Amino acid dipepetide frequency for Kocuria sp. WRN011

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.836AlaAla: 15.836 ± 0.202
0.793AlaCys: 0.793 ± 0.027
6.567AlaAsp: 6.567 ± 0.089
7.412AlaGlu: 7.412 ± 0.089
3.289AlaPhe: 3.289 ± 0.073
10.151AlaGly: 10.151 ± 0.143
2.469AlaHis: 2.469 ± 0.051
4.72AlaIle: 4.72 ± 0.095
3.211AlaLys: 3.211 ± 0.073
11.819AlaLeu: 11.819 ± 0.155
2.739AlaMet: 2.739 ± 0.056
2.534AlaAsn: 2.534 ± 0.057
5.504AlaPro: 5.504 ± 0.098
4.378AlaGln: 4.378 ± 0.079
7.546AlaArg: 7.546 ± 0.102
6.523AlaSer: 6.523 ± 0.09
6.495AlaThr: 6.495 ± 0.083
10.316AlaVal: 10.316 ± 0.129
1.679AlaTrp: 1.679 ± 0.042
2.187AlaTyr: 2.187 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.028
0.074CysCys: 0.074 ± 0.01
0.359CysAsp: 0.359 ± 0.021
0.329CysGlu: 0.329 ± 0.017
0.212CysPhe: 0.212 ± 0.017
0.73CysGly: 0.73 ± 0.033
0.156CysHis: 0.156 ± 0.013
0.295CysIle: 0.295 ± 0.019
0.116CysLys: 0.116 ± 0.011
0.611CysLeu: 0.611 ± 0.027
0.127CysMet: 0.127 ± 0.011
0.134CysAsn: 0.134 ± 0.013
0.349CysPro: 0.349 ± 0.022
0.166CysGln: 0.166 ± 0.014
0.378CysArg: 0.378 ± 0.022
0.428CysSer: 0.428 ± 0.021
0.42CysThr: 0.42 ± 0.022
0.553CysVal: 0.553 ± 0.025
0.081CysTrp: 0.081 ± 0.01
0.157CysTyr: 0.157 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.906AspAla: 6.906 ± 0.089
0.298AspCys: 0.298 ± 0.019
3.498AspAsp: 3.498 ± 0.074
4.154AspGlu: 4.154 ± 0.078
1.755AspPhe: 1.755 ± 0.046
5.119AspGly: 5.119 ± 0.085
1.635AspHis: 1.635 ± 0.047
2.506AspIle: 2.506 ± 0.055
1.444AspLys: 1.444 ± 0.044
5.891AspLeu: 5.891 ± 0.089
1.155AspMet: 1.155 ± 0.034
1.303AspAsn: 1.303 ± 0.034
4.264AspPro: 4.264 ± 0.065
2.374AspGln: 2.374 ± 0.058
4.18AspArg: 4.18 ± 0.063
3.435AspSer: 3.435 ± 0.067
3.263AspThr: 3.263 ± 0.06
5.112AspVal: 5.112 ± 0.073
0.927AspTrp: 0.927 ± 0.035
1.362AspTyr: 1.362 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.607GluAla: 6.607 ± 0.095
0.332GluCys: 0.332 ± 0.021
3.833GluAsp: 3.833 ± 0.072
3.656GluGlu: 3.656 ± 0.082
1.921GluPhe: 1.921 ± 0.044
4.057GluGly: 4.057 ± 0.067
1.911GluHis: 1.911 ± 0.041
2.966GluIle: 2.966 ± 0.052
1.965GluLys: 1.965 ± 0.053
6.846GluLeu: 6.846 ± 0.093
1.16GluMet: 1.16 ± 0.039
1.954GluAsn: 1.954 ± 0.052
3.171GluPro: 3.171 ± 0.071
2.909GluGln: 2.909 ± 0.068
4.887GluArg: 4.887 ± 0.067
3.468GluSer: 3.468 ± 0.067
3.616GluThr: 3.616 ± 0.07
4.442GluVal: 4.442 ± 0.083
0.918GluTrp: 0.918 ± 0.034
1.344GluTyr: 1.344 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.521PheAla: 3.521 ± 0.066
0.228PheCys: 0.228 ± 0.016
2.124PheAsp: 2.124 ± 0.053
1.79PheGlu: 1.79 ± 0.047
1.197PhePhe: 1.197 ± 0.039
3.184PheGly: 3.184 ± 0.06
0.684PheHis: 0.684 ± 0.03
1.274PheIle: 1.274 ± 0.04
0.693PheLys: 0.693 ± 0.03
2.761PheLeu: 2.761 ± 0.064
0.712PheMet: 0.712 ± 0.032
0.893PheAsn: 0.893 ± 0.029
1.391PhePro: 1.391 ± 0.034
0.874PheGln: 0.874 ± 0.032
1.73PheArg: 1.73 ± 0.044
1.931PheSer: 1.931 ± 0.049
2.191PheThr: 2.191 ± 0.051
2.695PheVal: 2.695 ± 0.056
0.475PheTrp: 0.475 ± 0.021
0.732PheTyr: 0.732 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.112GlyAla: 9.112 ± 0.121
0.636GlyCys: 0.636 ± 0.022
4.521GlyAsp: 4.521 ± 0.078
4.936GlyGlu: 4.936 ± 0.076
3.062GlyPhe: 3.062 ± 0.056
6.925GlyGly: 6.925 ± 0.117
2.079GlyHis: 2.079 ± 0.052
4.325GlyIle: 4.325 ± 0.085
2.694GlyLys: 2.694 ± 0.047
8.423GlyLeu: 8.423 ± 0.128
2.229GlyMet: 2.229 ± 0.051
2.144GlyAsn: 2.144 ± 0.055
3.795GlyPro: 3.795 ± 0.062
3.265GlyGln: 3.265 ± 0.056
5.494GlyArg: 5.494 ± 0.094
5.57GlySer: 5.57 ± 0.085
5.42GlyThr: 5.42 ± 0.08
7.123GlyVal: 7.123 ± 0.089
1.556GlyTrp: 1.556 ± 0.046
2.226GlyTyr: 2.226 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.297HisAla: 2.297 ± 0.056
0.176HisCys: 0.176 ± 0.013
1.398HisAsp: 1.398 ± 0.044
1.411HisGlu: 1.411 ± 0.041
0.643HisPhe: 0.643 ± 0.023
2.266HisGly: 2.266 ± 0.043
0.654HisHis: 0.654 ± 0.027
0.815HisIle: 0.815 ± 0.03
0.513HisLys: 0.513 ± 0.024
2.183HisLeu: 2.183 ± 0.048
0.489HisMet: 0.489 ± 0.024
0.56HisAsn: 0.56 ± 0.024
1.534HisPro: 1.534 ± 0.04
0.764HisGln: 0.764 ± 0.03
1.815HisArg: 1.815 ± 0.047
1.244HisSer: 1.244 ± 0.037
1.285HisThr: 1.285 ± 0.038
1.939HisVal: 1.939 ± 0.042
0.34HisTrp: 0.34 ± 0.023
0.504HisTyr: 0.504 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.465IleAla: 5.465 ± 0.095
0.289IleCys: 0.289 ± 0.017
2.788IleAsp: 2.788 ± 0.051
2.78IleGlu: 2.78 ± 0.057
1.379IlePhe: 1.379 ± 0.044
3.984IleGly: 3.984 ± 0.084
0.911IleHis: 0.911 ± 0.029
1.904IleIle: 1.904 ± 0.058
1.201IleLys: 1.201 ± 0.036
4.014IleLeu: 4.014 ± 0.074
0.963IleMet: 0.963 ± 0.037
1.246IleAsn: 1.246 ± 0.038
2.584IlePro: 2.584 ± 0.055
1.24IleGln: 1.24 ± 0.04
2.498IleArg: 2.498 ± 0.051
2.667IleSer: 2.667 ± 0.057
3.012IleThr: 3.012 ± 0.063
3.837IleVal: 3.837 ± 0.068
0.461IleTrp: 0.461 ± 0.023
0.863IleTyr: 0.863 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.086LysAla: 3.086 ± 0.07
0.122LysCys: 0.122 ± 0.012
1.839LysAsp: 1.839 ± 0.047
1.506LysGlu: 1.506 ± 0.046
0.775LysPhe: 0.775 ± 0.029
1.954LysGly: 1.954 ± 0.051
0.643LysHis: 0.643 ± 0.026
1.379LysIle: 1.379 ± 0.038
1.131LysLys: 1.131 ± 0.041
2.593LysLeu: 2.593 ± 0.053
0.586LysMet: 0.586 ± 0.028
0.863LysAsn: 0.863 ± 0.031
1.596LysPro: 1.596 ± 0.049
0.947LysGln: 0.947 ± 0.028
1.89LysArg: 1.89 ± 0.044
1.487LysSer: 1.487 ± 0.046
1.597LysThr: 1.597 ± 0.048
2.217LysVal: 2.217 ± 0.058
0.329LysTrp: 0.329 ± 0.019
0.673LysTyr: 0.673 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.979LeuAla: 11.979 ± 0.145
0.683LeuCys: 0.683 ± 0.028
6.28LeuAsp: 6.28 ± 0.084
5.422LeuGlu: 5.422 ± 0.088
2.837LeuPhe: 2.837 ± 0.067
8.639LeuGly: 8.639 ± 0.114
1.907LeuHis: 1.907 ± 0.048
4.487LeuIle: 4.487 ± 0.088
2.525LeuLys: 2.525 ± 0.057
9.468LeuLeu: 9.468 ± 0.137
2.06LeuMet: 2.06 ± 0.044
2.725LeuAsn: 2.725 ± 0.058
5.233LeuPro: 5.233 ± 0.087
2.621LeuGln: 2.621 ± 0.057
6.586LeuArg: 6.586 ± 0.087
6.093LeuSer: 6.093 ± 0.086
6.417LeuThr: 6.417 ± 0.087
8.33LeuVal: 8.33 ± 0.112
1.261LeuTrp: 1.261 ± 0.047
1.757LeuTyr: 1.757 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.704MetAla: 2.704 ± 0.064
0.177MetCys: 0.177 ± 0.012
1.222MetAsp: 1.222 ± 0.04
0.997MetGlu: 0.997 ± 0.03
0.704MetPhe: 0.704 ± 0.03
1.879MetGly: 1.879 ± 0.055
0.4MetHis: 0.4 ± 0.02
1.084MetIle: 1.084 ± 0.038
0.614MetLys: 0.614 ± 0.024
2.087MetLeu: 2.087 ± 0.051
0.458MetMet: 0.458 ± 0.023
0.673MetAsn: 0.673 ± 0.027
1.176MetPro: 1.176 ± 0.037
0.62MetGln: 0.62 ± 0.026
1.414MetArg: 1.414 ± 0.043
1.91MetSer: 1.91 ± 0.045
1.805MetThr: 1.805 ± 0.045
1.735MetVal: 1.735 ± 0.048
0.281MetTrp: 0.281 ± 0.019
0.381MetTyr: 0.381 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.938AsnAla: 2.938 ± 0.056
0.15AsnCys: 0.15 ± 0.014
1.443AsnAsp: 1.443 ± 0.047
1.44AsnGlu: 1.44 ± 0.037
0.789AsnPhe: 0.789 ± 0.032
2.409AsnGly: 2.409 ± 0.054
0.567AsnHis: 0.567 ± 0.023
1.127AsnIle: 1.127 ± 0.035
0.668AsnLys: 0.668 ± 0.026
2.4AsnLeu: 2.4 ± 0.053
0.566AsnMet: 0.566 ± 0.024
0.736AsnAsn: 0.736 ± 0.03
1.939AsnPro: 1.939 ± 0.048
0.931AsnGln: 0.931 ± 0.037
1.671AsnArg: 1.671 ± 0.042
1.516AsnSer: 1.516 ± 0.043
1.525AsnThr: 1.525 ± 0.04
2.149AsnVal: 2.149 ± 0.044
0.399AsnTrp: 0.399 ± 0.021
0.602AsnTyr: 0.602 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.995ProAla: 5.995 ± 0.1
0.221ProCys: 0.221 ± 0.014
3.602ProAsp: 3.602 ± 0.071
4.654ProGlu: 4.654 ± 0.077
1.6ProPhe: 1.6 ± 0.045
4.953ProGly: 4.953 ± 0.082
1.192ProHis: 1.192 ± 0.035
1.796ProIle: 1.796 ± 0.039
1.425ProLys: 1.425 ± 0.047
4.592ProLeu: 4.592 ± 0.069
1.047ProMet: 1.047 ± 0.033
1.275ProAsn: 1.275 ± 0.037
1.993ProPro: 1.993 ± 0.057
2.054ProGln: 2.054 ± 0.046
3.216ProArg: 3.216 ± 0.058
3.21ProSer: 3.21 ± 0.065
3.189ProThr: 3.189 ± 0.06
4.983ProVal: 4.983 ± 0.077
0.892ProTrp: 0.892 ± 0.032
1.069ProTyr: 1.069 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
4.044GlnAla: 4.044 ± 0.071
0.187GlnCys: 0.187 ± 0.015
2.173GlnAsp: 2.173 ± 0.056
2.093GlnGlu: 2.093 ± 0.055
1.01GlnPhe: 1.01 ± 0.032
2.567GlnGly: 2.567 ± 0.056
0.795GlnHis: 0.795 ± 0.029
1.563GlnIle: 1.563 ± 0.037
0.939GlnLys: 0.939 ± 0.032
3.779GlnLeu: 3.779 ± 0.067
0.654GlnMet: 0.654 ± 0.025
0.979GlnAsn: 0.979 ± 0.038
1.84GlnPro: 1.84 ± 0.046
1.556GlnGln: 1.556 ± 0.046
2.791GlnArg: 2.791 ± 0.057
1.845GlnSer: 1.845 ± 0.05
1.658GlnThr: 1.658 ± 0.041
2.594GlnVal: 2.594 ± 0.049
0.609GlnTrp: 0.609 ± 0.026
0.754GlnTyr: 0.754 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
7.295ArgAla: 7.295 ± 0.096
0.415ArgCys: 0.415 ± 0.021
3.93ArgAsp: 3.93 ± 0.071
4.612ArgGlu: 4.612 ± 0.077
2.153ArgPhe: 2.153 ± 0.047
5.001ArgGly: 5.001 ± 0.082
1.581ArgHis: 1.581 ± 0.046
3.158ArgIle: 3.158 ± 0.06
2.004ArgLys: 2.004 ± 0.053
6.076ArgLeu: 6.076 ± 0.087
1.755ArgMet: 1.755 ± 0.044
1.785ArgAsn: 1.785 ± 0.047
3.324ArgPro: 3.324 ± 0.063
2.181ArgGln: 2.181 ± 0.041
5.279ArgArg: 5.279 ± 0.094
4.147ArgSer: 4.147 ± 0.072
4.198ArgThr: 4.198 ± 0.064
5.365ArgVal: 5.365 ± 0.076
1.155ArgTrp: 1.155 ± 0.039
1.545ArgTyr: 1.545 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.789SerAla: 6.789 ± 0.088
0.362SerCys: 0.362 ± 0.023
3.364SerAsp: 3.364 ± 0.062
3.761SerGlu: 3.761 ± 0.063
1.867SerPhe: 1.867 ± 0.044
5.907SerGly: 5.907 ± 0.088
1.299SerHis: 1.299 ± 0.032
2.372SerIle: 2.372 ± 0.048
1.628SerLys: 1.628 ± 0.045
5.476SerLeu: 5.476 ± 0.074
1.646SerMet: 1.646 ± 0.047
1.526SerAsn: 1.526 ± 0.043
3.286SerPro: 3.286 ± 0.062
2.03SerGln: 2.03 ± 0.049
3.869SerArg: 3.869 ± 0.071
3.968SerSer: 3.968 ± 0.078
3.767SerThr: 3.767 ± 0.062
5.254SerVal: 5.254 ± 0.08
0.939SerTrp: 0.939 ± 0.036
1.375SerTyr: 1.375 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
7.148ThrAla: 7.148 ± 0.08
0.342ThrCys: 0.342 ± 0.02
3.819ThrAsp: 3.819 ± 0.069
3.775ThrGlu: 3.775 ± 0.077
1.805ThrPhe: 1.805 ± 0.044
5.944ThrGly: 5.944 ± 0.083
1.36ThrHis: 1.36 ± 0.036
2.478ThrIle: 2.478 ± 0.056
1.478ThrLys: 1.478 ± 0.039
5.504ThrLeu: 5.504 ± 0.076
1.292ThrMet: 1.292 ± 0.037
1.394ThrAsn: 1.394 ± 0.042
3.689ThrPro: 3.689 ± 0.062
1.824ThrGln: 1.824 ± 0.051
3.586ThrArg: 3.586 ± 0.069
3.647ThrSer: 3.647 ± 0.054
3.793ThrThr: 3.793 ± 0.066
6.253ThrVal: 6.253 ± 0.072
0.933ThrTrp: 0.933 ± 0.035
1.307ThrTyr: 1.307 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
9.889ValAla: 9.889 ± 0.115
0.675ValCys: 0.675 ± 0.029
5.543ValAsp: 5.543 ± 0.078
5.166ValGlu: 5.166 ± 0.081
2.681ValPhe: 2.681 ± 0.059
6.758ValGly: 6.758 ± 0.094
1.812ValHis: 1.812 ± 0.045
4.334ValIle: 4.334 ± 0.07
2.062ValLys: 2.062 ± 0.051
8.932ValLeu: 8.932 ± 0.106
1.947ValMet: 1.947 ± 0.047
2.176ValAsn: 2.176 ± 0.047
4.422ValPro: 4.422 ± 0.072
2.421ValGln: 2.421 ± 0.05
5.382ValArg: 5.382 ± 0.075
5.204ValSer: 5.204 ± 0.079
5.672ValThr: 5.672 ± 0.084
8.173ValVal: 8.173 ± 0.124
1.107ValTrp: 1.107 ± 0.036
1.612ValTyr: 1.612 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.545TrpAla: 1.545 ± 0.045
0.136TrpCys: 0.136 ± 0.011
0.886TrpAsp: 0.886 ± 0.033
0.732TrpGlu: 0.732 ± 0.031
0.613TrpPhe: 0.613 ± 0.026
1.085TrpGly: 1.085 ± 0.035
0.347TrpHis: 0.347 ± 0.016
0.805TrpIle: 0.805 ± 0.035
0.361TrpLys: 0.361 ± 0.019
1.788TrpLeu: 1.788 ± 0.049
0.313TrpMet: 0.313 ± 0.02
0.491TrpAsn: 0.491 ± 0.023
0.688TrpPro: 0.688 ± 0.026
0.548TrpGln: 0.548 ± 0.023
1.096TrpArg: 1.096 ± 0.033
0.887TrpSer: 0.887 ± 0.032
0.864TrpThr: 0.864 ± 0.033
1.168TrpVal: 1.168 ± 0.037
0.382TrpTrp: 0.382 ± 0.02
0.323TrpTyr: 0.323 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.254TyrAla: 2.254 ± 0.048
0.141TyrCys: 0.141 ± 0.012
1.393TyrAsp: 1.393 ± 0.046
1.339TyrGlu: 1.339 ± 0.04
0.787TyrPhe: 0.787 ± 0.027
2.025TyrGly: 2.025 ± 0.046
0.426TyrHis: 0.426 ± 0.023
0.697TyrIle: 0.697 ± 0.025
0.541TyrLys: 0.541 ± 0.025
2.066TyrLeu: 2.066 ± 0.046
0.422TyrMet: 0.422 ± 0.026
0.572TyrAsn: 0.572 ± 0.022
1.179TyrPro: 1.179 ± 0.038
0.728TyrGln: 0.728 ± 0.028
1.65TyrArg: 1.65 ± 0.043
1.305TyrSer: 1.305 ± 0.034
1.185TyrThr: 1.185 ± 0.04
1.731TyrVal: 1.731 ± 0.042
0.329TyrTrp: 0.329 ± 0.018
0.513TyrTyr: 0.513 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2905 proteins (959224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski