Amino acid dipepetide frequency for Streptococcus satellite phage Javan495

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.31AlaAla: 0.31 ± 0.339
1.861AlaCys: 1.861 ± 0.553
2.792AlaAsp: 2.792 ± 0.851
5.273AlaGlu: 5.273 ± 1.344
3.722AlaPhe: 3.722 ± 0.807
2.481AlaGly: 2.481 ± 0.791
0.31AlaHis: 0.31 ± 0.269
4.963AlaIle: 4.963 ± 1.244
4.963AlaLys: 4.963 ± 1.278
4.653AlaLeu: 4.653 ± 1.241
1.241AlaMet: 1.241 ± 0.54
2.481AlaAsn: 2.481 ± 0.741
1.241AlaPro: 1.241 ± 0.572
2.792AlaGln: 2.792 ± 0.813
2.481AlaArg: 2.481 ± 0.649
3.412AlaSer: 3.412 ± 1.046
3.102AlaThr: 3.102 ± 0.752
3.722AlaVal: 3.722 ± 1.147
0.931AlaTrp: 0.931 ± 0.726
1.861AlaTyr: 1.861 ± 0.634
0.0AlaXaa: 0.0 ± 0.0
Cys
0.62CysAla: 0.62 ± 0.377
0.31CysCys: 0.31 ± 0.338
0.62CysAsp: 0.62 ± 0.402
0.62CysGlu: 0.62 ± 0.394
0.0CysPhe: 0.0 ± 0.0
0.31CysGly: 0.31 ± 0.338
0.31CysHis: 0.31 ± 0.305
0.0CysIle: 0.0 ± 0.0
0.62CysLys: 0.62 ± 0.343
0.931CysLeu: 0.931 ± 0.472
0.0CysMet: 0.0 ± 0.0
0.931CysAsn: 0.931 ± 0.555
0.31CysPro: 0.31 ± 0.338
0.31CysGln: 0.31 ± 0.338
0.62CysArg: 0.62 ± 0.462
0.62CysSer: 0.62 ± 0.465
0.0CysThr: 0.0 ± 0.0
0.31CysVal: 0.31 ± 0.269
0.0CysTrp: 0.0 ± 0.0
0.931CysTyr: 0.931 ± 0.468
0.0CysXaa: 0.0 ± 0.0
Asp
1.241AspAla: 1.241 ± 0.515
0.931AspCys: 0.931 ± 0.719
2.171AspAsp: 2.171 ± 1.022
4.032AspGlu: 4.032 ± 1.485
2.792AspPhe: 2.792 ± 0.811
1.551AspGly: 1.551 ± 0.603
0.31AspHis: 0.31 ± 0.305
5.273AspIle: 5.273 ± 1.319
4.342AspLys: 4.342 ± 1.196
6.203AspLeu: 6.203 ± 1.042
2.171AspMet: 2.171 ± 1.042
1.551AspAsn: 1.551 ± 0.474
1.241AspPro: 1.241 ± 0.382
2.171AspGln: 2.171 ± 0.93
2.792AspArg: 2.792 ± 0.68
3.412AspSer: 3.412 ± 0.933
4.342AspThr: 4.342 ± 1.285
1.551AspVal: 1.551 ± 0.754
0.931AspTrp: 0.931 ± 0.574
5.583AspTyr: 5.583 ± 1.145
0.0AspXaa: 0.0 ± 0.0
Glu
7.134GluAla: 7.134 ± 1.253
0.931GluCys: 0.931 ± 0.66
3.722GluAsp: 3.722 ± 1.14
7.134GluGlu: 7.134 ± 1.802
2.792GluPhe: 2.792 ± 0.928
2.481GluGly: 2.481 ± 0.562
2.171GluHis: 2.171 ± 0.453
7.444GluIle: 7.444 ± 1.988
7.754GluLys: 7.754 ± 1.11
9.615GluLeu: 9.615 ± 1.407
1.861GluMet: 1.861 ± 0.619
2.171GluAsn: 2.171 ± 0.8
1.551GluPro: 1.551 ± 0.595
4.963GluGln: 4.963 ± 1.337
4.032GluArg: 4.032 ± 0.839
3.412GluSer: 3.412 ± 1.111
4.342GluThr: 4.342 ± 1.203
2.792GluVal: 2.792 ± 0.811
1.551GluTrp: 1.551 ± 0.654
3.722GluTyr: 3.722 ± 1.234
0.0GluXaa: 0.0 ± 0.0
Phe
1.861PheAla: 1.861 ± 0.61
0.62PheCys: 0.62 ± 0.345
2.481PheAsp: 2.481 ± 0.645
3.102PheGlu: 3.102 ± 1.01
0.931PhePhe: 0.931 ± 0.433
1.241PheGly: 1.241 ± 0.543
1.861PheHis: 1.861 ± 0.636
4.342PheIle: 4.342 ± 1.083
3.722PheLys: 3.722 ± 1.224
4.032PheLeu: 4.032 ± 0.845
0.31PheMet: 0.31 ± 0.305
4.653PheAsn: 4.653 ± 1.02
1.551PhePro: 1.551 ± 0.818
1.551PheGln: 1.551 ± 0.638
1.551PheArg: 1.551 ± 0.654
2.792PheSer: 2.792 ± 0.684
2.481PheThr: 2.481 ± 0.75
0.931PheVal: 0.931 ± 0.437
0.31PheTrp: 0.31 ± 0.267
2.171PheTyr: 2.171 ± 0.682
0.0PheXaa: 0.0 ± 0.0
Gly
3.102GlyAla: 3.102 ± 1.122
0.31GlyCys: 0.31 ± 0.326
4.342GlyAsp: 4.342 ± 1.244
3.102GlyGlu: 3.102 ± 0.856
1.861GlyPhe: 1.861 ± 0.81
2.792GlyGly: 2.792 ± 0.757
1.241GlyHis: 1.241 ± 0.59
3.412GlyIle: 3.412 ± 0.992
3.412GlyLys: 3.412 ± 0.936
4.963GlyLeu: 4.963 ± 1.409
1.241GlyMet: 1.241 ± 0.585
3.102GlyAsn: 3.102 ± 0.848
0.0GlyPro: 0.0 ± 0.0
1.551GlyGln: 1.551 ± 0.871
2.481GlyArg: 2.481 ± 0.865
1.241GlySer: 1.241 ± 0.559
2.481GlyThr: 2.481 ± 0.923
2.792GlyVal: 2.792 ± 0.988
0.62GlyTrp: 0.62 ± 0.533
2.481GlyTyr: 2.481 ± 0.826
0.0GlyXaa: 0.0 ± 0.0
His
2.481HisAla: 2.481 ± 0.917
0.0HisCys: 0.0 ± 0.0
0.31HisAsp: 0.31 ± 0.338
0.62HisGlu: 0.62 ± 0.533
0.931HisPhe: 0.931 ± 0.392
1.241HisGly: 1.241 ± 0.549
0.0HisHis: 0.0 ± 0.0
0.931HisIle: 0.931 ± 0.541
1.241HisLys: 1.241 ± 0.679
1.551HisLeu: 1.551 ± 0.69
0.0HisMet: 0.0 ± 0.0
2.481HisAsn: 2.481 ± 0.924
0.31HisPro: 0.31 ± 0.289
0.931HisGln: 0.931 ± 0.523
0.62HisArg: 0.62 ± 0.429
0.31HisSer: 0.31 ± 0.297
1.861HisThr: 1.861 ± 0.602
0.31HisVal: 0.31 ± 0.321
0.31HisTrp: 0.31 ± 0.338
2.171HisTyr: 2.171 ± 0.787
0.0HisXaa: 0.0 ± 0.0
Ile
4.342IleAla: 4.342 ± 1.126
0.62IleCys: 0.62 ± 0.403
6.514IleAsp: 6.514 ± 1.554
7.444IleGlu: 7.444 ± 1.385
1.861IlePhe: 1.861 ± 0.747
2.792IleGly: 2.792 ± 0.8
0.31IleHis: 0.31 ± 0.338
4.963IleIle: 4.963 ± 1.11
7.754IleLys: 7.754 ± 1.556
3.722IleLeu: 3.722 ± 0.85
1.241IleMet: 1.241 ± 0.466
5.273IleAsn: 5.273 ± 1.65
3.102IlePro: 3.102 ± 0.998
1.551IleGln: 1.551 ± 0.684
1.861IleArg: 1.861 ± 0.587
5.273IleSer: 5.273 ± 1.211
6.514IleThr: 6.514 ± 1.244
2.792IleVal: 2.792 ± 0.748
0.31IleTrp: 0.31 ± 0.263
3.412IleTyr: 3.412 ± 0.894
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.925
0.0LysCys: 0.0 ± 0.0
5.273LysAsp: 5.273 ± 1.476
9.305LysGlu: 9.305 ± 1.493
2.171LysPhe: 2.171 ± 0.633
4.342LysGly: 4.342 ± 0.965
3.102LysHis: 3.102 ± 0.899
6.824LysIle: 6.824 ± 1.639
5.583LysLys: 5.583 ± 1.424
6.824LysLeu: 6.824 ± 1.311
2.171LysMet: 2.171 ± 0.888
4.653LysAsn: 4.653 ± 0.8
5.583LysPro: 5.583 ± 1.657
3.102LysGln: 3.102 ± 0.953
5.893LysArg: 5.893 ± 1.495
3.412LysSer: 3.412 ± 1.091
5.583LysThr: 5.583 ± 1.205
5.273LysVal: 5.273 ± 1.079
0.62LysTrp: 0.62 ± 0.37
5.273LysTyr: 5.273 ± 1.06
0.0LysXaa: 0.0 ± 0.0
Leu
4.032LeuAla: 4.032 ± 1.024
0.31LeuCys: 0.31 ± 0.338
6.824LeuAsp: 6.824 ± 1.132
9.305LeuGlu: 9.305 ± 1.998
4.963LeuPhe: 4.963 ± 0.855
4.032LeuGly: 4.032 ± 1.057
0.931LeuHis: 0.931 ± 0.531
6.514LeuIle: 6.514 ± 1.415
7.134LeuLys: 7.134 ± 1.235
9.615LeuLeu: 9.615 ± 1.649
2.481LeuMet: 2.481 ± 0.762
4.653LeuAsn: 4.653 ± 1.073
3.412LeuPro: 3.412 ± 1.035
2.792LeuGln: 2.792 ± 0.844
3.102LeuArg: 3.102 ± 1.088
8.995LeuSer: 8.995 ± 1.594
5.583LeuThr: 5.583 ± 1.156
5.583LeuVal: 5.583 ± 0.982
0.31LeuTrp: 0.31 ± 0.263
4.653LeuTyr: 4.653 ± 1.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.241MetAla: 1.241 ± 0.542
0.0MetCys: 0.0 ± 0.0
1.551MetAsp: 1.551 ± 0.613
1.551MetGlu: 1.551 ± 0.628
0.62MetPhe: 0.62 ± 0.415
0.931MetGly: 0.931 ± 0.429
0.0MetHis: 0.0 ± 0.0
0.931MetIle: 0.931 ± 0.545
2.792MetLys: 2.792 ± 0.751
1.241MetLeu: 1.241 ± 0.428
0.31MetMet: 0.31 ± 0.348
0.62MetAsn: 0.62 ± 0.367
0.31MetPro: 0.31 ± 0.267
1.241MetGln: 1.241 ± 0.58
1.241MetArg: 1.241 ± 0.595
1.241MetSer: 1.241 ± 0.598
2.481MetThr: 2.481 ± 1.348
0.931MetVal: 0.931 ± 0.444
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.653AsnAla: 4.653 ± 1.339
0.0AsnCys: 0.0 ± 0.0
4.032AsnAsp: 4.032 ± 0.954
3.722AsnGlu: 3.722 ± 0.975
1.241AsnPhe: 1.241 ± 0.516
4.342AsnGly: 4.342 ± 0.852
1.551AsnHis: 1.551 ± 0.756
2.171AsnIle: 2.171 ± 0.729
4.653AsnLys: 4.653 ± 1.034
5.273AsnLeu: 5.273 ± 1.132
0.31AsnMet: 0.31 ± 0.347
4.653AsnAsn: 4.653 ± 1.667
3.102AsnPro: 3.102 ± 0.696
5.273AsnGln: 5.273 ± 1.25
3.102AsnArg: 3.102 ± 0.662
2.171AsnSer: 2.171 ± 0.598
0.931AsnThr: 0.931 ± 0.563
3.722AsnVal: 3.722 ± 1.001
0.62AsnTrp: 0.62 ± 0.469
1.861AsnTyr: 1.861 ± 0.471
0.0AsnXaa: 0.0 ± 0.0
Pro
1.241ProAla: 1.241 ± 0.558
0.31ProCys: 0.31 ± 0.321
1.241ProAsp: 1.241 ± 0.518
3.722ProGlu: 3.722 ± 1.067
2.481ProPhe: 2.481 ± 0.794
0.62ProGly: 0.62 ± 0.411
0.0ProHis: 0.0 ± 0.0
0.931ProIle: 0.931 ± 0.729
5.273ProLys: 5.273 ± 1.107
3.412ProLeu: 3.412 ± 0.864
0.31ProMet: 0.31 ± 0.338
3.102ProAsn: 3.102 ± 1.197
1.241ProPro: 1.241 ± 0.525
1.241ProGln: 1.241 ± 0.765
2.481ProArg: 2.481 ± 0.758
0.931ProSer: 0.931 ± 0.481
2.481ProThr: 2.481 ± 0.657
1.861ProVal: 1.861 ± 0.614
0.31ProTrp: 0.31 ± 0.267
0.31ProTyr: 0.31 ± 0.263
0.0ProXaa: 0.0 ± 0.0
Gln
2.792GlnAla: 2.792 ± 0.889
0.0GlnCys: 0.0 ± 0.0
2.481GlnAsp: 2.481 ± 0.675
3.722GlnGlu: 3.722 ± 1.082
1.241GlnPhe: 1.241 ± 0.54
2.481GlnGly: 2.481 ± 0.967
0.62GlnHis: 0.62 ± 0.369
2.481GlnIle: 2.481 ± 0.867
4.032GlnLys: 4.032 ± 1.085
5.273GlnLeu: 5.273 ± 1.069
0.931GlnMet: 0.931 ± 0.609
1.861GlnAsn: 1.861 ± 0.541
1.861GlnPro: 1.861 ± 0.675
2.481GlnGln: 2.481 ± 0.815
3.722GlnArg: 3.722 ± 0.855
3.102GlnSer: 3.102 ± 1.043
1.861GlnThr: 1.861 ± 0.787
2.792GlnVal: 2.792 ± 0.836
0.931GlnTrp: 0.931 ± 0.504
0.31GlnTyr: 0.31 ± 0.262
0.0GlnXaa: 0.0 ± 0.0
Arg
1.861ArgAla: 1.861 ± 0.727
0.62ArgCys: 0.62 ± 0.44
2.171ArgAsp: 2.171 ± 0.754
4.032ArgGlu: 4.032 ± 1.122
2.481ArgPhe: 2.481 ± 0.486
2.792ArgGly: 2.792 ± 1.014
0.931ArgHis: 0.931 ± 0.438
3.102ArgIle: 3.102 ± 0.96
5.893ArgLys: 5.893 ± 1.355
5.273ArgLeu: 5.273 ± 1.131
0.0ArgMet: 0.0 ± 0.347
2.171ArgAsn: 2.171 ± 0.662
1.241ArgPro: 1.241 ± 0.544
1.861ArgGln: 1.861 ± 0.861
2.171ArgArg: 2.171 ± 0.802
2.481ArgSer: 2.481 ± 0.859
4.342ArgThr: 4.342 ± 0.898
5.273ArgVal: 5.273 ± 0.832
0.62ArgTrp: 0.62 ± 0.413
3.412ArgTyr: 3.412 ± 1.104
0.0ArgXaa: 0.0 ± 0.0
Ser
3.102SerAla: 3.102 ± 1.043
0.31SerCys: 0.31 ± 0.338
3.412SerAsp: 3.412 ± 1.022
4.342SerGlu: 4.342 ± 0.89
2.171SerPhe: 2.171 ± 0.664
2.792SerGly: 2.792 ± 0.859
0.62SerHis: 0.62 ± 0.676
4.032SerIle: 4.032 ± 1.183
5.583SerLys: 5.583 ± 1.151
5.583SerLeu: 5.583 ± 1.103
0.931SerMet: 0.931 ± 0.442
2.481SerAsn: 2.481 ± 0.746
0.931SerPro: 0.931 ± 0.496
2.481SerGln: 2.481 ± 0.993
1.861SerArg: 1.861 ± 0.563
1.551SerSer: 1.551 ± 0.971
5.273SerThr: 5.273 ± 1.55
3.722SerVal: 3.722 ± 1.253
0.931SerTrp: 0.931 ± 0.482
1.861SerTyr: 1.861 ± 0.939
0.0SerXaa: 0.0 ± 0.0
Thr
4.653ThrAla: 4.653 ± 1.107
0.0ThrCys: 0.0 ± 0.0
1.241ThrAsp: 1.241 ± 0.518
2.481ThrGlu: 2.481 ± 0.85
5.273ThrPhe: 5.273 ± 1.9
3.102ThrGly: 3.102 ± 0.95
0.931ThrHis: 0.931 ± 0.371
5.583ThrIle: 5.583 ± 1.298
4.963ThrLys: 4.963 ± 1.351
6.824ThrLeu: 6.824 ± 1.023
1.241ThrMet: 1.241 ± 0.549
2.171ThrAsn: 2.171 ± 0.781
2.481ThrPro: 2.481 ± 0.853
2.171ThrGln: 2.171 ± 0.97
4.963ThrArg: 4.963 ± 0.963
3.722ThrSer: 3.722 ± 0.694
2.171ThrThr: 2.171 ± 0.932
2.481ThrVal: 2.481 ± 0.917
0.62ThrTrp: 0.62 ± 0.37
4.342ThrTyr: 4.342 ± 1.194
0.0ThrXaa: 0.0 ± 0.0
Val
2.792ValAla: 2.792 ± 0.74
0.31ValCys: 0.31 ± 0.267
1.551ValAsp: 1.551 ± 0.584
3.412ValGlu: 3.412 ± 1.091
3.102ValPhe: 3.102 ± 0.737
2.481ValGly: 2.481 ± 0.861
0.931ValHis: 0.931 ± 0.632
4.653ValIle: 4.653 ± 0.957
5.583ValLys: 5.583 ± 0.916
5.893ValLeu: 5.893 ± 1.217
0.62ValMet: 0.62 ± 0.453
4.342ValAsn: 4.342 ± 0.909
2.481ValPro: 2.481 ± 1.0
1.861ValGln: 1.861 ± 0.695
2.481ValArg: 2.481 ± 0.665
3.102ValSer: 3.102 ± 0.743
2.481ValThr: 2.481 ± 0.969
2.171ValVal: 2.171 ± 0.716
0.0ValTrp: 0.0 ± 0.0
1.861ValTyr: 1.861 ± 0.436
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.31TrpAsp: 0.31 ± 0.339
1.241TrpGlu: 1.241 ± 0.469
0.0TrpPhe: 0.0 ± 0.0
0.931TrpGly: 0.931 ± 0.392
0.62TrpHis: 0.62 ± 0.408
0.31TrpIle: 0.31 ± 0.267
0.31TrpLys: 0.31 ± 0.263
0.62TrpLeu: 0.62 ± 0.372
0.0TrpMet: 0.0 ± 0.0
0.31TrpAsn: 0.31 ± 0.263
0.31TrpPro: 0.31 ± 0.267
0.931TrpGln: 0.931 ± 0.424
1.241TrpArg: 1.241 ± 0.72
0.31TrpSer: 0.31 ± 0.263
0.62TrpThr: 0.62 ± 0.468
1.241TrpVal: 1.241 ± 0.549
0.62TrpTrp: 0.62 ± 0.525
1.241TrpTyr: 1.241 ± 0.473
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.792TyrAla: 2.792 ± 0.804
0.931TyrCys: 0.931 ± 0.419
1.551TyrAsp: 1.551 ± 0.523
3.412TyrGlu: 3.412 ± 0.968
1.861TyrPhe: 1.861 ± 0.727
2.792TyrGly: 2.792 ± 0.577
1.861TyrHis: 1.861 ± 0.75
2.792TyrIle: 2.792 ± 0.802
3.722TyrLys: 3.722 ± 1.056
3.722TyrLeu: 3.722 ± 1.016
1.551TyrMet: 1.551 ± 0.728
3.722TyrAsn: 3.722 ± 1.195
1.241TyrPro: 1.241 ± 0.792
3.722TyrGln: 3.722 ± 0.968
4.342TyrArg: 4.342 ± 1.095
2.481TyrSer: 2.481 ± 0.704
2.481TyrThr: 2.481 ± 0.567
1.861TyrVal: 1.861 ± 0.674
0.62TyrTrp: 0.62 ± 0.676
3.102TyrTyr: 3.102 ± 1.269
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (3225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski