 2.832 ± 0.004
0.944ArgLys: 0.944 ± 0.001
5.664ArgLeu: 5.664 ± 0.471
2.203ArgMet: 2.203 ± 0.198
0.629ArgAsn: 0.629 ± 0.639
7.237ArgPro: 7.237 ± 0.149
2.203ArgGln: 2.203 ± 0.316
7.867ArgArg: 7.867 ± 0.172
2.832ArgSer: 2.832 ± 0.484
4.72ArgThr: 4.72 ± 0.487
7.237ArgVal: 7.237 ± 0.811
3.461ArgTrp: 3.461 ± 0.155
2.203ArgTyr: 2.203 ± 1.123
0.0ArgXaa: 0.0 ± 0.0
Ser
5.035SerAla: 5.035 ± 0.647
1.573SerCys: 1.573 ± 1.117
3.461SerAsp: 3.461 ± 0.634
2.203SerGlu: 2.203 ± 0.163
0.629SerPhe: 0.629 ± 0.159
2.832SerGly: 2.832 ± 0.955
0.315SerHis: 0.315 ± 0.16
0.944SerIle: 0.944 ± 0.481
0.315SerLys: 0.315 ± 0.319
3.147SerLeu: 3.147 ± 1.124
0.0SerMet: 0.0 ± 0.0
0.629SerAsn: 0.629 ± 0.321
4.405SerPro: 4.405 ± 0.153
1.888SerGln: 1.888 ± 0.477
3.776SerArg: 3.776 ± 0.954
0.629SerSer: 0.629 ± 0.639
2.832SerThr: 2.832 ± 0.475
3.147SerVal: 3.147 ± 0.644
1.259SerTrp: 1.259 ± 0.162
1.888SerTyr: 1.888 ± 0.477
0.0SerXaa: 0.0 ± 0.0
Thr
9.44ThrAla: 9.44 ± 1.905
1.573ThrCys: 1.573 ± 0.158
2.203ThrAsp: 2.203 ± 0.163
4.72ThrGlu: 4.72 ± 0.007
0.629ThrPhe: 0.629 ± 0.159
3.461ThrGly: 3.461 ± 0.634
1.888ThrHis: 1.888 ± 0.003
0.944ThrIle: 0.944 ± 0.481
0.629ThrLys: 0.629 ± 0.159
5.664ThrLeu: 5.664 ± 0.968
0.315ThrMet: 0.315 ± 0.319
1.573ThrAsn: 1.573 ± 0.158
6.923ThrPro: 6.923 ± 1.749
1.259ThrGln: 1.259 ± 0.318
6.293ThrArg: 6.293 ± 0.15
2.203ThrSer: 2.203 ± 0.316
4.091ThrThr: 4.091 ± 1.753
4.72ThrVal: 4.72 ± 0.952
0.944ThrTrp: 0.944 ± 0.001
1.259ThrTyr: 1.259 ± 0.318
0.0ThrXaa: 0.0 ± 0.0
Val
9.755ValAla: 9.755 ± 3.053
2.517ValCys: 2.517 ± 0.156
2.517ValAsp: 2.517 ± 0.156
3.461ValGlu: 3.461 ± 0.634
1.888ValPhe: 1.888 ± 0.003
5.035ValGly: 5.035 ± 0.647
1.259ValHis: 1.259 ± 0.642
1.573ValIle: 1.573 ± 0.158
0.629ValLys: 0.629 ± 0.159
5.664ValLeu: 5.664 ± 0.488
1.259ValMet: 1.259 ± 0.162
1.259ValAsn: 1.259 ± 0.318
5.979ValPro: 5.979 ± 0.169
1.573ValGln: 1.573 ± 0.158
9.125ValArg: 9.125 ± 0.813
3.776ValSer: 3.776 ± 0.474
3.147ValThr: 3.147 ± 0.795
3.776ValVal: 3.776 ± 0.006
1.573ValTrp: 1.573 ± 0.637
1.573ValTyr: 1.573 ± 0.322
0.0ValXaa: 0.0 ± 0.0
Trp
3.776TrpAla: 3.776 ± 0.006
0.315TrpCys: 0.315 ± 0.319
1.888TrpAsp: 1.888 ± 0.003
1.259TrpGlu: 1.259 ± 0.162
0.315TrpPhe: 0.315 ± 0.16
2.203TrpGly: 2.203 ± 1.276
1.888TrpHis: 1.888 ± 0.477
0.944TrpIle: 0.944 ± 0.001
0.315TrpLys: 0.315 ± 0.16
2.832TrpLeu: 2.832 ± 0.004
0.0TrpMet: 0.0 ± 0.0
0.629TrpAsn: 0.629 ± 0.159
0.629TrpPro: 0.629 ± 0.321
1.259TrpGln: 1.259 ± 0.318
1.573TrpArg: 1.573 ± 0.322
1.259TrpSer: 1.259 ± 0.318
0.944TrpThr: 0.944 ± 0.001
2.203TrpVal: 2.203 ± 0.316
0.629TrpTrp: 0.629 ± 0.159
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.484
0.944TyrCys: 0.944 ± 0.481
0.944TyrAsp: 0.944 ± 0.481
0.315TyrGlu: 0.315 ± 0.16
0.315TyrPhe: 0.315 ± 0.319
2.203TyrGly: 2.203 ± 0.796
0.315TyrHis: 0.315 ± 0.319
0.629TyrIle: 0.629 ± 0.159
0.315TyrLys: 0.315 ± 0.319
1.259TyrLeu: 1.259 ± 0.318
0.315TyrMet: 0.315 ± 0.16
1.888TyrAsn: 1.888 ± 0.957
0.944TyrPro: 0.944 ± 0.001
0.944TyrGln: 0.944 ± 0.478
2.517TyrArg: 2.517 ± 0.324
1.259TyrSer: 1.259 ± 0.162
3.461TyrThr: 3.461 ± 1.285
1.888TyrVal: 1.888 ± 0.483
0.0TyrTrp: 0.0 ± 0.0
1.888TyrTyr: 1.888 ± 0.003
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski