Amino acid dipepetide frequency for Loktanella fryxellensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.651AlaAla: 20.651 ± 0.247	1.24AlaCys: 1.24 ± 0.033	9.307AlaAsp: 9.307 ± 0.115	6.428AlaGlu: 6.428 ± 0.079	4.409AlaPhe: 4.409 ± 0.062	12.093AlaGly: 12.093 ± 0.142	2.552AlaHis: 2.552 ± 0.064	6.311AlaIle: 6.311 ± 0.085	2.914AlaLys: 2.914 ± 0.068	14.851AlaLeu: 14.851 ± 0.155	4.244AlaMet: 4.244 ± 0.068	2.618AlaAsn: 2.618 ± 0.046	6.63AlaPro: 6.63 ± 0.118	5.442AlaGln: 5.442 ± 0.085	9.617AlaArg: 9.617 ± 0.115	5.474AlaSer: 5.474 ± 0.07	8.129AlaThr: 8.129 ± 0.108	10.133AlaVal: 10.133 ± 0.119	1.577AlaTrp: 1.577 ± 0.04	2.536AlaTyr: 2.536 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.164CysAla: 1.164 ± 0.034	0.106CysCys: 0.106 ± 0.01	0.684CysAsp: 0.684 ± 0.026	0.343CysGlu: 0.343 ± 0.018	0.273CysPhe: 0.273 ± 0.016	0.955CysGly: 0.955 ± 0.035	0.245CysHis: 0.245 ± 0.013	0.423CysIle: 0.423 ± 0.02	0.147CysLys: 0.147 ± 0.012	0.792CysLeu: 0.792 ± 0.027	0.186CysMet: 0.186 ± 0.013	0.179CysAsn: 0.179 ± 0.012	0.475CysPro: 0.475 ± 0.021	0.224CysGln: 0.224 ± 0.013	0.569CysArg: 0.569 ± 0.025	0.333CysSer: 0.333 ± 0.019	0.515CysThr: 0.515 ± 0.021	0.61CysVal: 0.61 ± 0.025	0.093CysTrp: 0.093 ± 0.01	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.913AspAla: 9.913 ± 0.122	0.517AspCys: 0.517 ± 0.022	4.384AspAsp: 4.384 ± 0.097	2.655AspGlu: 2.655 ± 0.054	2.224AspPhe: 2.224 ± 0.043	6.702AspGly: 6.702 ± 0.099	1.587AspHis: 1.587 ± 0.044	3.004AspIle: 3.004 ± 0.058	1.386AspLys: 1.386 ± 0.045	7.135AspLeu: 7.135 ± 0.083	1.87AspMet: 1.87 ± 0.049	1.273AspAsn: 1.273 ± 0.036	4.152AspPro: 4.152 ± 0.064	2.021AspGln: 2.021 ± 0.041	5.356AspArg: 5.356 ± 0.082	2.113AspSer: 2.113 ± 0.049	3.871AspThr: 3.871 ± 0.081	4.924AspVal: 4.924 ± 0.074	1.284AspTrp: 1.284 ± 0.036	1.496AspTyr: 1.496 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.21GluAla: 6.21 ± 0.09	0.243GluCys: 0.243 ± 0.015	2.453GluAsp: 2.453 ± 0.055	2.242GluGlu: 2.242 ± 0.049	1.243GluPhe: 1.243 ± 0.035	3.606GluGly: 3.606 ± 0.059	0.822GluHis: 0.822 ± 0.031	2.623GluIle: 2.623 ± 0.052	1.269GluLys: 1.269 ± 0.041	3.596GluLeu: 3.596 ± 0.072	1.421GluMet: 1.421 ± 0.034	1.16GluAsn: 1.16 ± 0.036	1.841GluPro: 1.841 ± 0.044	1.48GluGln: 1.48 ± 0.039	3.215GluArg: 3.215 ± 0.062	1.59GluSer: 1.59 ± 0.036	2.823GluThr: 2.823 ± 0.054	3.767GluVal: 3.767 ± 0.059	0.513GluTrp: 0.513 ± 0.024	0.762GluTyr: 0.762 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.825PheAla: 4.825 ± 0.073	0.381PheCys: 0.381 ± 0.018	2.854PheAsp: 2.854 ± 0.05	1.645PheGlu: 1.645 ± 0.042	1.18PhePhe: 1.18 ± 0.039	3.582PheGly: 3.582 ± 0.069	0.735PheHis: 0.735 ± 0.028	1.431PheIle: 1.431 ± 0.033	0.717PheLys: 0.717 ± 0.032	2.986PheLeu: 2.986 ± 0.066	0.82PheMet: 0.82 ± 0.031	0.876PheAsn: 0.876 ± 0.034	1.442PhePro: 1.442 ± 0.035	0.915PheGln: 0.915 ± 0.031	2.03PheArg: 2.03 ± 0.045	1.605PheSer: 1.605 ± 0.042	2.067PheThr: 2.067 ± 0.043	2.66PheVal: 2.66 ± 0.055	0.516PheTrp: 0.516 ± 0.021	0.901PheTyr: 0.901 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.471GlyAla: 10.471 ± 0.123	0.872GlyCys: 0.872 ± 0.03	5.685GlyAsp: 5.685 ± 0.099	3.567GlyGlu: 3.567 ± 0.068	3.411GlyPhe: 3.411 ± 0.061	7.856GlyGly: 7.856 ± 0.146	2.043GlyHis: 2.043 ± 0.044	4.603GlyIle: 4.603 ± 0.07	2.319GlyLys: 2.319 ± 0.057	9.419GlyLeu: 9.419 ± 0.119	2.502GlyMet: 2.502 ± 0.05	2.175GlyAsn: 2.175 ± 0.08	4.128GlyPro: 4.128 ± 0.066	3.467GlyGln: 3.467 ± 0.071	6.195GlyArg: 6.195 ± 0.075	4.104GlySer: 4.104 ± 0.073	5.783GlyThr: 5.783 ± 0.102	6.657GlyVal: 6.657 ± 0.093	1.531GlyTrp: 1.531 ± 0.044	2.22GlyTyr: 2.22 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.819HisAla: 2.819 ± 0.064	0.232HisCys: 0.232 ± 0.017	1.563HisAsp: 1.563 ± 0.045	0.761HisGlu: 0.761 ± 0.029	0.742HisPhe: 0.742 ± 0.024	2.043HisGly: 2.043 ± 0.049	0.62HisHis: 0.62 ± 0.03	0.958HisIle: 0.958 ± 0.027	0.42HisLys: 0.42 ± 0.021	2.267HisLeu: 2.267 ± 0.052	0.548HisMet: 0.548 ± 0.023	0.421HisAsn: 0.421 ± 0.023	1.415HisPro: 1.415 ± 0.041	0.532HisGln: 0.532 ± 0.025	1.515HisArg: 1.515 ± 0.043	0.68HisSer: 0.68 ± 0.027	0.959HisThr: 0.959 ± 0.031	1.721HisVal: 1.721 ± 0.042	0.344HisTrp: 0.344 ± 0.018	0.513HisTyr: 0.513 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.038IleAla: 8.038 ± 0.097	0.527IleCys: 0.527 ± 0.026	3.689IleAsp: 3.689 ± 0.061	2.505IleGlu: 2.505 ± 0.056	1.523IlePhe: 1.523 ± 0.044	4.836IleGly: 4.836 ± 0.079	0.931IleHis: 0.931 ± 0.029	1.936IleIle: 1.936 ± 0.052	1.109IleLys: 1.109 ± 0.04	4.477IleLeu: 4.477 ± 0.074	1.136IleMet: 1.136 ± 0.032	1.155IleAsn: 1.155 ± 0.036	2.278IlePro: 2.278 ± 0.053	1.016IleGln: 1.016 ± 0.034	3.198IleArg: 3.198 ± 0.059	2.214IleSer: 2.214 ± 0.046	2.988IleThr: 2.988 ± 0.058	4.256IleVal: 4.256 ± 0.061	0.663IleTrp: 0.663 ± 0.026	1.073IleTyr: 1.073 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.095LysAla: 3.095 ± 0.074	0.123LysCys: 0.123 ± 0.01	1.385LysAsp: 1.385 ± 0.04	0.924LysGlu: 0.924 ± 0.037	0.677LysPhe: 0.677 ± 0.028	2.03LysGly: 2.03 ± 0.05	0.461LysHis: 0.461 ± 0.021	1.146LysIle: 1.146 ± 0.038	0.784LysLys: 0.784 ± 0.035	2.15LysLeu: 2.15 ± 0.057	0.609LysMet: 0.609 ± 0.027	0.549LysAsn: 0.549 ± 0.025	1.409LysPro: 1.409 ± 0.049	0.635LysGln: 0.635 ± 0.029	1.662LysArg: 1.662 ± 0.052	1.31LysSer: 1.31 ± 0.038	1.463LysThr: 1.463 ± 0.042	1.795LysVal: 1.795 ± 0.052	0.278LysTrp: 0.278 ± 0.017	0.437LysTyr: 0.437 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.626LeuAla: 13.626 ± 0.152	0.934LeuCys: 0.934 ± 0.032	6.502LeuAsp: 6.502 ± 0.078	3.813LeuGlu: 3.813 ± 0.064	3.343LeuPhe: 3.343 ± 0.062	8.21LeuGly: 8.21 ± 0.097	2.075LeuHis: 2.075 ± 0.05	5.288LeuIle: 5.288 ± 0.082	2.337LeuLys: 2.337 ± 0.058	9.215LeuLeu: 9.215 ± 0.132	2.671LeuMet: 2.671 ± 0.046	2.417LeuAsn: 2.417 ± 0.048	5.718LeuPro: 5.718 ± 0.082	3.014LeuGln: 3.014 ± 0.058	7.634LeuArg: 7.634 ± 0.101	6.221LeuSer: 6.221 ± 0.079	7.448LeuThr: 7.448 ± 0.098	6.808LeuVal: 6.808 ± 0.087	1.307LeuTrp: 1.307 ± 0.038	1.8LeuTyr: 1.8 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.969MetAla: 3.969 ± 0.073	0.181MetCys: 0.181 ± 0.012	1.534MetAsp: 1.534 ± 0.038	1.048MetGlu: 1.048 ± 0.036	0.777MetPhe: 0.777 ± 0.029	2.321MetGly: 2.321 ± 0.05	0.478MetHis: 0.478 ± 0.022	1.555MetIle: 1.555 ± 0.046	0.799MetLys: 0.799 ± 0.027	2.571MetLeu: 2.571 ± 0.05	0.793MetMet: 0.793 ± 0.031	0.799MetAsn: 0.799 ± 0.026	1.634MetPro: 1.634 ± 0.037	1.047MetGln: 1.047 ± 0.036	1.903MetArg: 1.903 ± 0.048	1.447MetSer: 1.447 ± 0.035	2.65MetThr: 2.65 ± 0.045	1.868MetVal: 1.868 ± 0.043	0.26MetTrp: 0.26 ± 0.015	0.309MetTyr: 0.309 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.114AsnAla: 3.114 ± 0.062	0.202AsnCys: 0.202 ± 0.014	1.541AsnAsp: 1.541 ± 0.068	0.866AsnGlu: 0.866 ± 0.032	0.815AsnPhe: 0.815 ± 0.03	2.151AsnGly: 2.151 ± 0.059	0.44AsnHis: 0.44 ± 0.023	1.168AsnIle: 1.168 ± 0.036	0.482AsnLys: 0.482 ± 0.023	2.215AsnLeu: 2.215 ± 0.051	0.608AsnMet: 0.608 ± 0.026	0.527AsnAsn: 0.527 ± 0.024	1.658AsnPro: 1.658 ± 0.043	0.589AsnGln: 0.589 ± 0.025	1.645AsnArg: 1.645 ± 0.037	0.857AsnSer: 0.857 ± 0.029	1.311AsnThr: 1.311 ± 0.044	1.762AsnVal: 1.762 ± 0.047	0.36AsnTrp: 0.36 ± 0.021	0.565AsnTyr: 0.565 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.204ProAla: 7.204 ± 0.127	0.387ProCys: 0.387 ± 0.022	4.609ProAsp: 4.609 ± 0.076	2.775ProGlu: 2.775 ± 0.057	1.873ProPhe: 1.873 ± 0.04	4.703ProGly: 4.703 ± 0.077	1.229ProHis: 1.229 ± 0.032	2.077ProIle: 2.077 ± 0.044	1.163ProLys: 1.163 ± 0.037	5.094ProLeu: 5.094 ± 0.078	1.373ProMet: 1.373 ± 0.035	1.043ProAsn: 1.043 ± 0.029	2.53ProPro: 2.53 ± 0.061	2.01ProGln: 2.01 ± 0.044	3.099ProArg: 3.099 ± 0.066	2.261ProSer: 2.261 ± 0.041	2.846ProThr: 2.846 ± 0.058	4.988ProVal: 4.988 ± 0.079	0.676ProTrp: 0.676 ± 0.028	1.067ProTyr: 1.067 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.789GlnAla: 4.789 ± 0.063	0.184GlnCys: 0.184 ± 0.012	2.09GlnAsp: 2.09 ± 0.047	1.12GlnGlu: 1.12 ± 0.029	1.069GlnPhe: 1.069 ± 0.034	2.892GlnGly: 2.892 ± 0.059	0.619GlnHis: 0.619 ± 0.025	2.132GlnIle: 2.132 ± 0.044	0.716GlnLys: 0.716 ± 0.028	2.656GlnLeu: 2.656 ± 0.05	1.105GlnMet: 1.105 ± 0.034	0.752GlnAsn: 0.752 ± 0.027	1.835GlnPro: 1.835 ± 0.05	1.114GlnGln: 1.114 ± 0.037	2.427GlnArg: 2.427 ± 0.055	1.678GlnSer: 1.678 ± 0.035	2.279GlnThr: 2.279 ± 0.049	2.704GlnVal: 2.704 ± 0.057	0.392GlnTrp: 0.392 ± 0.02	0.515GlnTyr: 0.515 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.725ArgAla: 8.725 ± 0.104	0.484ArgCys: 0.484 ± 0.023	5.185ArgAsp: 5.185 ± 0.086	2.774ArgGlu: 2.774 ± 0.061	2.548ArgPhe: 2.548 ± 0.051	4.938ArgGly: 4.938 ± 0.077	1.755ArgHis: 1.755 ± 0.04	4.17ArgIle: 4.17 ± 0.066	1.673ArgLys: 1.673 ± 0.045	7.517ArgLeu: 7.517 ± 0.104	2.299ArgMet: 2.299 ± 0.048	1.727ArgAsn: 1.727 ± 0.042	3.51ArgPro: 3.51 ± 0.065	2.435ArgGln: 2.435 ± 0.056	5.254ArgArg: 5.254 ± 0.096	3.228ArgSer: 3.228 ± 0.054	3.882ArgThr: 3.882 ± 0.057	5.042ArgVal: 5.042 ± 0.071	1.007ArgTrp: 1.007 ± 0.03	1.43ArgTyr: 1.43 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.356SerAla: 5.356 ± 0.073	0.364SerCys: 0.364 ± 0.021	3.152SerAsp: 3.152 ± 0.053	1.986SerGlu: 1.986 ± 0.047	1.862SerPhe: 1.862 ± 0.042	4.778SerGly: 4.778 ± 0.069	1.004SerHis: 1.004 ± 0.035	2.096SerIle: 2.096 ± 0.052	1.033SerLys: 1.033 ± 0.035	4.631SerLeu: 4.631 ± 0.064	1.153SerMet: 1.153 ± 0.031	1.161SerAsn: 1.161 ± 0.038	2.396SerPro: 2.396 ± 0.048	1.417SerGln: 1.417 ± 0.038	3.168SerArg: 3.168 ± 0.059	1.983SerSer: 1.983 ± 0.054	2.395SerThr: 2.395 ± 0.05	3.482SerVal: 3.482 ± 0.059	0.558SerTrp: 0.558 ± 0.023	1.107SerTyr: 1.107 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	8.376ThrAla: 8.376 ± 0.101	0.52ThrCys: 0.52 ± 0.024	4.35ThrAsp: 4.35 ± 0.08	2.521ThrGlu: 2.521 ± 0.05	2.237ThrPhe: 2.237 ± 0.046	6.375ThrGly: 6.375 ± 0.095	1.268ThrHis: 1.268 ± 0.033	2.961ThrIle: 2.961 ± 0.056	1.142ThrLys: 1.142 ± 0.036	7.217ThrLeu: 7.217 ± 0.102	1.386ThrMet: 1.386 ± 0.037	1.208ThrAsn: 1.208 ± 0.042	4.077ThrPro: 4.077 ± 0.072	1.895ThrGln: 1.895 ± 0.049	3.853ThrArg: 3.853 ± 0.061	2.641ThrSer: 2.641 ± 0.054	3.803ThrThr: 3.803 ± 0.072	5.192ThrVal: 5.192 ± 0.094	0.761ThrTrp: 0.761 ± 0.03	1.416ThrTyr: 1.416 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	10.642ValAla: 10.642 ± 0.131	0.673ValCys: 0.673 ± 0.026	4.43ValAsp: 4.43 ± 0.072	3.524ValGlu: 3.524 ± 0.059	2.667ValPhe: 2.667 ± 0.051	5.873ValGly: 5.873 ± 0.079	1.395ValHis: 1.395 ± 0.039	4.17ValIle: 4.17 ± 0.059	1.747ValLys: 1.747 ± 0.048	7.962ValLeu: 7.962 ± 0.101	2.335ValMet: 2.335 ± 0.045	1.972ValAsn: 1.972 ± 0.051	4.109ValPro: 4.109 ± 0.067	2.505ValGln: 2.505 ± 0.056	4.598ValArg: 4.598 ± 0.077	3.716ValSer: 3.716 ± 0.067	6.0ValThr: 6.0 ± 0.101	6.455ValVal: 6.455 ± 0.091	1.2ValTrp: 1.2 ± 0.034	1.416ValTyr: 1.416 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.431TrpAla: 1.431 ± 0.04	0.144TrpCys: 0.144 ± 0.011	0.858TrpAsp: 0.858 ± 0.034	0.5TrpGlu: 0.5 ± 0.023	0.516TrpPhe: 0.516 ± 0.024	1.019TrpGly: 1.019 ± 0.035	0.357TrpHis: 0.357 ± 0.02	0.669TrpIle: 0.669 ± 0.029	0.314TrpLys: 0.314 ± 0.018	1.605TrpLeu: 1.605 ± 0.046	0.4TrpMet: 0.4 ± 0.019	0.36TrpAsn: 0.36 ± 0.019	0.734TrpPro: 0.734 ± 0.028	0.678TrpGln: 0.678 ± 0.026	1.144TrpArg: 1.144 ± 0.036	0.744TrpSer: 0.744 ± 0.026	0.917TrpThr: 0.917 ± 0.027	0.984TrpVal: 0.984 ± 0.034	0.256TrpTrp: 0.256 ± 0.015	0.245TrpTyr: 0.245 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.738TyrAla: 2.738 ± 0.054	0.179TyrCys: 0.179 ± 0.012	1.612TyrAsp: 1.612 ± 0.044	0.883TyrGlu: 0.883 ± 0.028	0.779TyrPhe: 0.779 ± 0.028	2.044TyrGly: 2.044 ± 0.047	0.456TyrHis: 0.456 ± 0.019	0.826TyrIle: 0.826 ± 0.028	0.451TyrLys: 0.451 ± 0.023	2.025TyrLeu: 2.025 ± 0.047	0.48TyrMet: 0.48 ± 0.024	0.504TyrAsn: 0.504 ± 0.021	1.037TyrPro: 1.037 ± 0.032	0.636TyrGln: 0.636 ± 0.025	1.497TyrArg: 1.497 ± 0.043	0.885TyrSer: 0.885 ± 0.028	1.07TyrThr: 1.07 ± 0.034	1.58TyrVal: 1.58 ± 0.043	0.296TyrTrp: 0.296 ± 0.02	0.502TyrTyr: 0.502 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3431 proteins (1062454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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