Amino acid dipepetide frequency for Brevibacterium yomogidense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.195AlaAla: 19.195 ± 0.295	0.718AlaCys: 0.718 ± 0.028	9.507AlaAsp: 9.507 ± 0.173	8.633AlaGlu: 8.633 ± 0.12	3.655AlaPhe: 3.655 ± 0.071	12.756AlaGly: 12.756 ± 0.137	2.899AlaHis: 2.899 ± 0.065	4.809AlaIle: 4.809 ± 0.074	2.492AlaLys: 2.492 ± 0.064	12.888AlaLeu: 12.888 ± 0.129	2.675AlaMet: 2.675 ± 0.051	2.057AlaAsn: 2.057 ± 0.063	6.239AlaPro: 6.239 ± 0.116	4.38AlaGln: 4.38 ± 0.075	8.598AlaArg: 8.598 ± 0.102	7.186AlaSer: 7.186 ± 0.141	6.507AlaThr: 6.507 ± 0.099	11.282AlaVal: 11.282 ± 0.12	1.572AlaTrp: 1.572 ± 0.049	2.159AlaTyr: 2.159 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.737CysAla: 0.737 ± 0.028	0.06CysCys: 0.06 ± 0.009	0.327CysAsp: 0.327 ± 0.019	0.308CysGlu: 0.308 ± 0.019	0.17CysPhe: 0.17 ± 0.013	0.612CysGly: 0.612 ± 0.026	0.12CysHis: 0.12 ± 0.011	0.209CysIle: 0.209 ± 0.014	0.057CysLys: 0.057 ± 0.009	0.498CysLeu: 0.498 ± 0.024	0.113CysMet: 0.113 ± 0.012	0.097CysAsn: 0.097 ± 0.01	0.314CysPro: 0.314 ± 0.02	0.116CysGln: 0.116 ± 0.01	0.35CysArg: 0.35 ± 0.018	0.32CysSer: 0.32 ± 0.016	0.436CysThr: 0.436 ± 0.025	0.481CysVal: 0.481 ± 0.023	0.055CysTrp: 0.055 ± 0.008	0.108CysTyr: 0.108 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.239AspAla: 9.239 ± 0.155	0.297AspCys: 0.297 ± 0.019	5.224AspAsp: 5.224 ± 0.112	5.25AspGlu: 5.25 ± 0.096	1.979AspPhe: 1.979 ± 0.048	6.561AspGly: 6.561 ± 0.108	1.488AspHis: 1.488 ± 0.038	2.447AspIle: 2.447 ± 0.053	0.901AspLys: 0.901 ± 0.036	6.513AspLeu: 6.513 ± 0.092	1.182AspMet: 1.182 ± 0.038	0.806AspAsn: 0.806 ± 0.029	4.524AspPro: 4.524 ± 0.083	1.76AspGln: 1.76 ± 0.048	4.921AspArg: 4.921 ± 0.088	3.735AspSer: 3.735 ± 0.078	3.216AspThr: 3.216 ± 0.064	5.833AspVal: 5.833 ± 0.074	0.94AspTrp: 0.94 ± 0.031	1.31AspTyr: 1.31 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.159GluAla: 8.159 ± 0.109	0.252GluCys: 0.252 ± 0.019	4.208GluAsp: 4.208 ± 0.08	4.125GluGlu: 4.125 ± 0.073	1.845GluPhe: 1.845 ± 0.04	4.539GluGly: 4.539 ± 0.081	1.654GluHis: 1.654 ± 0.043	2.627GluIle: 2.627 ± 0.053	1.453GluLys: 1.453 ± 0.047	5.767GluLeu: 5.767 ± 0.087	0.994GluMet: 0.994 ± 0.035	1.242GluAsn: 1.242 ± 0.037	3.175GluPro: 3.175 ± 0.066	2.402GluGln: 2.402 ± 0.051	4.685GluArg: 4.685 ± 0.082	3.7GluSer: 3.7 ± 0.062	3.219GluThr: 3.219 ± 0.076	4.933GluVal: 4.933 ± 0.078	0.849GluTrp: 0.849 ± 0.034	1.254GluTyr: 1.254 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.152PheAla: 4.152 ± 0.062	0.203PheCys: 0.203 ± 0.014	2.407PheAsp: 2.407 ± 0.051	1.744PheGlu: 1.744 ± 0.047	1.041PhePhe: 1.041 ± 0.037	3.224PheGly: 3.224 ± 0.071	0.668PheHis: 0.668 ± 0.026	1.207PheIle: 1.207 ± 0.042	0.452PheLys: 0.452 ± 0.022	2.797PheLeu: 2.797 ± 0.064	0.557PheMet: 0.557 ± 0.025	0.62PheAsn: 0.62 ± 0.027	1.382PhePro: 1.382 ± 0.038	0.716PheGln: 0.716 ± 0.027	1.682PheArg: 1.682 ± 0.048	1.935PheSer: 1.935 ± 0.046	2.093PheThr: 2.093 ± 0.051	2.687PheVal: 2.687 ± 0.06	0.428PheTrp: 0.428 ± 0.019	0.574PheTyr: 0.574 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.893GlyAla: 10.893 ± 0.129	0.591GlyCys: 0.591 ± 0.027	5.68GlyAsp: 5.68 ± 0.102	5.416GlyGlu: 5.416 ± 0.074	3.27GlyPhe: 3.27 ± 0.07	8.163GlyGly: 8.163 ± 0.135	1.957GlyHis: 1.957 ± 0.047	4.572GlyIle: 4.572 ± 0.08	1.945GlyLys: 1.945 ± 0.056	8.896GlyLeu: 8.896 ± 0.113	2.316GlyMet: 2.316 ± 0.058	1.48GlyAsn: 1.48 ± 0.044	4.203GlyPro: 4.203 ± 0.082	2.544GlyGln: 2.544 ± 0.062	6.498GlyArg: 6.498 ± 0.092	6.202GlySer: 6.202 ± 0.109	6.078GlyThr: 6.078 ± 0.091	7.402GlyVal: 7.402 ± 0.09	1.508GlyTrp: 1.508 ± 0.043	2.038GlyTyr: 2.038 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.625HisAla: 2.625 ± 0.055	0.148HisCys: 0.148 ± 0.012	1.456HisAsp: 1.456 ± 0.04	1.266HisGlu: 1.266 ± 0.041	0.611HisPhe: 0.611 ± 0.029	2.124HisGly: 2.124 ± 0.049	0.57HisHis: 0.57 ± 0.021	0.805HisIle: 0.805 ± 0.03	0.312HisLys: 0.312 ± 0.019	2.09HisLeu: 2.09 ± 0.049	0.413HisMet: 0.413 ± 0.023	0.319HisAsn: 0.319 ± 0.016	1.637HisPro: 1.637 ± 0.045	0.533HisGln: 0.533 ± 0.023	1.867HisArg: 1.867 ± 0.053	1.279HisSer: 1.279 ± 0.038	1.329HisThr: 1.329 ± 0.034	1.736HisVal: 1.736 ± 0.039	0.284HisTrp: 0.284 ± 0.017	0.434HisTyr: 0.434 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.374IleAla: 6.374 ± 0.087	0.278IleCys: 0.278 ± 0.015	3.427IleAsp: 3.427 ± 0.048	2.618IleGlu: 2.618 ± 0.053	1.047IlePhe: 1.047 ± 0.042	4.373IleGly: 4.373 ± 0.081	0.84IleHis: 0.84 ± 0.029	1.828IleIle: 1.828 ± 0.054	0.643IleLys: 0.643 ± 0.031	3.527IleLeu: 3.527 ± 0.078	0.764IleMet: 0.764 ± 0.03	0.806IleAsn: 0.806 ± 0.032	2.165IlePro: 2.165 ± 0.051	0.876IleGln: 0.876 ± 0.031	2.713IleArg: 2.713 ± 0.054	2.21IleSer: 2.21 ± 0.052	2.67IleThr: 2.67 ± 0.06	4.392IleVal: 4.392 ± 0.073	0.396IleTrp: 0.396 ± 0.022	0.656IleTyr: 0.656 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.123LysAla: 2.123 ± 0.051	0.07LysCys: 0.07 ± 0.009	1.251LysAsp: 1.251 ± 0.042	1.121LysGlu: 1.121 ± 0.041	0.435LysPhe: 0.435 ± 0.024	1.496LysGly: 1.496 ± 0.04	0.41LysHis: 0.41 ± 0.017	0.864LysIle: 0.864 ± 0.033	0.828LysLys: 0.828 ± 0.035	1.63LysLeu: 1.63 ± 0.043	0.382LysMet: 0.382 ± 0.02	0.489LysAsn: 0.489 ± 0.024	1.091LysPro: 1.091 ± 0.037	0.66LysGln: 0.66 ± 0.028	1.552LysArg: 1.552 ± 0.048	1.176LysSer: 1.176 ± 0.039	1.302LysThr: 1.302 ± 0.036	1.428LysVal: 1.428 ± 0.049	0.206LysTrp: 0.206 ± 0.016	0.402LysTyr: 0.402 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.717LeuAla: 12.717 ± 0.133	0.583LeuCys: 0.583 ± 0.025	6.401LeuAsp: 6.401 ± 0.098	5.29LeuGlu: 5.29 ± 0.076	2.791LeuPhe: 2.791 ± 0.061	8.473LeuGly: 8.473 ± 0.12	1.88LeuHis: 1.88 ± 0.048	4.172LeuIle: 4.172 ± 0.082	1.602LeuLys: 1.602 ± 0.048	9.767LeuLeu: 9.767 ± 0.152	1.801LeuMet: 1.801 ± 0.051	1.67LeuAsn: 1.67 ± 0.043	5.346LeuPro: 5.346 ± 0.083	2.308LeuGln: 2.308 ± 0.061	7.037LeuArg: 7.037 ± 0.085	6.042LeuSer: 6.042 ± 0.071	6.887LeuThr: 6.887 ± 0.097	8.792LeuVal: 8.792 ± 0.127	1.129LeuTrp: 1.129 ± 0.033	1.451LeuTyr: 1.451 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.05	0.129MetCys: 0.129 ± 0.011	1.098MetAsp: 1.098 ± 0.038	0.957MetGlu: 0.957 ± 0.031	0.623MetPhe: 0.623 ± 0.028	1.78MetGly: 1.78 ± 0.042	0.418MetHis: 0.418 ± 0.022	0.883MetIle: 0.883 ± 0.034	0.478MetLys: 0.478 ± 0.025	2.075MetLeu: 2.075 ± 0.05	0.382MetMet: 0.382 ± 0.02	0.488MetAsn: 0.488 ± 0.024	1.161MetPro: 1.161 ± 0.042	0.591MetGln: 0.591 ± 0.026	1.592MetArg: 1.592 ± 0.045	1.661MetSer: 1.661 ± 0.039	1.832MetThr: 1.832 ± 0.041	1.499MetVal: 1.499 ± 0.041	0.22MetTrp: 0.22 ± 0.015	0.348MetTyr: 0.348 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.307AsnAla: 2.307 ± 0.084	0.107AsnCys: 0.107 ± 0.011	0.979AsnAsp: 0.979 ± 0.034	0.862AsnGlu: 0.862 ± 0.031	0.554AsnPhe: 0.554 ± 0.026	1.736AsnGly: 1.736 ± 0.048	0.362AsnHis: 0.362 ± 0.02	0.807AsnIle: 0.807 ± 0.031	0.338AsnLys: 0.338 ± 0.021	1.708AsnLeu: 1.708 ± 0.048	0.325AsnMet: 0.325 ± 0.02	0.37AsnAsn: 0.37 ± 0.019	1.373AsnPro: 1.373 ± 0.041	0.489AsnGln: 0.489 ± 0.024	1.255AsnArg: 1.255 ± 0.036	0.976AsnSer: 0.976 ± 0.037	1.083AsnThr: 1.083 ± 0.034	1.421AsnVal: 1.421 ± 0.042	0.228AsnTrp: 0.228 ± 0.017	0.349AsnTyr: 0.349 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.128ProAla: 7.128 ± 0.101	0.194ProCys: 0.194 ± 0.013	4.208ProAsp: 4.208 ± 0.073	3.996ProGlu: 3.996 ± 0.067	1.604ProPhe: 1.604 ± 0.047	5.281ProGly: 5.281 ± 0.077	1.353ProHis: 1.353 ± 0.042	1.885ProIle: 1.885 ± 0.05	0.963ProLys: 0.963 ± 0.036	4.565ProLeu: 4.565 ± 0.07	0.983ProMet: 0.983 ± 0.03	0.934ProAsn: 0.934 ± 0.026	2.278ProPro: 2.278 ± 0.066	1.879ProGln: 1.879 ± 0.049	3.284ProArg: 3.284 ± 0.066	3.26ProSer: 3.26 ± 0.063	3.463ProThr: 3.463 ± 0.075	4.813ProVal: 4.813 ± 0.088	0.679ProTrp: 0.679 ± 0.03	1.059ProTyr: 1.059 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.484GlnAla: 3.484 ± 0.064	0.129GlnCys: 0.129 ± 0.012	1.566GlnAsp: 1.566 ± 0.046	1.682GlnGlu: 1.682 ± 0.042	0.827GlnPhe: 0.827 ± 0.028	2.083GlnGly: 2.083 ± 0.055	0.669GlnHis: 0.669 ± 0.025	1.382GlnIle: 1.382 ± 0.04	0.726GlnLys: 0.726 ± 0.026	2.853GlnLeu: 2.853 ± 0.055	0.687GlnMet: 0.687 ± 0.03	0.606GlnAsn: 0.606 ± 0.029	1.655GlnPro: 1.655 ± 0.05	1.314GlnGln: 1.314 ± 0.048	2.399GlnArg: 2.399 ± 0.05	1.796GlnSer: 1.796 ± 0.044	1.727GlnThr: 1.727 ± 0.045	2.304GlnVal: 2.304 ± 0.05	0.423GlnTrp: 0.423 ± 0.024	0.602GlnTyr: 0.602 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	8.492ArgAla: 8.492 ± 0.114	0.32ArgCys: 0.32 ± 0.018	4.217ArgAsp: 4.217 ± 0.079	4.374ArgGlu: 4.374 ± 0.067	2.324ArgPhe: 2.324 ± 0.055	5.433ArgGly: 5.433 ± 0.087	1.412ArgHis: 1.412 ± 0.038	3.762ArgIle: 3.762 ± 0.063	1.454ArgLys: 1.454 ± 0.045	6.812ArgLeu: 6.812 ± 0.093	1.866ArgMet: 1.866 ± 0.047	1.209ArgAsn: 1.209 ± 0.035	3.669ArgPro: 3.669 ± 0.07	1.773ArgGln: 1.773 ± 0.04	6.319ArgArg: 6.319 ± 0.118	4.595ArgSer: 4.595 ± 0.07	5.109ArgThr: 5.109 ± 0.074	5.676ArgVal: 5.676 ± 0.079	0.988ArgTrp: 0.988 ± 0.037	1.35ArgTyr: 1.35 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	8.394SerAla: 8.394 ± 0.133	0.286SerCys: 0.286 ± 0.018	3.779SerAsp: 3.779 ± 0.084	3.112SerGlu: 3.112 ± 0.06	1.923SerPhe: 1.923 ± 0.047	6.69SerGly: 6.69 ± 0.105	1.279SerHis: 1.279 ± 0.039	2.454SerIle: 2.454 ± 0.047	1.104SerLys: 1.104 ± 0.032	5.517SerLeu: 5.517 ± 0.071	1.407SerMet: 1.407 ± 0.043	1.011SerAsn: 1.011 ± 0.037	3.366SerPro: 3.366 ± 0.064	1.792SerGln: 1.792 ± 0.047	4.165SerArg: 4.165 ± 0.072	4.032SerSer: 4.032 ± 0.077	3.893SerThr: 3.893 ± 0.075	4.895SerVal: 4.895 ± 0.077	0.772SerTrp: 0.772 ± 0.027	1.154SerTyr: 1.154 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	8.49ThrAla: 8.49 ± 0.121	0.299ThrCys: 0.299 ± 0.018	4.273ThrAsp: 4.273 ± 0.062	3.336ThrGlu: 3.336 ± 0.062	1.758ThrPhe: 1.758 ± 0.042	6.263ThrGly: 6.263 ± 0.09	1.361ThrHis: 1.361 ± 0.041	2.63ThrIle: 2.63 ± 0.05	1.091ThrLys: 1.091 ± 0.035	5.508ThrLeu: 5.508 ± 0.081	1.211ThrMet: 1.211 ± 0.04	1.077ThrAsn: 1.077 ± 0.032	3.778ThrPro: 3.778 ± 0.071	1.683ThrGln: 1.683 ± 0.042	3.855ThrArg: 3.855 ± 0.067	3.672ThrSer: 3.672 ± 0.058	4.018ThrThr: 4.018 ± 0.068	6.079ThrVal: 6.079 ± 0.071	0.809ThrTrp: 0.809 ± 0.029	1.142ThrTyr: 1.142 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.925ValAla: 9.925 ± 0.127	0.594ValCys: 0.594 ± 0.021	6.157ValAsp: 6.157 ± 0.086	5.148ValGlu: 5.148 ± 0.085	2.887ValPhe: 2.887 ± 0.057	7.162ValGly: 7.162 ± 0.098	1.892ValHis: 1.892 ± 0.044	3.974ValIle: 3.974 ± 0.066	1.443ValLys: 1.443 ± 0.045	9.502ValLeu: 9.502 ± 0.113	1.7ValMet: 1.7 ± 0.044	1.636ValAsn: 1.636 ± 0.044	4.948ValPro: 4.948 ± 0.079	2.1ValGln: 2.1 ± 0.044	5.981ValArg: 5.981 ± 0.09	5.221ValSer: 5.221 ± 0.077	5.5ValThr: 5.5 ± 0.078	8.325ValVal: 8.325 ± 0.115	1.075ValTrp: 1.075 ± 0.04	1.385ValTyr: 1.385 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.423TrpAla: 1.423 ± 0.041	0.102TrpCys: 0.102 ± 0.01	0.697TrpAsp: 0.697 ± 0.026	0.751TrpGlu: 0.751 ± 0.026	0.566TrpPhe: 0.566 ± 0.022	1.016TrpGly: 1.016 ± 0.036	0.295TrpHis: 0.295 ± 0.018	0.635TrpIle: 0.635 ± 0.025	0.328TrpLys: 0.328 ± 0.02	1.411TrpLeu: 1.411 ± 0.04	0.321TrpMet: 0.321 ± 0.017	0.347TrpAsn: 0.347 ± 0.023	0.604TrpPro: 0.604 ± 0.025	0.448TrpGln: 0.448 ± 0.022	0.904TrpArg: 0.904 ± 0.032	0.818TrpSer: 0.818 ± 0.027	0.87TrpThr: 0.87 ± 0.031	1.041TrpVal: 1.041 ± 0.033	0.275TrpTrp: 0.275 ± 0.016	0.263TrpTyr: 0.263 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.154TyrAla: 2.154 ± 0.047	0.128TyrCys: 0.128 ± 0.012	1.263TyrAsp: 1.263 ± 0.037	1.094TyrGlu: 1.094 ± 0.035	0.659TyrPhe: 0.659 ± 0.025	1.889TyrGly: 1.889 ± 0.055	0.313TyrHis: 0.313 ± 0.018	0.654TyrIle: 0.654 ± 0.025	0.305TyrLys: 0.305 ± 0.017	1.814TyrLeu: 1.814 ± 0.047	0.333TyrMet: 0.333 ± 0.018	0.364TyrAsn: 0.364 ± 0.02	0.902TyrPro: 0.902 ± 0.028	0.546TyrGln: 0.546 ± 0.024	1.496TyrArg: 1.496 ± 0.038	1.207TyrSer: 1.207 ± 0.031	1.1TyrThr: 1.1 ± 0.035	1.538TyrVal: 1.538 ± 0.038	0.279TyrTrp: 0.279 ± 0.016	0.397TyrTyr: 0.397 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2868 proteins (977191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---