Amino acid dipepetide frequency for Arsenophonus endosymbiont of Aleurodicus floccissimus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.705AlaAla: 6.705 ± 0.149
0.969AlaCys: 0.969 ± 0.051
4.032AlaAsp: 4.032 ± 0.115
5.257AlaGlu: 5.257 ± 0.13
2.96AlaPhe: 2.96 ± 0.1
5.377AlaGly: 5.377 ± 0.116
1.394AlaHis: 1.394 ± 0.06
6.548AlaIle: 6.548 ± 0.141
5.252AlaLys: 5.252 ± 0.119
8.563AlaLeu: 8.563 ± 0.18
2.236AlaMet: 2.236 ± 0.082
3.623AlaAsn: 3.623 ± 0.097
2.302AlaPro: 2.302 ± 0.072
3.249AlaGln: 3.249 ± 0.108
3.679AlaArg: 3.679 ± 0.115
4.101AlaSer: 4.101 ± 0.1
4.03AlaThr: 4.03 ± 0.106
4.931AlaVal: 4.931 ± 0.134
0.773AlaTrp: 0.773 ± 0.047
2.317AlaTyr: 2.317 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.741CysAla: 0.741 ± 0.041
0.214CysCys: 0.214 ± 0.021
0.67CysAsp: 0.67 ± 0.04
0.572CysGlu: 0.572 ± 0.041
0.52CysPhe: 0.52 ± 0.039
0.992CysGly: 0.992 ± 0.057
0.378CysHis: 0.378 ± 0.033
0.788CysIle: 0.788 ± 0.042
0.496CysLys: 0.496 ± 0.04
1.247CysLeu: 1.247 ± 0.055
0.295CysMet: 0.295 ± 0.026
0.454CysAsn: 0.454 ± 0.037
0.43CysPro: 0.43 ± 0.033
0.677CysGln: 0.677 ± 0.044
0.645CysArg: 0.645 ± 0.044
0.746CysSer: 0.746 ± 0.048
0.513CysThr: 0.513 ± 0.037
0.631CysVal: 0.631 ± 0.042
0.206CysTrp: 0.206 ± 0.022
0.513CysTyr: 0.513 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
3.522AspAla: 3.522 ± 0.085
0.587AspCys: 0.587 ± 0.033
2.653AspAsp: 2.653 ± 0.094
3.441AspGlu: 3.441 ± 0.105
2.194AspPhe: 2.194 ± 0.069
3.046AspGly: 3.046 ± 0.101
0.984AspHis: 0.984 ± 0.045
4.482AspIle: 4.482 ± 0.104
3.362AspLys: 3.362 ± 0.108
4.693AspLeu: 4.693 ± 0.119
1.345AspMet: 1.345 ± 0.06
2.827AspAsn: 2.827 ± 0.094
2.047AspPro: 2.047 ± 0.084
1.639AspGln: 1.639 ± 0.06
2.322AspArg: 2.322 ± 0.079
2.913AspSer: 2.913 ± 0.088
2.44AspThr: 2.44 ± 0.079
3.303AspVal: 3.303 ± 0.101
0.739AspTrp: 0.739 ± 0.042
2.069AspTyr: 2.069 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.347GluAla: 4.347 ± 0.117
0.515GluCys: 0.515 ± 0.039
2.201GluAsp: 2.201 ± 0.076
3.48GluGlu: 3.48 ± 0.099
2.059GluPhe: 2.059 ± 0.07
3.058GluGly: 3.058 ± 0.088
1.296GluHis: 1.296 ± 0.057
4.759GluIle: 4.759 ± 0.098
4.523GluLys: 4.523 ± 0.117
6.136GluLeu: 6.136 ± 0.129
1.679GluMet: 1.679 ± 0.06
2.999GluAsn: 2.999 ± 0.094
1.74GluPro: 1.74 ± 0.078
3.593GluGln: 3.593 ± 0.098
3.549GluArg: 3.549 ± 0.1
2.913GluSer: 2.913 ± 0.095
2.948GluThr: 2.948 ± 0.091
3.458GluVal: 3.458 ± 0.105
0.623GluTrp: 0.623 ± 0.038
1.647GluTyr: 1.647 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
3.031PheAla: 3.031 ± 0.094
0.658PheCys: 0.658 ± 0.043
2.361PheAsp: 2.361 ± 0.07
1.956PheGlu: 1.956 ± 0.077
1.735PhePhe: 1.735 ± 0.077
2.776PheGly: 2.776 ± 0.084
0.915PheHis: 0.915 ± 0.046
3.561PheIle: 3.561 ± 0.096
1.961PheLys: 1.961 ± 0.07
3.483PheLeu: 3.483 ± 0.105
1.038PheMet: 1.038 ± 0.052
2.216PheAsn: 2.216 ± 0.088
1.436PhePro: 1.436 ± 0.056
1.183PheGln: 1.183 ± 0.05
1.681PheArg: 1.681 ± 0.068
3.318PheSer: 3.318 ± 0.112
2.324PheThr: 2.324 ± 0.084
2.27PheVal: 2.27 ± 0.08
0.542PheTrp: 0.542 ± 0.044
1.468PheTyr: 1.468 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.428GlyAla: 4.428 ± 0.115
0.908GlyCys: 0.908 ± 0.048
3.105GlyAsp: 3.105 ± 0.094
3.659GlyGlu: 3.659 ± 0.116
2.854GlyPhe: 2.854 ± 0.093
4.229GlyGly: 4.229 ± 0.116
1.6GlyHis: 1.6 ± 0.06
5.355GlyIle: 5.355 ± 0.128
4.452GlyLys: 4.452 ± 0.113
6.506GlyLeu: 6.506 ± 0.138
1.956GlyMet: 1.956 ± 0.07
2.845GlyAsn: 2.845 ± 0.108
1.399GlyPro: 1.399 ± 0.064
2.754GlyGln: 2.754 ± 0.084
3.159GlyArg: 3.159 ± 0.095
3.625GlySer: 3.625 ± 0.097
3.073GlyThr: 3.073 ± 0.088
4.332GlyVal: 4.332 ± 0.107
0.913GlyTrp: 0.913 ± 0.049
2.422GlyTyr: 2.422 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.066
0.346HisCys: 0.346 ± 0.032
1.095HisAsp: 1.095 ± 0.055
1.046HisGlu: 1.046 ± 0.056
1.112HisPhe: 1.112 ± 0.052
1.517HisGly: 1.517 ± 0.064
0.817HisHis: 0.817 ± 0.046
1.713HisIle: 1.713 ± 0.061
1.092HisLys: 1.092 ± 0.056
2.346HisLeu: 2.346 ± 0.082
0.577HisMet: 0.577 ± 0.037
1.102HisAsn: 1.102 ± 0.045
1.154HisPro: 1.154 ± 0.059
1.166HisGln: 1.166 ± 0.056
1.181HisArg: 1.181 ± 0.059
1.227HisSer: 1.227 ± 0.062
1.102HisThr: 1.102 ± 0.047
1.158HisVal: 1.158 ± 0.053
0.371HisTrp: 0.371 ± 0.03
1.011HisTyr: 1.011 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
6.862IleAla: 6.862 ± 0.151
0.979IleCys: 0.979 ± 0.053
4.835IleAsp: 4.835 ± 0.114
5.132IleGlu: 5.132 ± 0.114
3.004IlePhe: 3.004 ± 0.102
5.517IleGly: 5.517 ± 0.131
1.578IleHis: 1.578 ± 0.067
6.462IleIle: 6.462 ± 0.163
4.842IleLys: 4.842 ± 0.144
7.267IleLeu: 7.267 ± 0.159
1.846IleMet: 1.846 ± 0.076
4.506IleAsn: 4.506 ± 0.119
3.183IlePro: 3.183 ± 0.088
2.746IleGln: 2.746 ± 0.077
3.632IleArg: 3.632 ± 0.09
5.426IleSer: 5.426 ± 0.146
4.764IleThr: 4.764 ± 0.132
4.756IleVal: 4.756 ± 0.116
0.763IleTrp: 0.763 ± 0.045
2.459IleTyr: 2.459 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.545LysAla: 4.545 ± 0.11
0.493LysCys: 0.493 ± 0.036
2.584LysAsp: 2.584 ± 0.076
3.507LysGlu: 3.507 ± 0.104
1.767LysPhe: 1.767 ± 0.069
3.409LysGly: 3.409 ± 0.105
1.262LysHis: 1.262 ± 0.054
4.845LysIle: 4.845 ± 0.135
4.079LysLys: 4.079 ± 0.123
6.234LysLeu: 6.234 ± 0.135
1.919LysMet: 1.919 ± 0.071
3.308LysAsn: 3.308 ± 0.111
2.479LysPro: 2.479 ± 0.09
3.323LysGln: 3.323 ± 0.088
3.1LysArg: 3.1 ± 0.108
3.438LysSer: 3.438 ± 0.097
3.461LysThr: 3.461 ± 0.104
3.758LysVal: 3.758 ± 0.103
0.665LysTrp: 0.665 ± 0.043
1.743LysTyr: 1.743 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
9.424LeuAla: 9.424 ± 0.19
1.266LeuCys: 1.266 ± 0.058
5.326LeuAsp: 5.326 ± 0.118
5.336LeuGlu: 5.336 ± 0.115
4.332LeuPhe: 4.332 ± 0.123
6.03LeuGly: 6.03 ± 0.124
2.084LeuHis: 2.084 ± 0.065
8.021LeuIle: 8.021 ± 0.158
5.804LeuLys: 5.804 ± 0.133
11.177LeuLeu: 11.177 ± 0.247
2.778LeuMet: 2.778 ± 0.088
4.992LeuAsn: 4.992 ± 0.113
5.073LeuPro: 5.073 ± 0.118
4.072LeuGln: 4.072 ± 0.105
4.901LeuArg: 4.901 ± 0.126
7.122LeuSer: 7.122 ± 0.149
6.71LeuThr: 6.71 ± 0.142
6.384LeuVal: 6.384 ± 0.127
1.171LeuTrp: 1.171 ± 0.06
2.928LeuTyr: 2.928 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
2.471MetAla: 2.471 ± 0.085
0.223MetCys: 0.223 ± 0.023
1.22MetAsp: 1.22 ± 0.048
1.318MetGlu: 1.318 ± 0.053
0.793MetPhe: 0.793 ± 0.05
1.72MetGly: 1.72 ± 0.072
0.54MetHis: 0.54 ± 0.035
2.022MetIle: 2.022 ± 0.072
1.627MetLys: 1.627 ± 0.069
2.994MetLeu: 2.994 ± 0.086
0.805MetMet: 0.805 ± 0.051
1.239MetAsn: 1.239 ± 0.059
1.328MetPro: 1.328 ± 0.062
1.235MetGln: 1.235 ± 0.057
1.335MetArg: 1.335 ± 0.056
1.73MetSer: 1.73 ± 0.057
1.546MetThr: 1.546 ± 0.057
1.836MetVal: 1.836 ± 0.071
0.206MetTrp: 0.206 ± 0.024
0.528MetTyr: 0.528 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.276AsnAla: 3.276 ± 0.103
0.54AsnCys: 0.54 ± 0.034
2.413AsnAsp: 2.413 ± 0.092
2.768AsnGlu: 2.768 ± 0.088
1.878AsnPhe: 1.878 ± 0.082
3.159AsnGly: 3.159 ± 0.108
1.149AsnHis: 1.149 ± 0.048
4.364AsnIle: 4.364 ± 0.109
3.2AsnLys: 3.2 ± 0.09
4.609AsnLeu: 4.609 ± 0.091
1.259AsnMet: 1.259 ± 0.055
2.886AsnAsn: 2.886 ± 0.11
2.106AsnPro: 2.106 ± 0.064
2.44AsnGln: 2.44 ± 0.088
2.228AsnArg: 2.228 ± 0.08
2.818AsnSer: 2.818 ± 0.092
2.447AsnThr: 2.447 ± 0.079
2.602AsnVal: 2.602 ± 0.091
0.709AsnTrp: 0.709 ± 0.041
1.907AsnTyr: 1.907 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
2.982ProAla: 2.982 ± 0.089
0.393ProCys: 0.393 ± 0.032
2.312ProAsp: 2.312 ± 0.071
2.616ProGlu: 2.616 ± 0.077
1.696ProPhe: 1.696 ± 0.063
2.251ProGly: 2.251 ± 0.078
0.8ProHis: 0.8 ± 0.047
3.137ProIle: 3.137 ± 0.097
2.071ProLys: 2.071 ± 0.086
4.145ProLeu: 4.145 ± 0.119
0.906ProMet: 0.906 ± 0.047
1.88ProAsn: 1.88 ± 0.072
1.227ProPro: 1.227 ± 0.054
1.782ProGln: 1.782 ± 0.065
1.436ProArg: 1.436 ± 0.06
2.143ProSer: 2.143 ± 0.068
2.469ProThr: 2.469 ± 0.133
2.685ProVal: 2.685 ± 0.084
0.437ProTrp: 0.437 ± 0.036
1.431ProTyr: 1.431 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
3.983GlnAla: 3.983 ± 0.111
0.41GlnCys: 0.41 ± 0.034
1.792GlnAsp: 1.792 ± 0.068
2.177GlnGlu: 2.177 ± 0.083
1.838GlnPhe: 1.838 ± 0.069
2.444GlnGly: 2.444 ± 0.079
1.271GlnHis: 1.271 ± 0.061
3.357GlnIle: 3.357 ± 0.109
2.638GlnLys: 2.638 ± 0.081
5.581GlnLeu: 5.581 ± 0.145
1.2GlnMet: 1.2 ± 0.052
1.927GlnAsn: 1.927 ± 0.071
1.932GlnPro: 1.932 ± 0.072
3.583GlnGln: 3.583 ± 0.114
2.521GlnArg: 2.521 ± 0.088
2.597GlnSer: 2.597 ± 0.085
2.182GlnThr: 2.182 ± 0.075
2.702GlnVal: 2.702 ± 0.085
0.591GlnTrp: 0.591 ± 0.044
1.497GlnTyr: 1.497 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
3.365ArgAla: 3.365 ± 0.091
0.528ArgCys: 0.528 ± 0.036
2.317ArgAsp: 2.317 ± 0.086
3.097ArgGlu: 3.097 ± 0.08
2.317ArgPhe: 2.317 ± 0.078
2.746ArgGly: 2.746 ± 0.084
1.401ArgHis: 1.401 ± 0.065
3.866ArgIle: 3.866 ± 0.104
3.009ArgLys: 3.009 ± 0.089
5.488ArgLeu: 5.488 ± 0.118
1.266ArgMet: 1.266 ± 0.06
2.118ArgAsn: 2.118 ± 0.075
1.824ArgPro: 1.824 ± 0.068
2.795ArgGln: 2.795 ± 0.103
2.879ArgArg: 2.879 ± 0.099
2.533ArgSer: 2.533 ± 0.073
2.067ArgThr: 2.067 ± 0.066
2.805ArgVal: 2.805 ± 0.086
0.724ArgTrp: 0.724 ± 0.041
1.993ArgTyr: 1.993 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
4.585SerAla: 4.585 ± 0.106
0.695SerCys: 0.695 ± 0.044
3.227SerAsp: 3.227 ± 0.099
3.245SerGlu: 3.245 ± 0.096
2.528SerPhe: 2.528 ± 0.081
4.425SerGly: 4.425 ± 0.111
1.551SerHis: 1.551 ± 0.061
4.496SerIle: 4.496 ± 0.132
2.901SerLys: 2.901 ± 0.081
6.654SerLeu: 6.654 ± 0.135
1.519SerMet: 1.519 ± 0.056
2.579SerAsn: 2.579 ± 0.082
2.354SerPro: 2.354 ± 0.07
2.795SerGln: 2.795 ± 0.081
2.918SerArg: 2.918 ± 0.084
3.733SerSer: 3.733 ± 0.11
3.073SerThr: 3.073 ± 0.086
3.924SerVal: 3.924 ± 0.103
0.795SerTrp: 0.795 ± 0.049
2.047SerTyr: 2.047 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
4.383ThrAla: 4.383 ± 0.106
0.525ThrCys: 0.525 ± 0.039
2.859ThrAsp: 2.859 ± 0.09
3.218ThrGlu: 3.218 ± 0.112
1.963ThrPhe: 1.963 ± 0.077
3.946ThrGly: 3.946 ± 0.09
1.269ThrHis: 1.269 ± 0.062
4.214ThrIle: 4.214 ± 0.112
2.791ThrLys: 2.791 ± 0.088
6.249ThrLeu: 6.249 ± 0.13
1.168ThrMet: 1.168 ± 0.056
2.224ThrAsn: 2.224 ± 0.067
2.737ThrPro: 2.737 ± 0.129
2.133ThrGln: 2.133 ± 0.073
2.324ThrArg: 2.324 ± 0.078
2.884ThrSer: 2.884 ± 0.093
2.965ThrThr: 2.965 ± 0.098
3.696ThrVal: 3.696 ± 0.095
0.562ThrTrp: 0.562 ± 0.039
1.517ThrTyr: 1.517 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
5.088ValAla: 5.088 ± 0.114
0.726ValCys: 0.726 ± 0.044
3.38ValAsp: 3.38 ± 0.087
3.765ValGlu: 3.765 ± 0.113
2.278ValPhe: 2.278 ± 0.078
4.069ValGly: 4.069 ± 0.118
1.046ValHis: 1.046 ± 0.052
5.453ValIle: 5.453 ± 0.132
3.897ValLys: 3.897 ± 0.098
5.88ValLeu: 5.88 ± 0.115
1.858ValMet: 1.858 ± 0.066
3.1ValAsn: 3.1 ± 0.097
2.189ValPro: 2.189 ± 0.072
1.9ValGln: 1.9 ± 0.069
2.945ValArg: 2.945 ± 0.089
3.942ValSer: 3.942 ± 0.095
3.608ValThr: 3.608 ± 0.098
4.128ValVal: 4.128 ± 0.108
0.753ValTrp: 0.753 ± 0.045
1.782ValTyr: 1.782 ± 0.09
0.0ValXaa: 0.0 ± 0.0
Trp
0.734TrpAla: 0.734 ± 0.041
0.194TrpCys: 0.194 ± 0.019
0.483TrpAsp: 0.483 ± 0.038
0.437TrpGlu: 0.437 ± 0.032
0.579TrpPhe: 0.579 ± 0.041
0.717TrpGly: 0.717 ± 0.041
0.312TrpHis: 0.312 ± 0.022
0.864TrpIle: 0.864 ± 0.052
0.491TrpLys: 0.491 ± 0.031
1.978TrpLeu: 1.978 ± 0.079
0.373TrpMet: 0.373 ± 0.031
0.439TrpAsn: 0.439 ± 0.035
0.508TrpPro: 0.508 ± 0.032
1.077TrpGln: 1.077 ± 0.055
0.722TrpArg: 0.722 ± 0.044
0.697TrpSer: 0.697 ± 0.045
0.38TrpThr: 0.38 ± 0.03
0.653TrpVal: 0.653 ± 0.044
0.169TrpTrp: 0.169 ± 0.022
0.41TrpTyr: 0.41 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.255TyrAla: 2.255 ± 0.085
0.557TyrCys: 0.557 ± 0.036
1.743TyrAsp: 1.743 ± 0.071
1.497TyrGlu: 1.497 ± 0.069
1.507TyrPhe: 1.507 ± 0.063
2.145TyrGly: 2.145 ± 0.078
1.055TyrHis: 1.055 ± 0.049
2.255TyrIle: 2.255 ± 0.081
1.428TyrLys: 1.428 ± 0.073
3.701TyrLeu: 3.701 ± 0.095
0.692TyrMet: 0.692 ± 0.046
1.492TyrAsn: 1.492 ± 0.071
1.352TyrPro: 1.352 ± 0.062
2.081TyrGln: 2.081 ± 0.078
1.981TyrArg: 1.981 ± 0.07
2.138TyrSer: 2.138 ± 0.071
1.527TyrThr: 1.527 ± 0.063
1.774TyrVal: 1.774 ± 0.094
0.506TyrTrp: 0.506 ± 0.035
1.247TyrTyr: 1.247 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1780 proteins (407451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski