Amino acid dipepetide frequency for Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.741AlaAla: 12.741 ± 0.161	1.356AlaCys: 1.356 ± 0.04	5.697AlaAsp: 5.697 ± 0.102	6.866AlaGlu: 6.866 ± 0.1	3.698AlaPhe: 3.698 ± 0.055	9.923AlaGly: 9.923 ± 0.137	1.73AlaHis: 1.73 ± 0.04	5.255AlaIle: 5.255 ± 0.079	3.614AlaLys: 3.614 ± 0.071	10.432AlaLeu: 10.432 ± 0.125	2.613AlaMet: 2.613 ± 0.053	2.501AlaAsn: 2.501 ± 0.057	4.344AlaPro: 4.344 ± 0.079	2.544AlaGln: 2.544 ± 0.057	6.978AlaArg: 6.978 ± 0.095	5.112AlaSer: 5.112 ± 0.08	5.523AlaThr: 5.523 ± 0.107	8.63AlaVal: 8.63 ± 0.107	1.096AlaTrp: 1.096 ± 0.037	2.23AlaTyr: 2.23 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.154CysAla: 1.154 ± 0.037	0.225CysCys: 0.225 ± 0.017	0.578CysAsp: 0.578 ± 0.024	0.558CysGlu: 0.558 ± 0.024	0.459CysPhe: 0.459 ± 0.021	1.291CysGly: 1.291 ± 0.041	0.955CysHis: 0.955 ± 0.092	0.584CysIle: 0.584 ± 0.024	0.315CysLys: 0.315 ± 0.02	1.089CysLeu: 1.089 ± 0.032	0.276CysMet: 0.276 ± 0.017	0.33CysAsn: 0.33 ± 0.016	0.725CysPro: 0.725 ± 0.032	0.285CysGln: 0.285 ± 0.017	0.984CysArg: 0.984 ± 0.029	0.805CysSer: 0.805 ± 0.032	0.664CysThr: 0.664 ± 0.029	0.748CysVal: 0.748 ± 0.028	0.112CysTrp: 0.112 ± 0.01	0.32CysTyr: 0.32 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.957AspAla: 4.957 ± 0.08	0.689AspCys: 0.689 ± 0.031	2.9AspAsp: 2.9 ± 0.062	3.813AspGlu: 3.813 ± 0.07	2.174AspPhe: 2.174 ± 0.051	4.692AspGly: 4.692 ± 0.09	1.087AspHis: 1.087 ± 0.034	3.337AspIle: 3.337 ± 0.07	1.924AspLys: 1.924 ± 0.047	5.578AspLeu: 5.578 ± 0.081	1.161AspMet: 1.161 ± 0.035	1.501AspAsn: 1.501 ± 0.039	2.858AspPro: 2.858 ± 0.055	1.48AspGln: 1.48 ± 0.033	4.067AspArg: 4.067 ± 0.071	2.495AspSer: 2.495 ± 0.051	2.73AspThr: 2.73 ± 0.063	3.879AspVal: 3.879 ± 0.067	0.574AspTrp: 0.574 ± 0.028	1.716AspTyr: 1.716 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.475GluAla: 6.475 ± 0.107	0.584GluCys: 0.584 ± 0.025	2.588GluAsp: 2.588 ± 0.056	5.112GluGlu: 5.112 ± 0.086	2.273GluPhe: 2.273 ± 0.05	4.995GluGly: 4.995 ± 0.082	1.296GluHis: 1.296 ± 0.038	4.017GluIle: 4.017 ± 0.065	3.465GluLys: 3.465 ± 0.076	6.889GluLeu: 6.889 ± 0.1	1.82GluMet: 1.82 ± 0.041	1.891GluAsn: 1.891 ± 0.041	2.457GluPro: 2.457 ± 0.041	2.438GluGln: 2.438 ± 0.051	5.667GluArg: 5.667 ± 0.096	3.102GluSer: 3.102 ± 0.064	3.389GluThr: 3.389 ± 0.062	4.499GluVal: 4.499 ± 0.076	0.558GluTrp: 0.558 ± 0.022	1.588GluTyr: 1.588 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.757PheAla: 3.757 ± 0.076	0.544PheCys: 0.544 ± 0.024	2.371PheAsp: 2.371 ± 0.043	2.018PheGlu: 2.018 ± 0.045	1.817PhePhe: 1.817 ± 0.045	3.357PheGly: 3.357 ± 0.054	0.779PheHis: 0.779 ± 0.026	2.076PheIle: 2.076 ± 0.047	1.265PheLys: 1.265 ± 0.034	3.977PheLeu: 3.977 ± 0.084	0.868PheMet: 0.868 ± 0.028	1.272PheAsn: 1.272 ± 0.038	1.806PhePro: 1.806 ± 0.041	0.989PheGln: 0.989 ± 0.034	2.726PheArg: 2.726 ± 0.047	2.663PheSer: 2.663 ± 0.05	2.569PheThr: 2.569 ± 0.054	2.847PheVal: 2.847 ± 0.054	0.414PheTrp: 0.414 ± 0.018	1.103PheTyr: 1.103 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.759GlyAla: 7.759 ± 0.103	1.374GlyCys: 1.374 ± 0.037	4.44GlyAsp: 4.44 ± 0.077	5.537GlyGlu: 5.537 ± 0.089	3.397GlyPhe: 3.397 ± 0.058	7.166GlyGly: 7.166 ± 0.11	1.692GlyHis: 1.692 ± 0.042	5.582GlyIle: 5.582 ± 0.073	4.18GlyLys: 4.18 ± 0.067	7.556GlyLeu: 7.556 ± 0.096	2.401GlyMet: 2.401 ± 0.044	2.615GlyAsn: 2.615 ± 0.059	2.489GlyPro: 2.489 ± 0.05	2.133GlyGln: 2.133 ± 0.046	5.642GlyArg: 5.642 ± 0.086	4.811GlySer: 4.811 ± 0.105	5.558GlyThr: 5.558 ± 0.116	6.47GlyVal: 6.47 ± 0.083	0.974GlyTrp: 0.974 ± 0.028	2.665GlyTyr: 2.665 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.81HisAla: 1.81 ± 0.046	0.293HisCys: 0.293 ± 0.016	1.291HisAsp: 1.291 ± 0.035	1.213HisGlu: 1.213 ± 0.037	0.843HisPhe: 0.843 ± 0.028	1.974HisGly: 1.974 ± 0.055	0.572HisHis: 0.572 ± 0.025	1.002HisIle: 1.002 ± 0.03	0.647HisLys: 0.647 ± 0.024	2.273HisLeu: 2.273 ± 0.049	0.431HisMet: 0.431 ± 0.021	0.656HisAsn: 0.656 ± 0.027	1.369HisPro: 1.369 ± 0.041	0.577HisGln: 0.577 ± 0.024	1.473HisArg: 1.473 ± 0.037	1.021HisSer: 1.021 ± 0.034	0.946HisThr: 0.946 ± 0.03	1.328HisVal: 1.328 ± 0.033	0.219HisTrp: 0.219 ± 0.014	0.603HisTyr: 0.603 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.786IleAla: 5.786 ± 0.083	0.689IleCys: 0.689 ± 0.025	3.384IleAsp: 3.384 ± 0.061	3.346IleGlu: 3.346 ± 0.063	2.092IlePhe: 2.092 ± 0.047	4.524IleGly: 4.524 ± 0.059	1.148IleHis: 1.148 ± 0.036	3.34IleIle: 3.34 ± 0.068	2.074IleLys: 2.074 ± 0.053	5.393IleLeu: 5.393 ± 0.084	1.225IleMet: 1.225 ± 0.039	1.717IleAsn: 1.717 ± 0.04	2.998IlePro: 2.998 ± 0.05	1.394IleGln: 1.394 ± 0.037	3.782IleArg: 3.782 ± 0.058	3.354IleSer: 3.354 ± 0.061	3.462IleThr: 3.462 ± 0.07	4.382IleVal: 4.382 ± 0.066	0.433IleTrp: 0.433 ± 0.018	1.365IleTyr: 1.365 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.913LysAla: 3.913 ± 0.07	0.388LysCys: 0.388 ± 0.022	2.101LysAsp: 2.101 ± 0.05	3.035LysGlu: 3.035 ± 0.069	1.107LysPhe: 1.107 ± 0.035	3.678LysGly: 3.678 ± 0.057	0.705LysHis: 0.705 ± 0.028	2.416LysIle: 2.416 ± 0.053	2.631LysLys: 2.631 ± 0.079	3.685LysLeu: 3.685 ± 0.068	1.108LysMet: 1.108 ± 0.037	1.386LysAsn: 1.386 ± 0.032	1.931LysPro: 1.931 ± 0.044	1.241LysGln: 1.241 ± 0.038	2.797LysArg: 2.797 ± 0.054	2.098LysSer: 2.098 ± 0.052	2.08LysThr: 2.08 ± 0.048	3.151LysVal: 3.151 ± 0.073	0.324LysTrp: 0.324 ± 0.018	1.036LysTyr: 1.036 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.176LeuAla: 12.176 ± 0.164	1.224LeuCys: 1.224 ± 0.036	5.489LeuAsp: 5.489 ± 0.073	6.275LeuGlu: 6.275 ± 0.107	4.162LeuPhe: 4.162 ± 0.08	7.64LeuGly: 7.64 ± 0.104	1.944LeuHis: 1.944 ± 0.043	4.772LeuIle: 4.772 ± 0.078	4.606LeuLys: 4.606 ± 0.073	10.439LeuLeu: 10.439 ± 0.127	2.365LeuMet: 2.365 ± 0.053	2.972LeuAsn: 2.972 ± 0.057	4.999LeuPro: 4.999 ± 0.076	2.688LeuGln: 2.688 ± 0.05	6.825LeuArg: 6.825 ± 0.098	6.185LeuSer: 6.185 ± 0.087	5.824LeuThr: 5.824 ± 0.082	7.815LeuVal: 7.815 ± 0.087	0.92LeuTrp: 0.92 ± 0.038	2.365LeuTyr: 2.365 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.811MetAla: 2.811 ± 0.062	0.169MetCys: 0.169 ± 0.012	1.228MetAsp: 1.228 ± 0.036	1.732MetGlu: 1.732 ± 0.043	0.679MetPhe: 0.679 ± 0.023	1.961MetGly: 1.961 ± 0.045	0.405MetHis: 0.405 ± 0.019	1.24MetIle: 1.24 ± 0.034	1.466MetLys: 1.466 ± 0.044	2.222MetLeu: 2.222 ± 0.049	0.573MetMet: 0.573 ± 0.022	0.861MetAsn: 0.861 ± 0.026	1.192MetPro: 1.192 ± 0.033	0.622MetGln: 0.622 ± 0.024	1.439MetArg: 1.439 ± 0.035	1.318MetSer: 1.318 ± 0.033	1.612MetThr: 1.612 ± 0.034	1.938MetVal: 1.938 ± 0.043	0.118MetTrp: 0.118 ± 0.01	0.406MetTyr: 0.406 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.702AsnAla: 2.702 ± 0.063	0.394AsnCys: 0.394 ± 0.021	1.493AsnAsp: 1.493 ± 0.042	1.491AsnGlu: 1.491 ± 0.036	1.02AsnPhe: 1.02 ± 0.029	2.613AsnGly: 2.613 ± 0.061	0.616AsnHis: 0.616 ± 0.024	1.74AsnIle: 1.74 ± 0.044	0.937AsnLys: 0.937 ± 0.029	3.268AsnLeu: 3.268 ± 0.053	0.623AsnMet: 0.623 ± 0.024	0.971AsnAsn: 0.971 ± 0.039	1.967AsnPro: 1.967 ± 0.048	0.784AsnGln: 0.784 ± 0.03	2.284AsnArg: 2.284 ± 0.041	1.498AsnSer: 1.498 ± 0.048	1.405AsnThr: 1.405 ± 0.05	2.211AsnVal: 2.211 ± 0.048	0.336AsnTrp: 0.336 ± 0.019	0.903AsnTyr: 0.903 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.385ProAla: 5.385 ± 0.085	0.47ProCys: 0.47 ± 0.022	2.943ProAsp: 2.943 ± 0.066	3.552ProGlu: 3.552 ± 0.067	2.058ProPhe: 2.058 ± 0.053	3.993ProGly: 3.993 ± 0.072	0.98ProHis: 0.98 ± 0.03	1.946ProIle: 1.946 ± 0.048	1.479ProLys: 1.479 ± 0.044	4.999ProLeu: 4.999 ± 0.073	0.952ProMet: 0.952 ± 0.033	1.085ProAsn: 1.085 ± 0.035	2.425ProPro: 2.425 ± 0.059	1.269ProGln: 1.269 ± 0.034	2.635ProArg: 2.635 ± 0.053	2.447ProSer: 2.447 ± 0.049	2.302ProThr: 2.302 ± 0.052	4.283ProVal: 4.283 ± 0.071	0.539ProTrp: 0.539 ± 0.023	1.225ProTyr: 1.225 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.914GlnAla: 2.914 ± 0.05	0.312GlnCys: 0.312 ± 0.019	1.198GlnAsp: 1.198 ± 0.035	1.878GlnGlu: 1.878 ± 0.041	1.015GlnPhe: 1.015 ± 0.032	2.303GlnGly: 2.303 ± 0.05	0.503GlnHis: 0.503 ± 0.02	1.588GlnIle: 1.588 ± 0.041	1.343GlnLys: 1.343 ± 0.032	2.642GlnLeu: 2.642 ± 0.05	0.737GlnMet: 0.737 ± 0.026	0.813GlnAsn: 0.813 ± 0.033	1.222GlnPro: 1.222 ± 0.037	1.052GlnGln: 1.052 ± 0.034	2.014GlnArg: 2.014 ± 0.048	1.422GlnSer: 1.422 ± 0.039	1.437GlnThr: 1.437 ± 0.039	2.387GlnVal: 2.387 ± 0.047	0.312GlnTrp: 0.312 ± 0.018	0.67GlnTyr: 0.67 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.625ArgAla: 5.625 ± 0.083	0.812ArgCys: 0.812 ± 0.028	3.861ArgAsp: 3.861 ± 0.067	5.938ArgGlu: 5.938 ± 0.095	3.078ArgPhe: 3.078 ± 0.059	4.78ArgGly: 4.78 ± 0.068	1.713ArgHis: 1.713 ± 0.05	4.37ArgIle: 4.37 ± 0.067	2.936ArgLys: 2.936 ± 0.068	7.681ArgLeu: 7.681 ± 0.106	1.844ArgMet: 1.844 ± 0.038	2.087ArgAsn: 2.087 ± 0.046	2.758ArgPro: 2.758 ± 0.052	2.507ArgGln: 2.507 ± 0.052	5.314ArgArg: 5.314 ± 0.097	3.568ArgSer: 3.568 ± 0.054	3.466ArgThr: 3.466 ± 0.051	5.013ArgVal: 5.013 ± 0.078	0.745ArgTrp: 0.745 ± 0.025	2.122ArgTyr: 2.122 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.376SerAla: 5.376 ± 0.097	0.825SerCys: 0.825 ± 0.036	2.921SerAsp: 2.921 ± 0.054	2.769SerGlu: 2.769 ± 0.053	2.644SerPhe: 2.644 ± 0.06	5.153SerGly: 5.153 ± 0.097	1.205SerHis: 1.205 ± 0.033	3.053SerIle: 3.053 ± 0.063	1.576SerLys: 1.576 ± 0.04	6.173SerLeu: 6.173 ± 0.067	1.168SerMet: 1.168 ± 0.029	1.384SerAsn: 1.384 ± 0.045	2.86SerPro: 2.86 ± 0.059	1.464SerGln: 1.464 ± 0.036	3.927SerArg: 3.927 ± 0.062	3.308SerSer: 3.308 ± 0.073	2.819SerThr: 2.819 ± 0.071	4.061SerVal: 4.061 ± 0.081	0.655SerTrp: 0.655 ± 0.03	1.568SerTyr: 1.568 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.005ThrAla: 6.005 ± 0.106	0.666ThrCys: 0.666 ± 0.032	2.881ThrAsp: 2.881 ± 0.06	2.841ThrGlu: 2.841 ± 0.05	2.37ThrPhe: 2.37 ± 0.064	5.528ThrGly: 5.528 ± 0.083	0.981ThrHis: 0.981 ± 0.026	3.462ThrIle: 3.462 ± 0.093	1.675ThrLys: 1.675 ± 0.046	5.868ThrLeu: 5.868 ± 0.087	1.204ThrMet: 1.204 ± 0.037	1.529ThrAsn: 1.529 ± 0.048	3.153ThrPro: 3.153 ± 0.065	1.093ThrGln: 1.093 ± 0.035	3.171ThrArg: 3.171 ± 0.056	3.068ThrSer: 3.068 ± 0.077	3.243ThrThr: 3.243 ± 0.091	5.319ThrVal: 5.319 ± 0.114	0.582ThrTrp: 0.582 ± 0.022	1.425ThrTyr: 1.425 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.583ValAla: 8.583 ± 0.099	0.956ValCys: 0.956 ± 0.032	4.125ValAsp: 4.125 ± 0.059	5.095ValGlu: 5.095 ± 0.085	2.725ValPhe: 2.725 ± 0.06	5.718ValGly: 5.718 ± 0.085	1.339ValHis: 1.339 ± 0.038	4.551ValIle: 4.551 ± 0.067	3.418ValLys: 3.418 ± 0.068	7.165ValLeu: 7.165 ± 0.093	1.971ValMet: 1.971 ± 0.047	2.502ValAsn: 2.502 ± 0.064	3.67ValPro: 3.67 ± 0.059	1.946ValGln: 1.946 ± 0.04	5.371ValArg: 5.371 ± 0.077	4.604ValSer: 4.604 ± 0.082	5.133ValThr: 5.133 ± 0.096	6.535ValVal: 6.535 ± 0.089	0.656ValTrp: 0.656 ± 0.028	1.82ValTyr: 1.82 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.027	0.13TrpCys: 0.13 ± 0.01	0.558TrpAsp: 0.558 ± 0.023	0.599TrpGlu: 0.599 ± 0.022	0.475TrpPhe: 0.475 ± 0.021	0.845TrpGly: 0.845 ± 0.034	0.27TrpHis: 0.27 ± 0.016	0.488TrpIle: 0.488 ± 0.02	0.461TrpLys: 0.461 ± 0.023	1.19TrpLeu: 1.19 ± 0.042	0.218TrpMet: 0.218 ± 0.014	0.317TrpAsn: 0.317 ± 0.016	0.41TrpPro: 0.41 ± 0.021	0.405TrpGln: 0.405 ± 0.022	0.743TrpArg: 0.743 ± 0.029	0.59TrpSer: 0.59 ± 0.027	0.501TrpThr: 0.501 ± 0.026	0.631TrpVal: 0.631 ± 0.027	0.163TrpTrp: 0.163 ± 0.011	0.308TrpTyr: 0.308 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.049	0.358TyrCys: 0.358 ± 0.016	1.567TyrAsp: 1.567 ± 0.041	1.433TyrGlu: 1.433 ± 0.043	1.133TyrPhe: 1.133 ± 0.031	2.305TyrGly: 2.305 ± 0.042	0.62TyrHis: 0.62 ± 0.022	1.072TyrIle: 1.072 ± 0.034	0.804TyrLys: 0.804 ± 0.033	3.165TyrLeu: 3.165 ± 0.052	0.436TyrMet: 0.436 ± 0.021	0.865TyrAsn: 0.865 ± 0.029	1.332TyrPro: 1.332 ± 0.035	0.849TyrGln: 0.849 ± 0.028	2.375TyrArg: 2.375 ± 0.047	1.438TyrSer: 1.438 ± 0.051	1.402TyrThr: 1.402 ± 0.042	1.756TyrVal: 1.756 ± 0.043	0.287TyrTrp: 0.287 ± 0.017	0.848TyrTyr: 0.848 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3402 proteins (1144256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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