Amino acid dipepetide frequency for Candidatus Poseidoniales archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.773AlaAla: 6.773 ± 0.158	0.968AlaCys: 0.968 ± 0.044	4.631AlaAsp: 4.631 ± 0.104	5.035AlaGlu: 5.035 ± 0.112	2.689AlaPhe: 2.689 ± 0.089	6.36AlaGly: 6.36 ± 0.112	1.549AlaHis: 1.549 ± 0.056	5.462AlaIle: 5.462 ± 0.111	3.668AlaLys: 3.668 ± 0.109	7.055AlaLeu: 7.055 ± 0.142	2.434AlaMet: 2.434 ± 0.077	3.335AlaAsn: 3.335 ± 0.091	3.023AlaPro: 3.023 ± 0.087	2.244AlaGln: 2.244 ± 0.06	3.768AlaArg: 3.768 ± 0.094	5.272AlaSer: 5.272 ± 0.1	4.456AlaThr: 4.456 ± 0.097	4.908AlaVal: 4.908 ± 0.104	1.579AlaTrp: 1.579 ± 0.054	1.604AlaTyr: 1.604 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.793CysAla: 0.793 ± 0.041	0.135CysCys: 0.135 ± 0.014	0.94CysAsp: 0.94 ± 0.048	0.801CysGlu: 0.801 ± 0.038	0.392CysPhe: 0.392 ± 0.024	1.12CysGly: 1.12 ± 0.042	0.287CysHis: 0.287 ± 0.022	0.659CysIle: 0.659 ± 0.038	0.421CysLys: 0.421 ± 0.028	0.962CysLeu: 0.962 ± 0.037	0.254CysMet: 0.254 ± 0.023	0.472CysAsn: 0.472 ± 0.031	0.83CysPro: 0.83 ± 0.053	0.329CysGln: 0.329 ± 0.024	0.499CysArg: 0.499 ± 0.029	0.785CysSer: 0.785 ± 0.038	0.654CysThr: 0.654 ± 0.039	0.641CysVal: 0.641 ± 0.03	0.197CysTrp: 0.197 ± 0.019	0.275CysTyr: 0.275 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	5.242AspAla: 5.242 ± 0.113	0.873AspCys: 0.873 ± 0.045	5.664AspAsp: 5.664 ± 0.18	5.728AspGlu: 5.728 ± 0.103	2.451AspPhe: 2.451 ± 0.071	7.586AspGly: 7.586 ± 0.244	1.349AspHis: 1.349 ± 0.062	4.224AspIle: 4.224 ± 0.078	2.194AspLys: 2.194 ± 0.068	6.457AspLeu: 6.457 ± 0.097	1.851AspMet: 1.851 ± 0.054	2.885AspAsn: 2.885 ± 0.115	2.935AspPro: 2.935 ± 0.103	1.651AspGln: 1.651 ± 0.056	2.88AspArg: 2.88 ± 0.073	5.527AspSer: 5.527 ± 0.13	3.16AspThr: 3.16 ± 0.091	4.848AspVal: 4.848 ± 0.108	1.694AspTrp: 1.694 ± 0.056	1.79AspTyr: 1.79 ± 0.06	0.002AspXaa: 0.002 ± 0.002
Glu	5.294GluAla: 5.294 ± 0.123	0.664GluCys: 0.664 ± 0.035	4.911GluAsp: 4.911 ± 0.094	5.993GluGlu: 5.993 ± 0.16	2.382GluPhe: 2.382 ± 0.065	5.095GluGly: 5.095 ± 0.101	1.462GluHis: 1.462 ± 0.058	5.31GluIle: 5.31 ± 0.103	2.936GluLys: 2.936 ± 0.088	6.232GluLeu: 6.232 ± 0.113	2.633GluMet: 2.633 ± 0.066	3.332GluAsn: 3.332 ± 0.077	2.364GluPro: 2.364 ± 0.087	2.113GluGln: 2.113 ± 0.063	3.247GluArg: 3.247 ± 0.092	4.835GluSer: 4.835 ± 0.094	3.372GluThr: 3.372 ± 0.082	5.127GluVal: 5.127 ± 0.095	1.421GluTrp: 1.421 ± 0.053	1.761GluTyr: 1.761 ± 0.058	0.002GluXaa: 0.002 ± 0.002
Phe	2.776PheAla: 2.776 ± 0.081	0.411PheCys: 0.411 ± 0.029	2.755PheAsp: 2.755 ± 0.082	2.619PheGlu: 2.619 ± 0.069	1.192PhePhe: 1.192 ± 0.05	3.052PheGly: 3.052 ± 0.078	0.733PheHis: 0.733 ± 0.032	2.187PheIle: 2.187 ± 0.07	1.189PheLys: 1.189 ± 0.047	2.903PheLeu: 2.903 ± 0.09	0.876PheMet: 0.876 ± 0.04	1.417PheAsn: 1.417 ± 0.053	1.442PhePro: 1.442 ± 0.065	1.035PheGln: 1.035 ± 0.042	1.431PheArg: 1.431 ± 0.051	2.766PheSer: 2.766 ± 0.074	2.187PheThr: 2.187 ± 0.057	2.442PheVal: 2.442 ± 0.074	0.518PheTrp: 0.518 ± 0.028	0.815PheTyr: 0.815 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.81GlyAla: 5.81 ± 0.11	1.19GlyCys: 1.19 ± 0.065	6.185GlyAsp: 6.185 ± 0.167	5.467GlyGlu: 5.467 ± 0.095	3.123GlyPhe: 3.123 ± 0.076	6.639GlyGly: 6.639 ± 0.133	1.86GlyHis: 1.86 ± 0.061	6.077GlyIle: 6.077 ± 0.113	3.501GlyLys: 3.501 ± 0.094	7.269GlyLeu: 7.269 ± 0.15	2.649GlyMet: 2.649 ± 0.075	3.477GlyAsn: 3.477 ± 0.102	2.751GlyPro: 2.751 ± 0.082	2.561GlyGln: 2.561 ± 0.073	3.709GlyArg: 3.709 ± 0.102	5.439GlySer: 5.439 ± 0.133	4.586GlyThr: 4.586 ± 0.115	5.648GlyVal: 5.648 ± 0.103	1.781GlyTrp: 1.781 ± 0.065	2.237GlyTyr: 2.237 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.449HisAla: 1.449 ± 0.056	0.304HisCys: 0.304 ± 0.024	1.497HisAsp: 1.497 ± 0.06	1.341HisGlu: 1.341 ± 0.048	0.758HisPhe: 0.758 ± 0.033	1.775HisGly: 1.775 ± 0.07	0.676HisHis: 0.676 ± 0.038	1.342HisIle: 1.342 ± 0.051	0.726HisLys: 0.726 ± 0.036	2.277HisLeu: 2.277 ± 0.072	0.554HisMet: 0.554 ± 0.029	0.775HisAsn: 0.775 ± 0.037	1.267HisPro: 1.267 ± 0.052	0.694HisGln: 0.694 ± 0.035	1.189HisArg: 1.189 ± 0.048	1.524HisSer: 1.524 ± 0.059	1.035HisThr: 1.035 ± 0.044	1.477HisVal: 1.477 ± 0.052	0.402HisTrp: 0.402 ± 0.026	0.611HisTyr: 0.611 ± 0.035	0.002HisXaa: 0.002 ± 0.001
Ile	5.509IleAla: 5.509 ± 0.111	0.828IleCys: 0.828 ± 0.039	5.416IleAsp: 5.416 ± 0.11	5.113IleGlu: 5.113 ± 0.106	2.227IlePhe: 2.227 ± 0.071	5.317IleGly: 5.317 ± 0.126	1.669IleHis: 1.669 ± 0.047	4.312IleIle: 4.312 ± 0.098	2.105IleLys: 2.105 ± 0.059	5.885IleLeu: 5.885 ± 0.129	1.591IleMet: 1.591 ± 0.058	2.521IleAsn: 2.521 ± 0.075	3.274IlePro: 3.274 ± 0.069	2.038IleGln: 2.038 ± 0.064	2.925IleArg: 2.925 ± 0.081	5.464IleSer: 5.464 ± 0.106	3.955IleThr: 3.955 ± 0.097	4.721IleVal: 4.721 ± 0.097	0.997IleTrp: 0.997 ± 0.04	1.331IleTyr: 1.331 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.282LysAla: 3.282 ± 0.099	0.369LysCys: 0.369 ± 0.025	2.369LysAsp: 2.369 ± 0.082	2.746LysGlu: 2.746 ± 0.084	1.197LysPhe: 1.197 ± 0.044	3.025LysGly: 3.025 ± 0.083	0.831LysHis: 0.831 ± 0.041	2.623LysIle: 2.623 ± 0.081	2.277LysLys: 2.277 ± 0.087	3.446LysLeu: 3.446 ± 0.106	1.282LysMet: 1.282 ± 0.049	1.432LysAsn: 1.432 ± 0.056	1.74LysPro: 1.74 ± 0.062	1.396LysGln: 1.396 ± 0.056	2.259LysArg: 2.259 ± 0.079	2.995LysSer: 2.995 ± 0.084	2.005LysThr: 2.005 ± 0.066	2.84LysVal: 2.84 ± 0.073	0.73LysTrp: 0.73 ± 0.036	0.903LysTyr: 0.903 ± 0.034	0.002LysXaa: 0.002 ± 0.002
Leu	7.835LeuAla: 7.835 ± 0.154	0.928LeuCys: 0.928 ± 0.038	6.656LeuAsp: 6.656 ± 0.14	6.704LeuGlu: 6.704 ± 0.132	3.083LeuPhe: 3.083 ± 0.084	6.753LeuGly: 6.753 ± 0.136	1.86LeuHis: 1.86 ± 0.055	5.856LeuIle: 5.856 ± 0.128	3.411LeuLys: 3.411 ± 0.095	8.215LeuLeu: 8.215 ± 0.18	2.527LeuMet: 2.527 ± 0.069	3.412LeuAsn: 3.412 ± 0.076	4.377LeuPro: 4.377 ± 0.097	2.678LeuGln: 2.678 ± 0.069	4.138LeuArg: 4.138 ± 0.108	7.037LeuSer: 7.037 ± 0.126	4.985LeuThr: 4.985 ± 0.103	6.496LeuVal: 6.496 ± 0.116	1.322LeuTrp: 1.322 ± 0.048	1.853LeuTyr: 1.853 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.616MetAla: 2.616 ± 0.066	0.28MetCys: 0.28 ± 0.023	1.828MetAsp: 1.828 ± 0.05	1.836MetGlu: 1.836 ± 0.057	0.993MetPhe: 0.993 ± 0.044	2.259MetGly: 2.259 ± 0.057	0.646MetHis: 0.646 ± 0.033	1.967MetIle: 1.967 ± 0.064	1.185MetLys: 1.185 ± 0.042	2.699MetLeu: 2.699 ± 0.077	0.982MetMet: 0.982 ± 0.045	1.195MetAsn: 1.195 ± 0.046	1.421MetPro: 1.421 ± 0.055	0.896MetGln: 0.896 ± 0.041	1.546MetArg: 1.546 ± 0.054	2.167MetSer: 2.167 ± 0.056	1.666MetThr: 1.666 ± 0.064	2.077MetVal: 2.077 ± 0.058	0.409MetTrp: 0.409 ± 0.032	0.646MetTyr: 0.646 ± 0.035	0.002MetXaa: 0.002 ± 0.002
Asn	3.179AsnAla: 3.179 ± 0.083	0.534AsnCys: 0.534 ± 0.029	2.988AsnAsp: 2.988 ± 0.123	2.459AsnGlu: 2.459 ± 0.066	1.234AsnPhe: 1.234 ± 0.052	4.085AsnGly: 4.085 ± 0.11	1.007AsnHis: 1.007 ± 0.041	2.579AsnIle: 2.579 ± 0.073	1.326AsnLys: 1.326 ± 0.045	3.853AsnLeu: 3.853 ± 0.077	1.11AsnMet: 1.11 ± 0.044	2.007AsnAsn: 2.007 ± 0.081	2.532AsnPro: 2.532 ± 0.068	1.586AsnGln: 1.586 ± 0.051	1.875AsnArg: 1.875 ± 0.063	3.466AsnSer: 3.466 ± 0.098	2.26AsnThr: 2.26 ± 0.089	2.743AsnVal: 2.743 ± 0.077	0.918AsnTrp: 0.918 ± 0.041	1.119AsnTyr: 1.119 ± 0.053	0.002AsnXaa: 0.002 ± 0.002
Pro	2.975ProAla: 2.975 ± 0.088	0.417ProCys: 0.417 ± 0.028	3.269ProAsp: 3.269 ± 0.101	3.718ProGlu: 3.718 ± 0.091	1.591ProPhe: 1.591 ± 0.059	3.476ProGly: 3.476 ± 0.088	0.906ProHis: 0.906 ± 0.038	2.631ProIle: 2.631 ± 0.079	1.674ProLys: 1.674 ± 0.065	3.731ProLeu: 3.731 ± 0.079	1.127ProMet: 1.127 ± 0.043	1.831ProAsn: 1.831 ± 0.066	1.868ProPro: 1.868 ± 0.076	1.159ProGln: 1.159 ± 0.04	1.81ProArg: 1.81 ± 0.063	3.357ProSer: 3.357 ± 0.086	2.536ProThr: 2.536 ± 0.076	3.302ProVal: 3.302 ± 0.091	0.841ProTrp: 0.841 ± 0.04	1.07ProTyr: 1.07 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.347GlnAla: 2.347 ± 0.073	0.289GlnCys: 0.289 ± 0.022	1.781GlnAsp: 1.781 ± 0.06	1.92GlnGlu: 1.92 ± 0.062	1.112GlnPhe: 1.112 ± 0.041	2.237GlnGly: 2.237 ± 0.066	0.608GlnHis: 0.608 ± 0.029	2.088GlnIle: 2.088 ± 0.064	1.352GlnLys: 1.352 ± 0.055	2.673GlnLeu: 2.673 ± 0.079	0.983GlnMet: 0.983 ± 0.046	1.437GlnAsn: 1.437 ± 0.048	1.262GlnPro: 1.262 ± 0.049	1.129GlnGln: 1.129 ± 0.078	1.649GlnArg: 1.649 ± 0.05	2.205GlnSer: 2.205 ± 0.069	1.746GlnThr: 1.746 ± 0.053	2.053GlnVal: 2.053 ± 0.063	0.649GlnTrp: 0.649 ± 0.047	0.815GlnTyr: 0.815 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.192ArgAla: 3.192 ± 0.085	0.529ArgCys: 0.529 ± 0.034	2.893ArgAsp: 2.893 ± 0.074	2.99ArgGlu: 2.99 ± 0.09	1.798ArgPhe: 1.798 ± 0.062	3.239ArgGly: 3.239 ± 0.085	1.07ArgHis: 1.07 ± 0.04	3.426ArgIle: 3.426 ± 0.089	2.28ArgLys: 2.28 ± 0.071	4.754ArgLeu: 4.754 ± 0.121	1.544ArgMet: 1.544 ± 0.052	1.987ArgAsn: 1.987 ± 0.055	1.803ArgPro: 1.803 ± 0.066	1.461ArgGln: 1.461 ± 0.053	3.055ArgArg: 3.055 ± 0.096	2.94ArgSer: 2.94 ± 0.084	2.446ArgThr: 2.446 ± 0.067	3.133ArgVal: 3.133 ± 0.08	0.841ArgTrp: 0.841 ± 0.037	1.157ArgTyr: 1.157 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.02SerAla: 5.02 ± 0.092	0.855SerCys: 0.855 ± 0.037	5.148SerAsp: 5.148 ± 0.126	4.931SerGlu: 4.931 ± 0.102	2.521SerPhe: 2.521 ± 0.067	6.804SerGly: 6.804 ± 0.144	1.461SerHis: 1.461 ± 0.053	4.943SerIle: 4.943 ± 0.11	3.185SerLys: 3.185 ± 0.089	6.576SerLeu: 6.576 ± 0.127	2.229SerMet: 2.229 ± 0.065	3.781SerAsn: 3.781 ± 0.098	2.952SerPro: 2.952 ± 0.073	2.462SerGln: 2.462 ± 0.059	3.309SerArg: 3.309 ± 0.085	5.978SerSer: 5.978 ± 0.175	4.444SerThr: 4.444 ± 0.122	4.659SerVal: 4.659 ± 0.096	1.634SerTrp: 1.634 ± 0.056	1.629SerTyr: 1.629 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.01ThrAla: 4.01 ± 0.075	0.618ThrCys: 0.618 ± 0.032	3.584ThrAsp: 3.584 ± 0.112	3.157ThrGlu: 3.157 ± 0.069	2.133ThrPhe: 2.133 ± 0.073	4.893ThrGly: 4.893 ± 0.119	1.204ThrHis: 1.204 ± 0.048	4.244ThrIle: 4.244 ± 0.095	1.901ThrLys: 1.901 ± 0.059	5.135ThrLeu: 5.135 ± 0.105	1.549ThrMet: 1.549 ± 0.061	2.462ThrAsn: 2.462 ± 0.084	2.818ThrPro: 2.818 ± 0.071	1.604ThrGln: 1.604 ± 0.054	2.29ThrArg: 2.29 ± 0.066	4.179ThrSer: 4.179 ± 0.131	3.366ThrThr: 3.366 ± 0.101	4.073ThrVal: 4.073 ± 0.098	1.249ThrTrp: 1.249 ± 0.055	1.502ThrTyr: 1.502 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	5.626ValAla: 5.626 ± 0.111	0.728ValCys: 0.728 ± 0.037	5.155ValAsp: 5.155 ± 0.105	5.262ValGlu: 5.262 ± 0.094	2.254ValPhe: 2.254 ± 0.068	4.828ValGly: 4.828 ± 0.106	1.574ValHis: 1.574 ± 0.058	4.783ValIle: 4.783 ± 0.093	2.78ValLys: 2.78 ± 0.079	6.212ValLeu: 6.212 ± 0.119	1.95ValMet: 1.95 ± 0.066	2.965ValAsn: 2.965 ± 0.079	2.845ValPro: 2.845 ± 0.075	1.891ValGln: 1.891 ± 0.062	3.008ValArg: 3.008 ± 0.082	5.047ValSer: 5.047 ± 0.11	4.399ValThr: 4.399 ± 0.12	4.92ValVal: 4.92 ± 0.121	1.117ValTrp: 1.117 ± 0.048	1.512ValTyr: 1.512 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.391TrpAla: 1.391 ± 0.051	0.18TrpCys: 0.18 ± 0.018	1.302TrpAsp: 1.302 ± 0.063	1.139TrpGlu: 1.139 ± 0.047	0.725TrpPhe: 0.725 ± 0.038	1.229TrpGly: 1.229 ± 0.043	0.351TrpHis: 0.351 ± 0.025	1.232TrpIle: 1.232 ± 0.046	0.911TrpLys: 0.911 ± 0.035	1.726TrpLeu: 1.726 ± 0.064	0.616TrpMet: 0.616 ± 0.036	1.139TrpAsn: 1.139 ± 0.047	0.698TrpPro: 0.698 ± 0.041	0.634TrpGln: 0.634 ± 0.035	0.863TrpArg: 0.863 ± 0.038	1.588TrpSer: 1.588 ± 0.059	1.31TrpThr: 1.31 ± 0.056	1.189TrpVal: 1.189 ± 0.048	0.439TrpTrp: 0.439 ± 0.032	0.536TrpTyr: 0.536 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.698TyrAla: 1.698 ± 0.051	0.346TyrCys: 0.346 ± 0.027	2.015TyrAsp: 2.015 ± 0.068	1.528TyrGlu: 1.528 ± 0.061	0.89TyrPhe: 0.89 ± 0.047	2.189TyrGly: 2.189 ± 0.063	0.571TyrHis: 0.571 ± 0.038	1.252TyrIle: 1.252 ± 0.046	0.725TyrLys: 0.725 ± 0.034	2.068TyrLeu: 2.068 ± 0.062	0.573TyrMet: 0.573 ± 0.032	0.995TyrAsn: 0.995 ± 0.052	1.085TyrPro: 1.085 ± 0.049	0.773TyrGln: 0.773 ± 0.039	1.088TyrArg: 1.088 ± 0.043	1.953TyrSer: 1.953 ± 0.064	1.404TyrThr: 1.404 ± 0.059	1.558TyrVal: 1.558 ± 0.063	0.457TyrTrp: 0.457 ± 0.032	0.75TyrTyr: 0.75 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.002XaaHis: 0.002 ± 0.002	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.003XaaPro: 0.003 ± 0.003	0.002XaaGln: 0.002 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1593 proteins (599017 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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