Amino acid dipepetide frequency for Cocksfoot mild mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.532AlaAla: 10.532 ± 2.437
1.109AlaCys: 1.109 ± 0.419
1.663AlaAsp: 1.663 ± 1.624
2.772AlaGlu: 2.772 ± 1.262
3.326AlaPhe: 3.326 ± 0.599
5.543AlaGly: 5.543 ± 0.992
1.109AlaHis: 1.109 ± 1.355
3.88AlaIle: 3.88 ± 0.898
5.543AlaLys: 5.543 ± 0.764
14.967AlaLeu: 14.967 ± 3.205
1.663AlaMet: 1.663 ± 0.581
4.435AlaAsn: 4.435 ± 1.677
2.772AlaPro: 2.772 ± 1.406
2.217AlaGln: 2.217 ± 1.023
8.315AlaArg: 8.315 ± 1.772
6.652AlaSer: 6.652 ± 1.577
5.543AlaThr: 5.543 ± 2.661
6.652AlaVal: 6.652 ± 0.679
2.217AlaTrp: 2.217 ± 0.838
3.326AlaTyr: 3.326 ± 0.857
0.0AlaXaa: 0.0 ± 0.0
Cys
1.109CysAla: 1.109 ± 0.549
1.109CysCys: 1.109 ± 0.419
0.0CysAsp: 0.0 ± 0.0
3.88CysGlu: 3.88 ± 1.263
0.554CysPhe: 0.554 ± 0.313
0.554CysGly: 0.554 ± 0.313
1.109CysHis: 1.109 ± 0.524
1.663CysIle: 1.663 ± 0.496
0.554CysLys: 0.554 ± 0.313
0.554CysLeu: 0.554 ± 0.313
1.109CysMet: 1.109 ± 0.419
0.0CysAsn: 0.0 ± 0.0
2.772CysPro: 2.772 ± 0.831
0.554CysGln: 0.554 ± 0.313
0.554CysArg: 0.554 ± 0.313
1.663CysSer: 1.663 ± 1.27
0.0CysThr: 0.0 ± 0.0
1.109CysVal: 1.109 ± 0.626
0.0CysTrp: 0.0 ± 0.0
1.109CysTyr: 1.109 ± 0.419
0.0CysXaa: 0.0 ± 0.0
Asp
6.098AspAla: 6.098 ± 1.593
1.109AspCys: 1.109 ± 0.419
3.88AspAsp: 3.88 ± 1.551
4.435AspGlu: 4.435 ± 1.014
0.0AspPhe: 0.0 ± 0.0
2.217AspGly: 2.217 ± 0.928
1.663AspHis: 1.663 ± 0.496
1.109AspIle: 1.109 ± 0.626
2.217AspLys: 2.217 ± 0.773
2.217AspLeu: 2.217 ± 0.393
1.663AspMet: 1.663 ± 0.691
2.772AspAsn: 2.772 ± 0.635
3.326AspPro: 3.326 ± 0.628
2.217AspGln: 2.217 ± 0.715
1.109AspArg: 1.109 ± 0.803
4.435AspSer: 4.435 ± 1.431
4.435AspThr: 4.435 ± 1.576
2.772AspVal: 2.772 ± 1.22
1.109AspTrp: 1.109 ± 0.419
1.109AspTyr: 1.109 ± 0.549
0.0AspXaa: 0.0 ± 0.0
Glu
4.435GluAla: 4.435 ± 1.368
1.109GluCys: 1.109 ± 0.626
3.88GluAsp: 3.88 ± 0.931
3.326GluGlu: 3.326 ± 1.257
4.435GluPhe: 4.435 ± 0.737
1.663GluGly: 1.663 ± 0.691
1.663GluHis: 1.663 ± 0.94
2.217GluIle: 2.217 ± 0.393
6.098GluLys: 6.098 ± 0.939
1.109GluLeu: 1.109 ± 0.63
2.772GluMet: 2.772 ± 0.702
0.554GluAsn: 0.554 ± 0.313
0.554GluPro: 0.554 ± 0.313
1.109GluGln: 1.109 ± 0.626
3.88GluArg: 3.88 ± 0.768
0.0GluSer: 0.0 ± 0.0
0.0GluThr: 0.0 ± 0.0
4.435GluVal: 4.435 ± 0.951
2.217GluTrp: 2.217 ± 0.393
1.109GluTyr: 1.109 ± 0.419
0.0GluXaa: 0.0 ± 0.0
Phe
3.326PheAla: 3.326 ± 0.854
1.109PheCys: 1.109 ± 0.626
3.88PheAsp: 3.88 ± 0.9
0.554PheGlu: 0.554 ± 0.313
3.326PhePhe: 3.326 ± 0.599
2.217PheGly: 2.217 ± 1.04
2.217PheHis: 2.217 ± 0.838
1.109PheIle: 1.109 ± 0.626
1.663PheLys: 1.663 ± 0.94
6.098PheLeu: 6.098 ± 1.326
1.109PheMet: 1.109 ± 0.628
2.217PheAsn: 2.217 ± 0.768
1.109PhePro: 1.109 ± 0.549
1.663PheGln: 1.663 ± 0.496
0.554PheArg: 0.554 ± 0.313
3.326PheSer: 3.326 ± 1.628
0.554PheThr: 0.554 ± 0.668
2.772PheVal: 2.772 ± 0.91
0.0PheTrp: 0.0 ± 0.0
2.217PheTyr: 2.217 ± 0.715
0.0PheXaa: 0.0 ± 0.0
Gly
3.88GlyAla: 3.88 ± 0.836
1.109GlyCys: 1.109 ± 0.63
6.098GlyAsp: 6.098 ± 1.098
0.554GlyGlu: 0.554 ± 0.313
2.217GlyPhe: 2.217 ± 1.253
4.989GlyGly: 4.989 ± 1.19
1.109GlyHis: 1.109 ± 0.626
2.772GlyIle: 2.772 ± 0.998
2.772GlyLys: 2.772 ± 0.42
7.206GlyLeu: 7.206 ± 0.55
1.663GlyMet: 1.663 ± 0.847
3.326GlyAsn: 3.326 ± 0.857
3.326GlyPro: 3.326 ± 1.379
2.217GlyGln: 2.217 ± 0.817
5.543GlyArg: 5.543 ± 2.817
1.663GlySer: 1.663 ± 0.496
2.772GlyThr: 2.772 ± 0.787
1.663GlyVal: 1.663 ± 0.496
0.0GlyTrp: 0.0 ± 0.0
3.326GlyTyr: 3.326 ± 0.441
0.0GlyXaa: 0.0 ± 0.0
His
1.109HisAla: 1.109 ± 0.419
0.554HisCys: 0.554 ± 0.566
0.0HisAsp: 0.0 ± 0.0
1.663HisGlu: 1.663 ± 0.781
2.772HisPhe: 2.772 ± 0.987
1.109HisGly: 1.109 ± 0.626
0.554HisHis: 0.554 ± 0.566
1.109HisIle: 1.109 ± 0.626
1.663HisLys: 1.663 ± 0.94
2.217HisLeu: 2.217 ± 0.715
0.0HisMet: 0.0 ± 0.0
2.772HisAsn: 2.772 ± 0.831
1.663HisPro: 1.663 ± 0.728
0.0HisGln: 0.0 ± 0.0
2.217HisArg: 2.217 ± 0.622
3.326HisSer: 3.326 ± 0.628
1.109HisThr: 1.109 ± 0.549
1.109HisVal: 1.109 ± 0.626
0.554HisTrp: 0.554 ± 0.677
0.554HisTyr: 0.554 ± 0.677
0.0HisXaa: 0.0 ± 0.0
Ile
2.772IleAla: 2.772 ± 1.542
0.554IleCys: 0.554 ± 0.313
2.217IleAsp: 2.217 ± 0.928
2.217IleGlu: 2.217 ± 0.719
0.554IlePhe: 0.554 ± 0.313
2.217IleGly: 2.217 ± 1.841
3.88IleHis: 3.88 ± 1.577
5.543IleIle: 5.543 ± 2.726
1.663IleLys: 1.663 ± 0.496
4.989IleLeu: 4.989 ± 1.021
0.554IleMet: 0.554 ± 0.313
0.0IleAsn: 0.0 ± 0.0
4.989IlePro: 4.989 ± 1.578
2.217IleGln: 2.217 ± 0.393
1.663IleArg: 1.663 ± 0.94
2.217IleSer: 2.217 ± 0.726
4.989IleThr: 4.989 ± 0.494
0.554IleVal: 0.554 ± 0.566
0.554IleTrp: 0.554 ± 0.677
1.663IleTyr: 1.663 ± 0.94
0.0IleXaa: 0.0 ± 0.0
Lys
2.772LysAla: 2.772 ± 0.42
0.554LysCys: 0.554 ± 0.313
5.543LysAsp: 5.543 ± 1.489
4.435LysGlu: 4.435 ± 1.343
5.543LysPhe: 5.543 ± 1.35
2.217LysGly: 2.217 ± 0.773
1.109LysHis: 1.109 ± 0.549
2.772LysIle: 2.772 ± 0.987
1.663LysLys: 1.663 ± 0.94
3.88LysLeu: 3.88 ± 1.137
2.217LysMet: 2.217 ± 0.58
1.663LysAsn: 1.663 ± 0.496
1.109LysPro: 1.109 ± 0.549
2.217LysGln: 2.217 ± 1.04
2.217LysArg: 2.217 ± 0.715
1.663LysSer: 1.663 ± 0.691
2.772LysThr: 2.772 ± 0.42
2.772LysVal: 2.772 ± 0.863
1.109LysTrp: 1.109 ± 0.626
2.772LysTyr: 2.772 ± 0.787
0.554LysXaa: 0.554 ± 0.313
Leu
8.315LeuAla: 8.315 ± 0.44
4.435LeuCys: 4.435 ± 1.192
7.206LeuAsp: 7.206 ± 1.963
2.772LeuGlu: 2.772 ± 0.577
3.326LeuPhe: 3.326 ± 0.599
4.435LeuGly: 4.435 ± 0.737
3.326LeuHis: 3.326 ± 0.862
4.435LeuIle: 4.435 ± 1.732
6.098LeuLys: 6.098 ± 0.876
5.543LeuLeu: 5.543 ± 0.904
0.554LeuMet: 0.554 ± 0.668
3.88LeuAsn: 3.88 ± 0.944
6.098LeuPro: 6.098 ± 1.237
3.326LeuGln: 3.326 ± 0.857
4.435LeuArg: 4.435 ± 0.462
8.869LeuSer: 8.869 ± 0.925
3.326LeuThr: 3.326 ± 0.441
6.098LeuVal: 6.098 ± 0.939
1.663LeuTrp: 1.663 ± 0.691
3.88LeuTyr: 3.88 ± 1.263
0.0LeuXaa: 0.0 ± 0.0
Met
3.326MetAla: 3.326 ± 0.876
0.0MetCys: 0.0 ± 0.0
0.554MetAsp: 0.554 ± 0.668
4.435MetGlu: 4.435 ± 1.192
0.554MetPhe: 0.554 ± 0.313
4.435MetGly: 4.435 ± 1.039
0.0MetHis: 0.0 ± 0.0
1.109MetIle: 1.109 ± 0.419
0.554MetLys: 0.554 ± 0.313
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.109MetAsn: 1.109 ± 0.549
0.0MetPro: 0.0 ± 0.0
0.554MetGln: 0.554 ± 0.313
0.554MetArg: 0.554 ± 0.313
2.217MetSer: 2.217 ± 1.002
1.109MetThr: 1.109 ± 0.419
1.109MetVal: 1.109 ± 0.549
1.663MetTrp: 1.663 ± 0.691
1.109MetTyr: 1.109 ± 0.419
0.0MetXaa: 0.0 ± 0.0
Asn
2.217AsnAla: 2.217 ± 0.838
0.554AsnCys: 0.554 ± 0.313
0.554AsnAsp: 0.554 ± 0.313
0.0AsnGlu: 0.0 ± 0.0
1.663AsnPhe: 1.663 ± 1.624
3.326AsnGly: 3.326 ± 0.628
0.0AsnHis: 0.0 ± 0.0
1.109AsnIle: 1.109 ± 0.949
1.663AsnLys: 1.663 ± 0.593
2.217AsnLeu: 2.217 ± 0.928
2.772AsnMet: 2.772 ± 0.921
1.663AsnAsn: 1.663 ± 0.875
3.326AsnPro: 3.326 ± 0.881
1.109AsnGln: 1.109 ± 0.419
2.772AsnArg: 2.772 ± 0.749
0.554AsnSer: 0.554 ± 0.313
4.989AsnThr: 4.989 ± 0.89
3.326AsnVal: 3.326 ± 0.739
0.0AsnTrp: 0.0 ± 0.0
1.663AsnTyr: 1.663 ± 1.182
0.0AsnXaa: 0.0 ± 0.0
Pro
4.435ProAla: 4.435 ± 1.951
1.109ProCys: 1.109 ± 0.626
3.326ProAsp: 3.326 ± 0.53
2.217ProGlu: 2.217 ± 0.393
1.109ProPhe: 1.109 ± 0.524
2.772ProGly: 2.772 ± 1.75
0.554ProHis: 0.554 ± 0.313
3.326ProIle: 3.326 ± 0.946
3.326ProLys: 3.326 ± 0.984
6.098ProLeu: 6.098 ± 1.215
0.554ProMet: 0.554 ± 0.677
2.217ProAsn: 2.217 ± 0.773
3.88ProPro: 3.88 ± 1.899
2.217ProGln: 2.217 ± 1.04
7.206ProArg: 7.206 ± 0.892
4.989ProSer: 4.989 ± 2.92
2.772ProThr: 2.772 ± 1.406
4.435ProVal: 4.435 ± 1.102
0.0ProTrp: 0.0 ± 0.0
0.554ProTyr: 0.554 ± 0.668
0.0ProXaa: 0.0 ± 0.0
Gln
4.989GlnAla: 4.989 ± 1.459
1.109GlnCys: 1.109 ± 0.626
2.217GlnAsp: 2.217 ± 0.768
2.217GlnGlu: 2.217 ± 0.838
2.217GlnPhe: 2.217 ± 0.393
0.554GlnGly: 0.554 ± 0.313
1.109GlnHis: 1.109 ± 0.549
0.554GlnIle: 0.554 ± 0.313
2.772GlnLys: 2.772 ± 0.95
4.435GlnLeu: 4.435 ± 0.956
2.217GlnMet: 2.217 ± 0.393
0.554GlnAsn: 0.554 ± 0.566
3.88GlnPro: 3.88 ± 1.342
0.0GlnGln: 0.0 ± 0.0
2.772GlnArg: 2.772 ± 0.749
1.109GlnSer: 1.109 ± 0.626
2.217GlnThr: 2.217 ± 0.768
2.217GlnVal: 2.217 ± 1.097
0.554GlnTrp: 0.554 ± 0.677
1.663GlnTyr: 1.663 ± 0.593
0.0GlnXaa: 0.0 ± 0.0
Arg
12.749ArgAla: 12.749 ± 2.927
1.663ArgCys: 1.663 ± 0.496
2.772ArgAsp: 2.772 ± 0.825
1.109ArgGlu: 1.109 ± 0.63
1.663ArgPhe: 1.663 ± 0.496
3.326ArgGly: 3.326 ± 1.628
2.217ArgHis: 2.217 ± 1.259
1.109ArgIle: 1.109 ± 1.337
2.772ArgLys: 2.772 ± 1.178
9.424ArgLeu: 9.424 ± 0.818
1.663ArgMet: 1.663 ± 0.496
1.109ArgAsn: 1.109 ± 0.626
2.217ArgPro: 2.217 ± 0.726
3.88ArgGln: 3.88 ± 0.836
6.098ArgArg: 6.098 ± 2.396
3.88ArgSer: 3.88 ± 2.041
5.543ArgThr: 5.543 ± 1.495
2.772ArgVal: 2.772 ± 1.262
1.109ArgTrp: 1.109 ± 0.419
4.435ArgTyr: 4.435 ± 1.431
0.0ArgXaa: 0.0 ± 0.0
Ser
6.652SerAla: 6.652 ± 1.77
1.109SerCys: 1.109 ± 0.971
1.109SerAsp: 1.109 ± 0.549
1.109SerGlu: 1.109 ± 0.626
2.217SerPhe: 2.217 ± 0.768
3.88SerGly: 3.88 ± 0.889
2.772SerHis: 2.772 ± 1.146
4.435SerIle: 4.435 ± 1.328
3.326SerLys: 3.326 ± 1.278
6.652SerLeu: 6.652 ± 0.882
1.109SerMet: 1.109 ± 0.595
0.554SerAsn: 0.554 ± 0.668
3.326SerPro: 3.326 ± 1.083
2.772SerGln: 2.772 ± 1.82
4.989SerArg: 4.989 ± 0.494
7.761SerSer: 7.761 ± 2.292
8.869SerThr: 8.869 ± 1.284
3.88SerVal: 3.88 ± 0.979
1.109SerTrp: 1.109 ± 0.419
2.772SerTyr: 2.772 ± 1.202
0.0SerXaa: 0.0 ± 0.0
Thr
4.989ThrAla: 4.989 ± 2.274
1.663ThrCys: 1.663 ± 0.66
1.109ThrAsp: 1.109 ± 0.549
2.217ThrGlu: 2.217 ± 0.622
2.217ThrPhe: 2.217 ± 1.097
3.326ThrGly: 3.326 ± 1.048
0.554ThrHis: 0.554 ± 0.313
1.663ThrIle: 1.663 ± 0.496
2.217ThrLys: 2.217 ± 0.838
5.543ThrLeu: 5.543 ± 1.155
1.663ThrMet: 1.663 ± 0.496
1.663ThrAsn: 1.663 ± 1.933
7.206ThrPro: 7.206 ± 1.944
3.326ThrGln: 3.326 ± 0.857
6.098ThrArg: 6.098 ± 1.625
3.326ThrSer: 3.326 ± 1.838
4.435ThrThr: 4.435 ± 2.574
6.098ThrVal: 6.098 ± 2.422
1.109ThrTrp: 1.109 ± 0.549
2.217ThrTyr: 2.217 ± 0.602
0.0ThrXaa: 0.0 ± 0.0
Val
6.652ValAla: 6.652 ± 1.266
0.0ValCys: 0.0 ± 0.0
2.772ValAsp: 2.772 ± 0.825
4.435ValGlu: 4.435 ± 1.192
2.217ValPhe: 2.217 ± 0.715
3.88ValGly: 3.88 ± 0.816
0.554ValHis: 0.554 ± 0.313
3.88ValIle: 3.88 ± 0.88
1.109ValLys: 1.109 ± 0.626
2.772ValLeu: 2.772 ± 1.549
0.0ValMet: 0.0 ± 0.0
1.663ValAsn: 1.663 ± 0.593
2.772ValPro: 2.772 ± 1.323
4.989ValGln: 4.989 ± 1.287
3.88ValArg: 3.88 ± 1.19
6.652ValSer: 6.652 ± 0.939
4.435ValThr: 4.435 ± 1.831
3.88ValVal: 3.88 ± 0.596
1.663ValTrp: 1.663 ± 0.66
0.554ValTyr: 0.554 ± 0.677
0.0ValXaa: 0.0 ± 0.0
Trp
1.663TrpAla: 1.663 ± 0.691
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.554TrpGlu: 0.554 ± 0.313
0.554TrpPhe: 0.554 ± 0.677
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.109TrpIle: 1.109 ± 0.549
2.217TrpLys: 2.217 ± 0.838
1.663TrpLeu: 1.663 ± 0.691
0.0TrpMet: 0.0 ± 0.0
1.109TrpAsn: 1.109 ± 0.419
1.663TrpPro: 1.663 ± 1.59
1.109TrpGln: 1.109 ± 0.626
1.663TrpArg: 1.663 ± 0.573
2.217TrpSer: 2.217 ± 0.838
0.0TrpThr: 0.0 ± 0.0
1.109TrpVal: 1.109 ± 0.419
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.217TyrAla: 2.217 ± 0.715
0.0TyrCys: 0.0 ± 0.0
1.109TyrAsp: 1.109 ± 0.419
1.663TyrGlu: 1.663 ± 0.593
1.109TyrPhe: 1.109 ± 0.63
4.989TyrGly: 4.989 ± 1.062
0.554TyrHis: 0.554 ± 0.566
1.109TyrIle: 1.109 ± 0.626
1.663TyrLys: 1.663 ± 0.728
4.435TyrLeu: 4.435 ± 1.244
0.554TyrMet: 0.554 ± 0.668
2.217TyrAsn: 2.217 ± 0.393
1.109TyrPro: 1.109 ± 0.63
1.663TyrGln: 1.663 ± 0.66
4.989TyrArg: 4.989 ± 1.062
3.88TyrSer: 3.88 ± 0.9
2.772TyrThr: 2.772 ± 1.02
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
1.663TyrTyr: 1.663 ± 0.94
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.554XaaGly: 0.554 ± 0.313
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski