Amino acid dipepetide frequency for Salmonella phage SE-W109

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.515AlaAla: 11.515 ± 1.472
0.953AlaCys: 0.953 ± 0.28
5.797AlaAsp: 5.797 ± 0.651
6.83AlaGlu: 6.83 ± 0.906
4.05AlaPhe: 4.05 ± 0.606
7.544AlaGly: 7.544 ± 0.881
1.747AlaHis: 1.747 ± 0.434
3.891AlaIle: 3.891 ± 0.611
5.241AlaLys: 5.241 ± 0.913
7.703AlaLeu: 7.703 ± 0.963
2.303AlaMet: 2.303 ± 0.507
3.097AlaAsn: 3.097 ± 0.453
3.335AlaPro: 3.335 ± 0.548
3.733AlaGln: 3.733 ± 0.733
4.606AlaArg: 4.606 ± 0.648
6.115AlaSer: 6.115 ± 0.823
5.797AlaThr: 5.797 ± 0.755
7.465AlaVal: 7.465 ± 0.867
1.112AlaTrp: 1.112 ± 0.274
3.018AlaTyr: 3.018 ± 0.588
0.0AlaXaa: 0.0 ± 0.0
Cys
0.635CysAla: 0.635 ± 0.217
0.159CysCys: 0.159 ± 0.155
0.953CysAsp: 0.953 ± 0.312
1.112CysGlu: 1.112 ± 0.307
0.318CysPhe: 0.318 ± 0.151
0.794CysGly: 0.794 ± 0.286
0.159CysHis: 0.159 ± 0.104
0.238CysIle: 0.238 ± 0.116
0.635CysLys: 0.635 ± 0.227
0.874CysLeu: 0.874 ± 0.322
0.397CysMet: 0.397 ± 0.215
0.238CysAsn: 0.238 ± 0.184
0.318CysPro: 0.318 ± 0.158
0.079CysGln: 0.079 ± 0.092
0.874CysArg: 0.874 ± 0.286
0.318CysSer: 0.318 ± 0.171
0.397CysThr: 0.397 ± 0.157
0.635CysVal: 0.635 ± 0.257
0.238CysTrp: 0.238 ± 0.154
0.238CysTyr: 0.238 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
6.591AspAla: 6.591 ± 0.806
0.556AspCys: 0.556 ± 0.239
3.812AspAsp: 3.812 ± 0.572
3.574AspGlu: 3.574 ± 0.576
3.018AspPhe: 3.018 ± 0.422
6.671AspGly: 6.671 ± 0.941
0.715AspHis: 0.715 ± 0.225
2.938AspIle: 2.938 ± 0.361
3.494AspLys: 3.494 ± 0.429
4.844AspLeu: 4.844 ± 0.632
1.588AspMet: 1.588 ± 0.269
2.621AspAsn: 2.621 ± 0.574
1.827AspPro: 1.827 ± 0.434
0.556AspGln: 0.556 ± 0.186
2.78AspArg: 2.78 ± 0.423
3.335AspSer: 3.335 ± 0.554
5.083AspThr: 5.083 ± 0.663
3.653AspVal: 3.653 ± 0.41
0.556AspTrp: 0.556 ± 0.211
1.985AspTyr: 1.985 ± 0.354
0.0AspXaa: 0.0 ± 0.0
Glu
6.353GluAla: 6.353 ± 0.783
0.397GluCys: 0.397 ± 0.205
3.653GluAsp: 3.653 ± 0.522
4.844GluGlu: 4.844 ± 1.032
3.256GluPhe: 3.256 ± 0.686
4.844GluGly: 4.844 ± 0.669
1.112GluHis: 1.112 ± 0.289
3.653GluIle: 3.653 ± 0.513
4.05GluLys: 4.05 ± 0.747
6.274GluLeu: 6.274 ± 0.75
2.621GluMet: 2.621 ± 0.489
2.382GluAsn: 2.382 ± 0.476
1.668GluPro: 1.668 ± 0.525
3.733GluGln: 3.733 ± 0.57
3.574GluArg: 3.574 ± 0.589
3.653GluSer: 3.653 ± 0.529
4.13GluThr: 4.13 ± 0.613
4.368GluVal: 4.368 ± 0.563
1.112GluTrp: 1.112 ± 0.333
1.588GluTyr: 1.588 ± 0.363
0.0GluXaa: 0.0 ± 0.0
Phe
2.7PheAla: 2.7 ± 0.549
0.476PheCys: 0.476 ± 0.184
3.097PheAsp: 3.097 ± 0.636
3.018PheGlu: 3.018 ± 0.545
0.794PhePhe: 0.794 ± 0.229
2.78PheGly: 2.78 ± 0.425
0.874PheHis: 0.874 ± 0.247
2.938PheIle: 2.938 ± 0.527
2.382PheLys: 2.382 ± 0.552
2.541PheLeu: 2.541 ± 0.495
0.476PheMet: 0.476 ± 0.18
1.429PheAsn: 1.429 ± 0.36
1.588PhePro: 1.588 ± 0.453
1.271PheGln: 1.271 ± 0.37
2.065PheArg: 2.065 ± 0.35
2.303PheSer: 2.303 ± 0.53
3.335PheThr: 3.335 ± 0.596
2.224PheVal: 2.224 ± 0.488
1.032PheTrp: 1.032 ± 0.318
1.032PheTyr: 1.032 ± 0.259
0.0PheXaa: 0.0 ± 0.0
Gly
7.624GlyAla: 7.624 ± 0.789
0.874GlyCys: 0.874 ± 0.28
3.812GlyAsp: 3.812 ± 0.71
5.559GlyGlu: 5.559 ± 1.042
3.018GlyPhe: 3.018 ± 0.535
6.591GlyGly: 6.591 ± 0.765
1.588GlyHis: 1.588 ± 0.485
3.335GlyIle: 3.335 ± 0.514
5.559GlyLys: 5.559 ± 0.648
6.115GlyLeu: 6.115 ± 0.591
2.462GlyMet: 2.462 ± 0.563
3.653GlyAsn: 3.653 ± 0.605
1.827GlyPro: 1.827 ± 0.362
2.938GlyGln: 2.938 ± 0.468
4.765GlyArg: 4.765 ± 0.515
5.639GlySer: 5.639 ± 0.773
3.256GlyThr: 3.256 ± 0.645
6.115GlyVal: 6.115 ± 0.839
1.032GlyTrp: 1.032 ± 0.301
2.621GlyTyr: 2.621 ± 0.422
0.0GlyXaa: 0.0 ± 0.0
His
1.191HisAla: 1.191 ± 0.374
0.397HisCys: 0.397 ± 0.192
1.032HisAsp: 1.032 ± 0.255
0.953HisGlu: 0.953 ± 0.26
0.635HisPhe: 0.635 ± 0.249
1.032HisGly: 1.032 ± 0.366
0.874HisHis: 0.874 ± 0.345
1.112HisIle: 1.112 ± 0.342
1.191HisLys: 1.191 ± 0.318
1.191HisLeu: 1.191 ± 0.284
0.476HisMet: 0.476 ± 0.197
0.318HisAsn: 0.318 ± 0.171
1.032HisPro: 1.032 ± 0.293
0.874HisGln: 0.874 ± 0.256
0.874HisArg: 0.874 ± 0.261
1.191HisSer: 1.191 ± 0.359
0.715HisThr: 0.715 ± 0.336
0.715HisVal: 0.715 ± 0.218
0.238HisTrp: 0.238 ± 0.156
1.112HisTyr: 1.112 ± 0.353
0.0HisXaa: 0.0 ± 0.0
Ile
4.13IleAla: 4.13 ± 0.683
0.635IleCys: 0.635 ± 0.257
3.733IleAsp: 3.733 ± 0.607
3.097IleGlu: 3.097 ± 0.504
1.191IlePhe: 1.191 ± 0.338
3.097IleGly: 3.097 ± 0.441
0.476IleHis: 0.476 ± 0.196
2.144IleIle: 2.144 ± 0.476
3.256IleLys: 3.256 ± 0.536
3.018IleLeu: 3.018 ± 0.589
1.112IleMet: 1.112 ± 0.267
2.224IleAsn: 2.224 ± 0.456
2.7IlePro: 2.7 ± 0.42
1.827IleGln: 1.827 ± 0.425
2.621IleArg: 2.621 ± 0.366
3.335IleSer: 3.335 ± 0.554
4.765IleThr: 4.765 ± 0.742
3.335IleVal: 3.335 ± 0.582
0.794IleTrp: 0.794 ± 0.318
1.191IleTyr: 1.191 ± 0.414
0.0IleXaa: 0.0 ± 0.0
Lys
5.956LysAla: 5.956 ± 0.819
0.953LysCys: 0.953 ± 0.292
3.653LysAsp: 3.653 ± 0.601
4.288LysGlu: 4.288 ± 0.699
1.985LysPhe: 1.985 ± 0.407
3.812LysGly: 3.812 ± 0.562
1.191LysHis: 1.191 ± 0.307
1.985LysIle: 1.985 ± 0.346
3.256LysLys: 3.256 ± 0.596
5.083LysLeu: 5.083 ± 0.751
2.859LysMet: 2.859 ± 0.6
2.462LysAsn: 2.462 ± 0.414
2.541LysPro: 2.541 ± 0.559
2.541LysGln: 2.541 ± 0.405
3.653LysArg: 3.653 ± 0.698
2.7LysSer: 2.7 ± 0.456
3.971LysThr: 3.971 ± 0.522
3.653LysVal: 3.653 ± 0.614
0.715LysTrp: 0.715 ± 0.279
2.938LysTyr: 2.938 ± 0.477
0.0LysXaa: 0.0 ± 0.0
Leu
6.512LeuAla: 6.512 ± 0.589
0.556LeuCys: 0.556 ± 0.211
3.812LeuAsp: 3.812 ± 0.63
5.083LeuGlu: 5.083 ± 0.949
1.985LeuPhe: 1.985 ± 0.459
4.924LeuGly: 4.924 ± 0.607
1.271LeuHis: 1.271 ± 0.363
4.527LeuIle: 4.527 ± 0.551
5.162LeuLys: 5.162 ± 0.576
5.797LeuLeu: 5.797 ± 0.671
2.382LeuMet: 2.382 ± 0.405
4.686LeuAsn: 4.686 ± 0.65
3.891LeuPro: 3.891 ± 0.496
2.78LeuGln: 2.78 ± 0.389
5.4LeuArg: 5.4 ± 0.758
4.527LeuSer: 4.527 ± 0.486
5.4LeuThr: 5.4 ± 0.501
5.241LeuVal: 5.241 ± 0.451
1.271LeuTrp: 1.271 ± 0.424
2.224LeuTyr: 2.224 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
2.7MetAla: 2.7 ± 0.386
0.159MetCys: 0.159 ± 0.118
1.509MetAsp: 1.509 ± 0.377
1.35MetGlu: 1.35 ± 0.319
1.271MetPhe: 1.271 ± 0.387
2.224MetGly: 2.224 ± 0.401
0.318MetHis: 0.318 ± 0.142
1.112MetIle: 1.112 ± 0.317
1.429MetLys: 1.429 ± 0.372
1.985MetLeu: 1.985 ± 0.438
0.715MetMet: 0.715 ± 0.307
1.032MetAsn: 1.032 ± 0.285
1.429MetPro: 1.429 ± 0.421
1.112MetGln: 1.112 ± 0.263
1.271MetArg: 1.271 ± 0.269
1.747MetSer: 1.747 ± 0.331
2.382MetThr: 2.382 ± 0.442
2.144MetVal: 2.144 ± 0.376
0.476MetTrp: 0.476 ± 0.168
0.715MetTyr: 0.715 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
4.13AsnAla: 4.13 ± 0.557
0.397AsnCys: 0.397 ± 0.171
2.859AsnAsp: 2.859 ± 0.394
2.303AsnGlu: 2.303 ± 0.436
1.985AsnPhe: 1.985 ± 0.322
3.971AsnGly: 3.971 ± 0.552
0.635AsnHis: 0.635 ± 0.268
2.621AsnIle: 2.621 ± 0.463
1.827AsnLys: 1.827 ± 0.432
3.812AsnLeu: 3.812 ± 0.48
0.476AsnMet: 0.476 ± 0.215
2.382AsnAsn: 2.382 ± 0.435
1.668AsnPro: 1.668 ± 0.465
1.271AsnGln: 1.271 ± 0.334
2.7AsnArg: 2.7 ± 0.422
2.224AsnSer: 2.224 ± 0.359
2.065AsnThr: 2.065 ± 0.376
3.494AsnVal: 3.494 ± 0.433
0.794AsnTrp: 0.794 ± 0.259
1.429AsnTyr: 1.429 ± 0.261
0.0AsnXaa: 0.0 ± 0.0
Pro
2.7ProAla: 2.7 ± 0.511
0.238ProCys: 0.238 ± 0.142
3.177ProAsp: 3.177 ± 0.583
3.256ProGlu: 3.256 ± 0.515
1.747ProPhe: 1.747 ± 0.331
3.177ProGly: 3.177 ± 0.489
0.397ProHis: 0.397 ± 0.164
1.429ProIle: 1.429 ± 0.372
2.621ProLys: 2.621 ± 0.442
3.574ProLeu: 3.574 ± 0.433
0.874ProMet: 0.874 ± 0.286
1.509ProAsn: 1.509 ± 0.589
1.271ProPro: 1.271 ± 0.384
1.271ProGln: 1.271 ± 0.308
1.985ProArg: 1.985 ± 0.351
2.303ProSer: 2.303 ± 0.45
1.588ProThr: 1.588 ± 0.365
3.891ProVal: 3.891 ± 0.553
0.476ProTrp: 0.476 ± 0.212
1.588ProTyr: 1.588 ± 0.422
0.0ProXaa: 0.0 ± 0.0
Gln
4.765GlnAla: 4.765 ± 0.635
0.238GlnCys: 0.238 ± 0.123
1.35GlnAsp: 1.35 ± 0.321
2.303GlnGlu: 2.303 ± 0.484
1.271GlnPhe: 1.271 ± 0.386
2.144GlnGly: 2.144 ± 0.47
0.715GlnHis: 0.715 ± 0.261
1.509GlnIle: 1.509 ± 0.399
2.065GlnLys: 2.065 ± 0.338
3.018GlnLeu: 3.018 ± 0.499
1.509GlnMet: 1.509 ± 0.384
1.588GlnAsn: 1.588 ± 0.373
2.065GlnPro: 2.065 ± 0.379
2.065GlnGln: 2.065 ± 0.501
1.668GlnArg: 1.668 ± 0.382
2.382GlnSer: 2.382 ± 0.377
1.906GlnThr: 1.906 ± 0.333
2.7GlnVal: 2.7 ± 0.463
0.635GlnTrp: 0.635 ± 0.215
1.429GlnTyr: 1.429 ± 0.295
0.0GlnXaa: 0.0 ± 0.0
Arg
4.368ArgAla: 4.368 ± 0.42
0.318ArgCys: 0.318 ± 0.147
3.733ArgAsp: 3.733 ± 0.469
3.653ArgGlu: 3.653 ± 0.528
2.144ArgPhe: 2.144 ± 0.484
4.13ArgGly: 4.13 ± 0.428
0.953ArgHis: 0.953 ± 0.255
3.415ArgIle: 3.415 ± 0.512
3.891ArgLys: 3.891 ± 0.739
3.574ArgLeu: 3.574 ± 0.525
1.985ArgMet: 1.985 ± 0.432
2.7ArgAsn: 2.7 ± 0.475
1.827ArgPro: 1.827 ± 0.377
3.097ArgGln: 3.097 ± 0.54
4.209ArgArg: 4.209 ± 0.835
2.462ArgSer: 2.462 ± 0.414
2.938ArgThr: 2.938 ± 0.499
4.13ArgVal: 4.13 ± 0.506
1.112ArgTrp: 1.112 ± 0.33
1.271ArgTyr: 1.271 ± 0.36
0.0ArgXaa: 0.0 ± 0.0
Ser
6.591SerAla: 6.591 ± 1.011
0.318SerCys: 0.318 ± 0.195
2.462SerAsp: 2.462 ± 0.422
3.415SerGlu: 3.415 ± 0.569
2.224SerPhe: 2.224 ± 0.399
6.989SerGly: 6.989 ± 0.849
0.794SerHis: 0.794 ± 0.186
2.78SerIle: 2.78 ± 0.41
2.541SerLys: 2.541 ± 0.517
4.844SerLeu: 4.844 ± 0.654
1.112SerMet: 1.112 ± 0.268
2.938SerAsn: 2.938 ± 0.35
1.985SerPro: 1.985 ± 0.512
2.144SerGln: 2.144 ± 0.381
3.177SerArg: 3.177 ± 0.465
2.7SerSer: 2.7 ± 0.468
4.527SerThr: 4.527 ± 0.69
5.241SerVal: 5.241 ± 0.793
0.715SerTrp: 0.715 ± 0.25
2.144SerTyr: 2.144 ± 0.335
0.0SerXaa: 0.0 ± 0.0
Thr
6.353ThrAla: 6.353 ± 0.745
0.635ThrCys: 0.635 ± 0.217
4.844ThrAsp: 4.844 ± 0.51
3.097ThrGlu: 3.097 ± 0.484
3.256ThrPhe: 3.256 ± 0.543
6.036ThrGly: 6.036 ± 0.757
0.794ThrHis: 0.794 ± 0.293
2.78ThrIle: 2.78 ± 0.561
3.415ThrLys: 3.415 ± 0.52
5.48ThrLeu: 5.48 ± 0.596
1.191ThrMet: 1.191 ± 0.328
2.065ThrAsn: 2.065 ± 0.372
4.209ThrPro: 4.209 ± 0.584
1.985ThrGln: 1.985 ± 0.356
2.859ThrArg: 2.859 ± 0.499
4.527ThrSer: 4.527 ± 0.622
3.494ThrThr: 3.494 ± 0.504
4.527ThrVal: 4.527 ± 0.813
0.794ThrTrp: 0.794 ± 0.216
2.382ThrTyr: 2.382 ± 0.485
0.0ThrXaa: 0.0 ± 0.0
Val
6.989ValAla: 6.989 ± 0.823
0.874ValCys: 0.874 ± 0.272
3.891ValAsp: 3.891 ± 0.507
6.194ValGlu: 6.194 ± 0.73
2.144ValPhe: 2.144 ± 0.448
3.812ValGly: 3.812 ± 0.565
1.35ValHis: 1.35 ± 0.277
4.13ValIle: 4.13 ± 0.54
5.162ValLys: 5.162 ± 0.698
4.368ValLeu: 4.368 ± 0.685
1.191ValMet: 1.191 ± 0.318
3.494ValAsn: 3.494 ± 0.505
2.144ValPro: 2.144 ± 0.692
1.985ValGln: 1.985 ± 0.415
3.733ValArg: 3.733 ± 0.513
5.48ValSer: 5.48 ± 0.747
6.036ValThr: 6.036 ± 0.729
5.003ValVal: 5.003 ± 0.7
1.112ValTrp: 1.112 ± 0.246
2.859ValTyr: 2.859 ± 0.437
0.0ValXaa: 0.0 ± 0.0
Trp
1.112TrpAla: 1.112 ± 0.455
0.079TrpCys: 0.079 ± 0.092
0.874TrpAsp: 0.874 ± 0.291
0.556TrpGlu: 0.556 ± 0.216
0.874TrpPhe: 0.874 ± 0.359
0.794TrpGly: 0.794 ± 0.207
0.476TrpHis: 0.476 ± 0.24
0.635TrpIle: 0.635 ± 0.207
0.715TrpLys: 0.715 ± 0.284
1.668TrpLeu: 1.668 ± 0.42
0.476TrpMet: 0.476 ± 0.195
0.794TrpAsn: 0.794 ± 0.289
0.476TrpPro: 0.476 ± 0.231
0.635TrpGln: 0.635 ± 0.234
1.112TrpArg: 1.112 ± 0.367
0.556TrpSer: 0.556 ± 0.185
0.635TrpThr: 0.635 ± 0.206
1.509TrpVal: 1.509 ± 0.286
0.238TrpTrp: 0.238 ± 0.147
0.238TrpTyr: 0.238 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.938TyrAla: 2.938 ± 0.454
0.397TyrCys: 0.397 ± 0.2
2.144TyrAsp: 2.144 ± 0.596
2.78TyrGlu: 2.78 ± 0.479
1.191TyrPhe: 1.191 ± 0.324
3.018TyrGly: 3.018 ± 0.474
0.715TyrHis: 0.715 ± 0.195
1.509TyrIle: 1.509 ± 0.308
2.382TyrLys: 2.382 ± 0.557
1.668TyrLeu: 1.668 ± 0.403
0.794TyrMet: 0.794 ± 0.224
1.429TyrAsn: 1.429 ± 0.383
1.271TyrPro: 1.271 ± 0.378
1.429TyrGln: 1.429 ± 0.297
1.985TyrArg: 1.985 ± 0.453
2.144TyrSer: 2.144 ± 0.504
2.303TyrThr: 2.303 ± 0.332
1.906TyrVal: 1.906 ± 0.491
0.0TyrTrp: 0.0 ± 0.0
1.668TyrTyr: 1.668 ± 0.324
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (12593 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski