Amino acid dipepetide frequency for Halorubrum pleomorphic virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.647AlaAla: 8.647 ± 2.107
0.376AlaCys: 0.376 ± 0.374
8.647AlaAsp: 8.647 ± 1.329
4.511AlaGlu: 4.511 ± 1.552
2.256AlaPhe: 2.256 ± 0.961
9.023AlaGly: 9.023 ± 1.913
1.88AlaHis: 1.88 ± 0.871
6.391AlaIle: 6.391 ± 1.373
2.632AlaLys: 2.632 ± 0.932
7.895AlaLeu: 7.895 ± 2.401
3.008AlaMet: 3.008 ± 1.426
2.632AlaAsn: 2.632 ± 0.866
3.759AlaPro: 3.759 ± 0.749
1.88AlaGln: 1.88 ± 0.88
6.015AlaArg: 6.015 ± 1.933
3.759AlaSer: 3.759 ± 1.15
4.511AlaThr: 4.511 ± 1.839
7.895AlaVal: 7.895 ± 1.815
1.504AlaTrp: 1.504 ± 0.708
0.752AlaTyr: 0.752 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.128CysGlu: 1.128 ± 0.662
0.0CysPhe: 0.0 ± 0.0
0.752CysGly: 0.752 ± 0.452
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.376CysLys: 0.376 ± 0.381
0.376CysLeu: 0.376 ± 0.533
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.376CysPro: 0.376 ± 0.372
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.376CysVal: 0.376 ± 0.372
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.263AspAla: 5.263 ± 0.889
0.0AspCys: 0.0 ± 0.0
3.008AspAsp: 3.008 ± 0.715
7.143AspGlu: 7.143 ± 2.337
1.128AspPhe: 1.128 ± 0.638
11.654AspGly: 11.654 ± 1.757
2.256AspHis: 2.256 ± 1.506
2.632AspIle: 2.632 ± 0.7
0.752AspLys: 0.752 ± 0.473
5.263AspLeu: 5.263 ± 1.398
1.504AspMet: 1.504 ± 0.875
2.256AspAsn: 2.256 ± 0.919
5.639AspPro: 5.639 ± 1.259
1.128AspGln: 1.128 ± 0.481
6.015AspArg: 6.015 ± 1.09
4.511AspSer: 4.511 ± 1.15
4.887AspThr: 4.887 ± 0.921
3.383AspVal: 3.383 ± 1.455
1.128AspTrp: 1.128 ± 0.565
0.752AspTyr: 0.752 ± 0.572
0.0AspXaa: 0.0 ± 0.0
Glu
7.519GluAla: 7.519 ± 1.489
0.376GluCys: 0.376 ± 0.362
1.88GluAsp: 1.88 ± 0.863
5.263GluGlu: 5.263 ± 1.763
3.008GluPhe: 3.008 ± 0.803
5.639GluGly: 5.639 ± 1.661
1.128GluHis: 1.128 ± 0.481
3.759GluIle: 3.759 ± 0.915
3.008GluLys: 3.008 ± 1.084
4.511GluLeu: 4.511 ± 1.39
0.752GluMet: 0.752 ± 0.397
2.632GluAsn: 2.632 ± 0.841
3.383GluPro: 3.383 ± 1.456
2.632GluGln: 2.632 ± 0.876
6.015GluArg: 6.015 ± 1.695
10.15GluSer: 10.15 ± 2.278
8.271GluThr: 8.271 ± 1.455
3.759GluVal: 3.759 ± 0.975
1.88GluTrp: 1.88 ± 0.551
4.135GluTyr: 4.135 ± 0.945
0.0GluXaa: 0.0 ± 0.0
Phe
2.632PheAla: 2.632 ± 1.484
0.0PheCys: 0.0 ± 0.0
0.752PheAsp: 0.752 ± 0.526
3.383PheGlu: 3.383 ± 1.173
0.752PhePhe: 0.752 ± 0.445
5.263PheGly: 5.263 ± 1.221
0.0PheHis: 0.0 ± 0.0
1.504PheIle: 1.504 ± 0.528
1.128PheLys: 1.128 ± 0.802
1.128PheLeu: 1.128 ± 0.428
0.376PheMet: 0.376 ± 0.334
1.128PheAsn: 1.128 ± 0.553
1.504PhePro: 1.504 ± 0.612
0.0PheGln: 0.0 ± 0.0
2.256PheArg: 2.256 ± 0.841
2.256PheSer: 2.256 ± 0.717
3.759PheThr: 3.759 ± 1.263
3.008PheVal: 3.008 ± 1.149
0.0PheTrp: 0.0 ± 0.0
0.752PheTyr: 0.752 ± 0.452
0.0PheXaa: 0.0 ± 0.0
Gly
7.895GlyAla: 7.895 ± 1.917
0.376GlyCys: 0.376 ± 0.372
7.519GlyAsp: 7.519 ± 1.801
7.519GlyGlu: 7.519 ± 1.54
3.008GlyPhe: 3.008 ± 0.961
12.406GlyGly: 12.406 ± 2.212
2.256GlyHis: 2.256 ± 1.043
3.759GlyIle: 3.759 ± 0.795
1.88GlyLys: 1.88 ± 1.146
7.143GlyLeu: 7.143 ± 1.26
3.008GlyMet: 3.008 ± 1.039
4.135GlyAsn: 4.135 ± 0.965
4.135GlyPro: 4.135 ± 1.015
1.504GlyGln: 1.504 ± 0.757
2.632GlyArg: 2.632 ± 0.581
4.887GlySer: 4.887 ± 1.305
11.278GlyThr: 11.278 ± 2.127
9.023GlyVal: 9.023 ± 0.874
3.383GlyTrp: 3.383 ± 1.018
3.008GlyTyr: 3.008 ± 0.982
0.0GlyXaa: 0.0 ± 0.0
His
1.504HisAla: 1.504 ± 0.473
0.0HisCys: 0.0 ± 0.0
1.504HisAsp: 1.504 ± 0.89
3.008HisGlu: 3.008 ± 1.57
1.128HisPhe: 1.128 ± 0.631
3.759HisGly: 3.759 ± 1.511
0.0HisHis: 0.0 ± 0.0
0.752HisIle: 0.752 ± 0.445
0.376HisLys: 0.376 ± 0.372
2.256HisLeu: 2.256 ± 1.051
0.376HisMet: 0.376 ± 0.362
0.0HisAsn: 0.0 ± 0.0
2.632HisPro: 2.632 ± 0.834
0.752HisGln: 0.752 ± 0.479
1.504HisArg: 1.504 ± 0.871
0.376HisSer: 0.376 ± 0.315
1.128HisThr: 1.128 ± 0.713
1.128HisVal: 1.128 ± 0.59
0.376HisTrp: 0.376 ± 0.315
0.376HisTyr: 0.376 ± 0.315
0.0HisXaa: 0.0 ± 0.0
Ile
6.391IleAla: 6.391 ± 1.753
0.752IleCys: 0.752 ± 0.606
4.511IleAsp: 4.511 ± 1.075
1.88IleGlu: 1.88 ± 0.58
1.128IlePhe: 1.128 ± 0.695
2.632IleGly: 2.632 ± 1.13
0.376IleHis: 0.376 ± 0.381
1.128IleIle: 1.128 ± 0.469
0.752IleLys: 0.752 ± 0.397
1.88IleLeu: 1.88 ± 0.773
0.376IleMet: 0.376 ± 0.362
3.008IleAsn: 3.008 ± 0.888
3.383IlePro: 3.383 ± 0.757
1.504IleGln: 1.504 ± 0.579
3.383IleArg: 3.383 ± 1.016
7.143IleSer: 7.143 ± 2.015
3.008IleThr: 3.008 ± 1.041
2.632IleVal: 2.632 ± 1.432
1.128IleTrp: 1.128 ± 0.577
1.504IleTyr: 1.504 ± 0.869
0.0IleXaa: 0.0 ± 0.0
Lys
2.632LysAla: 2.632 ± 0.769
0.0LysCys: 0.0 ± 0.0
2.632LysAsp: 2.632 ± 1.227
1.88LysGlu: 1.88 ± 0.817
1.88LysPhe: 1.88 ± 0.675
2.256LysGly: 2.256 ± 0.691
1.88LysHis: 1.88 ± 1.102
3.759LysIle: 3.759 ± 0.935
3.759LysLys: 3.759 ± 1.307
3.008LysLeu: 3.008 ± 0.966
0.376LysMet: 0.376 ± 0.381
1.504LysAsn: 1.504 ± 0.794
1.504LysPro: 1.504 ± 0.994
0.752LysGln: 0.752 ± 0.404
0.0LysArg: 0.0 ± 0.0
1.504LysSer: 1.504 ± 0.883
1.504LysThr: 1.504 ± 0.881
0.752LysVal: 0.752 ± 0.63
1.504LysTrp: 1.504 ± 0.655
1.504LysTyr: 1.504 ± 0.826
0.0LysXaa: 0.0 ± 0.0
Leu
7.895LeuAla: 7.895 ± 2.149
0.0LeuCys: 0.0 ± 0.0
3.759LeuAsp: 3.759 ± 1.129
4.887LeuGlu: 4.887 ± 1.215
3.383LeuPhe: 3.383 ± 0.864
6.015LeuGly: 6.015 ± 0.95
1.128LeuHis: 1.128 ± 0.713
3.008LeuIle: 3.008 ± 1.085
3.383LeuLys: 3.383 ± 1.266
6.391LeuLeu: 6.391 ± 2.047
1.504LeuMet: 1.504 ± 0.837
1.88LeuAsn: 1.88 ± 0.852
3.008LeuPro: 3.008 ± 0.848
1.504LeuGln: 1.504 ± 0.818
4.135LeuArg: 4.135 ± 1.272
4.887LeuSer: 4.887 ± 0.892
6.391LeuThr: 6.391 ± 1.565
4.135LeuVal: 4.135 ± 1.178
1.504LeuTrp: 1.504 ± 0.597
1.88LeuTyr: 1.88 ± 0.876
0.0LeuXaa: 0.0 ± 0.0
Met
0.752MetAla: 0.752 ± 0.705
0.0MetCys: 0.0 ± 0.0
1.88MetAsp: 1.88 ± 0.803
1.88MetGlu: 1.88 ± 0.741
0.376MetPhe: 0.376 ± 0.362
4.511MetGly: 4.511 ± 1.563
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.504MetLys: 1.504 ± 0.656
1.128MetLeu: 1.128 ± 0.76
0.752MetMet: 0.752 ± 0.398
0.376MetAsn: 0.376 ± 0.386
1.128MetPro: 1.128 ± 0.499
0.376MetGln: 0.376 ± 0.273
0.752MetArg: 0.752 ± 0.504
1.128MetSer: 1.128 ± 0.508
1.128MetThr: 1.128 ± 0.782
2.256MetVal: 2.256 ± 0.688
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.383AsnAla: 3.383 ± 1.227
0.376AsnCys: 0.376 ± 0.273
3.383AsnAsp: 3.383 ± 1.147
1.128AsnGlu: 1.128 ± 0.525
1.504AsnPhe: 1.504 ± 0.626
3.383AsnGly: 3.383 ± 0.941
0.376AsnHis: 0.376 ± 0.533
3.383AsnIle: 3.383 ± 0.924
0.752AsnLys: 0.752 ± 0.546
0.376AsnLeu: 0.376 ± 0.273
0.0AsnMet: 0.0 ± 0.0
0.376AsnAsn: 0.376 ± 0.426
2.632AsnPro: 2.632 ± 1.367
1.504AsnGln: 1.504 ± 0.564
2.256AsnArg: 2.256 ± 0.808
1.88AsnSer: 1.88 ± 0.852
1.88AsnThr: 1.88 ± 1.1
3.759AsnVal: 3.759 ± 0.894
0.0AsnTrp: 0.0 ± 0.0
1.504AsnTyr: 1.504 ± 0.918
0.0AsnXaa: 0.0 ± 0.0
Pro
3.383ProAla: 3.383 ± 0.85
0.376ProCys: 0.376 ± 0.533
4.511ProAsp: 4.511 ± 1.234
5.263ProGlu: 5.263 ± 1.437
1.128ProPhe: 1.128 ± 0.558
2.632ProGly: 2.632 ± 0.698
0.752ProHis: 0.752 ± 0.404
3.008ProIle: 3.008 ± 1.186
1.128ProLys: 1.128 ± 0.615
3.383ProLeu: 3.383 ± 0.865
0.752ProMet: 0.752 ± 0.397
1.88ProAsn: 1.88 ± 0.746
1.128ProPro: 1.128 ± 0.807
1.504ProGln: 1.504 ± 0.642
1.88ProArg: 1.88 ± 0.719
3.759ProSer: 3.759 ± 0.882
3.008ProThr: 3.008 ± 1.482
3.759ProVal: 3.759 ± 0.812
1.504ProTrp: 1.504 ± 0.68
1.88ProTyr: 1.88 ± 0.526
0.0ProXaa: 0.0 ± 0.0
Gln
1.88GlnAla: 1.88 ± 0.631
0.0GlnCys: 0.0 ± 0.0
2.256GlnAsp: 2.256 ± 0.988
2.632GlnGlu: 2.632 ± 0.988
0.0GlnPhe: 0.0 ± 0.0
2.256GlnGly: 2.256 ± 0.78
0.0GlnHis: 0.0 ± 0.0
1.504GlnIle: 1.504 ± 0.802
1.504GlnLys: 1.504 ± 0.506
1.504GlnLeu: 1.504 ± 0.626
0.752GlnMet: 0.752 ± 0.535
0.752GlnAsn: 0.752 ± 0.63
0.0GlnPro: 0.0 ± 0.0
1.128GlnGln: 1.128 ± 0.535
1.128GlnArg: 1.128 ± 0.491
2.632GlnSer: 2.632 ± 0.716
2.256GlnThr: 2.256 ± 0.938
1.88GlnVal: 1.88 ± 0.696
0.0GlnTrp: 0.0 ± 0.0
1.128GlnTyr: 1.128 ± 0.631
0.0GlnXaa: 0.0 ± 0.0
Arg
4.887ArgAla: 4.887 ± 1.199
0.376ArgCys: 0.376 ± 0.381
5.639ArgAsp: 5.639 ± 1.6
8.271ArgGlu: 8.271 ± 1.185
0.752ArgPhe: 0.752 ± 0.404
3.008ArgGly: 3.008 ± 0.875
2.632ArgHis: 2.632 ± 1.339
4.511ArgIle: 4.511 ± 1.781
1.88ArgLys: 1.88 ± 0.7
4.511ArgLeu: 4.511 ± 1.079
2.632ArgMet: 2.632 ± 0.836
1.128ArgAsn: 1.128 ± 0.706
1.88ArgPro: 1.88 ± 0.697
0.376ArgGln: 0.376 ± 0.381
4.887ArgArg: 4.887 ± 1.357
3.383ArgSer: 3.383 ± 0.989
1.88ArgThr: 1.88 ± 0.726
4.135ArgVal: 4.135 ± 0.681
1.504ArgTrp: 1.504 ± 0.718
2.256ArgTyr: 2.256 ± 0.883
0.0ArgXaa: 0.0 ± 0.0
Ser
6.391SerAla: 6.391 ± 2.107
0.0SerCys: 0.0 ± 0.0
4.511SerAsp: 4.511 ± 1.219
5.263SerGlu: 5.263 ± 1.731
3.759SerPhe: 3.759 ± 1.464
10.526SerGly: 10.526 ± 1.558
3.008SerHis: 3.008 ± 1.047
2.256SerIle: 2.256 ± 0.911
2.632SerLys: 2.632 ± 0.571
4.887SerLeu: 4.887 ± 1.155
2.256SerMet: 2.256 ± 1.005
3.008SerAsn: 3.008 ± 0.843
3.383SerPro: 3.383 ± 0.96
1.88SerGln: 1.88 ± 0.988
1.88SerArg: 1.88 ± 0.787
3.383SerSer: 3.383 ± 1.074
3.008SerThr: 3.008 ± 1.035
6.767SerVal: 6.767 ± 1.782
1.128SerTrp: 1.128 ± 0.499
1.504SerTyr: 1.504 ± 0.646
0.0SerXaa: 0.0 ± 0.0
Thr
6.015ThrAla: 6.015 ± 1.087
0.0ThrCys: 0.0 ± 0.0
4.887ThrAsp: 4.887 ± 1.413
3.759ThrGlu: 3.759 ± 1.09
1.88ThrPhe: 1.88 ± 0.612
5.639ThrGly: 5.639 ± 1.177
0.752ThrHis: 0.752 ± 0.476
4.135ThrIle: 4.135 ± 1.689
2.256ThrLys: 2.256 ± 1.009
6.767ThrLeu: 6.767 ± 1.229
0.752ThrMet: 0.752 ± 0.504
3.008ThrAsn: 3.008 ± 0.906
2.632ThrPro: 2.632 ± 0.725
3.008ThrGln: 3.008 ± 1.006
4.511ThrArg: 4.511 ± 0.942
4.887ThrSer: 4.887 ± 0.721
3.759ThrThr: 3.759 ± 1.602
7.519ThrVal: 7.519 ± 2.021
1.88ThrTrp: 1.88 ± 0.877
0.376ThrTyr: 0.376 ± 0.273
0.0ThrXaa: 0.0 ± 0.0
Val
7.143ValAla: 7.143 ± 2.316
0.376ValCys: 0.376 ± 0.372
4.887ValAsp: 4.887 ± 1.204
8.271ValGlu: 8.271 ± 1.516
2.632ValPhe: 2.632 ± 1.418
5.639ValGly: 5.639 ± 1.065
1.88ValHis: 1.88 ± 0.812
2.256ValIle: 2.256 ± 1.079
3.383ValLys: 3.383 ± 0.761
3.008ValLeu: 3.008 ± 0.727
0.376ValMet: 0.376 ± 0.386
2.256ValAsn: 2.256 ± 0.808
3.759ValPro: 3.759 ± 0.842
1.88ValGln: 1.88 ± 0.664
7.895ValArg: 7.895 ± 2.422
6.767ValSer: 6.767 ± 1.502
3.383ValThr: 3.383 ± 1.163
3.759ValVal: 3.759 ± 0.605
1.88ValTrp: 1.88 ± 0.783
3.008ValTyr: 3.008 ± 1.331
0.0ValXaa: 0.0 ± 0.0
Trp
3.008TrpAla: 3.008 ± 0.772
0.0TrpCys: 0.0 ± 0.0
1.128TrpAsp: 1.128 ± 0.598
1.128TrpGlu: 1.128 ± 0.536
0.752TrpPhe: 0.752 ± 0.614
0.752TrpGly: 0.752 ± 0.398
1.128TrpHis: 1.128 ± 0.561
0.376TrpIle: 0.376 ± 0.533
0.752TrpLys: 0.752 ± 0.439
1.88TrpLeu: 1.88 ± 1.159
0.0TrpMet: 0.0 ± 0.0
1.128TrpAsn: 1.128 ± 0.533
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.128TrpArg: 1.128 ± 1.143
1.88TrpSer: 1.88 ± 0.64
2.256TrpThr: 2.256 ± 0.594
2.256TrpVal: 2.256 ± 1.124
0.0TrpTrp: 0.0 ± 0.0
0.752TrpTyr: 0.752 ± 0.445
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.752TyrAla: 0.752 ± 0.342
0.0TyrCys: 0.0 ± 0.0
3.383TyrAsp: 3.383 ± 1.187
1.504TyrGlu: 1.504 ± 0.386
1.128TyrPhe: 1.128 ± 0.598
3.008TyrGly: 3.008 ± 0.87
1.504TyrHis: 1.504 ± 0.836
0.376TyrIle: 0.376 ± 0.273
0.752TyrLys: 0.752 ± 0.503
3.383TyrLeu: 3.383 ± 1.088
0.0TyrMet: 0.0 ± 0.0
0.752TyrAsn: 0.752 ± 0.567
0.752TyrPro: 0.752 ± 0.655
1.88TyrGln: 1.88 ± 0.852
2.256TyrArg: 2.256 ± 0.794
2.256TyrSer: 2.256 ± 1.168
1.128TyrThr: 1.128 ± 0.565
2.256TyrVal: 2.256 ± 0.915
0.0TyrTrp: 0.0 ± 0.0
1.88TyrTyr: 1.88 ± 0.851
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (2661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski