Amino acid dipepetide frequency for Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.575AlaAla: 5.575 ± 0.79
3.066AlaCys: 3.066 ± 0.834
2.578AlaAsp: 2.578 ± 0.335
2.16AlaGlu: 2.16 ± 0.283
3.275AlaPhe: 3.275 ± 0.47
4.181AlaGly: 4.181 ± 0.452
1.254AlaHis: 1.254 ± 0.415
4.599AlaIle: 4.599 ± 0.698
3.415AlaLys: 3.415 ± 0.621
6.272AlaLeu: 6.272 ± 0.691
1.882AlaMet: 1.882 ± 0.279
5.714AlaAsn: 5.714 ± 0.601
2.509AlaPro: 2.509 ± 0.671
2.16AlaGln: 2.16 ± 0.331
2.787AlaArg: 2.787 ± 0.194
5.157AlaSer: 5.157 ± 0.688
4.878AlaThr: 4.878 ± 0.546
4.808AlaVal: 4.808 ± 0.423
0.767AlaTrp: 0.767 ± 0.181
3.693AlaTyr: 3.693 ± 0.324
0.0AlaXaa: 0.0 ± 0.0
Cys
1.533CysAla: 1.533 ± 0.452
0.836CysCys: 0.836 ± 0.239
2.021CysAsp: 2.021 ± 0.192
0.767CysGlu: 0.767 ± 0.383
1.045CysPhe: 1.045 ± 0.25
2.787CysGly: 2.787 ± 0.436
0.348CysHis: 0.348 ± 0.252
1.463CysIle: 1.463 ± 0.19
2.3CysLys: 2.3 ± 0.349
2.439CysLeu: 2.439 ± 0.226
0.139CysMet: 0.139 ± 0.105
1.812CysAsn: 1.812 ± 0.331
0.906CysPro: 0.906 ± 0.257
0.836CysGln: 0.836 ± 0.106
1.115CysArg: 1.115 ± 0.234
2.16CysSer: 2.16 ± 0.452
2.718CysThr: 2.718 ± 0.32
3.066CysVal: 3.066 ± 0.376
0.209CysTrp: 0.209 ± 0.136
2.021CysTyr: 2.021 ± 0.551
0.0CysXaa: 0.0 ± 0.0
Asp
4.599AspAla: 4.599 ± 0.638
2.091AspCys: 2.091 ± 0.303
2.787AspAsp: 2.787 ± 0.503
2.23AspGlu: 2.23 ± 0.322
2.091AspPhe: 2.091 ± 0.532
4.321AspGly: 4.321 ± 0.294
0.697AspHis: 0.697 ± 0.196
3.833AspIle: 3.833 ± 0.884
2.091AspLys: 2.091 ± 0.201
5.226AspLeu: 5.226 ± 0.408
1.463AspMet: 1.463 ± 0.186
2.16AspAsn: 2.16 ± 0.181
2.578AspPro: 2.578 ± 0.269
0.976AspGln: 0.976 ± 0.323
1.533AspArg: 1.533 ± 0.316
3.624AspSer: 3.624 ± 0.396
2.997AspThr: 2.997 ± 0.363
5.993AspVal: 5.993 ± 1.195
0.627AspTrp: 0.627 ± 0.184
2.857AspTyr: 2.857 ± 0.388
0.0AspXaa: 0.0 ± 0.0
Glu
2.648GluAla: 2.648 ± 0.252
1.115GluCys: 1.115 ± 0.466
2.927GluAsp: 2.927 ± 0.367
2.091GluGlu: 2.091 ± 0.273
2.3GluPhe: 2.3 ± 0.311
1.394GluGly: 1.394 ± 0.208
1.324GluHis: 1.324 ± 0.184
1.672GluIle: 1.672 ± 0.242
1.951GluLys: 1.951 ± 0.427
3.275GluLeu: 3.275 ± 0.355
0.209GluMet: 0.209 ± 0.109
1.812GluAsn: 1.812 ± 0.211
1.185GluPro: 1.185 ± 0.193
1.324GluGln: 1.324 ± 0.485
1.324GluArg: 1.324 ± 0.418
2.369GluSer: 2.369 ± 0.379
3.484GluThr: 3.484 ± 0.481
3.345GluVal: 3.345 ± 0.654
0.836GluTrp: 0.836 ± 0.419
1.882GluTyr: 1.882 ± 0.339
0.0GluXaa: 0.0 ± 0.0
Phe
2.927PheAla: 2.927 ± 0.425
1.394PheCys: 1.394 ± 0.169
2.718PheAsp: 2.718 ± 0.44
1.742PheGlu: 1.742 ± 0.245
2.16PhePhe: 2.16 ± 0.612
2.23PheGly: 2.23 ± 0.573
0.279PheHis: 0.279 ± 0.247
3.972PheIle: 3.972 ± 0.31
2.718PheLys: 2.718 ± 0.436
4.321PheLeu: 4.321 ± 0.755
0.697PheMet: 0.697 ± 0.18
3.206PheAsn: 3.206 ± 0.359
1.115PhePro: 1.115 ± 0.463
1.254PheGln: 1.254 ± 0.19
1.742PheArg: 1.742 ± 0.26
4.042PheSer: 4.042 ± 1.092
2.927PheThr: 2.927 ± 0.54
5.923PheVal: 5.923 ± 0.649
0.488PheTrp: 0.488 ± 0.212
2.997PheTyr: 2.997 ± 0.556
0.0PheXaa: 0.0 ± 0.0
Gly
3.833GlyAla: 3.833 ± 0.432
2.021GlyCys: 2.021 ± 0.351
3.972GlyAsp: 3.972 ± 0.582
1.463GlyGlu: 1.463 ± 0.296
3.136GlyPhe: 3.136 ± 0.48
4.46GlyGly: 4.46 ± 0.199
1.463GlyHis: 1.463 ± 0.211
2.787GlyIle: 2.787 ± 0.258
3.693GlyLys: 3.693 ± 0.594
5.366GlyLeu: 5.366 ± 0.41
1.045GlyMet: 1.045 ± 0.427
2.439GlyAsn: 2.439 ± 0.884
1.672GlyPro: 1.672 ± 0.274
1.672GlyGln: 1.672 ± 0.303
1.185GlyArg: 1.185 ± 0.67
4.111GlySer: 4.111 ± 0.355
4.599GlyThr: 4.599 ± 0.746
7.247GlyVal: 7.247 ± 0.987
0.348GlyTrp: 0.348 ± 0.085
2.857GlyTyr: 2.857 ± 0.71
0.0GlyXaa: 0.0 ± 0.0
His
1.324HisAla: 1.324 ± 0.378
0.348HisCys: 0.348 ± 0.426
0.836HisAsp: 0.836 ± 0.242
0.279HisGlu: 0.279 ± 0.219
1.115HisPhe: 1.115 ± 0.323
1.603HisGly: 1.603 ± 0.213
0.0HisHis: 0.0 ± 0.0
1.603HisIle: 1.603 ± 0.201
0.767HisLys: 0.767 ± 0.215
1.882HisLeu: 1.882 ± 0.307
0.488HisMet: 0.488 ± 0.149
0.976HisAsn: 0.976 ± 0.228
0.697HisPro: 0.697 ± 0.186
0.697HisGln: 0.697 ± 0.168
0.906HisArg: 0.906 ± 0.176
1.603HisSer: 1.603 ± 0.421
1.533HisThr: 1.533 ± 0.36
1.603HisVal: 1.603 ± 0.168
0.348HisTrp: 0.348 ± 0.149
0.697HisTyr: 0.697 ± 0.332
0.0HisXaa: 0.0 ± 0.0
Ile
3.415IleAla: 3.415 ± 0.393
1.045IleCys: 1.045 ± 0.239
2.578IleAsp: 2.578 ± 0.259
1.951IleGlu: 1.951 ± 0.255
1.533IlePhe: 1.533 ± 0.5
2.718IleGly: 2.718 ± 0.262
0.906IleHis: 0.906 ± 0.204
1.324IleIle: 1.324 ± 0.841
2.648IleLys: 2.648 ± 0.377
5.017IleLeu: 5.017 ± 0.586
1.185IleMet: 1.185 ± 0.391
3.624IleAsn: 3.624 ± 0.427
2.509IlePro: 2.509 ± 0.538
1.254IleGln: 1.254 ± 0.206
1.812IleArg: 1.812 ± 0.582
4.042IleSer: 4.042 ± 0.466
3.345IleThr: 3.345 ± 0.537
5.923IleVal: 5.923 ± 1.0
0.279IleTrp: 0.279 ± 0.099
2.3IleTyr: 2.3 ± 0.274
0.0IleXaa: 0.0 ± 0.0
Lys
3.902LysAla: 3.902 ± 0.37
1.185LysCys: 1.185 ± 0.211
3.136LysAsp: 3.136 ± 0.463
2.021LysGlu: 2.021 ± 0.283
2.997LysPhe: 2.997 ± 0.357
2.857LysGly: 2.857 ± 0.525
2.16LysHis: 2.16 ± 0.521
2.23LysIle: 2.23 ± 0.262
2.648LysLys: 2.648 ± 0.417
6.62LysLeu: 6.62 ± 0.493
1.672LysMet: 1.672 ± 0.308
2.23LysAsn: 2.23 ± 0.404
3.763LysPro: 3.763 ± 0.511
2.16LysGln: 2.16 ± 0.524
2.16LysArg: 2.16 ± 0.505
2.021LysSer: 2.021 ± 0.591
2.787LysThr: 2.787 ± 0.493
3.763LysVal: 3.763 ± 0.418
0.697LysTrp: 0.697 ± 0.242
2.718LysTyr: 2.718 ± 0.842
0.0LysXaa: 0.0 ± 0.0
Leu
7.596LeuAla: 7.596 ± 0.719
3.833LeuCys: 3.833 ± 0.344
3.763LeuAsp: 3.763 ± 0.379
4.042LeuGlu: 4.042 ± 0.338
5.784LeuPhe: 5.784 ± 0.74
4.669LeuGly: 4.669 ± 0.602
2.718LeuHis: 2.718 ± 0.415
3.902LeuIle: 3.902 ± 0.229
5.017LeuLys: 5.017 ± 0.818
10.174LeuLeu: 10.174 ± 1.727
1.254LeuMet: 1.254 ± 0.3
4.669LeuAsn: 4.669 ± 0.33
3.624LeuPro: 3.624 ± 0.652
4.46LeuGln: 4.46 ± 0.383
4.181LeuArg: 4.181 ± 0.693
6.341LeuSer: 6.341 ± 0.391
7.526LeuThr: 7.526 ± 0.547
6.62LeuVal: 6.62 ± 0.656
1.324LeuTrp: 1.324 ± 0.302
3.972LeuTyr: 3.972 ± 0.624
0.0LeuXaa: 0.0 ± 0.0
Met
1.115MetAla: 1.115 ± 0.472
0.976MetCys: 0.976 ± 0.298
0.697MetAsp: 0.697 ± 0.186
1.185MetGlu: 1.185 ± 0.346
1.185MetPhe: 1.185 ± 0.214
0.906MetGly: 0.906 ± 0.3
0.767MetHis: 0.767 ± 0.179
0.627MetIle: 0.627 ± 0.157
1.045MetLys: 1.045 ± 0.252
3.345MetLeu: 3.345 ± 0.686
0.767MetMet: 0.767 ± 0.174
0.836MetAsn: 0.836 ± 0.253
0.836MetPro: 0.836 ± 0.234
1.045MetGln: 1.045 ± 0.111
0.976MetArg: 0.976 ± 0.301
2.021MetSer: 2.021 ± 0.611
1.185MetThr: 1.185 ± 0.117
1.394MetVal: 1.394 ± 0.329
0.418MetTrp: 0.418 ± 0.132
1.185MetTyr: 1.185 ± 0.331
0.0MetXaa: 0.0 ± 0.0
Asn
4.042AsnAla: 4.042 ± 0.282
1.882AsnCys: 1.882 ± 0.245
3.066AsnAsp: 3.066 ± 0.314
2.648AsnGlu: 2.648 ± 0.652
2.997AsnPhe: 2.997 ± 0.305
4.669AsnGly: 4.669 ± 0.332
0.627AsnHis: 0.627 ± 0.157
2.578AsnIle: 2.578 ± 0.147
3.136AsnLys: 3.136 ± 0.331
4.53AsnLeu: 4.53 ± 0.471
1.045AsnMet: 1.045 ± 0.211
3.136AsnAsn: 3.136 ± 0.247
2.091AsnPro: 2.091 ± 0.638
1.882AsnGln: 1.882 ± 0.431
1.533AsnArg: 1.533 ± 0.264
4.251AsnSer: 4.251 ± 0.605
2.787AsnThr: 2.787 ± 0.368
4.251AsnVal: 4.251 ± 0.635
0.836AsnTrp: 0.836 ± 0.202
3.275AsnTyr: 3.275 ± 0.444
0.0AsnXaa: 0.0 ± 0.0
Pro
2.23ProAla: 2.23 ± 0.513
1.394ProCys: 1.394 ± 0.258
1.533ProAsp: 1.533 ± 0.299
1.603ProGlu: 1.603 ± 0.277
1.812ProPhe: 1.812 ± 0.416
2.439ProGly: 2.439 ± 0.318
0.627ProHis: 0.627 ± 0.156
2.787ProIle: 2.787 ± 0.318
2.021ProLys: 2.021 ± 0.905
5.296ProLeu: 5.296 ± 1.063
0.976ProMet: 0.976 ± 0.332
2.16ProAsn: 2.16 ± 0.392
1.533ProPro: 1.533 ± 0.878
0.906ProGln: 0.906 ± 0.419
1.742ProArg: 1.742 ± 0.671
2.509ProSer: 2.509 ± 0.516
3.275ProThr: 3.275 ± 0.207
2.369ProVal: 2.369 ± 0.199
0.627ProTrp: 0.627 ± 0.139
1.603ProTyr: 1.603 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
1.812GlnAla: 1.812 ± 0.771
0.767GlnCys: 0.767 ± 0.197
1.812GlnAsp: 1.812 ± 0.516
1.115GlnGlu: 1.115 ± 0.193
1.115GlnPhe: 1.115 ± 0.744
1.742GlnGly: 1.742 ± 0.242
0.279GlnHis: 0.279 ± 0.422
1.463GlnIle: 1.463 ± 0.235
0.976GlnLys: 0.976 ± 0.251
3.206GlnLeu: 3.206 ± 0.286
1.185GlnMet: 1.185 ± 0.208
1.463GlnAsn: 1.463 ± 0.22
1.603GlnPro: 1.603 ± 0.142
1.672GlnGln: 1.672 ± 0.331
0.836GlnArg: 0.836 ± 0.201
2.927GlnSer: 2.927 ± 0.487
2.369GlnThr: 2.369 ± 0.337
2.648GlnVal: 2.648 ± 0.454
0.418GlnTrp: 0.418 ± 0.144
1.463GlnTyr: 1.463 ± 0.418
0.0GlnXaa: 0.0 ± 0.0
Arg
3.136ArgAla: 3.136 ± 0.728
0.767ArgCys: 0.767 ± 0.236
2.578ArgAsp: 2.578 ± 0.445
1.115ArgGlu: 1.115 ± 0.158
1.672ArgPhe: 1.672 ± 0.462
2.091ArgGly: 2.091 ± 0.491
0.906ArgHis: 0.906 ± 0.194
1.324ArgIle: 1.324 ± 0.272
1.951ArgLys: 1.951 ± 0.394
3.275ArgLeu: 3.275 ± 1.139
0.488ArgMet: 0.488 ± 0.162
2.578ArgAsn: 2.578 ± 0.312
1.185ArgPro: 1.185 ± 0.335
1.324ArgGln: 1.324 ± 0.171
1.672ArgArg: 1.672 ± 0.168
2.439ArgSer: 2.439 ± 1.019
2.16ArgThr: 2.16 ± 0.113
3.206ArgVal: 3.206 ± 0.501
0.209ArgTrp: 0.209 ± 0.367
1.812ArgTyr: 1.812 ± 0.279
0.0ArgXaa: 0.0 ± 0.0
Ser
5.784SerAla: 5.784 ± 0.761
1.324SerCys: 1.324 ± 0.256
4.53SerAsp: 4.53 ± 0.351
2.091SerGlu: 2.091 ± 0.271
3.972SerPhe: 3.972 ± 0.805
4.808SerGly: 4.808 ± 0.57
1.324SerHis: 1.324 ± 0.215
2.509SerIle: 2.509 ± 0.615
4.39SerLys: 4.39 ± 0.603
5.714SerLeu: 5.714 ± 0.996
2.3SerMet: 2.3 ± 0.313
4.042SerAsn: 4.042 ± 0.74
1.463SerPro: 1.463 ± 0.545
2.16SerGln: 2.16 ± 0.979
2.997SerArg: 2.997 ± 0.683
7.317SerSer: 7.317 ± 1.468
4.669SerThr: 4.669 ± 0.367
7.805SerVal: 7.805 ± 0.517
1.394SerTrp: 1.394 ± 0.204
3.902SerTyr: 3.902 ± 0.696
0.0SerXaa: 0.0 ± 0.0
Thr
5.436ThrAla: 5.436 ± 0.447
1.045ThrCys: 1.045 ± 0.253
2.578ThrAsp: 2.578 ± 0.333
2.439ThrGlu: 2.439 ± 0.313
3.902ThrPhe: 3.902 ± 0.379
4.599ThrGly: 4.599 ± 0.915
1.185ThrHis: 1.185 ± 0.142
4.39ThrIle: 4.39 ± 0.21
3.136ThrLys: 3.136 ± 0.584
5.854ThrLeu: 5.854 ± 0.451
1.463ThrMet: 1.463 ± 0.244
3.415ThrAsn: 3.415 ± 0.452
3.206ThrPro: 3.206 ± 0.51
1.951ThrGln: 1.951 ± 0.751
1.882ThrArg: 1.882 ± 0.307
5.157ThrSer: 5.157 ± 0.533
4.878ThrThr: 4.878 ± 0.575
7.805ThrVal: 7.805 ± 0.738
0.488ThrTrp: 0.488 ± 0.162
2.787ThrTyr: 2.787 ± 0.524
0.0ThrXaa: 0.0 ± 0.0
Val
6.272ValAla: 6.272 ± 1.113
3.415ValCys: 3.415 ± 0.556
6.132ValAsp: 6.132 ± 0.493
5.714ValGlu: 5.714 ± 1.135
2.927ValPhe: 2.927 ± 0.248
4.39ValGly: 4.39 ± 0.505
1.324ValHis: 1.324 ± 0.342
3.484ValIle: 3.484 ± 0.732
5.575ValLys: 5.575 ± 0.864
9.268ValLeu: 9.268 ± 1.269
2.718ValMet: 2.718 ± 0.365
5.226ValAsn: 5.226 ± 0.413
4.251ValPro: 4.251 ± 0.409
2.509ValGln: 2.509 ± 0.33
3.206ValArg: 3.206 ± 0.408
6.899ValSer: 6.899 ± 0.361
5.575ValThr: 5.575 ± 0.281
8.153ValVal: 8.153 ± 0.974
1.045ValTrp: 1.045 ± 0.178
3.902ValTyr: 3.902 ± 0.373
0.0ValXaa: 0.0 ± 0.0
Trp
0.836TrpAla: 0.836 ± 0.182
0.697TrpCys: 0.697 ± 0.183
0.906TrpAsp: 0.906 ± 0.256
0.279TrpGlu: 0.279 ± 0.11
1.254TrpPhe: 1.254 ± 0.162
0.139TrpGly: 0.139 ± 0.091
0.209TrpHis: 0.209 ± 0.072
0.279TrpIle: 0.279 ± 0.267
0.488TrpLys: 0.488 ± 0.162
1.254TrpLeu: 1.254 ± 0.276
0.139TrpMet: 0.139 ± 0.05
0.697TrpAsn: 0.697 ± 0.166
0.906TrpPro: 0.906 ± 0.283
0.07TrpGln: 0.07 ± 0.223
0.557TrpArg: 0.557 ± 0.144
1.115TrpSer: 1.115 ± 0.252
0.348TrpThr: 0.348 ± 0.19
0.976TrpVal: 0.976 ± 0.245
0.07TrpTrp: 0.07 ± 0.117
0.557TrpTyr: 0.557 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.718TyrAla: 2.718 ± 0.609
1.324TyrCys: 1.324 ± 0.242
3.624TyrAsp: 3.624 ± 0.478
1.533TyrGlu: 1.533 ± 0.531
2.578TyrPhe: 2.578 ± 0.273
2.369TyrGly: 2.369 ± 0.511
0.906TyrHis: 0.906 ± 0.247
2.578TyrIle: 2.578 ± 0.553
3.763TyrLys: 3.763 ± 0.408
3.206TyrLeu: 3.206 ± 0.546
1.324TyrMet: 1.324 ± 0.333
3.066TyrAsn: 3.066 ± 0.165
1.812TyrPro: 1.812 ± 0.428
0.557TyrGln: 0.557 ± 0.147
1.742TyrArg: 1.742 ± 0.272
4.39TyrSer: 4.39 ± 1.093
3.554TyrThr: 3.554 ± 0.504
5.087TyrVal: 5.087 ± 0.452
0.348TyrTrp: 0.348 ± 0.126
3.066TyrTyr: 3.066 ± 0.432
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (14351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski