Amino acid dipepetide frequency for Streptococcus satellite phage Javan518

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.853AlaAla: 0.853 ± 0.454
0.853AlaCys: 0.853 ± 0.406
3.41AlaAsp: 3.41 ± 1.154
4.547AlaGlu: 4.547 ± 1.124
4.547AlaPhe: 4.547 ± 1.064
2.273AlaGly: 2.273 ± 0.955
0.0AlaHis: 0.0 ± 0.0
6.252AlaIle: 6.252 ± 1.369
4.547AlaLys: 4.547 ± 1.244
4.263AlaLeu: 4.263 ± 1.252
1.421AlaMet: 1.421 ± 0.524
3.978AlaAsn: 3.978 ± 0.795
1.705AlaPro: 1.705 ± 0.657
2.273AlaGln: 2.273 ± 0.563
2.842AlaArg: 2.842 ± 0.779
3.126AlaSer: 3.126 ± 1.03
3.694AlaThr: 3.694 ± 0.497
2.558AlaVal: 2.558 ± 0.84
0.853AlaTrp: 0.853 ± 0.706
2.273AlaTyr: 2.273 ± 0.636
0.0AlaXaa: 0.0 ± 0.0
Cys
1.421CysAla: 1.421 ± 0.452
0.284CysCys: 0.284 ± 0.271
0.853CysAsp: 0.853 ± 0.497
0.568CysGlu: 0.568 ± 0.398
0.0CysPhe: 0.0 ± 0.0
1.137CysGly: 1.137 ± 0.718
0.284CysHis: 0.284 ± 0.253
0.284CysIle: 0.284 ± 0.253
0.568CysLys: 0.568 ± 0.401
1.137CysLeu: 1.137 ± 0.463
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.284CysPro: 0.284 ± 0.271
0.284CysGln: 0.284 ± 0.271
0.568CysArg: 0.568 ± 0.386
0.568CysSer: 0.568 ± 0.462
0.0CysThr: 0.0 ± 0.0
0.284CysVal: 0.284 ± 0.253
0.0CysTrp: 0.0 ± 0.0
0.568CysTyr: 0.568 ± 0.42
0.0CysXaa: 0.0 ± 0.0
Asp
2.273AspAla: 2.273 ± 0.77
1.989AspCys: 1.989 ± 0.918
2.558AspAsp: 2.558 ± 0.601
2.842AspGlu: 2.842 ± 1.138
2.842AspPhe: 2.842 ± 0.972
2.842AspGly: 2.842 ± 0.993
0.853AspHis: 0.853 ± 0.589
6.536AspIle: 6.536 ± 1.492
5.115AspLys: 5.115 ± 1.174
4.831AspLeu: 4.831 ± 0.836
1.705AspMet: 1.705 ± 0.772
1.989AspAsn: 1.989 ± 0.803
1.137AspPro: 1.137 ± 0.457
1.989AspGln: 1.989 ± 0.588
1.705AspArg: 1.705 ± 0.671
4.263AspSer: 4.263 ± 1.438
4.263AspThr: 4.263 ± 1.213
1.137AspVal: 1.137 ± 0.5
0.568AspTrp: 0.568 ± 0.425
5.115AspTyr: 5.115 ± 1.426
0.0AspXaa: 0.0 ± 0.0
Glu
4.547GluAla: 4.547 ± 1.168
1.137GluCys: 1.137 ± 0.72
3.978GluAsp: 3.978 ± 0.959
5.968GluGlu: 5.968 ± 1.515
2.273GluPhe: 2.273 ± 1.184
1.705GluGly: 1.705 ± 0.574
2.273GluHis: 2.273 ± 0.732
6.82GluIle: 6.82 ± 1.571
5.683GluLys: 5.683 ± 0.905
9.378GluLeu: 9.378 ± 1.522
0.853GluMet: 0.853 ± 0.459
2.842GluAsn: 2.842 ± 0.978
2.273GluPro: 2.273 ± 0.88
4.547GluGln: 4.547 ± 1.119
4.547GluArg: 4.547 ± 1.344
1.989GluSer: 1.989 ± 0.748
3.978GluThr: 3.978 ± 1.102
4.547GluVal: 4.547 ± 1.114
0.284GluTrp: 0.284 ± 0.264
2.842GluTyr: 2.842 ± 0.947
0.0GluXaa: 0.0 ± 0.0
Phe
1.989PheAla: 1.989 ± 0.551
0.0PheCys: 0.0 ± 0.0
2.842PheAsp: 2.842 ± 0.772
3.41PheGlu: 3.41 ± 0.952
1.421PhePhe: 1.421 ± 0.551
2.558PheGly: 2.558 ± 0.731
1.421PheHis: 1.421 ± 0.537
2.558PheIle: 2.558 ± 0.939
4.263PheLys: 4.263 ± 1.176
3.41PheLeu: 3.41 ± 0.97
0.0PheMet: 0.0 ± 0.0
2.842PheAsn: 2.842 ± 0.784
0.568PhePro: 0.568 ± 0.368
0.568PheGln: 0.568 ± 0.432
2.273PheArg: 2.273 ± 0.699
1.421PheSer: 1.421 ± 0.604
2.842PheThr: 2.842 ± 0.555
1.705PheVal: 1.705 ± 0.613
0.0PheTrp: 0.0 ± 0.0
1.137PheTyr: 1.137 ± 0.635
0.0PheXaa: 0.0 ± 0.0
Gly
3.126GlyAla: 3.126 ± 1.06
0.284GlyCys: 0.284 ± 0.253
4.263GlyAsp: 4.263 ± 1.296
2.842GlyGlu: 2.842 ± 0.988
1.989GlyPhe: 1.989 ± 0.631
3.694GlyGly: 3.694 ± 1.064
1.137GlyHis: 1.137 ± 0.653
2.273GlyIle: 2.273 ± 0.79
5.115GlyLys: 5.115 ± 1.193
5.683GlyLeu: 5.683 ± 1.145
1.137GlyMet: 1.137 ± 0.515
3.126GlyAsn: 3.126 ± 1.317
0.284GlyPro: 0.284 ± 0.222
1.705GlyGln: 1.705 ± 0.737
2.842GlyArg: 2.842 ± 0.566
1.989GlySer: 1.989 ± 0.7
4.263GlyThr: 4.263 ± 1.129
2.558GlyVal: 2.558 ± 0.81
0.568GlyTrp: 0.568 ± 0.506
2.842GlyTyr: 2.842 ± 0.926
0.0GlyXaa: 0.0 ± 0.0
His
3.126HisAla: 3.126 ± 1.124
0.284HisCys: 0.284 ± 0.253
0.284HisAsp: 0.284 ± 0.292
0.284HisGlu: 0.284 ± 0.251
0.284HisPhe: 0.284 ± 0.285
1.137HisGly: 1.137 ± 0.543
0.0HisHis: 0.0 ± 0.0
1.705HisIle: 1.705 ± 0.592
1.421HisLys: 1.421 ± 0.684
2.558HisLeu: 2.558 ± 0.937
0.0HisMet: 0.0 ± 0.0
1.705HisAsn: 1.705 ± 0.667
1.137HisPro: 1.137 ± 0.807
1.137HisGln: 1.137 ± 0.513
0.853HisArg: 0.853 ± 0.547
0.568HisSer: 0.568 ± 0.522
1.137HisThr: 1.137 ± 0.384
0.0HisVal: 0.0 ± 0.0
0.284HisTrp: 0.284 ± 0.271
1.705HisTyr: 1.705 ± 0.76
0.0HisXaa: 0.0 ± 0.0
Ile
5.399IleAla: 5.399 ± 1.047
0.568IleCys: 0.568 ± 0.35
7.104IleAsp: 7.104 ± 1.233
5.968IleGlu: 5.968 ± 1.352
1.137IlePhe: 1.137 ± 0.448
2.558IleGly: 2.558 ± 0.716
1.421IleHis: 1.421 ± 0.736
4.831IleIle: 4.831 ± 1.1
7.104IleLys: 7.104 ± 1.045
3.694IleLeu: 3.694 ± 0.629
1.137IleMet: 1.137 ± 0.614
4.263IleAsn: 4.263 ± 0.998
2.558IlePro: 2.558 ± 0.826
2.273IleGln: 2.273 ± 0.697
2.273IleArg: 2.273 ± 0.773
5.115IleSer: 5.115 ± 1.137
4.547IleThr: 4.547 ± 1.089
1.989IleVal: 1.989 ± 0.631
0.0IleTrp: 0.0 ± 0.0
2.273IleTyr: 2.273 ± 0.711
0.0IleXaa: 0.0 ± 0.0
Lys
6.252LysAla: 6.252 ± 1.389
0.0LysCys: 0.0 ± 0.0
3.694LysAsp: 3.694 ± 1.09
8.809LysGlu: 8.809 ± 1.575
2.273LysPhe: 2.273 ± 0.685
4.831LysGly: 4.831 ± 1.315
1.989LysHis: 1.989 ± 0.616
2.558LysIle: 2.558 ± 0.738
7.104LysLys: 7.104 ± 1.573
6.82LysLeu: 6.82 ± 1.349
2.842LysMet: 2.842 ± 0.989
5.399LysAsn: 5.399 ± 1.131
5.115LysPro: 5.115 ± 1.156
3.126LysGln: 3.126 ± 0.624
6.82LysArg: 6.82 ± 0.947
3.126LysSer: 3.126 ± 0.906
6.82LysThr: 6.82 ± 1.942
5.968LysVal: 5.968 ± 1.042
1.421LysTrp: 1.421 ± 0.526
3.126LysTyr: 3.126 ± 0.797
0.0LysXaa: 0.0 ± 0.0
Leu
3.978LeuAla: 3.978 ± 0.992
0.284LeuCys: 0.284 ± 0.253
5.399LeuAsp: 5.399 ± 0.946
9.378LeuGlu: 9.378 ± 1.61
4.263LeuPhe: 4.263 ± 1.044
5.968LeuGly: 5.968 ± 1.39
1.421LeuHis: 1.421 ± 0.566
7.388LeuIle: 7.388 ± 1.185
8.241LeuLys: 8.241 ± 1.488
9.093LeuLeu: 9.093 ± 1.443
1.705LeuMet: 1.705 ± 0.585
5.399LeuAsn: 5.399 ± 1.592
4.547LeuPro: 4.547 ± 1.164
3.694LeuGln: 3.694 ± 0.682
2.558LeuArg: 2.558 ± 0.67
8.809LeuSer: 8.809 ± 1.342
5.683LeuThr: 5.683 ± 1.03
3.978LeuVal: 3.978 ± 1.27
0.853LeuTrp: 0.853 ± 0.332
5.115LeuTyr: 5.115 ± 1.151
0.0LeuXaa: 0.0 ± 0.0
Met
2.842MetAla: 2.842 ± 1.168
0.0MetCys: 0.0 ± 0.0
1.137MetAsp: 1.137 ± 0.556
1.137MetGlu: 1.137 ± 0.493
0.284MetPhe: 0.284 ± 0.313
0.284MetGly: 0.284 ± 0.291
0.0MetHis: 0.0 ± 0.0
1.137MetIle: 1.137 ± 0.53
2.273MetLys: 2.273 ± 0.596
1.421MetLeu: 1.421 ± 0.487
0.568MetMet: 0.568 ± 0.411
2.273MetAsn: 2.273 ± 0.613
0.284MetPro: 0.284 ± 0.264
0.284MetGln: 0.284 ± 0.257
2.273MetArg: 2.273 ± 0.759
1.705MetSer: 1.705 ± 0.705
2.842MetThr: 2.842 ± 1.1
0.284MetVal: 0.284 ± 0.253
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.41AsnAla: 3.41 ± 0.874
0.284AsnCys: 0.284 ± 0.295
2.273AsnAsp: 2.273 ± 0.928
2.842AsnGlu: 2.842 ± 0.91
0.853AsnPhe: 0.853 ± 0.476
3.694AsnGly: 3.694 ± 1.075
1.705AsnHis: 1.705 ± 0.587
3.126AsnIle: 3.126 ± 0.759
4.263AsnLys: 4.263 ± 0.991
5.968AsnLeu: 5.968 ± 1.44
1.705AsnMet: 1.705 ± 0.819
3.126AsnAsn: 3.126 ± 0.825
2.558AsnPro: 2.558 ± 0.75
3.126AsnGln: 3.126 ± 0.905
4.263AsnArg: 4.263 ± 0.841
3.41AsnSer: 3.41 ± 0.889
1.989AsnThr: 1.989 ± 0.775
3.41AsnVal: 3.41 ± 0.866
0.568AsnTrp: 0.568 ± 0.44
2.842AsnTyr: 2.842 ± 0.767
0.0AsnXaa: 0.0 ± 0.0
Pro
1.137ProAla: 1.137 ± 0.815
0.568ProCys: 0.568 ± 0.462
0.853ProAsp: 0.853 ± 0.594
3.978ProGlu: 3.978 ± 1.19
1.421ProPhe: 1.421 ± 0.687
0.853ProGly: 0.853 ± 0.531
0.284ProHis: 0.284 ± 0.253
1.705ProIle: 1.705 ± 0.918
3.694ProLys: 3.694 ± 1.146
2.558ProLeu: 2.558 ± 0.78
0.853ProMet: 0.853 ± 0.383
2.558ProAsn: 2.558 ± 1.154
0.568ProPro: 0.568 ± 0.346
1.137ProGln: 1.137 ± 0.602
3.126ProArg: 3.126 ± 0.685
2.273ProSer: 2.273 ± 0.679
2.558ProThr: 2.558 ± 0.548
2.558ProVal: 2.558 ± 0.838
0.284ProTrp: 0.284 ± 0.253
1.989ProTyr: 1.989 ± 0.769
0.0ProXaa: 0.0 ± 0.0
Gln
2.842GlnAla: 2.842 ± 0.766
0.568GlnCys: 0.568 ± 0.394
2.558GlnAsp: 2.558 ± 0.841
1.989GlnGlu: 1.989 ± 0.682
0.853GlnPhe: 0.853 ± 0.413
3.126GlnGly: 3.126 ± 0.827
0.568GlnHis: 0.568 ± 0.375
2.273GlnIle: 2.273 ± 0.666
4.263GlnLys: 4.263 ± 1.132
7.388GlnLeu: 7.388 ± 1.189
0.853GlnMet: 0.853 ± 0.793
1.421GlnAsn: 1.421 ± 0.617
1.705GlnPro: 1.705 ± 0.678
1.989GlnGln: 1.989 ± 0.619
3.126GlnArg: 3.126 ± 0.58
1.705GlnSer: 1.705 ± 0.626
1.989GlnThr: 1.989 ± 0.607
3.41GlnVal: 3.41 ± 0.761
0.568GlnTrp: 0.568 ± 0.437
1.989GlnTyr: 1.989 ± 0.559
0.0GlnXaa: 0.0 ± 0.0
Arg
1.421ArgAla: 1.421 ± 0.783
0.568ArgCys: 0.568 ± 0.314
3.126ArgAsp: 3.126 ± 0.728
1.989ArgGlu: 1.989 ± 0.79
1.705ArgPhe: 1.705 ± 0.566
2.558ArgGly: 2.558 ± 0.737
1.705ArgHis: 1.705 ± 0.589
3.41ArgIle: 3.41 ± 0.725
6.82ArgLys: 6.82 ± 1.237
5.683ArgLeu: 5.683 ± 1.178
0.284ArgMet: 0.284 ± 0.299
2.558ArgAsn: 2.558 ± 1.005
2.273ArgPro: 2.273 ± 0.975
3.694ArgGln: 3.694 ± 0.806
2.842ArgArg: 2.842 ± 1.086
3.694ArgSer: 3.694 ± 0.806
2.273ArgThr: 2.273 ± 0.532
3.978ArgVal: 3.978 ± 1.057
0.568ArgTrp: 0.568 ± 0.399
4.547ArgTyr: 4.547 ± 1.104
0.0ArgXaa: 0.0 ± 0.0
Ser
2.558SerAla: 2.558 ± 0.799
0.284SerCys: 0.284 ± 0.271
5.399SerAsp: 5.399 ± 0.946
3.694SerGlu: 3.694 ± 1.314
2.558SerPhe: 2.558 ± 0.541
2.842SerGly: 2.842 ± 0.873
0.853SerHis: 0.853 ± 0.42
3.978SerIle: 3.978 ± 1.262
5.683SerLys: 5.683 ± 1.127
5.399SerLeu: 5.399 ± 0.927
1.421SerMet: 1.421 ± 0.684
1.421SerAsn: 1.421 ± 0.686
1.421SerPro: 1.421 ± 0.592
3.694SerGln: 3.694 ± 0.948
1.705SerArg: 1.705 ± 0.76
1.989SerSer: 1.989 ± 0.734
3.41SerThr: 3.41 ± 1.259
3.126SerVal: 3.126 ± 1.244
0.568SerTrp: 0.568 ± 0.453
2.558SerTyr: 2.558 ± 0.895
0.0SerXaa: 0.0 ± 0.0
Thr
5.115ThrAla: 5.115 ± 1.258
0.0ThrCys: 0.0 ± 0.0
1.705ThrAsp: 1.705 ± 0.667
2.842ThrGlu: 2.842 ± 0.779
2.273ThrPhe: 2.273 ± 1.198
4.831ThrGly: 4.831 ± 0.733
1.137ThrHis: 1.137 ± 0.493
4.263ThrIle: 4.263 ± 1.213
3.126ThrLys: 3.126 ± 1.041
8.525ThrLeu: 8.525 ± 1.926
1.421ThrMet: 1.421 ± 0.713
1.989ThrAsn: 1.989 ± 0.623
3.694ThrPro: 3.694 ± 1.049
3.694ThrGln: 3.694 ± 0.585
3.978ThrArg: 3.978 ± 1.038
3.126ThrSer: 3.126 ± 0.757
2.273ThrThr: 2.273 ± 1.136
3.694ThrVal: 3.694 ± 0.979
0.853ThrTrp: 0.853 ± 0.44
5.399ThrTyr: 5.399 ± 0.876
0.0ThrXaa: 0.0 ± 0.0
Val
2.842ValAla: 2.842 ± 0.715
0.853ValCys: 0.853 ± 0.501
1.705ValAsp: 1.705 ± 0.573
3.41ValGlu: 3.41 ± 0.9
3.126ValPhe: 3.126 ± 0.669
1.705ValGly: 1.705 ± 0.5
0.284ValHis: 0.284 ± 0.271
3.978ValIle: 3.978 ± 0.986
4.547ValLys: 4.547 ± 1.036
5.115ValLeu: 5.115 ± 1.248
1.705ValMet: 1.705 ± 0.625
3.41ValAsn: 3.41 ± 0.87
1.421ValPro: 1.421 ± 0.782
1.989ValGln: 1.989 ± 0.773
2.558ValArg: 2.558 ± 0.832
3.126ValSer: 3.126 ± 0.782
4.831ValThr: 4.831 ± 1.254
2.273ValVal: 2.273 ± 0.803
0.568ValTrp: 0.568 ± 0.506
2.273ValTyr: 2.273 ± 0.709
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.137TrpAsp: 1.137 ± 0.591
1.137TrpGlu: 1.137 ± 0.512
0.284TrpPhe: 0.284 ± 0.253
0.284TrpGly: 0.284 ± 0.264
0.284TrpHis: 0.284 ± 0.295
0.0TrpIle: 0.0 ± 0.0
0.568TrpLys: 0.568 ± 0.345
1.421TrpLeu: 1.421 ± 0.481
0.0TrpMet: 0.0 ± 0.0
0.284TrpAsn: 0.284 ± 0.295
0.0TrpPro: 0.0 ± 0.0
0.568TrpGln: 0.568 ± 0.42
0.568TrpArg: 0.568 ± 0.366
0.853TrpSer: 0.853 ± 0.382
0.568TrpThr: 0.568 ± 0.345
1.137TrpVal: 1.137 ± 0.62
0.284TrpTrp: 0.284 ± 0.295
0.284TrpTyr: 0.284 ± 0.308
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.137TyrAla: 1.137 ± 0.522
0.284TyrCys: 0.284 ± 0.222
2.273TyrAsp: 2.273 ± 0.957
4.831TyrGlu: 4.831 ± 1.137
2.842TyrPhe: 2.842 ± 0.846
2.842TyrGly: 2.842 ± 0.902
1.989TyrHis: 1.989 ± 0.617
1.137TyrIle: 1.137 ± 0.407
3.694TyrLys: 3.694 ± 1.136
3.694TyrLeu: 3.694 ± 0.772
1.137TyrMet: 1.137 ± 0.646
4.831TyrAsn: 4.831 ± 0.868
1.421TyrPro: 1.421 ± 0.693
3.41TyrGln: 3.41 ± 0.797
3.978TyrArg: 3.978 ± 0.914
1.705TyrSer: 1.705 ± 0.74
3.978TyrThr: 3.978 ± 0.701
3.126TyrVal: 3.126 ± 0.757
0.568TyrTrp: 0.568 ± 0.541
3.978TyrTyr: 3.978 ± 0.983
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (3520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski