Amino acid dipepetide frequency for Chlamydia phage 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.458AlaAla: 3.458 ± 1.906
0.0AlaCys: 0.0 ± 0.0
2.075AlaAsp: 2.075 ± 0.832
3.458AlaGlu: 3.458 ± 1.301
5.533AlaPhe: 5.533 ± 2.043
5.533AlaGly: 5.533 ± 1.917
0.692AlaHis: 0.692 ± 0.774
2.766AlaIle: 2.766 ± 1.491
4.149AlaLys: 4.149 ± 2.801
5.533AlaLeu: 5.533 ± 2.274
2.075AlaMet: 2.075 ± 1.811
1.383AlaAsn: 1.383 ± 1.244
2.075AlaPro: 2.075 ± 0.895
4.841AlaGln: 4.841 ± 1.634
5.533AlaArg: 5.533 ± 1.664
4.149AlaSer: 4.149 ± 2.166
5.533AlaThr: 5.533 ± 1.828
3.458AlaVal: 3.458 ± 1.712
0.692AlaTrp: 0.692 ± 0.458
4.149AlaTyr: 4.149 ± 0.75
0.0AlaXaa: 0.0 ± 0.0
Cys
1.383CysAla: 1.383 ± 0.58
0.0CysCys: 0.0 ± 0.0
2.766CysAsp: 2.766 ± 1.036
0.692CysGlu: 0.692 ± 0.912
1.383CysPhe: 1.383 ± 1.265
2.075CysGly: 2.075 ± 0.832
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.692CysLys: 0.692 ± 0.632
0.692CysLeu: 0.692 ± 0.458
2.075CysMet: 2.075 ± 1.197
0.0CysAsn: 0.0 ± 0.0
0.692CysPro: 0.692 ± 0.912
0.692CysGln: 0.692 ± 0.458
1.383CysArg: 1.383 ± 1.265
0.692CysSer: 0.692 ± 0.632
0.0CysThr: 0.0 ± 0.0
0.692CysVal: 0.692 ± 0.458
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.075AspAla: 2.075 ± 1.375
1.383AspCys: 1.383 ± 1.244
2.766AspAsp: 2.766 ± 1.088
3.458AspGlu: 3.458 ± 0.997
4.149AspPhe: 4.149 ± 0.991
1.383AspGly: 1.383 ± 0.711
2.075AspHis: 2.075 ± 1.123
2.766AspIle: 2.766 ± 1.877
4.149AspLys: 4.149 ± 3.036
2.766AspLeu: 2.766 ± 1.594
1.383AspMet: 1.383 ± 1.129
2.075AspAsn: 2.075 ± 0.832
2.766AspPro: 2.766 ± 1.744
2.075AspGln: 2.075 ± 1.526
4.149AspArg: 4.149 ± 1.062
4.841AspSer: 4.841 ± 1.317
2.075AspThr: 2.075 ± 1.375
1.383AspVal: 1.383 ± 0.846
0.692AspTrp: 0.692 ± 0.632
3.458AspTyr: 3.458 ± 1.075
0.0AspXaa: 0.0 ± 0.0
Glu
6.916GluAla: 6.916 ± 3.641
0.692GluCys: 0.692 ± 0.794
3.458GluAsp: 3.458 ± 1.778
4.841GluGlu: 4.841 ± 2.561
2.075GluPhe: 2.075 ± 0.832
2.075GluGly: 2.075 ± 0.983
2.075GluHis: 2.075 ± 0.728
3.458GluIle: 3.458 ± 1.906
2.766GluLys: 2.766 ± 1.982
2.075GluLeu: 2.075 ± 1.298
1.383GluMet: 1.383 ± 0.88
4.149GluAsn: 4.149 ± 1.362
2.075GluPro: 2.075 ± 0.895
4.841GluGln: 4.841 ± 2.009
4.841GluArg: 4.841 ± 2.525
2.766GluSer: 2.766 ± 1.002
0.692GluThr: 0.692 ± 0.912
3.458GluVal: 3.458 ± 1.359
0.0GluTrp: 0.0 ± 0.0
4.149GluTyr: 4.149 ± 1.127
0.0GluXaa: 0.0 ± 0.0
Phe
2.075PheAla: 2.075 ± 1.105
2.075PheCys: 2.075 ± 0.832
3.458PheAsp: 3.458 ± 0.806
1.383PheGlu: 1.383 ± 0.711
2.766PhePhe: 2.766 ± 0.859
3.458PheGly: 3.458 ± 1.726
0.0PheHis: 0.0 ± 0.0
3.458PheIle: 3.458 ± 1.075
2.766PheLys: 2.766 ± 1.278
5.533PheLeu: 5.533 ± 1.157
1.383PheMet: 1.383 ± 1.459
2.075PheAsn: 2.075 ± 1.123
2.075PhePro: 2.075 ± 1.123
2.075PheGln: 2.075 ± 0.983
2.075PheArg: 2.075 ± 0.891
5.533PheSer: 5.533 ± 2.11
4.149PheThr: 4.149 ± 1.678
3.458PheVal: 3.458 ± 1.05
2.075PheTrp: 2.075 ± 1.743
0.692PheTyr: 0.692 ± 0.458
0.0PheXaa: 0.0 ± 0.0
Gly
4.841GlyAla: 4.841 ± 2.251
0.692GlyCys: 0.692 ± 0.632
2.075GlyAsp: 2.075 ± 0.832
2.766GlyGlu: 2.766 ± 1.212
2.766GlyPhe: 2.766 ± 0.743
4.841GlyGly: 4.841 ± 2.074
0.0GlyHis: 0.0 ± 0.0
2.766GlyIle: 2.766 ± 1.125
4.149GlyLys: 4.149 ± 2.069
8.299GlyLeu: 8.299 ± 2.652
0.0GlyMet: 0.0 ± 0.0
3.458GlyAsn: 3.458 ± 0.997
2.075GlyPro: 2.075 ± 0.895
0.692GlyGln: 0.692 ± 0.632
0.692GlyArg: 0.692 ± 0.814
5.533GlySer: 5.533 ± 1.202
3.458GlyThr: 3.458 ± 1.663
5.533GlyVal: 5.533 ± 1.917
0.692GlyTrp: 0.692 ± 0.458
3.458GlyTyr: 3.458 ± 1.301
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.692HisAsp: 0.692 ± 0.458
0.692HisGlu: 0.692 ± 0.632
1.383HisPhe: 1.383 ± 0.917
0.692HisGly: 0.692 ± 0.458
0.0HisHis: 0.0 ± 0.0
0.692HisIle: 0.692 ± 0.632
1.383HisLys: 1.383 ± 0.846
2.766HisLeu: 2.766 ± 1.159
0.0HisMet: 0.0 ± 0.0
0.692HisAsn: 0.692 ± 0.794
2.075HisPro: 2.075 ± 1.533
0.0HisGln: 0.0 ± 0.0
0.692HisArg: 0.692 ± 0.458
1.383HisSer: 1.383 ± 0.58
0.0HisThr: 0.0 ± 0.0
1.383HisVal: 1.383 ± 0.711
0.0HisTrp: 0.0 ± 0.0
1.383HisTyr: 1.383 ± 1.265
0.0HisXaa: 0.0 ± 0.0
Ile
3.458IleAla: 3.458 ± 2.35
0.692IleCys: 0.692 ± 0.632
1.383IleAsp: 1.383 ± 0.58
4.149IleGlu: 4.149 ± 1.334
3.458IlePhe: 3.458 ± 1.672
2.766IleGly: 2.766 ± 0.888
0.692IleHis: 0.692 ± 0.458
1.383IleIle: 1.383 ± 0.89
0.692IleLys: 0.692 ± 0.774
2.766IleLeu: 2.766 ± 1.38
0.692IleMet: 0.692 ± 1.134
1.383IleAsn: 1.383 ± 0.711
2.075IlePro: 2.075 ± 1.105
1.383IleGln: 1.383 ± 0.917
5.533IleArg: 5.533 ± 3.036
2.075IleSer: 2.075 ± 0.891
0.692IleThr: 0.692 ± 0.458
1.383IleVal: 1.383 ± 0.711
1.383IleTrp: 1.383 ± 0.58
3.458IleTyr: 3.458 ± 1.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.149LysAla: 4.149 ± 1.516
1.383LysCys: 1.383 ± 1.052
1.383LysAsp: 1.383 ± 1.588
1.383LysGlu: 1.383 ± 0.917
3.458LysPhe: 3.458 ± 0.997
3.458LysGly: 3.458 ± 1.49
1.383LysHis: 1.383 ± 0.837
2.075LysIle: 2.075 ± 1.123
4.149LysLys: 4.149 ± 2.201
5.533LysLeu: 5.533 ± 2.406
2.766LysMet: 2.766 ± 2.201
2.075LysAsn: 2.075 ± 1.052
2.075LysPro: 2.075 ± 1.123
3.458LysGln: 3.458 ± 1.775
4.149LysArg: 4.149 ± 1.739
4.841LysSer: 4.841 ± 2.867
2.766LysThr: 2.766 ± 0.888
4.149LysVal: 4.149 ± 1.618
0.0LysTrp: 0.0 ± 0.0
1.383LysTyr: 1.383 ± 0.88
0.0LysXaa: 0.0 ± 0.0
Leu
6.916LeuAla: 6.916 ± 2.051
0.0LeuCys: 0.0 ± 0.0
6.916LeuAsp: 6.916 ± 2.404
2.075LeuGlu: 2.075 ± 0.728
4.149LeuPhe: 4.149 ± 2.499
6.916LeuGly: 6.916 ± 2.497
0.692LeuHis: 0.692 ± 0.632
3.458LeuIle: 3.458 ± 0.945
4.149LeuLys: 4.149 ± 1.246
5.533LeuLeu: 5.533 ± 1.925
4.841LeuMet: 4.841 ± 3.082
4.841LeuAsn: 4.841 ± 1.292
8.299LeuPro: 8.299 ± 1.32
4.841LeuGln: 4.841 ± 1.38
6.916LeuArg: 6.916 ± 3.06
5.533LeuSer: 5.533 ± 1.306
5.533LeuThr: 5.533 ± 1.516
1.383LeuVal: 1.383 ± 1.265
1.383LeuTrp: 1.383 ± 0.58
3.458LeuTyr: 3.458 ± 1.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.766MetAla: 2.766 ± 1.125
0.692MetCys: 0.692 ± 0.632
3.458MetAsp: 3.458 ± 1.293
0.692MetGlu: 0.692 ± 0.814
0.692MetPhe: 0.692 ± 0.794
0.692MetGly: 0.692 ± 0.458
1.383MetHis: 1.383 ± 1.187
0.692MetIle: 0.692 ± 0.632
2.075MetLys: 2.075 ± 1.381
3.458MetLeu: 3.458 ± 2.077
0.0MetMet: 0.0 ± 0.0
2.075MetAsn: 2.075 ± 1.524
1.383MetPro: 1.383 ± 0.58
1.383MetGln: 1.383 ± 1.129
3.458MetArg: 3.458 ± 2.456
1.383MetSer: 1.383 ± 0.777
0.692MetThr: 0.692 ± 1.212
1.383MetVal: 1.383 ± 0.837
1.383MetTrp: 1.383 ± 0.89
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.458AsnAla: 3.458 ± 1.083
1.383AsnCys: 1.383 ± 1.052
1.383AsnAsp: 1.383 ± 0.964
1.383AsnGlu: 1.383 ± 0.846
0.692AsnPhe: 0.692 ± 0.458
2.075AsnGly: 2.075 ± 1.123
0.0AsnHis: 0.0 ± 0.0
2.075AsnIle: 2.075 ± 0.895
2.075AsnLys: 2.075 ± 0.895
4.149AsnLeu: 4.149 ± 1.966
0.0AsnMet: 0.0 ± 0.0
2.075AsnAsn: 2.075 ± 0.948
4.841AsnPro: 4.841 ± 2.037
4.149AsnGln: 4.149 ± 0.707
2.075AsnArg: 2.075 ± 1.305
4.149AsnSer: 4.149 ± 1.699
1.383AsnThr: 1.383 ± 1.628
3.458AsnVal: 3.458 ± 1.293
0.0AsnTrp: 0.0 ± 0.0
3.458AsnTyr: 3.458 ± 0.997
0.0AsnXaa: 0.0 ± 0.0
Pro
4.841ProAla: 4.841 ± 1.701
0.692ProCys: 0.692 ± 0.632
2.766ProAsp: 2.766 ± 1.212
6.224ProGlu: 6.224 ± 2.581
2.075ProPhe: 2.075 ± 1.277
3.458ProGly: 3.458 ± 0.624
1.383ProHis: 1.383 ± 1.265
4.149ProIle: 4.149 ± 2.051
2.075ProLys: 2.075 ± 1.117
2.766ProLeu: 2.766 ± 0.888
2.075ProMet: 2.075 ± 0.983
0.692ProAsn: 0.692 ± 0.814
1.383ProPro: 1.383 ± 0.58
4.841ProGln: 4.841 ± 1.771
4.841ProArg: 4.841 ± 2.626
2.075ProSer: 2.075 ± 1.375
2.075ProThr: 2.075 ± 1.105
4.149ProVal: 4.149 ± 1.966
2.075ProTrp: 2.075 ± 0.891
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.458GlnAla: 3.458 ± 1.45
0.692GlnCys: 0.692 ± 0.458
4.149GlnAsp: 4.149 ± 2.247
4.149GlnGlu: 4.149 ± 1.503
1.383GlnPhe: 1.383 ± 1.11
3.458GlnGly: 3.458 ± 1.718
0.692GlnHis: 0.692 ± 0.794
1.383GlnIle: 1.383 ± 0.777
5.533GlnLys: 5.533 ± 1.267
2.075GlnLeu: 2.075 ± 0.665
2.766GlnMet: 2.766 ± 1.462
4.149GlnAsn: 4.149 ± 2.502
1.383GlnPro: 1.383 ± 0.846
2.075GlnGln: 2.075 ± 0.999
4.149GlnArg: 4.149 ± 1.329
2.766GlnSer: 2.766 ± 1.212
2.075GlnThr: 2.075 ± 0.895
2.075GlnVal: 2.075 ± 1.328
0.0GlnTrp: 0.0 ± 0.0
2.075GlnTyr: 2.075 ± 0.832
0.0GlnXaa: 0.0 ± 0.0
Arg
3.458ArgAla: 3.458 ± 1.425
2.075ArgCys: 2.075 ± 1.123
4.149ArgAsp: 4.149 ± 1.135
5.533ArgGlu: 5.533 ± 2.477
3.458ArgPhe: 3.458 ± 1.62
2.766ArgGly: 2.766 ± 1.008
0.692ArgHis: 0.692 ± 0.632
4.149ArgIle: 4.149 ± 2.295
2.075ArgLys: 2.075 ± 1.851
11.065ArgLeu: 11.065 ± 4.238
3.458ArgMet: 3.458 ± 1.817
2.075ArgAsn: 2.075 ± 1.305
2.075ArgPro: 2.075 ± 1.123
0.692ArgGln: 0.692 ± 0.632
7.607ArgArg: 7.607 ± 6.914
4.841ArgSer: 4.841 ± 2.11
4.149ArgThr: 4.149 ± 2.295
4.149ArgVal: 4.149 ± 1.296
1.383ArgTrp: 1.383 ± 0.58
5.533ArgTyr: 5.533 ± 1.433
0.0ArgXaa: 0.0 ± 0.0
Ser
4.841SerAla: 4.841 ± 2.009
2.075SerCys: 2.075 ± 1.083
2.075SerAsp: 2.075 ± 1.537
2.766SerGlu: 2.766 ± 1.409
5.533SerPhe: 5.533 ± 2.493
4.841SerGly: 4.841 ± 3.042
2.075SerHis: 2.075 ± 1.375
1.383SerIle: 1.383 ± 1.186
4.149SerLys: 4.149 ± 1.434
7.607SerLeu: 7.607 ± 2.382
0.0SerMet: 0.0 ± 0.0
2.766SerAsn: 2.766 ± 1.322
6.224SerPro: 6.224 ± 2.012
2.075SerGln: 2.075 ± 1.123
5.533SerArg: 5.533 ± 3.286
7.607SerSer: 7.607 ± 2.089
5.533SerThr: 5.533 ± 2.445
4.841SerVal: 4.841 ± 1.771
2.075SerTrp: 2.075 ± 1.136
2.075SerTyr: 2.075 ± 1.277
0.0SerXaa: 0.0 ± 0.0
Thr
3.458ThrAla: 3.458 ± 1.825
0.0ThrCys: 0.0 ± 0.0
2.075ThrAsp: 2.075 ± 1.375
4.149ThrGlu: 4.149 ± 1.603
2.766ThrPhe: 2.766 ± 1.088
4.149ThrGly: 4.149 ± 2.356
0.0ThrHis: 0.0 ± 0.0
1.383ThrIle: 1.383 ± 0.917
4.149ThrLys: 4.149 ± 1.649
3.458ThrLeu: 3.458 ± 1.019
0.0ThrMet: 0.0 ± 0.0
0.692ThrAsn: 0.692 ± 0.814
3.458ThrPro: 3.458 ± 2.292
3.458ThrGln: 3.458 ± 1.293
2.766ThrArg: 2.766 ± 1.159
5.533ThrSer: 5.533 ± 2.288
3.458ThrThr: 3.458 ± 1.787
2.075ThrVal: 2.075 ± 0.736
0.0ThrTrp: 0.0 ± 0.0
2.075ThrTyr: 2.075 ± 1.259
0.0ThrXaa: 0.0 ± 0.0
Val
4.841ValAla: 4.841 ± 1.634
0.692ValCys: 0.692 ± 0.632
0.692ValAsp: 0.692 ± 0.458
2.075ValGlu: 2.075 ± 0.948
2.766ValPhe: 2.766 ± 1.673
2.075ValGly: 2.075 ± 0.832
0.0ValHis: 0.0 ± 0.0
1.383ValIle: 1.383 ± 0.711
3.458ValLys: 3.458 ± 1.726
6.916ValLeu: 6.916 ± 1.345
1.383ValMet: 1.383 ± 0.58
4.149ValAsn: 4.149 ± 1.594
3.458ValPro: 3.458 ± 1.425
4.149ValGln: 4.149 ± 1.062
4.149ValArg: 4.149 ± 1.566
2.075ValSer: 2.075 ± 0.665
2.766ValThr: 2.766 ± 1.212
1.383ValVal: 1.383 ± 0.964
0.0ValTrp: 0.0 ± 0.0
3.458ValTyr: 3.458 ± 0.919
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.383TrpAsp: 1.383 ± 0.58
0.0TrpGlu: 0.0 ± 0.0
0.692TrpPhe: 0.692 ± 0.458
0.0TrpGly: 0.0 ± 0.0
1.383TrpHis: 1.383 ± 0.917
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.383TrpAsn: 1.383 ± 0.89
2.075TrpPro: 2.075 ± 0.832
0.0TrpGln: 0.0 ± 0.0
1.383TrpArg: 1.383 ± 1.824
4.149TrpSer: 4.149 ± 1.678
0.0TrpThr: 0.0 ± 0.0
0.692TrpVal: 0.692 ± 0.632
0.0TrpTrp: 0.0 ± 0.0
1.383TrpTyr: 1.383 ± 0.58
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.692TyrAla: 0.692 ± 0.458
0.692TyrCys: 0.692 ± 0.458
2.766TyrAsp: 2.766 ± 1.088
6.916TyrGlu: 6.916 ± 2.598
2.075TyrPhe: 2.075 ± 0.832
2.075TyrGly: 2.075 ± 1.123
0.692TyrHis: 0.692 ± 0.632
2.075TyrIle: 2.075 ± 0.736
1.383TyrLys: 1.383 ± 0.58
4.841TyrLeu: 4.841 ± 1.316
2.766TyrMet: 2.766 ± 0.852
2.075TyrAsn: 2.075 ± 0.832
2.075TyrPro: 2.075 ± 1.897
2.766TyrGln: 2.766 ± 1.166
3.458TyrArg: 3.458 ± 1.18
4.149TyrSer: 4.149 ± 1.792
2.075TyrThr: 2.075 ± 1.375
1.383TyrVal: 1.383 ± 0.58
0.692TyrTrp: 0.692 ± 0.458
2.075TyrTyr: 2.075 ± 0.832
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski