Amino acid dipepetide frequency for Dokdonella immobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.058AlaAla: 16.058 ± 0.169
1.348AlaCys: 1.348 ± 0.034
7.327AlaAsp: 7.327 ± 0.072
7.379AlaGlu: 7.379 ± 0.091
4.138AlaPhe: 4.138 ± 0.06
10.563AlaGly: 10.563 ± 0.104
2.6AlaHis: 2.6 ± 0.045
6.126AlaIle: 6.126 ± 0.082
2.926AlaLys: 2.926 ± 0.066
14.493AlaLeu: 14.493 ± 0.152
3.044AlaMet: 3.044 ± 0.052
3.27AlaAsn: 3.27 ± 0.063
5.562AlaPro: 5.562 ± 0.065
4.221AlaGln: 4.221 ± 0.068
9.848AlaArg: 9.848 ± 0.111
7.282AlaSer: 7.282 ± 0.079
6.212AlaThr: 6.212 ± 0.091
8.019AlaVal: 8.019 ± 0.074
2.04AlaTrp: 2.04 ± 0.047
2.367AlaTyr: 2.367 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.264CysAla: 1.264 ± 0.035
0.135CysCys: 0.135 ± 0.011
0.482CysAsp: 0.482 ± 0.02
0.488CysGlu: 0.488 ± 0.021
0.32CysPhe: 0.32 ± 0.017
1.006CysGly: 1.006 ± 0.031
0.297CysHis: 0.297 ± 0.023
0.382CysIle: 0.382 ± 0.015
0.184CysLys: 0.184 ± 0.013
0.941CysLeu: 0.941 ± 0.028
0.168CysMet: 0.168 ± 0.012
0.255CysAsn: 0.255 ± 0.013
0.496CysPro: 0.496 ± 0.023
0.253CysGln: 0.253 ± 0.015
0.733CysArg: 0.733 ± 0.028
0.609CysSer: 0.609 ± 0.023
0.501CysThr: 0.501 ± 0.02
0.741CysVal: 0.741 ± 0.025
0.135CysTrp: 0.135 ± 0.009
0.227CysTyr: 0.227 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.788AspAla: 7.788 ± 0.08
0.541AspCys: 0.541 ± 0.022
3.309AspAsp: 3.309 ± 0.061
3.393AspGlu: 3.393 ± 0.051
2.207AspPhe: 2.207 ± 0.037
5.633AspGly: 5.633 ± 0.09
1.179AspHis: 1.179 ± 0.029
2.662AspIle: 2.662 ± 0.048
1.429AspLys: 1.429 ± 0.038
5.994AspLeu: 5.994 ± 0.079
1.113AspMet: 1.113 ± 0.032
1.383AspAsn: 1.383 ± 0.039
3.758AspPro: 3.758 ± 0.06
1.745AspGln: 1.745 ± 0.037
4.314AspArg: 4.314 ± 0.062
3.171AspSer: 3.171 ± 0.051
2.621AspThr: 2.621 ± 0.05
3.963AspVal: 3.963 ± 0.06
1.073AspTrp: 1.073 ± 0.032
1.63AspTyr: 1.63 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.886GluAla: 6.886 ± 0.093
0.447GluCys: 0.447 ± 0.017
2.583GluAsp: 2.583 ± 0.046
2.557GluGlu: 2.557 ± 0.05
2.102GluPhe: 2.102 ± 0.043
3.768GluGly: 3.768 ± 0.054
1.397GluHis: 1.397 ± 0.038
2.918GluIle: 2.918 ± 0.053
1.713GluLys: 1.713 ± 0.047
6.135GluLeu: 6.135 ± 0.086
1.073GluMet: 1.073 ± 0.028
1.426GluAsn: 1.426 ± 0.032
2.69GluPro: 2.69 ± 0.047
2.351GluGln: 2.351 ± 0.045
5.384GluArg: 5.384 ± 0.082
3.368GluSer: 3.368 ± 0.049
2.816GluThr: 2.816 ± 0.047
3.954GluVal: 3.954 ± 0.064
0.78GluTrp: 0.78 ± 0.025
1.098GluTyr: 1.098 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.622PheAla: 4.622 ± 0.074
0.357PheCys: 0.357 ± 0.014
2.773PheAsp: 2.773 ± 0.046
2.298PheGlu: 2.298 ± 0.041
1.198PhePhe: 1.198 ± 0.037
3.484PheGly: 3.484 ± 0.061
0.751PheHis: 0.751 ± 0.025
1.403PheIle: 1.403 ± 0.035
0.81PheLys: 0.81 ± 0.026
3.162PheLeu: 3.162 ± 0.056
0.61PheMet: 0.61 ± 0.022
1.134PheAsn: 1.134 ± 0.028
1.59PhePro: 1.59 ± 0.035
0.881PheGln: 0.881 ± 0.028
2.35PheArg: 2.35 ± 0.052
2.391PheSer: 2.391 ± 0.043
1.714PheThr: 1.714 ± 0.045
2.811PheVal: 2.811 ± 0.05
0.495PheTrp: 0.495 ± 0.022
0.837PheTyr: 0.837 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
8.953GlyAla: 8.953 ± 0.107
0.916GlyCys: 0.916 ± 0.032
4.789GlyAsp: 4.789 ± 0.067
4.797GlyGlu: 4.797 ± 0.071
3.482GlyPhe: 3.482 ± 0.054
7.216GlyGly: 7.216 ± 0.098
1.975GlyHis: 1.975 ± 0.045
4.371GlyIle: 4.371 ± 0.055
2.968GlyLys: 2.968 ± 0.059
8.401GlyLeu: 8.401 ± 0.087
2.104GlyMet: 2.104 ± 0.045
2.81GlyAsn: 2.81 ± 0.071
3.356GlyPro: 3.356 ± 0.066
2.931GlyGln: 2.931 ± 0.046
5.934GlyArg: 5.934 ± 0.072
5.71GlySer: 5.71 ± 0.077
4.595GlyThr: 4.595 ± 0.093
6.081GlyVal: 6.081 ± 0.059
1.406GlyTrp: 1.406 ± 0.037
2.31GlyTyr: 2.31 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
3.033HisAla: 3.033 ± 0.055
0.27HisCys: 0.27 ± 0.014
1.256HisAsp: 1.256 ± 0.034
1.221HisGlu: 1.221 ± 0.031
0.886HisPhe: 0.886 ± 0.029
2.155HisGly: 2.155 ± 0.051
0.563HisHis: 0.563 ± 0.02
0.792HisIle: 0.792 ± 0.026
0.412HisLys: 0.412 ± 0.017
2.23HisLeu: 2.23 ± 0.04
0.472HisMet: 0.472 ± 0.019
0.438HisAsn: 0.438 ± 0.018
1.343HisPro: 1.343 ± 0.033
0.587HisGln: 0.587 ± 0.021
1.636HisArg: 1.636 ± 0.036
1.085HisSer: 1.085 ± 0.028
0.827HisThr: 0.827 ± 0.025
1.698HisVal: 1.698 ± 0.037
0.447HisTrp: 0.447 ± 0.017
0.645HisTyr: 0.645 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.779IleAla: 6.779 ± 0.077
0.424IleCys: 0.424 ± 0.017
3.921IleAsp: 3.921 ± 0.055
3.697IleGlu: 3.697 ± 0.053
1.339IlePhe: 1.339 ± 0.035
4.875IleGly: 4.875 ± 0.068
0.942IleHis: 0.942 ± 0.029
1.644IleIle: 1.644 ± 0.04
1.167IleLys: 1.167 ± 0.033
3.76IleLeu: 3.76 ± 0.051
0.667IleMet: 0.667 ± 0.022
1.363IleAsn: 1.363 ± 0.039
2.218IlePro: 2.218 ± 0.044
1.139IleGln: 1.139 ± 0.031
3.153IleArg: 3.153 ± 0.048
2.667IleSer: 2.667 ± 0.052
2.178IleThr: 2.178 ± 0.044
3.796IleVal: 3.796 ± 0.057
0.54IleTrp: 0.54 ± 0.022
0.975IleTyr: 0.975 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.23LysAla: 3.23 ± 0.068
0.152LysCys: 0.152 ± 0.012
1.393LysAsp: 1.393 ± 0.035
1.147LysGlu: 1.147 ± 0.037
0.742LysPhe: 0.742 ± 0.027
1.853LysGly: 1.853 ± 0.043
0.582LysHis: 0.582 ± 0.02
1.16LysIle: 1.16 ± 0.032
0.955LysLys: 0.955 ± 0.043
2.807LysLeu: 2.807 ± 0.052
0.544LysMet: 0.544 ± 0.022
0.688LysAsn: 0.688 ± 0.023
1.908LysPro: 1.908 ± 0.043
0.998LysGln: 0.998 ± 0.03
2.184LysArg: 2.184 ± 0.046
1.641LysSer: 1.641 ± 0.039
1.503LysThr: 1.503 ± 0.039
2.004LysVal: 2.004 ± 0.049
0.26LysTrp: 0.26 ± 0.014
0.497LysTyr: 0.497 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.581LeuAla: 14.581 ± 0.147
0.999LeuCys: 0.999 ± 0.031
6.71LeuAsp: 6.71 ± 0.081
5.66LeuGlu: 5.66 ± 0.081
3.584LeuPhe: 3.584 ± 0.061
8.907LeuGly: 8.907 ± 0.103
2.232LeuHis: 2.232 ± 0.044
4.688LeuIle: 4.688 ± 0.073
2.962LeuLys: 2.962 ± 0.052
11.236LeuLeu: 11.236 ± 0.139
1.925LeuMet: 1.925 ± 0.037
2.527LeuAsn: 2.527 ± 0.047
5.883LeuPro: 5.883 ± 0.079
3.065LeuGln: 3.065 ± 0.046
8.681LeuArg: 8.681 ± 0.119
6.15LeuSer: 6.15 ± 0.08
4.797LeuThr: 4.797 ± 0.064
7.859LeuVal: 7.859 ± 0.084
1.297LeuTrp: 1.297 ± 0.036
2.145LeuTyr: 2.145 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.471MetAla: 2.471 ± 0.047
0.159MetCys: 0.159 ± 0.011
0.977MetAsp: 0.977 ± 0.026
0.731MetGlu: 0.731 ± 0.024
0.653MetPhe: 0.653 ± 0.018
1.349MetGly: 1.349 ± 0.036
0.507MetHis: 0.507 ± 0.02
0.985MetIle: 0.985 ± 0.028
0.765MetLys: 0.765 ± 0.025
2.4MetLeu: 2.4 ± 0.045
0.392MetMet: 0.392 ± 0.019
0.748MetAsn: 0.748 ± 0.024
1.336MetPro: 1.336 ± 0.033
0.927MetGln: 0.927 ± 0.029
1.807MetArg: 1.807 ± 0.04
1.521MetSer: 1.521 ± 0.032
1.236MetThr: 1.236 ± 0.03
1.328MetVal: 1.328 ± 0.035
0.171MetTrp: 0.171 ± 0.011
0.319MetTyr: 0.319 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.456AsnAla: 3.456 ± 0.054
0.265AsnCys: 0.265 ± 0.016
1.531AsnAsp: 1.531 ± 0.05
1.322AsnGlu: 1.322 ± 0.032
0.971AsnPhe: 0.971 ± 0.026
2.666AsnGly: 2.666 ± 0.065
0.537AsnHis: 0.537 ± 0.023
1.113AsnIle: 1.113 ± 0.034
0.57AsnLys: 0.57 ± 0.021
2.758AsnLeu: 2.758 ± 0.051
0.466AsnMet: 0.466 ± 0.018
0.783AsnAsn: 0.783 ± 0.034
1.961AsnPro: 1.961 ± 0.047
0.829AsnGln: 0.829 ± 0.03
1.984AsnArg: 1.984 ± 0.044
1.452AsnSer: 1.452 ± 0.045
1.417AsnThr: 1.417 ± 0.04
1.9AsnVal: 1.9 ± 0.044
0.447AsnTrp: 0.447 ± 0.019
0.708AsnTyr: 0.708 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
6.833ProAla: 6.833 ± 0.082
0.399ProCys: 0.399 ± 0.019
3.489ProAsp: 3.489 ± 0.062
3.195ProGlu: 3.195 ± 0.053
1.768ProPhe: 1.768 ± 0.035
4.933ProGly: 4.933 ± 0.074
0.984ProHis: 0.984 ± 0.027
2.272ProIle: 2.272 ± 0.041
1.352ProLys: 1.352 ± 0.035
5.005ProLeu: 5.005 ± 0.066
1.271ProMet: 1.271 ± 0.031
1.394ProAsn: 1.394 ± 0.037
2.681ProPro: 2.681 ± 0.059
1.673ProGln: 1.673 ± 0.036
3.293ProArg: 3.293 ± 0.058
2.884ProSer: 2.884 ± 0.047
2.6ProThr: 2.6 ± 0.055
3.964ProVal: 3.964 ± 0.051
0.76ProTrp: 0.76 ± 0.026
1.112ProTyr: 1.112 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.304GlnAla: 4.304 ± 0.062
0.286GlnCys: 0.286 ± 0.017
1.308GlnAsp: 1.308 ± 0.034
1.277GlnGlu: 1.277 ± 0.035
1.173GlnPhe: 1.173 ± 0.029
2.513GlnGly: 2.513 ± 0.054
0.731GlnHis: 0.731 ± 0.02
1.627GlnIle: 1.627 ± 0.033
0.823GlnLys: 0.823 ± 0.029
3.508GlnLeu: 3.508 ± 0.056
0.742GlnMet: 0.742 ± 0.026
0.758GlnAsn: 0.758 ± 0.029
1.85GlnPro: 1.85 ± 0.035
1.334GlnGln: 1.334 ± 0.038
3.178GlnArg: 3.178 ± 0.056
1.903GlnSer: 1.903 ± 0.041
1.588GlnThr: 1.588 ± 0.041
2.525GlnVal: 2.525 ± 0.044
0.515GlnTrp: 0.515 ± 0.018
0.613GlnTyr: 0.613 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.355ArgAla: 8.355 ± 0.089
0.716ArgCys: 0.716 ± 0.023
4.494ArgAsp: 4.494 ± 0.073
4.941ArgGlu: 4.941 ± 0.081
3.222ArgPhe: 3.222 ± 0.056
5.09ArgGly: 5.09 ± 0.061
1.969ArgHis: 1.969 ± 0.037
4.615ArgIle: 4.615 ± 0.06
2.189ArgLys: 2.189 ± 0.047
8.714ArgLeu: 8.714 ± 0.103
1.857ArgMet: 1.857 ± 0.039
2.168ArgAsn: 2.168 ± 0.038
3.353ArgPro: 3.353 ± 0.059
2.768ArgGln: 2.768 ± 0.041
6.331ArgArg: 6.331 ± 0.091
4.446ArgSer: 4.446 ± 0.063
3.368ArgThr: 3.368 ± 0.05
5.4ArgVal: 5.4 ± 0.069
1.378ArgTrp: 1.378 ± 0.039
2.197ArgTyr: 2.197 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
7.445SerAla: 7.445 ± 0.087
0.528SerCys: 0.528 ± 0.023
3.292SerAsp: 3.292 ± 0.054
3.059SerGlu: 3.059 ± 0.049
2.104SerPhe: 2.104 ± 0.043
6.298SerGly: 6.298 ± 0.093
1.222SerHis: 1.222 ± 0.033
2.899SerIle: 2.899 ± 0.047
1.429SerLys: 1.429 ± 0.042
6.034SerLeu: 6.034 ± 0.07
1.314SerMet: 1.314 ± 0.031
1.738SerAsn: 1.738 ± 0.04
3.073SerPro: 3.073 ± 0.047
1.719SerGln: 1.719 ± 0.037
4.203SerArg: 4.203 ± 0.057
3.605SerSer: 3.605 ± 0.064
3.191SerThr: 3.191 ± 0.06
4.181SerVal: 4.181 ± 0.069
0.892SerTrp: 0.892 ± 0.029
1.364SerTyr: 1.364 ± 0.037
0.001SerXaa: 0.001 ± 0.001
Thr
5.691ThrAla: 5.691 ± 0.064
0.513ThrCys: 0.513 ± 0.025
2.638ThrAsp: 2.638 ± 0.051
2.247ThrGlu: 2.247 ± 0.042
1.664ThrPhe: 1.664 ± 0.041
4.574ThrGly: 4.574 ± 0.086
1.067ThrHis: 1.067 ± 0.028
2.468ThrIle: 2.468 ± 0.056
0.9ThrLys: 0.9 ± 0.033
5.899ThrLeu: 5.899 ± 0.076
0.887ThrMet: 0.887 ± 0.024
1.221ThrAsn: 1.221 ± 0.041
3.15ThrPro: 3.15 ± 0.043
1.483ThrGln: 1.483 ± 0.034
3.684ThrArg: 3.684 ± 0.056
2.903ThrSer: 2.903 ± 0.059
2.806ThrThr: 2.806 ± 0.074
3.763ThrVal: 3.763 ± 0.069
0.781ThrTrp: 0.781 ± 0.028
1.164ThrTyr: 1.164 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.036ValAla: 9.036 ± 0.084
0.745ValCys: 0.745 ± 0.023
4.713ValAsp: 4.713 ± 0.057
4.374ValGlu: 4.374 ± 0.063
2.572ValPhe: 2.572 ± 0.045
5.538ValGly: 5.538 ± 0.067
1.606ValHis: 1.606 ± 0.038
3.566ValIle: 3.566 ± 0.063
1.644ValLys: 1.644 ± 0.046
7.9ValLeu: 7.9 ± 0.091
1.368ValMet: 1.368 ± 0.036
1.934ValAsn: 1.934 ± 0.041
3.769ValPro: 3.769 ± 0.051
2.129ValGln: 2.129 ± 0.04
5.438ValArg: 5.438 ± 0.07
4.363ValSer: 4.363 ± 0.061
3.511ValThr: 3.511 ± 0.065
5.785ValVal: 5.785 ± 0.078
0.844ValTrp: 0.844 ± 0.027
1.555ValTyr: 1.555 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.182TrpAla: 1.182 ± 0.029
0.159TrpCys: 0.159 ± 0.01
0.645TrpAsp: 0.645 ± 0.021
0.507TrpGlu: 0.507 ± 0.02
0.582TrpPhe: 0.582 ± 0.021
0.806TrpGly: 0.806 ± 0.026
0.383TrpHis: 0.383 ± 0.02
0.875TrpIle: 0.875 ± 0.026
0.511TrpLys: 0.511 ± 0.023
2.099TrpLeu: 2.099 ± 0.04
0.398TrpMet: 0.398 ± 0.018
0.513TrpAsn: 0.513 ± 0.021
0.765TrpPro: 0.765 ± 0.027
0.714TrpGln: 0.714 ± 0.022
1.319TrpArg: 1.319 ± 0.038
1.053TrpSer: 1.053 ± 0.029
0.825TrpThr: 0.825 ± 0.026
0.955TrpVal: 0.955 ± 0.028
0.261TrpTrp: 0.261 ± 0.016
0.363TrpTyr: 0.363 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.047
0.257TyrCys: 0.257 ± 0.014
1.276TyrAsp: 1.276 ± 0.036
1.159TyrGlu: 1.159 ± 0.03
0.964TyrPhe: 0.964 ± 0.026
1.88TyrGly: 1.88 ± 0.044
0.472TyrHis: 0.472 ± 0.017
0.678TyrIle: 0.678 ± 0.021
0.536TyrLys: 0.536 ± 0.024
2.411TyrLeu: 2.411 ± 0.042
0.369TyrMet: 0.369 ± 0.015
0.584TyrAsn: 0.584 ± 0.024
1.121TyrPro: 1.121 ± 0.026
0.805TyrGln: 0.805 ± 0.025
2.118TyrArg: 2.118 ± 0.039
1.388TyrSer: 1.388 ± 0.04
1.197TyrThr: 1.197 ± 0.034
1.662TyrVal: 1.662 ± 0.04
0.395TyrTrp: 0.395 ± 0.015
0.621TyrTyr: 0.621 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.001
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.002
Statistics based on 3897 proteins (1348227 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski