Amino acid dipepetide frequency for Armatimonadetes bacterium Uphvl-Ar2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.959AlaAla: 11.959 ± 0.161	1.027AlaCys: 1.027 ± 0.041	5.464AlaAsp: 5.464 ± 0.078	7.181AlaGlu: 7.181 ± 0.121	3.835AlaPhe: 3.835 ± 0.07	8.934AlaGly: 8.934 ± 0.12	2.107AlaHis: 2.107 ± 0.064	5.04AlaIle: 5.04 ± 0.089	3.946AlaLys: 3.946 ± 0.088	11.079AlaLeu: 11.079 ± 0.156	3.327AlaMet: 3.327 ± 0.075	3.175AlaAsn: 3.175 ± 0.069	5.455AlaPro: 5.455 ± 0.094	4.461AlaGln: 4.461 ± 0.09	7.243AlaArg: 7.243 ± 0.111	5.574AlaSer: 5.574 ± 0.091	6.184AlaThr: 6.184 ± 0.101	7.423AlaVal: 7.423 ± 0.11	1.776AlaTrp: 1.776 ± 0.055	2.543AlaTyr: 2.543 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.742CysAla: 0.742 ± 0.037	0.122CysCys: 0.122 ± 0.015	0.491CysAsp: 0.491 ± 0.026	0.505CysGlu: 0.505 ± 0.026	0.272CysPhe: 0.272 ± 0.018	0.894CysGly: 0.894 ± 0.038	0.265CysHis: 0.265 ± 0.016	0.361CysIle: 0.361 ± 0.021	0.188CysLys: 0.188 ± 0.018	0.841CysLeu: 0.841 ± 0.035	0.196CysMet: 0.196 ± 0.015	0.19CysAsn: 0.19 ± 0.016	0.517CysPro: 0.517 ± 0.029	0.328CysGln: 0.328 ± 0.023	0.575CysArg: 0.575 ± 0.029	0.42CysSer: 0.42 ± 0.022	0.439CysThr: 0.439 ± 0.024	0.633CysVal: 0.633 ± 0.029	0.119CysTrp: 0.119 ± 0.011	0.199CysTyr: 0.199 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.009AspAla: 6.009 ± 0.086	0.363AspCys: 0.363 ± 0.02	2.782AspAsp: 2.782 ± 0.065	3.73AspGlu: 3.73 ± 0.069	2.042AspPhe: 2.042 ± 0.045	4.711AspGly: 4.711 ± 0.094	1.135AspHis: 1.135 ± 0.042	2.324AspIle: 2.324 ± 0.052	1.611AspLys: 1.611 ± 0.049	5.729AspLeu: 5.729 ± 0.089	1.164AspMet: 1.164 ± 0.036	1.39AspAsn: 1.39 ± 0.046	3.609AspPro: 3.609 ± 0.074	2.092AspGln: 2.092 ± 0.052	3.831AspArg: 3.831 ± 0.077	2.357AspSer: 2.357 ± 0.056	2.558AspThr: 2.558 ± 0.054	4.079AspVal: 4.079 ± 0.079	1.0AspTrp: 1.0 ± 0.04	1.436AspTyr: 1.436 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.307GluAla: 7.307 ± 0.125	0.449GluCys: 0.449 ± 0.025	3.106GluAsp: 3.106 ± 0.073	3.868GluGlu: 3.868 ± 0.092	2.365GluPhe: 2.365 ± 0.056	4.986GluGly: 4.986 ± 0.075	1.192GluHis: 1.192 ± 0.042	3.428GluIle: 3.428 ± 0.084	2.083GluLys: 2.083 ± 0.063	5.87GluLeu: 5.87 ± 0.092	1.707GluMet: 1.707 ± 0.049	1.834GluAsn: 1.834 ± 0.055	3.199GluPro: 3.199 ± 0.071	2.266GluGln: 2.266 ± 0.058	4.873GluArg: 4.873 ± 0.096	3.37GluSer: 3.37 ± 0.069	3.266GluThr: 3.266 ± 0.067	4.895GluVal: 4.895 ± 0.078	1.128GluTrp: 1.128 ± 0.04	1.332GluTyr: 1.332 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.932PheAla: 3.932 ± 0.078	0.32PheCys: 0.32 ± 0.02	2.326PheAsp: 2.326 ± 0.055	2.191PheGlu: 2.191 ± 0.046	1.368PhePhe: 1.368 ± 0.045	3.576PheGly: 3.576 ± 0.074	0.662PheHis: 0.662 ± 0.029	1.538PheIle: 1.538 ± 0.046	1.057PheLys: 1.057 ± 0.04	3.367PheLeu: 3.367 ± 0.064	0.768PheMet: 0.768 ± 0.028	1.13PheAsn: 1.13 ± 0.044	1.765PhePro: 1.765 ± 0.046	1.154PheGln: 1.154 ± 0.043	2.503PheArg: 2.503 ± 0.058	2.075PheSer: 2.075 ± 0.05	2.024PheThr: 2.024 ± 0.048	2.851PheVal: 2.851 ± 0.059	0.558PheTrp: 0.558 ± 0.029	0.935PheTyr: 0.935 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.233GlyAla: 8.233 ± 0.115	0.839GlyCys: 0.839 ± 0.034	4.475GlyAsp: 4.475 ± 0.086	5.008GlyGlu: 5.008 ± 0.075	3.356GlyPhe: 3.356 ± 0.075	7.429GlyGly: 7.429 ± 0.147	1.997GlyHis: 1.997 ± 0.05	4.013GlyIle: 4.013 ± 0.082	3.047GlyLys: 3.047 ± 0.068	8.169GlyLeu: 8.169 ± 0.128	2.403GlyMet: 2.403 ± 0.057	2.727GlyAsn: 2.727 ± 0.083	3.734GlyPro: 3.734 ± 0.072	3.661GlyGln: 3.661 ± 0.07	5.847GlyArg: 5.847 ± 0.1	4.582GlySer: 4.582 ± 0.08	5.426GlyThr: 5.426 ± 0.1	6.575GlyVal: 6.575 ± 0.106	1.653GlyTrp: 1.653 ± 0.054	2.551GlyTyr: 2.551 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.029HisAla: 2.029 ± 0.054	0.235HisCys: 0.235 ± 0.018	1.046HisAsp: 1.046 ± 0.042	1.263HisGlu: 1.263 ± 0.04	0.747HisPhe: 0.747 ± 0.034	1.796HisGly: 1.796 ± 0.058	0.565HisHis: 0.565 ± 0.033	0.91HisIle: 0.91 ± 0.036	0.476HisLys: 0.476 ± 0.025	2.109HisLeu: 2.109 ± 0.055	0.448HisMet: 0.448 ± 0.027	0.507HisAsn: 0.507 ± 0.025	1.432HisPro: 1.432 ± 0.046	0.724HisGln: 0.724 ± 0.029	1.468HisArg: 1.468 ± 0.051	0.912HisSer: 0.912 ± 0.036	1.037HisThr: 1.037 ± 0.039	1.431HisVal: 1.431 ± 0.043	0.366HisTrp: 0.366 ± 0.024	0.535HisTyr: 0.535 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.046IleAla: 5.046 ± 0.088	0.452IleCys: 0.452 ± 0.026	2.63IleAsp: 2.63 ± 0.057	3.389IleGlu: 3.389 ± 0.075	1.511IlePhe: 1.511 ± 0.046	4.14IleGly: 4.14 ± 0.086	1.023IleHis: 1.023 ± 0.033	1.863IleIle: 1.863 ± 0.054	1.465IleLys: 1.465 ± 0.043	4.214IleLeu: 4.214 ± 0.09	0.917IleMet: 0.917 ± 0.035	1.506IleAsn: 1.506 ± 0.041	2.546IlePro: 2.546 ± 0.058	1.713IleGln: 1.713 ± 0.049	3.252IleArg: 3.252 ± 0.065	2.621IleSer: 2.621 ± 0.065	2.705IleThr: 2.705 ± 0.067	3.6IleVal: 3.6 ± 0.07	0.641IleTrp: 0.641 ± 0.03	1.251IleTyr: 1.251 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.489LysAla: 3.489 ± 0.079	0.251LysCys: 0.251 ± 0.018	1.831LysAsp: 1.831 ± 0.054	2.166LysGlu: 2.166 ± 0.057	1.215LysPhe: 1.215 ± 0.047	2.603LysGly: 2.603 ± 0.061	0.593LysHis: 0.593 ± 0.027	1.436LysIle: 1.436 ± 0.047	1.292LysLys: 1.292 ± 0.049	2.87LysLeu: 2.87 ± 0.064	0.881LysMet: 0.881 ± 0.032	1.014LysAsn: 1.014 ± 0.041	1.882LysPro: 1.882 ± 0.05	1.173LysGln: 1.173 ± 0.041	2.222LysArg: 2.222 ± 0.062	1.952LysSer: 1.952 ± 0.055	1.947LysThr: 1.947 ± 0.051	2.516LysVal: 2.516 ± 0.059	0.558LysTrp: 0.558 ± 0.03	0.819LysTyr: 0.819 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.826LeuAla: 11.826 ± 0.162	0.807LeuCys: 0.807 ± 0.03	5.441LeuAsp: 5.441 ± 0.103	5.538LeuGlu: 5.538 ± 0.097	3.008LeuPhe: 3.008 ± 0.067	8.201LeuGly: 8.201 ± 0.116	1.684LeuHis: 1.684 ± 0.043	4.457LeuIle: 4.457 ± 0.084	3.521LeuLys: 3.521 ± 0.07	8.24LeuLeu: 8.24 ± 0.135	2.487LeuMet: 2.487 ± 0.06	3.197LeuAsn: 3.197 ± 0.07	4.955LeuPro: 4.955 ± 0.09	3.269LeuGln: 3.269 ± 0.073	6.878LeuArg: 6.878 ± 0.102	5.518LeuSer: 5.518 ± 0.09	5.696LeuThr: 5.696 ± 0.09	7.292LeuVal: 7.292 ± 0.126	1.239LeuTrp: 1.239 ± 0.048	2.01LeuTyr: 2.01 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.159MetAla: 3.159 ± 0.062	0.151MetCys: 0.151 ± 0.013	1.351MetAsp: 1.351 ± 0.046	1.49MetGlu: 1.49 ± 0.047	0.796MetPhe: 0.796 ± 0.034	2.263MetGly: 2.263 ± 0.054	0.438MetHis: 0.438 ± 0.028	1.311MetIle: 1.311 ± 0.038	1.028MetLys: 1.028 ± 0.032	2.194MetLeu: 2.194 ± 0.058	0.758MetMet: 0.758 ± 0.031	0.956MetAsn: 0.956 ± 0.035	1.563MetPro: 1.563 ± 0.041	0.899MetGln: 0.899 ± 0.041	1.963MetArg: 1.963 ± 0.056	1.688MetSer: 1.688 ± 0.045	1.653MetThr: 1.653 ± 0.047	2.041MetVal: 2.041 ± 0.052	0.352MetTrp: 0.352 ± 0.019	0.386MetTyr: 0.386 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.062AsnAla: 3.062 ± 0.064	0.214AsnCys: 0.214 ± 0.017	1.603AsnAsp: 1.603 ± 0.054	1.858AsnGlu: 1.858 ± 0.049	1.135AsnPhe: 1.135 ± 0.042	3.008AsnGly: 3.008 ± 0.083	0.597AsnHis: 0.597 ± 0.025	1.21AsnIle: 1.21 ± 0.04	0.825AsnLys: 0.825 ± 0.033	3.134AsnLeu: 3.134 ± 0.059	0.679AsnMet: 0.679 ± 0.034	0.922AsnAsn: 0.922 ± 0.042	2.552AsnPro: 2.552 ± 0.063	1.265AsnGln: 1.265 ± 0.041	2.114AsnArg: 2.114 ± 0.052	1.596AsnSer: 1.596 ± 0.051	1.656AsnThr: 1.656 ± 0.054	2.33AsnVal: 2.33 ± 0.061	0.587AsnTrp: 0.587 ± 0.029	0.905AsnTyr: 0.905 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.816ProAla: 5.816 ± 0.098	0.413ProCys: 0.413 ± 0.026	3.541ProAsp: 3.541 ± 0.064	4.157ProGlu: 4.157 ± 0.075	1.935ProPhe: 1.935 ± 0.054	4.976ProGly: 4.976 ± 0.093	1.161ProHis: 1.161 ± 0.037	2.293ProIle: 2.293 ± 0.053	1.801ProLys: 1.801 ± 0.049	4.737ProLeu: 4.737 ± 0.086	1.473ProMet: 1.473 ± 0.038	1.882ProAsn: 1.882 ± 0.054	2.539ProPro: 2.539 ± 0.077	1.934ProGln: 1.934 ± 0.054	3.037ProArg: 3.037 ± 0.068	2.95ProSer: 2.95 ± 0.068	3.317ProThr: 3.317 ± 0.075	4.544ProVal: 4.544 ± 0.081	0.906ProTrp: 0.906 ± 0.04	1.356ProTyr: 1.356 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.55GlnAla: 4.55 ± 0.08	0.26GlnCys: 0.26 ± 0.019	1.854GlnAsp: 1.854 ± 0.051	2.268GlnGlu: 2.268 ± 0.056	1.352GlnPhe: 1.352 ± 0.04	3.209GlnGly: 3.209 ± 0.063	0.642GlnHis: 0.642 ± 0.029	2.003GlnIle: 2.003 ± 0.052	1.016GlnLys: 1.016 ± 0.035	3.27GlnLeu: 3.27 ± 0.066	1.113GlnMet: 1.113 ± 0.044	1.142GlnAsn: 1.142 ± 0.037	1.972GlnPro: 1.972 ± 0.044	1.404GlnGln: 1.404 ± 0.056	2.844GlnArg: 2.844 ± 0.069	2.095GlnSer: 2.095 ± 0.058	2.103GlnThr: 2.103 ± 0.054	3.121GlnVal: 3.121 ± 0.057	0.732GlnTrp: 0.732 ± 0.027	0.903GlnTyr: 0.903 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	7.159ArgAla: 7.159 ± 0.102	0.489ArgCys: 0.489 ± 0.024	3.629ArgAsp: 3.629 ± 0.083	4.489ArgGlu: 4.489 ± 0.087	2.548ArgPhe: 2.548 ± 0.06	4.862ArgGly: 4.862 ± 0.078	1.433ArgHis: 1.433 ± 0.045	3.788ArgIle: 3.788 ± 0.074	2.106ArgLys: 2.106 ± 0.055	7.018ArgLeu: 7.018 ± 0.118	2.166ArgMet: 2.166 ± 0.05	2.166ArgAsn: 2.166 ± 0.055	3.844ArgPro: 3.844 ± 0.081	2.849ArgGln: 2.849 ± 0.067	5.418ArgArg: 5.418 ± 0.099	3.497ArgSer: 3.497 ± 0.067	4.182ArgThr: 4.182 ± 0.073	5.392ArgVal: 5.392 ± 0.08	1.177ArgTrp: 1.177 ± 0.038	1.796ArgTyr: 1.796 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.416SerAla: 5.416 ± 0.092	0.421SerCys: 0.421 ± 0.022	2.685SerAsp: 2.685 ± 0.062	3.174SerGlu: 3.174 ± 0.063	2.05SerPhe: 2.05 ± 0.05	5.319SerGly: 5.319 ± 0.091	1.066SerHis: 1.066 ± 0.041	2.305SerIle: 2.305 ± 0.057	1.622SerLys: 1.622 ± 0.05	5.784SerLeu: 5.784 ± 0.089	1.513SerMet: 1.513 ± 0.046	1.667SerAsn: 1.667 ± 0.052	3.141SerPro: 3.141 ± 0.063	2.092SerGln: 2.092 ± 0.051	3.594SerArg: 3.594 ± 0.068	3.103SerSer: 3.103 ± 0.067	3.004SerThr: 3.004 ± 0.072	4.09SerVal: 4.09 ± 0.069	0.807SerTrp: 0.807 ± 0.035	1.475SerTyr: 1.475 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.495ThrAla: 5.495 ± 0.088	0.413ThrCys: 0.413 ± 0.023	2.912ThrAsp: 2.912 ± 0.055	3.344ThrGlu: 3.344 ± 0.057	2.287ThrPhe: 2.287 ± 0.056	5.257ThrGly: 5.257 ± 0.102	1.139ThrHis: 1.139 ± 0.043	2.721ThrIle: 2.721 ± 0.057	1.833ThrLys: 1.833 ± 0.049	5.904ThrLeu: 5.904 ± 0.097	1.463ThrMet: 1.463 ± 0.047	1.803ThrAsn: 1.803 ± 0.057	3.717ThrPro: 3.717 ± 0.077	2.035ThrGln: 2.035 ± 0.054	3.395ThrArg: 3.395 ± 0.068	3.336ThrSer: 3.336 ± 0.086	3.645ThrThr: 3.645 ± 0.098	4.596ThrVal: 4.596 ± 0.087	1.016ThrTrp: 1.016 ± 0.04	1.781ThrTyr: 1.781 ± 0.076	0.0ThrXaa: 0.0 ± 0.0
Val	8.357ValAla: 8.357 ± 0.114	0.659ValCys: 0.659 ± 0.03	4.222ValAsp: 4.222 ± 0.077	4.414ValGlu: 4.414 ± 0.079	2.721ValPhe: 2.721 ± 0.064	6.145ValGly: 6.145 ± 0.102	1.412ValHis: 1.412 ± 0.049	3.757ValIle: 3.757 ± 0.081	2.579ValLys: 2.579 ± 0.065	6.88ValLeu: 6.88 ± 0.102	1.93ValMet: 1.93 ± 0.052	2.556ValAsn: 2.556 ± 0.056	4.27ValPro: 4.27 ± 0.075	2.748ValGln: 2.748 ± 0.06	5.799ValArg: 5.799 ± 0.099	4.316ValSer: 4.316 ± 0.074	4.924ValThr: 4.924 ± 0.088	6.481ValVal: 6.481 ± 0.1	1.087ValTrp: 1.087 ± 0.039	1.766ValTyr: 1.766 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.568TrpAla: 1.568 ± 0.053	0.15TrpCys: 0.15 ± 0.014	0.817TrpAsp: 0.817 ± 0.04	0.86TrpGlu: 0.86 ± 0.035	0.633TrpPhe: 0.633 ± 0.028	1.188TrpGly: 1.188 ± 0.042	0.4TrpHis: 0.4 ± 0.023	0.732TrpIle: 0.732 ± 0.031	0.531TrpLys: 0.531 ± 0.028	1.577TrpLeu: 1.577 ± 0.049	0.539TrpMet: 0.539 ± 0.026	0.599TrpAsn: 0.599 ± 0.028	0.853TrpPro: 0.853 ± 0.037	0.781TrpGln: 0.781 ± 0.033	1.25TrpArg: 1.25 ± 0.042	1.011TrpSer: 1.011 ± 0.041	0.951TrpThr: 0.951 ± 0.041	1.283TrpVal: 1.283 ± 0.042	0.314TrpTrp: 0.314 ± 0.022	0.373TrpTyr: 0.373 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.579TyrAla: 2.579 ± 0.055	0.262TyrCys: 0.262 ± 0.018	1.746TyrAsp: 1.746 ± 0.068	1.63TyrGlu: 1.63 ± 0.043	0.923TyrPhe: 0.923 ± 0.032	2.227TyrGly: 2.227 ± 0.052	0.524TyrHis: 0.524 ± 0.024	0.998TyrIle: 0.998 ± 0.036	0.681TyrLys: 0.681 ± 0.032	2.277TyrLeu: 2.277 ± 0.058	0.508TyrMet: 0.508 ± 0.026	0.887TyrAsn: 0.887 ± 0.045	1.221TyrPro: 1.221 ± 0.042	1.007TyrGln: 1.007 ± 0.038	1.902TyrArg: 1.902 ± 0.054	1.356TyrSer: 1.356 ± 0.041	1.375TyrThr: 1.375 ± 0.05	1.851TyrVal: 1.851 ± 0.051	0.397TyrTrp: 0.397 ± 0.021	0.646TyrTyr: 0.646 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2524 proteins (792677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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