Amino acid dipepetide frequency for Desulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.415AlaAla: 16.415 ± 0.196	2.01AlaCys: 2.01 ± 0.046	5.565AlaAsp: 5.565 ± 0.077	6.562AlaGlu: 6.562 ± 0.094	3.953AlaPhe: 3.953 ± 0.068	10.283AlaGly: 10.283 ± 0.103	2.351AlaHis: 2.351 ± 0.048	4.689AlaIle: 4.689 ± 0.062	3.662AlaLys: 3.662 ± 0.066	14.058AlaLeu: 14.058 ± 0.146	4.061AlaMet: 4.061 ± 0.059	2.449AlaAsn: 2.449 ± 0.059	5.794AlaPro: 5.794 ± 0.102	4.593AlaGln: 4.593 ± 0.075	8.585AlaArg: 8.585 ± 0.106	5.83AlaSer: 5.83 ± 0.079	5.686AlaThr: 5.686 ± 0.076	9.153AlaVal: 9.153 ± 0.106	1.718AlaTrp: 1.718 ± 0.044	2.3AlaTyr: 2.3 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.37CysAla: 1.37 ± 0.037	0.36CysCys: 0.36 ± 0.02	0.566CysAsp: 0.566 ± 0.022	0.626CysGlu: 0.626 ± 0.026	0.549CysPhe: 0.549 ± 0.022	1.261CysGly: 1.261 ± 0.04	0.468CysHis: 0.468 ± 0.031	0.828CysIle: 0.828 ± 0.031	0.438CysLys: 0.438 ± 0.022	1.71CysLeu: 1.71 ± 0.042	0.373CysMet: 0.373 ± 0.019	0.414CysAsn: 0.414 ± 0.019	0.858CysPro: 0.858 ± 0.032	0.456CysGln: 0.456 ± 0.021	1.077CysArg: 1.077 ± 0.035	0.799CysSer: 0.799 ± 0.028	0.769CysThr: 0.769 ± 0.028	0.931CysVal: 0.931 ± 0.03	0.218CysTrp: 0.218 ± 0.014	0.336CysTyr: 0.336 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.894AspAla: 6.894 ± 0.088	0.708AspCys: 0.708 ± 0.027	2.712AspAsp: 2.712 ± 0.055	3.066AspGlu: 3.066 ± 0.064	2.038AspPhe: 2.038 ± 0.053	4.105AspGly: 4.105 ± 0.074	1.096AspHis: 1.096 ± 0.032	2.712AspIle: 2.712 ± 0.053	1.845AspLys: 1.845 ± 0.043	5.536AspLeu: 5.536 ± 0.083	1.383AspMet: 1.383 ± 0.033	1.148AspAsn: 1.148 ± 0.034	3.261AspPro: 3.261 ± 0.056	1.621AspGln: 1.621 ± 0.044	3.289AspArg: 3.289 ± 0.051	2.154AspSer: 2.154 ± 0.047	2.47AspThr: 2.47 ± 0.051	4.233AspVal: 4.233 ± 0.068	0.813AspTrp: 0.813 ± 0.028	1.259AspTyr: 1.259 ± 0.035	0.001AspXaa: 0.001 ± 0.001
Glu	7.582GluAla: 7.582 ± 0.102	0.624GluCys: 0.624 ± 0.024	3.26GluAsp: 3.26 ± 0.061	4.09GluGlu: 4.09 ± 0.082	2.058GluPhe: 2.058 ± 0.041	3.827GluGly: 3.827 ± 0.057	1.688GluHis: 1.688 ± 0.041	2.91GluIle: 2.91 ± 0.06	2.423GluLys: 2.423 ± 0.059	6.622GluLeu: 6.622 ± 0.089	1.659GluMet: 1.659 ± 0.04	1.516GluAsn: 1.516 ± 0.035	2.521GluPro: 2.521 ± 0.056	2.83GluGln: 2.83 ± 0.058	4.356GluArg: 4.356 ± 0.063	2.814GluSer: 2.814 ± 0.056	3.307GluThr: 3.307 ± 0.054	4.008GluVal: 4.008 ± 0.067	0.543GluTrp: 0.543 ± 0.023	1.381GluTyr: 1.381 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.72PheAla: 3.72 ± 0.063	0.607PheCys: 0.607 ± 0.021	2.04PheAsp: 2.04 ± 0.042	2.01PheGlu: 2.01 ± 0.042	1.68PhePhe: 1.68 ± 0.046	2.732PheGly: 2.732 ± 0.056	0.927PheHis: 0.927 ± 0.031	1.575PheIle: 1.575 ± 0.04	1.281PheLys: 1.281 ± 0.037	4.244PheLeu: 4.244 ± 0.069	0.899PheMet: 0.899 ± 0.031	1.057PheAsn: 1.057 ± 0.034	1.808PhePro: 1.808 ± 0.037	1.311PheGln: 1.311 ± 0.042	2.164PheArg: 2.164 ± 0.051	2.331PheSer: 2.331 ± 0.052	1.995PheThr: 1.995 ± 0.044	2.535PheVal: 2.535 ± 0.046	0.546PheTrp: 0.546 ± 0.023	0.928PheTyr: 0.928 ± 0.028	0.002PheXaa: 0.002 ± 0.001
Gly	7.498GlyAla: 7.498 ± 0.091	1.258GlyCys: 1.258 ± 0.037	3.787GlyAsp: 3.787 ± 0.07	4.665GlyGlu: 4.665 ± 0.074	3.013GlyPhe: 3.013 ± 0.055	6.237GlyGly: 6.237 ± 0.101	1.888GlyHis: 1.888 ± 0.047	3.63GlyIle: 3.63 ± 0.063	3.311GlyLys: 3.311 ± 0.061	9.219GlyLeu: 9.219 ± 0.124	2.721GlyMet: 2.721 ± 0.055	1.894GlyAsn: 1.894 ± 0.045	3.216GlyPro: 3.216 ± 0.057	3.254GlyGln: 3.254 ± 0.057	5.613GlyArg: 5.613 ± 0.074	3.829GlySer: 3.829 ± 0.073	3.646GlyThr: 3.646 ± 0.069	6.567GlyVal: 6.567 ± 0.081	1.202GlyTrp: 1.202 ± 0.039	2.04GlyTyr: 2.04 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.943HisAla: 2.943 ± 0.056	0.44HisCys: 0.44 ± 0.024	1.188HisAsp: 1.188 ± 0.034	1.227HisGlu: 1.227 ± 0.035	0.931HisPhe: 0.931 ± 0.032	2.212HisGly: 2.212 ± 0.045	0.637HisHis: 0.637 ± 0.027	1.015HisIle: 1.015 ± 0.029	0.716HisLys: 0.716 ± 0.024	2.783HisLeu: 2.783 ± 0.059	0.54HisMet: 0.54 ± 0.021	0.569HisAsn: 0.569 ± 0.021	1.679HisPro: 1.679 ± 0.042	0.768HisGln: 0.768 ± 0.03	1.566HisArg: 1.566 ± 0.04	1.114HisSer: 1.114 ± 0.029	1.164HisThr: 1.164 ± 0.032	1.692HisVal: 1.692 ± 0.039	0.309HisTrp: 0.309 ± 0.017	0.563HisTyr: 0.563 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.637IleAla: 4.637 ± 0.074	0.639IleCys: 0.639 ± 0.025	2.17IleAsp: 2.17 ± 0.05	2.404IleGlu: 2.404 ± 0.057	1.671IlePhe: 1.671 ± 0.034	3.034IleGly: 3.034 ± 0.058	1.061IleHis: 1.061 ± 0.034	2.206IleIle: 2.206 ± 0.055	1.788IleLys: 1.788 ± 0.045	4.798IleLeu: 4.798 ± 0.068	1.07IleMet: 1.07 ± 0.036	1.369IleAsn: 1.369 ± 0.041	2.494IlePro: 2.494 ± 0.048	1.566IleGln: 1.566 ± 0.038	2.905IleArg: 2.905 ± 0.048	2.434IleSer: 2.434 ± 0.055	2.302IleThr: 2.302 ± 0.048	3.135IleVal: 3.135 ± 0.058	0.509IleTrp: 0.509 ± 0.024	1.073IleTyr: 1.073 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.286LysAla: 4.286 ± 0.077	0.31LysCys: 0.31 ± 0.017	2.193LysAsp: 2.193 ± 0.053	2.388LysGlu: 2.388 ± 0.055	0.975LysPhe: 0.975 ± 0.032	2.665LysGly: 2.665 ± 0.051	0.745LysHis: 0.745 ± 0.027	1.618LysIle: 1.618 ± 0.045	1.838LysLys: 1.838 ± 0.052	3.102LysLeu: 3.102 ± 0.061	0.878LysMet: 0.878 ± 0.029	1.041LysAsn: 1.041 ± 0.032	1.854LysPro: 1.854 ± 0.05	1.248LysGln: 1.248 ± 0.038	2.167LysArg: 2.167 ± 0.039	1.788LysSer: 1.788 ± 0.041	2.028LysThr: 2.028 ± 0.046	2.345LysVal: 2.345 ± 0.053	0.311LysTrp: 0.311 ± 0.019	0.796LysTyr: 0.796 ± 0.033	0.001LysXaa: 0.001 ± 0.001
Leu	15.626LeuAla: 15.626 ± 0.158	1.641LeuCys: 1.641 ± 0.045	6.768LeuAsp: 6.768 ± 0.082	7.566LeuGlu: 7.566 ± 0.104	4.061LeuPhe: 4.061 ± 0.065	9.124LeuGly: 9.124 ± 0.117	2.873LeuHis: 2.873 ± 0.061	3.616LeuIle: 3.616 ± 0.064	3.892LeuLys: 3.892 ± 0.062	13.109LeuLeu: 13.109 ± 0.166	2.399LeuMet: 2.399 ± 0.05	2.442LeuAsn: 2.442 ± 0.049	6.758LeuPro: 6.758 ± 0.081	4.721LeuGln: 4.721 ± 0.077	7.639LeuArg: 7.639 ± 0.093	5.603LeuSer: 5.603 ± 0.076	5.81LeuThr: 5.81 ± 0.08	7.904LeuVal: 7.904 ± 0.085	1.132LeuTrp: 1.132 ± 0.041	2.303LeuTyr: 2.303 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.502MetAla: 3.502 ± 0.057	0.259MetCys: 0.259 ± 0.015	1.75MetAsp: 1.75 ± 0.042	1.752MetGlu: 1.752 ± 0.041	0.702MetPhe: 0.702 ± 0.03	1.992MetGly: 1.992 ± 0.047	0.793MetHis: 0.793 ± 0.023	0.893MetIle: 0.893 ± 0.033	0.804MetLys: 0.804 ± 0.03	3.094MetLeu: 3.094 ± 0.058	0.526MetMet: 0.526 ± 0.025	0.672MetAsn: 0.672 ± 0.028	1.677MetPro: 1.677 ± 0.041	1.275MetGln: 1.275 ± 0.037	1.836MetArg: 1.836 ± 0.04	1.328MetSer: 1.328 ± 0.037	1.526MetThr: 1.526 ± 0.039	1.836MetVal: 1.836 ± 0.042	0.203MetTrp: 0.203 ± 0.013	0.394MetTyr: 0.394 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.928AsnAla: 2.928 ± 0.058	0.365AsnCys: 0.365 ± 0.019	1.056AsnAsp: 1.056 ± 0.036	1.184AsnGlu: 1.184 ± 0.036	0.894AsnPhe: 0.894 ± 0.029	1.705AsnGly: 1.705 ± 0.045	0.513AsnHis: 0.513 ± 0.02	1.409AsnIle: 1.409 ± 0.038	0.892AsnLys: 0.892 ± 0.033	2.669AsnLeu: 2.669 ± 0.057	0.682AsnMet: 0.682 ± 0.023	0.708AsnAsn: 0.708 ± 0.033	1.73AsnPro: 1.73 ± 0.038	0.828AsnGln: 0.828 ± 0.031	1.526AsnArg: 1.526 ± 0.037	1.098AsnSer: 1.098 ± 0.036	1.304AsnThr: 1.304 ± 0.038	1.702AsnVal: 1.702 ± 0.038	0.325AsnTrp: 0.325 ± 0.02	0.632AsnTyr: 0.632 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	7.427ProAla: 7.427 ± 0.11	0.727ProCys: 0.727 ± 0.029	3.404ProAsp: 3.404 ± 0.058	3.945ProGlu: 3.945 ± 0.071	1.946ProPhe: 1.946 ± 0.039	5.094ProGly: 5.094 ± 0.077	1.252ProHis: 1.252 ± 0.035	1.577ProIle: 1.577 ± 0.043	1.509ProLys: 1.509 ± 0.048	5.502ProLeu: 5.502 ± 0.077	1.338ProMet: 1.338 ± 0.036	1.09ProAsn: 1.09 ± 0.035	3.403ProPro: 3.403 ± 0.077	2.086ProGln: 2.086 ± 0.05	3.21ProArg: 3.21 ± 0.057	2.539ProSer: 2.539 ± 0.053	2.274ProThr: 2.274 ± 0.052	4.389ProVal: 4.389 ± 0.07	0.858ProTrp: 0.858 ± 0.029	1.136ProTyr: 1.136 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.949GlnAla: 5.949 ± 0.093	0.481GlnCys: 0.481 ± 0.024	2.239GlnAsp: 2.239 ± 0.047	2.799GlnGlu: 2.799 ± 0.055	1.213GlnPhe: 1.213 ± 0.038	3.422GlnGly: 3.422 ± 0.057	1.018GlnHis: 1.018 ± 0.033	1.432GlnIle: 1.432 ± 0.036	1.129GlnLys: 1.129 ± 0.035	3.855GlnLeu: 3.855 ± 0.066	0.89GlnMet: 0.89 ± 0.027	0.793GlnAsn: 0.793 ± 0.025	1.99GlnPro: 1.99 ± 0.047	1.967GlnGln: 1.967 ± 0.058	2.698GlnArg: 2.698 ± 0.056	1.752GlnSer: 1.752 ± 0.041	2.088GlnThr: 2.088 ± 0.047	2.743GlnVal: 2.743 ± 0.048	0.459GlnTrp: 0.459 ± 0.02	0.88GlnTyr: 0.88 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.443ArgAla: 6.443 ± 0.081	0.961ArgCys: 0.961 ± 0.031	3.283ArgAsp: 3.283 ± 0.058	4.627ArgGlu: 4.627 ± 0.069	2.731ArgPhe: 2.731 ± 0.042	4.181ArgGly: 4.181 ± 0.044	1.923ArgHis: 1.923 ± 0.043	3.636ArgIle: 3.636 ± 0.06	2.479ArgLys: 2.479 ± 0.053	8.818ArgLeu: 8.818 ± 0.11	1.998ArgMet: 1.998 ± 0.048	1.705ArgAsn: 1.705 ± 0.04	3.493ArgPro: 3.493 ± 0.064	3.461ArgGln: 3.461 ± 0.061	5.287ArgArg: 5.287 ± 0.085	2.985ArgSer: 2.985 ± 0.055	3.411ArgThr: 3.411 ± 0.055	4.306ArgVal: 4.306 ± 0.067	0.89ArgTrp: 0.89 ± 0.03	1.634ArgTyr: 1.634 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	4.658SerAla: 4.658 ± 0.076	0.716SerCys: 0.716 ± 0.027	2.079SerAsp: 2.079 ± 0.05	2.284SerGlu: 2.284 ± 0.051	1.974SerPhe: 1.974 ± 0.046	4.298SerGly: 4.298 ± 0.076	1.16SerHis: 1.16 ± 0.035	2.579SerIle: 2.579 ± 0.051	1.609SerLys: 1.609 ± 0.046	6.391SerLeu: 6.391 ± 0.089	1.525SerMet: 1.525 ± 0.04	1.168SerAsn: 1.168 ± 0.04	3.16SerPro: 3.16 ± 0.048	1.872SerGln: 1.872 ± 0.038	3.647SerArg: 3.647 ± 0.063	2.791SerSer: 2.791 ± 0.055	2.473SerThr: 2.473 ± 0.049	3.15SerVal: 3.15 ± 0.063	0.687SerTrp: 0.687 ± 0.026	1.05SerTyr: 1.05 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.001ThrAla: 6.001 ± 0.082	0.614ThrCys: 0.614 ± 0.027	2.259ThrAsp: 2.259 ± 0.044	2.282ThrGlu: 2.282 ± 0.044	1.75ThrPhe: 1.75 ± 0.042	4.506ThrGly: 4.506 ± 0.076	1.075ThrHis: 1.075 ± 0.033	2.335ThrIle: 2.335 ± 0.041	1.318ThrLys: 1.318 ± 0.043	6.401ThrLeu: 6.401 ± 0.081	1.33ThrMet: 1.33 ± 0.035	1.168ThrAsn: 1.168 ± 0.033	3.764ThrPro: 3.764 ± 0.065	1.609ThrGln: 1.609 ± 0.035	3.203ThrArg: 3.203 ± 0.049	2.492ThrSer: 2.492 ± 0.053	2.597ThrThr: 2.597 ± 0.051	4.115ThrVal: 4.115 ± 0.065	0.623ThrTrp: 0.623 ± 0.025	1.108ThrTyr: 1.108 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.393ValAla: 8.393 ± 0.107	1.136ValCys: 1.136 ± 0.036	4.066ValAsp: 4.066 ± 0.066	4.568ValGlu: 4.568 ± 0.07	2.822ValPhe: 2.822 ± 0.057	4.894ValGly: 4.894 ± 0.071	1.747ValHis: 1.747 ± 0.038	3.154ValIle: 3.154 ± 0.061	2.341ValLys: 2.341 ± 0.053	9.054ValLeu: 9.054 ± 0.096	1.704ValMet: 1.704 ± 0.043	1.87ValAsn: 1.87 ± 0.043	3.383ValPro: 3.383 ± 0.054	2.948ValGln: 2.948 ± 0.053	4.973ValArg: 4.973 ± 0.067	3.84ValSer: 3.84 ± 0.058	3.764ValThr: 3.764 ± 0.054	5.985ValVal: 5.985 ± 0.084	0.858ValTrp: 0.858 ± 0.03	1.585ValTyr: 1.585 ± 0.039	0.001ValXaa: 0.001 ± 0.001
Trp	1.093TrpAla: 1.093 ± 0.03	0.2TrpCys: 0.2 ± 0.014	0.666TrpAsp: 0.666 ± 0.026	0.794TrpGlu: 0.794 ± 0.027	0.438TrpPhe: 0.438 ± 0.02	0.912TrpGly: 0.912 ± 0.035	0.321TrpHis: 0.321 ± 0.017	0.534TrpIle: 0.534 ± 0.021	0.515TrpLys: 0.515 ± 0.023	1.609TrpLeu: 1.609 ± 0.044	0.346TrpMet: 0.346 ± 0.02	0.407TrpAsn: 0.407 ± 0.019	0.717TrpPro: 0.717 ± 0.025	0.618TrpGln: 0.618 ± 0.027	1.018TrpArg: 1.018 ± 0.036	0.607TrpSer: 0.607 ± 0.02	0.754TrpThr: 0.754 ± 0.029	0.717TrpVal: 0.717 ± 0.024	0.236TrpTrp: 0.236 ± 0.016	0.254TrpTyr: 0.254 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.351TyrAla: 2.351 ± 0.047	0.352TyrCys: 0.352 ± 0.017	1.294TyrAsp: 1.294 ± 0.031	1.18TyrGlu: 1.18 ± 0.033	0.994TyrPhe: 0.994 ± 0.037	2.005TyrGly: 2.005 ± 0.045	0.522TyrHis: 0.522 ± 0.02	0.918TyrIle: 0.918 ± 0.032	0.787TyrLys: 0.787 ± 0.029	2.412TyrLeu: 2.412 ± 0.054	0.49TyrMet: 0.49 ± 0.02	0.669TyrAsn: 0.669 ± 0.022	1.147TyrPro: 1.147 ± 0.034	0.762TyrGln: 0.762 ± 0.028	1.495TyrArg: 1.495 ± 0.037	1.143TyrSer: 1.143 ± 0.04	1.18TyrThr: 1.18 ± 0.034	1.638TyrVal: 1.638 ± 0.042	0.313TyrTrp: 0.313 ± 0.019	0.706TyrTyr: 0.706 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3321 proteins (1099738 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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