Amino acid dipepetide frequency for Salipaludibacillus aurantiacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.668AlaAla: 6.668 ± 0.093	0.62AlaCys: 0.62 ± 0.023	4.566AlaAsp: 4.566 ± 0.427	5.595AlaGlu: 5.595 ± 0.085	3.37AlaPhe: 3.37 ± 0.054	6.497AlaGly: 6.497 ± 0.088	1.378AlaHis: 1.378 ± 0.039	4.81AlaIle: 4.81 ± 0.075	3.898AlaLys: 3.898 ± 0.067	7.179AlaLeu: 7.179 ± 0.089	2.106AlaMet: 2.106 ± 0.044	2.454AlaAsn: 2.454 ± 0.052	2.224AlaPro: 2.224 ± 0.045	2.078AlaGln: 2.078 ± 0.042	2.844AlaArg: 2.844 ± 0.052	4.264AlaSer: 4.264 ± 0.061	3.055AlaThr: 3.055 ± 0.06	6.216AlaVal: 6.216 ± 0.084	0.698AlaTrp: 0.698 ± 0.022	2.301AlaTyr: 2.301 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.421CysAla: 0.421 ± 0.022	0.099CysCys: 0.099 ± 0.01	0.355CysAsp: 0.355 ± 0.018	0.412CysGlu: 0.412 ± 0.021	0.262CysPhe: 0.262 ± 0.013	0.669CysGly: 0.669 ± 0.025	0.221CysHis: 0.221 ± 0.015	0.406CysIle: 0.406 ± 0.02	0.324CysLys: 0.324 ± 0.017	0.639CysLeu: 0.639 ± 0.024	0.166CysMet: 0.166 ± 0.011	0.265CysAsn: 0.265 ± 0.015	0.394CysPro: 0.394 ± 0.02	0.251CysGln: 0.251 ± 0.016	0.349CysArg: 0.349 ± 0.018	0.439CysSer: 0.439 ± 0.022	0.37CysThr: 0.37 ± 0.019	0.361CysVal: 0.361 ± 0.019	0.054CysTrp: 0.054 ± 0.006	0.229CysTyr: 0.229 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.697AspAla: 3.697 ± 0.424	0.333AspCys: 0.333 ± 0.02	2.931AspAsp: 2.931 ± 0.061	4.939AspGlu: 4.939 ± 0.082	2.468AspPhe: 2.468 ± 0.051	3.771AspGly: 3.771 ± 0.071	1.42AspHis: 1.42 ± 0.036	4.024AspIle: 4.024 ± 0.064	3.186AspLys: 3.186 ± 0.059	5.461AspLeu: 5.461 ± 0.06	1.585AspMet: 1.585 ± 0.034	2.113AspAsn: 2.113 ± 0.045	2.344AspPro: 2.344 ± 0.046	2.03AspGln: 2.03 ± 0.045	2.703AspArg: 2.703 ± 0.051	2.832AspSer: 2.832 ± 0.1	2.575AspThr: 2.575 ± 0.051	3.796AspVal: 3.796 ± 0.057	0.687AspTrp: 0.687 ± 0.025	2.381AspTyr: 2.381 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.429GluAla: 6.429 ± 0.092	0.362GluCys: 0.362 ± 0.019	4.831GluAsp: 4.831 ± 0.077	9.163GluGlu: 9.163 ± 0.156	2.625GluPhe: 2.625 ± 0.047	5.337GluGly: 5.337 ± 0.075	1.529GluHis: 1.529 ± 0.034	5.071GluIle: 5.071 ± 0.064	6.643GluLys: 6.643 ± 0.091	7.202GluLeu: 7.202 ± 0.092	2.489GluMet: 2.489 ± 0.04	3.928GluAsn: 3.928 ± 0.063	2.43GluPro: 2.43 ± 0.048	3.118GluGln: 3.118 ± 0.065	3.843GluArg: 3.843 ± 0.061	3.801GluSer: 3.801 ± 0.061	4.554GluThr: 4.554 ± 0.072	5.402GluVal: 5.402 ± 0.065	0.977GluTrp: 0.977 ± 0.033	2.155GluTyr: 2.155 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.994PheAla: 2.994 ± 0.056	0.31PheCys: 0.31 ± 0.017	2.39PheAsp: 2.39 ± 0.047	2.921PheGlu: 2.921 ± 0.05	2.444PhePhe: 2.444 ± 0.064	3.246PheGly: 3.246 ± 0.06	1.015PheHis: 1.015 ± 0.029	3.841PheIle: 3.841 ± 0.074	2.418PheLys: 2.418 ± 0.048	4.413PheLeu: 4.413 ± 0.079	1.237PheMet: 1.237 ± 0.034	1.959PheAsn: 1.959 ± 0.042	1.748PhePro: 1.748 ± 0.04	1.612PheGln: 1.612 ± 0.037	1.66PheArg: 1.66 ± 0.039	3.251PheSer: 3.251 ± 0.058	2.71PheThr: 2.71 ± 0.048	2.777PheVal: 2.777 ± 0.057	0.496PheTrp: 0.496 ± 0.02	1.74PheTyr: 1.74 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.302GlyAla: 5.302 ± 0.079	0.594GlyCys: 0.594 ± 0.024	3.657GlyAsp: 3.657 ± 0.062	5.337GlyGlu: 5.337 ± 0.074	3.471GlyPhe: 3.471 ± 0.057	5.332GlyGly: 5.332 ± 0.087	1.529GlyHis: 1.529 ± 0.036	5.531GlyIle: 5.531 ± 0.073	4.776GlyLys: 4.776 ± 0.067	6.851GlyLeu: 6.851 ± 0.098	2.242GlyMet: 2.242 ± 0.048	2.847GlyAsn: 2.847 ± 0.059	2.011GlyPro: 2.011 ± 0.045	2.266GlyGln: 2.266 ± 0.047	3.045GlyArg: 3.045 ± 0.045	4.076GlySer: 4.076 ± 0.071	4.169GlyThr: 4.169 ± 0.063	5.328GlyVal: 5.328 ± 0.083	0.828GlyTrp: 0.828 ± 0.028	2.776GlyTyr: 2.776 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.343HisAla: 1.343 ± 0.038	0.18HisCys: 0.18 ± 0.011	1.052HisAsp: 1.052 ± 0.033	1.541HisGlu: 1.541 ± 0.034	1.067HisPhe: 1.067 ± 0.031	1.501HisGly: 1.501 ± 0.039	0.716HisHis: 0.716 ± 0.028	1.551HisIle: 1.551 ± 0.039	1.01HisLys: 1.01 ± 0.029	2.308HisLeu: 2.308 ± 0.045	0.602HisMet: 0.602 ± 0.023	0.776HisAsn: 0.776 ± 0.028	1.213HisPro: 1.213 ± 0.031	0.8HisGln: 0.8 ± 0.027	0.975HisArg: 0.975 ± 0.029	1.315HisSer: 1.315 ± 0.035	1.206HisThr: 1.206 ± 0.031	1.431HisVal: 1.431 ± 0.035	0.278HisTrp: 0.278 ± 0.015	0.866HisTyr: 0.866 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.141IleAla: 5.141 ± 0.082	0.509IleCys: 0.509 ± 0.022	4.161IleAsp: 4.161 ± 0.051	5.283IleGlu: 5.283 ± 0.069	3.106IlePhe: 3.106 ± 0.055	5.312IleGly: 5.312 ± 0.09	1.568IleHis: 1.568 ± 0.031	5.225IleIle: 5.225 ± 0.091	4.004IleLys: 4.004 ± 0.066	6.316IleLeu: 6.316 ± 0.094	1.669IleMet: 1.669 ± 0.038	3.064IleAsn: 3.064 ± 0.051	3.126IlePro: 3.126 ± 0.051	2.454IleGln: 2.454 ± 0.049	2.998IleArg: 2.998 ± 0.052	4.554IleSer: 4.554 ± 0.063	3.764IleThr: 3.764 ± 0.055	4.639IleVal: 4.639 ± 0.077	0.613IleTrp: 0.613 ± 0.024	2.336IleTyr: 2.336 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.475LysAla: 4.475 ± 0.072	0.312LysCys: 0.312 ± 0.016	3.68LysAsp: 3.68 ± 0.059	6.76LysGlu: 6.76 ± 0.104	1.618LysPhe: 1.618 ± 0.039	4.335LysGly: 4.335 ± 0.064	1.306LysHis: 1.306 ± 0.034	3.735LysIle: 3.735 ± 0.058	5.791LysLys: 5.791 ± 0.085	5.261LysLeu: 5.261 ± 0.071	1.984LysMet: 1.984 ± 0.039	3.001LysAsn: 3.001 ± 0.057	2.171LysPro: 2.171 ± 0.046	2.71LysGln: 2.71 ± 0.056	3.192LysArg: 3.192 ± 0.052	3.18LysSer: 3.18 ± 0.055	3.404LysThr: 3.404 ± 0.055	4.334LysVal: 4.334 ± 0.063	0.748LysTrp: 0.748 ± 0.025	1.888LysTyr: 1.888 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.352LeuAla: 7.352 ± 0.092	0.61LeuCys: 0.61 ± 0.023	4.877LeuAsp: 4.877 ± 0.073	6.714LeuGlu: 6.714 ± 0.085	4.759LeuPhe: 4.759 ± 0.081	6.129LeuGly: 6.129 ± 0.079	1.933LeuHis: 1.933 ± 0.045	7.045LeuIle: 7.045 ± 0.116	6.466LeuLys: 6.466 ± 0.094	9.415LeuLeu: 9.415 ± 0.126	2.609LeuMet: 2.609 ± 0.055	4.283LeuAsn: 4.283 ± 0.069	4.157LeuPro: 4.157 ± 0.065	3.194LeuGln: 3.194 ± 0.053	3.603LeuArg: 3.603 ± 0.061	6.658LeuSer: 6.658 ± 0.078	5.967LeuThr: 5.967 ± 0.069	6.029LeuVal: 6.029 ± 0.068	0.814LeuTrp: 0.814 ± 0.028	2.984LeuTyr: 2.984 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.048	0.148MetCys: 0.148 ± 0.011	1.657MetAsp: 1.657 ± 0.039	2.181MetGlu: 2.181 ± 0.042	1.076MetPhe: 1.076 ± 0.033	1.868MetGly: 1.868 ± 0.044	0.448MetHis: 0.448 ± 0.019	2.114MetIle: 2.114 ± 0.051	2.335MetLys: 2.335 ± 0.041	2.454MetLeu: 2.454 ± 0.054	0.873MetMet: 0.873 ± 0.028	1.479MetAsn: 1.479 ± 0.035	1.105MetPro: 1.105 ± 0.033	0.824MetGln: 0.824 ± 0.026	1.1MetArg: 1.1 ± 0.031	1.817MetSer: 1.817 ± 0.033	1.912MetThr: 1.912 ± 0.04	1.917MetVal: 1.917 ± 0.041	0.196MetTrp: 0.196 ± 0.013	0.692MetTyr: 0.692 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.497AsnAla: 2.497 ± 0.044	0.259AsnCys: 0.259 ± 0.015	2.494AsnAsp: 2.494 ± 0.057	3.817AsnGlu: 3.817 ± 0.066	1.554AsnPhe: 1.554 ± 0.038	3.169AsnGly: 3.169 ± 0.059	1.012AsnHis: 1.012 ± 0.028	2.954AsnIle: 2.954 ± 0.052	2.655AsnLys: 2.655 ± 0.058	3.6AsnLeu: 3.6 ± 0.056	1.234AsnMet: 1.234 ± 0.029	2.199AsnAsn: 2.199 ± 0.068	1.97AsnPro: 1.97 ± 0.043	1.69AsnGln: 1.69 ± 0.039	2.108AsnArg: 2.108 ± 0.046	2.199AsnSer: 2.199 ± 0.05	2.037AsnThr: 2.037 ± 0.04	2.737AsnVal: 2.737 ± 0.052	0.523AsnTrp: 0.523 ± 0.021	1.546AsnTyr: 1.546 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.902ProAla: 2.902 ± 0.052	0.221ProCys: 0.221 ± 0.014	2.501ProAsp: 2.501 ± 0.051	3.767ProGlu: 3.767 ± 0.071	2.157ProPhe: 2.157 ± 0.04	2.857ProGly: 2.857 ± 0.055	0.906ProHis: 0.906 ± 0.028	1.924ProIle: 1.924 ± 0.037	1.76ProLys: 1.76 ± 0.043	3.73ProLeu: 3.73 ± 0.053	0.884ProMet: 0.884 ± 0.027	1.245ProAsn: 1.245 ± 0.035	1.247ProPro: 1.247 ± 0.034	1.135ProGln: 1.135 ± 0.033	1.231ProArg: 1.231 ± 0.032	2.399ProSer: 2.399 ± 0.049	1.445ProThr: 1.445 ± 0.033	3.786ProVal: 3.786 ± 0.055	0.421ProTrp: 0.421 ± 0.019	1.516ProTyr: 1.516 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.716GlnAla: 2.716 ± 0.052	0.215GlnCys: 0.215 ± 0.012	1.555GlnAsp: 1.555 ± 0.037	2.88GlnGlu: 2.88 ± 0.052	1.558GlnPhe: 1.558 ± 0.034	2.243GlnGly: 2.243 ± 0.045	0.695GlnHis: 0.695 ± 0.026	2.241GlnIle: 2.241 ± 0.043	2.32GlnLys: 2.32 ± 0.04	3.739GlnLeu: 3.739 ± 0.061	1.109GlnMet: 1.109 ± 0.034	1.364GlnAsn: 1.364 ± 0.038	1.291GlnPro: 1.291 ± 0.033	1.637GlnGln: 1.637 ± 0.054	1.496GlnArg: 1.496 ± 0.033	2.119GlnSer: 2.119 ± 0.043	2.004GlnThr: 2.004 ± 0.037	2.259GlnVal: 2.259 ± 0.043	0.449GlnTrp: 0.449 ± 0.02	1.077GlnTyr: 1.077 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.571ArgAla: 2.571 ± 0.039	0.261ArgCys: 0.261 ± 0.015	2.234ArgAsp: 2.234 ± 0.038	3.629ArgGlu: 3.629 ± 0.065	1.984ArgPhe: 1.984 ± 0.037	2.725ArgGly: 2.725 ± 0.045	1.001ArgHis: 1.001 ± 0.027	2.899ArgIle: 2.899 ± 0.06	3.315ArgLys: 3.315 ± 0.058	4.319ArgLeu: 4.319 ± 0.063	1.372ArgMet: 1.372 ± 0.034	1.848ArgAsn: 1.848 ± 0.039	1.479ArgPro: 1.479 ± 0.033	1.79ArgGln: 1.79 ± 0.037	2.117ArgArg: 2.117 ± 0.049	2.378ArgSer: 2.378 ± 0.046	2.189ArgThr: 2.189 ± 0.041	2.696ArgVal: 2.696 ± 0.053	0.467ArgTrp: 0.467 ± 0.018	1.566ArgTyr: 1.566 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.09SerAla: 4.09 ± 0.068	0.416SerCys: 0.416 ± 0.019	3.144SerAsp: 3.144 ± 0.107	4.475SerGlu: 4.475 ± 0.077	3.247SerPhe: 3.247 ± 0.059	4.78SerGly: 4.78 ± 0.077	1.355SerHis: 1.355 ± 0.032	4.017SerIle: 4.017 ± 0.061	3.218SerLys: 3.218 ± 0.052	6.281SerLeu: 6.281 ± 0.074	1.733SerMet: 1.733 ± 0.042	2.158SerAsn: 2.158 ± 0.052	2.31SerPro: 2.31 ± 0.047	2.112SerGln: 2.112 ± 0.043	2.634SerArg: 2.634 ± 0.046	4.039SerSer: 4.039 ± 0.081	2.755SerThr: 2.755 ± 0.049	4.324SerVal: 4.324 ± 0.061	0.639SerTrp: 0.639 ± 0.024	2.117SerTyr: 2.117 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.413ThrAla: 4.413 ± 0.065	0.35ThrCys: 0.35 ± 0.019	3.031ThrAsp: 3.031 ± 0.059	3.905ThrGlu: 3.905 ± 0.06	2.727ThrPhe: 2.727 ± 0.049	4.916ThrGly: 4.916 ± 0.065	1.146ThrHis: 1.146 ± 0.034	3.681ThrIle: 3.681 ± 0.062	2.757ThrLys: 2.757 ± 0.049	5.06ThrLeu: 5.06 ± 0.06	1.377ThrMet: 1.377 ± 0.035	2.117ThrAsn: 2.117 ± 0.045	2.212ThrPro: 2.212 ± 0.047	1.38ThrGln: 1.38 ± 0.034	1.914ThrArg: 1.914 ± 0.038	3.077ThrSer: 3.077 ± 0.053	2.527ThrThr: 2.527 ± 0.05	4.565ThrVal: 4.565 ± 0.064	0.51ThrTrp: 0.51 ± 0.022	1.912ThrTyr: 1.912 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.788ValAla: 4.788 ± 0.076	0.54ValCys: 0.54 ± 0.02	3.61ValAsp: 3.61 ± 0.055	5.007ValGlu: 5.007 ± 0.064	3.356ValPhe: 3.356 ± 0.054	4.035ValGly: 4.035 ± 0.057	1.435ValHis: 1.435 ± 0.038	5.711ValIle: 5.711 ± 0.073	4.384ValLys: 4.384 ± 0.067	6.805ValLeu: 6.805 ± 0.076	1.997ValMet: 1.997 ± 0.048	3.251ValAsn: 3.251 ± 0.049	2.864ValPro: 2.864 ± 0.044	2.243ValGln: 2.243 ± 0.048	2.929ValArg: 2.929 ± 0.055	4.815ValSer: 4.815 ± 0.064	4.547ValThr: 4.547 ± 0.069	4.717ValVal: 4.717 ± 0.073	0.689ValTrp: 0.689 ± 0.026	2.435ValTyr: 2.435 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.676TrpAla: 0.676 ± 0.021	0.068TrpCys: 0.068 ± 0.007	0.548TrpAsp: 0.548 ± 0.022	0.813TrpGlu: 0.813 ± 0.029	0.508TrpPhe: 0.508 ± 0.021	0.74TrpGly: 0.74 ± 0.028	0.256TrpHis: 0.256 ± 0.017	0.802TrpIle: 0.802 ± 0.031	0.717TrpLys: 0.717 ± 0.023	1.174TrpLeu: 1.174 ± 0.035	0.399TrpMet: 0.399 ± 0.016	0.47TrpAsn: 0.47 ± 0.019	0.332TrpPro: 0.332 ± 0.018	0.411TrpGln: 0.411 ± 0.018	0.43TrpArg: 0.43 ± 0.017	0.544TrpSer: 0.544 ± 0.02	0.538TrpThr: 0.538 ± 0.021	0.702TrpVal: 0.702 ± 0.025	0.148TrpTrp: 0.148 ± 0.012	0.343TrpTyr: 0.343 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.993TyrAla: 1.993 ± 0.04	0.279TyrCys: 0.279 ± 0.017	2.001TyrAsp: 2.001 ± 0.04	2.748TyrGlu: 2.748 ± 0.055	1.827TyrPhe: 1.827 ± 0.037	2.506TyrGly: 2.506 ± 0.045	0.863TyrHis: 0.863 ± 0.027	2.26TyrIle: 2.26 ± 0.046	1.908TyrLys: 1.908 ± 0.045	3.389TyrLeu: 3.389 ± 0.055	0.88TyrMet: 0.88 ± 0.03	1.431TyrAsn: 1.431 ± 0.037	1.408TyrPro: 1.408 ± 0.036	1.232TyrGln: 1.232 ± 0.031	1.67TyrArg: 1.67 ± 0.035	2.086TyrSer: 2.086 ± 0.043	1.848TyrThr: 1.848 ± 0.045	2.143TyrVal: 2.143 ± 0.046	0.385TyrTrp: 0.385 ± 0.016	1.413TyrTyr: 1.413 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4227 proteins (1241661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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