Amino acid dipepetide frequency for Changjiang tombus-like virus 16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.765AlaAla: 11.765 ± 2.418
0.98AlaCys: 0.98 ± 0.926
4.902AlaAsp: 4.902 ± 2.123
3.922AlaGlu: 3.922 ± 2.009
2.941AlaPhe: 2.941 ± 1.473
8.824AlaGly: 8.824 ± 1.924
0.98AlaHis: 0.98 ± 1.166
3.922AlaIle: 3.922 ± 1.275
3.922AlaLys: 3.922 ± 1.328
9.804AlaLeu: 9.804 ± 1.707
4.902AlaMet: 4.902 ± 0.797
0.98AlaAsn: 0.98 ± 0.926
5.882AlaPro: 5.882 ± 0.334
3.922AlaGln: 3.922 ± 2.009
6.863AlaArg: 6.863 ± 3.763
4.902AlaSer: 4.902 ± 2.123
6.863AlaThr: 6.863 ± 3.926
5.882AlaVal: 5.882 ± 4.548
0.0AlaTrp: 0.0 ± 0.0
4.902AlaTyr: 4.902 ± 1.442
0.0AlaXaa: 0.0 ± 0.0
Cys
0.98CysAla: 0.98 ± 0.926
0.0CysCys: 0.0 ± 0.0
0.98CysAsp: 0.98 ± 0.926
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
4.902CysGly: 4.902 ± 0.664
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.941CysLeu: 2.941 ± 0.938
0.98CysMet: 0.98 ± 0.793
0.0CysAsn: 0.0 ± 0.0
0.98CysPro: 0.98 ± 0.926
0.98CysGln: 0.98 ± 0.654
1.961CysArg: 1.961 ± 1.308
2.941CysSer: 2.941 ± 0.938
1.961CysThr: 1.961 ± 1.286
3.922CysVal: 3.922 ± 1.328
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.882AspAla: 5.882 ± 0.334
0.0AspCys: 0.0 ± 0.0
1.961AspAsp: 1.961 ± 0.664
3.922AspGlu: 3.922 ± 2.009
1.961AspPhe: 1.961 ± 0.664
6.863AspGly: 6.863 ± 1.552
0.98AspHis: 0.98 ± 1.166
0.0AspIle: 0.0 ± 0.0
1.961AspLys: 1.961 ± 1.852
4.902AspLeu: 4.902 ± 0.797
1.961AspMet: 1.961 ± 1.005
1.961AspAsn: 1.961 ± 1.005
0.98AspPro: 0.98 ± 0.926
1.961AspGln: 1.961 ± 1.308
2.941AspArg: 2.941 ± 0.678
2.941AspSer: 2.941 ± 1.473
1.961AspThr: 1.961 ± 1.005
2.941AspVal: 2.941 ± 0.678
0.0AspTrp: 0.0 ± 0.0
3.922AspTyr: 3.922 ± 1.474
0.0AspXaa: 0.0 ± 0.0
Glu
6.863GluAla: 6.863 ± 2.44
0.98GluCys: 0.98 ± 0.926
2.941GluAsp: 2.941 ± 3.499
3.922GluGlu: 3.922 ± 2.009
3.922GluPhe: 3.922 ± 2.616
0.98GluGly: 0.98 ± 0.654
3.922GluHis: 3.922 ± 1.695
0.0GluIle: 0.0 ± 0.0
3.922GluLys: 3.922 ± 1.695
4.902GluLeu: 4.902 ± 2.256
0.98GluMet: 0.98 ± 0.552
1.961GluAsn: 1.961 ± 1.005
0.98GluPro: 0.98 ± 0.654
0.98GluGln: 0.98 ± 0.654
5.882GluArg: 5.882 ± 3.014
0.98GluSer: 0.98 ± 0.926
1.961GluThr: 1.961 ± 1.308
3.922GluVal: 3.922 ± 1.275
1.961GluTrp: 1.961 ± 0.664
1.961GluTyr: 1.961 ± 1.286
0.0GluXaa: 0.0 ± 0.0
Phe
0.98PheAla: 0.98 ± 1.166
1.961PheCys: 1.961 ± 0.664
3.922PheAsp: 3.922 ± 0.346
1.961PheGlu: 1.961 ± 1.308
2.941PhePhe: 2.941 ± 1.962
3.922PheGly: 3.922 ± 1.275
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.961PheLys: 1.961 ± 1.005
3.922PheLeu: 3.922 ± 1.328
0.98PheMet: 0.98 ± 0.926
1.961PheAsn: 1.961 ± 0.664
1.961PhePro: 1.961 ± 0.664
0.98PheGln: 0.98 ± 0.654
0.98PheArg: 0.98 ± 0.654
0.0PheSer: 0.0 ± 0.0
0.98PheThr: 0.98 ± 0.654
1.961PheVal: 1.961 ± 1.308
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
8.824GlyAla: 8.824 ± 3.08
1.961GlyCys: 1.961 ± 0.664
5.882GlyAsp: 5.882 ± 1.876
1.961GlyGlu: 1.961 ± 1.308
1.961GlyPhe: 1.961 ± 1.005
2.941GlyGly: 2.941 ± 1.473
0.98GlyHis: 0.98 ± 0.654
3.922GlyIle: 3.922 ± 1.328
2.941GlyLys: 2.941 ± 1.23
9.804GlyLeu: 9.804 ± 0.143
2.941GlyMet: 2.941 ± 0.678
2.941GlyAsn: 2.941 ± 0.938
1.961GlyPro: 1.961 ± 1.005
0.98GlyGln: 0.98 ± 0.926
3.922GlyArg: 3.922 ± 1.695
2.941GlySer: 2.941 ± 0.938
5.882GlyThr: 5.882 ± 4.201
9.804GlyVal: 9.804 ± 3.898
2.941GlyTrp: 2.941 ± 1.23
6.863GlyTyr: 6.863 ± 2.44
0.0GlyXaa: 0.0 ± 0.0
His
1.961HisAla: 1.961 ± 1.308
0.98HisCys: 0.98 ± 0.654
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.98HisGly: 0.98 ± 0.654
0.0HisHis: 0.0 ± 0.0
0.98HisIle: 0.98 ± 0.654
0.0HisLys: 0.0 ± 0.0
0.98HisLeu: 0.98 ± 0.654
0.98HisMet: 0.98 ± 1.166
0.98HisAsn: 0.98 ± 1.166
1.961HisPro: 1.961 ± 1.308
0.98HisGln: 0.98 ± 0.654
0.0HisArg: 0.0 ± 0.0
1.961HisSer: 1.961 ± 1.005
0.98HisThr: 0.98 ± 1.166
0.98HisVal: 0.98 ± 0.654
0.0HisTrp: 0.0 ± 0.0
0.98HisTyr: 0.98 ± 1.166
0.0HisXaa: 0.0 ± 0.0
Ile
2.941IleAla: 2.941 ± 0.938
0.0IleCys: 0.0 ± 0.0
0.98IleAsp: 0.98 ± 0.654
1.961IleGlu: 1.961 ± 0.664
0.0IlePhe: 0.0 ± 0.0
5.882IleGly: 5.882 ± 0.334
0.0IleHis: 0.0 ± 0.0
0.98IleIle: 0.98 ± 0.654
0.0IleLys: 0.0 ± 0.0
2.941IleLeu: 2.941 ± 1.962
0.98IleMet: 0.98 ± 0.926
1.961IleAsn: 1.961 ± 1.852
2.941IlePro: 2.941 ± 0.938
1.961IleGln: 1.961 ± 0.664
0.98IleArg: 0.98 ± 0.654
2.941IleSer: 2.941 ± 1.23
0.98IleThr: 0.98 ± 0.654
1.961IleVal: 1.961 ± 1.005
0.98IleTrp: 0.98 ± 0.926
0.98IleTyr: 0.98 ± 0.926
0.0IleXaa: 0.0 ± 0.0
Lys
6.863LysAla: 6.863 ± 0.854
0.0LysCys: 0.0 ± 0.0
0.98LysAsp: 0.98 ± 0.926
3.922LysGlu: 3.922 ± 1.788
0.98LysPhe: 0.98 ± 0.926
3.922LysGly: 3.922 ± 2.009
0.98LysHis: 0.98 ± 1.166
1.961LysIle: 1.961 ± 1.308
4.902LysLys: 4.902 ± 4.631
2.941LysLeu: 2.941 ± 1.23
0.0LysMet: 0.0 ± 0.0
1.961LysAsn: 1.961 ± 1.852
1.961LysPro: 1.961 ± 0.664
2.941LysGln: 2.941 ± 0.938
3.922LysArg: 3.922 ± 2.616
1.961LysSer: 1.961 ± 1.852
3.922LysThr: 3.922 ± 2.37
4.902LysVal: 4.902 ± 2.079
0.98LysTrp: 0.98 ± 0.654
0.98LysTyr: 0.98 ± 0.926
0.0LysXaa: 0.0 ± 0.0
Leu
6.863LeuAla: 6.863 ± 2.889
2.941LeuCys: 2.941 ± 0.938
4.902LeuAsp: 4.902 ± 0.797
5.882LeuGlu: 5.882 ± 2.949
4.902LeuPhe: 4.902 ± 2.256
8.824LeuGly: 8.824 ± 2.033
0.0LeuHis: 0.0 ± 0.0
2.941LeuIle: 2.941 ± 1.962
5.882LeuLys: 5.882 ± 1.876
9.804LeuLeu: 9.804 ± 4.005
3.922LeuMet: 3.922 ± 1.788
5.882LeuAsn: 5.882 ± 1.992
3.922LeuPro: 3.922 ± 1.474
2.941LeuGln: 2.941 ± 1.23
5.882LeuArg: 5.882 ± 3.924
6.863LeuSer: 6.863 ± 3.344
4.902LeuThr: 4.902 ± 1.949
5.882LeuVal: 5.882 ± 1.876
0.98LeuTrp: 0.98 ± 1.166
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
3.922MetAla: 3.922 ± 1.275
0.0MetCys: 0.0 ± 0.0
1.961MetAsp: 1.961 ± 2.332
4.902MetGlu: 4.902 ± 1.442
0.98MetPhe: 0.98 ± 0.654
0.0MetGly: 0.0 ± 0.0
0.98MetHis: 0.98 ± 0.654
1.961MetIle: 1.961 ± 1.852
2.941MetLys: 2.941 ± 1.962
1.961MetLeu: 1.961 ± 1.005
0.0MetMet: 0.0 ± 0.689
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.961MetArg: 1.961 ± 1.005
0.98MetSer: 0.98 ± 0.654
1.961MetThr: 1.961 ± 1.005
2.941MetVal: 2.941 ± 3.499
0.0MetTrp: 0.0 ± 0.0
1.961MetTyr: 1.961 ± 1.852
0.0MetXaa: 0.0 ± 0.0
Asn
4.902AsnAla: 4.902 ± 3.127
2.941AsnCys: 2.941 ± 0.678
2.941AsnAsp: 2.941 ± 0.678
0.0AsnGlu: 0.0 ± 0.0
1.961AsnPhe: 1.961 ± 1.852
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
1.961AsnLys: 1.961 ± 1.852
2.941AsnLeu: 2.941 ± 1.914
0.98AsnMet: 0.98 ± 0.654
1.961AsnAsn: 1.961 ± 0.664
0.98AsnPro: 0.98 ± 0.926
0.98AsnGln: 0.98 ± 0.654
0.98AsnArg: 0.98 ± 0.926
1.961AsnSer: 1.961 ± 0.664
6.863AsnThr: 6.863 ± 3.836
4.902AsnVal: 4.902 ± 0.797
0.98AsnTrp: 0.98 ± 0.926
1.961AsnTyr: 1.961 ± 1.005
0.0AsnXaa: 0.0 ± 0.0
Pro
3.922ProAla: 3.922 ± 0.346
0.98ProCys: 0.98 ± 0.926
1.961ProAsp: 1.961 ± 1.005
3.922ProGlu: 3.922 ± 2.616
0.98ProPhe: 0.98 ± 0.654
6.863ProGly: 6.863 ± 2.496
0.0ProHis: 0.0 ± 0.0
0.98ProIle: 0.98 ± 0.654
0.0ProLys: 0.0 ± 0.0
5.882ProLeu: 5.882 ± 0.334
0.0ProMet: 0.0 ± 0.0
3.922ProAsn: 3.922 ± 3.705
2.941ProPro: 2.941 ± 1.23
0.98ProGln: 0.98 ± 0.654
3.922ProArg: 3.922 ± 1.695
1.961ProSer: 1.961 ± 0.664
0.98ProThr: 0.98 ± 0.926
3.922ProVal: 3.922 ± 1.474
0.0ProTrp: 0.0 ± 0.0
0.98ProTyr: 0.98 ± 0.654
0.0ProXaa: 0.0 ± 0.0
Gln
2.941GlnAla: 2.941 ± 0.938
0.98GlnCys: 0.98 ± 0.654
1.961GlnAsp: 1.961 ± 1.308
0.98GlnGlu: 0.98 ± 0.654
0.0GlnPhe: 0.0 ± 0.0
1.961GlnGly: 1.961 ± 0.664
1.961GlnHis: 1.961 ± 1.308
1.961GlnIle: 1.961 ± 0.664
0.98GlnLys: 0.98 ± 0.926
5.882GlnLeu: 5.882 ± 2.461
0.98GlnMet: 0.98 ± 0.654
1.961GlnAsn: 1.961 ± 1.005
0.98GlnPro: 0.98 ± 0.654
1.961GlnGln: 1.961 ± 1.308
0.0GlnArg: 0.0 ± 0.0
1.961GlnSer: 1.961 ± 1.005
0.98GlnThr: 0.98 ± 0.926
1.961GlnVal: 1.961 ± 1.308
0.98GlnTrp: 0.98 ± 0.654
0.98GlnTyr: 0.98 ± 0.926
0.0GlnXaa: 0.0 ± 0.0
Arg
9.804ArgAla: 9.804 ± 4.704
1.961ArgCys: 1.961 ± 0.664
2.941ArgAsp: 2.941 ± 1.962
2.941ArgGlu: 2.941 ± 1.23
1.961ArgPhe: 1.961 ± 0.664
1.961ArgGly: 1.961 ± 1.005
0.0ArgHis: 0.0 ± 0.0
1.961ArgIle: 1.961 ± 1.308
2.941ArgLys: 2.941 ± 2.076
5.882ArgLeu: 5.882 ± 3.014
1.961ArgMet: 1.961 ± 1.308
1.961ArgAsn: 1.961 ± 1.308
3.922ArgPro: 3.922 ± 1.328
3.922ArgGln: 3.922 ± 1.695
5.882ArgArg: 5.882 ± 5.526
3.922ArgSer: 3.922 ± 1.474
4.902ArgThr: 4.902 ± 3.27
7.843ArgVal: 7.843 ± 2.704
1.961ArgTrp: 1.961 ± 0.664
2.941ArgTyr: 2.941 ± 0.678
0.0ArgXaa: 0.0 ± 0.0
Ser
2.941SerAla: 2.941 ± 1.914
0.98SerCys: 0.98 ± 0.654
4.902SerAsp: 4.902 ± 2.089
2.941SerGlu: 2.941 ± 1.914
0.98SerPhe: 0.98 ± 0.654
6.863SerGly: 6.863 ± 2.105
0.98SerHis: 0.98 ± 0.654
2.941SerIle: 2.941 ± 0.678
7.843SerLys: 7.843 ± 1.165
5.882SerLeu: 5.882 ± 0.334
0.98SerMet: 0.98 ± 0.654
0.98SerAsn: 0.98 ± 0.926
3.922SerPro: 3.922 ± 1.328
0.98SerGln: 0.98 ± 0.926
4.902SerArg: 4.902 ± 2.079
4.902SerSer: 4.902 ± 2.256
0.98SerThr: 0.98 ± 0.654
4.902SerVal: 4.902 ± 2.079
0.0SerTrp: 0.0 ± 0.0
1.961SerTyr: 1.961 ± 1.005
0.0SerXaa: 0.0 ± 0.0
Thr
5.882ThrAla: 5.882 ± 0.334
0.98ThrCys: 0.98 ± 0.926
1.961ThrAsp: 1.961 ± 1.005
2.941ThrGlu: 2.941 ± 1.23
1.961ThrPhe: 1.961 ± 1.286
5.882ThrGly: 5.882 ± 1.355
0.0ThrHis: 0.0 ± 0.0
1.961ThrIle: 1.961 ± 1.852
1.961ThrLys: 1.961 ± 0.664
5.882ThrLeu: 5.882 ± 1.876
0.0ThrMet: 0.0 ± 0.0
2.941ThrAsn: 2.941 ± 1.914
0.0ThrPro: 0.0 ± 0.0
2.941ThrGln: 2.941 ± 0.938
4.902ThrArg: 4.902 ± 1.488
3.922ThrSer: 3.922 ± 1.328
0.98ThrThr: 0.98 ± 0.654
6.863ThrVal: 6.863 ± 5.123
0.0ThrTrp: 0.0 ± 0.0
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
6.863ValAla: 6.863 ± 6.483
2.941ValCys: 2.941 ± 2.076
3.922ValAsp: 3.922 ± 1.695
5.882ValGlu: 5.882 ± 1.416
1.961ValPhe: 1.961 ± 1.005
6.863ValGly: 6.863 ± 0.799
2.941ValHis: 2.941 ± 1.23
2.941ValIle: 2.941 ± 1.23
4.902ValLys: 4.902 ± 1.488
3.922ValLeu: 3.922 ± 1.474
3.922ValMet: 3.922 ± 2.572
2.941ValAsn: 2.941 ± 1.914
7.843ValPro: 7.843 ± 2.352
0.98ValGln: 0.98 ± 0.654
8.824ValArg: 8.824 ± 0.512
6.863ValSer: 6.863 ± 1.552
0.98ValThr: 0.98 ± 0.926
5.882ValVal: 5.882 ± 1.992
0.0ValTrp: 0.0 ± 0.0
2.941ValTyr: 2.941 ± 0.938
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.98TrpCys: 0.98 ± 0.926
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.98TrpGly: 0.98 ± 0.654
0.0TrpHis: 0.0 ± 0.0
1.961TrpIle: 1.961 ± 1.308
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.98TrpMet: 0.98 ± 1.166
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
2.941TrpArg: 2.941 ± 0.678
1.961TrpSer: 1.961 ± 1.852
0.98TrpThr: 0.98 ± 0.654
0.98TrpVal: 0.98 ± 0.654
1.961TrpTrp: 1.961 ± 1.852
0.98TrpTyr: 0.98 ± 0.654
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.961TyrAla: 1.961 ± 1.005
0.98TyrCys: 0.98 ± 0.654
0.0TyrAsp: 0.0 ± 0.0
1.961TyrGlu: 1.961 ± 1.308
0.98TyrPhe: 0.98 ± 0.926
2.941TyrGly: 2.941 ± 0.678
0.98TyrHis: 0.98 ± 0.654
0.98TyrIle: 0.98 ± 0.926
1.961TyrLys: 1.961 ± 1.286
2.941TyrLeu: 2.941 ± 1.23
0.98TyrMet: 0.98 ± 1.166
2.941TyrAsn: 2.941 ± 1.914
0.98TyrPro: 0.98 ± 0.926
0.98TyrGln: 0.98 ± 0.926
3.922TyrArg: 3.922 ± 0.346
4.902TyrSer: 4.902 ± 2.123
1.961TyrThr: 1.961 ± 1.308
1.961TyrVal: 1.961 ± 2.332
0.98TyrTrp: 0.98 ± 0.654
1.961TyrTyr: 1.961 ± 1.286
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski