Amino acid dipepetide frequency for Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.468AlaAla: 6.468 ± 0.151
0.928AlaCys: 0.928 ± 0.044
4.845AlaAsp: 4.845 ± 0.092
5.824AlaGlu: 5.824 ± 0.121
3.481AlaPhe: 3.481 ± 0.071
5.59AlaGly: 5.59 ± 0.114
1.45AlaHis: 1.45 ± 0.052
5.376AlaIle: 5.376 ± 0.111
4.105AlaLys: 4.105 ± 0.084
7.747AlaLeu: 7.747 ± 0.145
2.14AlaMet: 2.14 ± 0.063
2.808AlaAsn: 2.808 ± 0.072
2.708AlaPro: 2.708 ± 0.075
2.727AlaGln: 2.727 ± 0.073
4.109AlaArg: 4.109 ± 0.095
4.579AlaSer: 4.579 ± 0.121
4.054AlaThr: 4.054 ± 0.083
5.278AlaVal: 5.278 ± 0.101
0.71AlaTrp: 0.71 ± 0.041
2.977AlaTyr: 2.977 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.034
0.183CysCys: 0.183 ± 0.019
0.631CysAsp: 0.631 ± 0.034
0.607CysGlu: 0.607 ± 0.036
0.501CysPhe: 0.501 ± 0.029
0.94CysGly: 0.94 ± 0.041
0.338CysHis: 0.338 ± 0.026
0.83CysIle: 0.83 ± 0.037
0.514CysLys: 0.514 ± 0.035
1.106CysLeu: 1.106 ± 0.042
0.288CysMet: 0.288 ± 0.021
0.456CysAsn: 0.456 ± 0.027
0.601CysPro: 0.601 ± 0.036
0.312CysGln: 0.312 ± 0.024
0.876CysArg: 0.876 ± 0.037
0.846CysSer: 0.846 ± 0.045
0.599CysThr: 0.599 ± 0.031
0.701CysVal: 0.701 ± 0.041
0.131CysTrp: 0.131 ± 0.015
0.482CysTyr: 0.482 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.032AspAla: 4.032 ± 0.085
0.66AspCys: 0.66 ± 0.033
2.428AspAsp: 2.428 ± 0.071
3.725AspGlu: 3.725 ± 0.084
2.912AspPhe: 2.912 ± 0.062
3.649AspGly: 3.649 ± 0.096
0.954AspHis: 0.954 ± 0.04
3.961AspIle: 3.961 ± 0.081
3.361AspLys: 3.361 ± 0.094
5.18AspLeu: 5.18 ± 0.089
1.601AspMet: 1.601 ± 0.05
2.175AspAsn: 2.175 ± 0.073
2.063AspPro: 2.063 ± 0.058
1.294AspGln: 1.294 ± 0.043
3.369AspArg: 3.369 ± 0.081
3.409AspSer: 3.409 ± 0.09
2.754AspThr: 2.754 ± 0.067
3.274AspVal: 3.274 ± 0.075
0.679AspTrp: 0.679 ± 0.029
2.64AspTyr: 2.64 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.694GluAla: 5.694 ± 0.126
0.53GluCys: 0.53 ± 0.031
3.309GluAsp: 3.309 ± 0.086
5.903GluGlu: 5.903 ± 0.157
2.11GluPhe: 2.11 ± 0.06
4.31GluGly: 4.31 ± 0.092
1.392GluHis: 1.392 ± 0.045
4.431GluIle: 4.431 ± 0.097
4.736GluLys: 4.736 ± 0.113
6.598GluLeu: 6.598 ± 0.133
2.137GluMet: 2.137 ± 0.062
2.687GluAsn: 2.687 ± 0.068
1.965GluPro: 1.965 ± 0.051
2.86GluGln: 2.86 ± 0.079
4.264GluArg: 4.264 ± 0.116
3.504GluSer: 3.504 ± 0.078
3.165GluThr: 3.165 ± 0.072
4.459GluVal: 4.459 ± 0.09
0.736GluTrp: 0.736 ± 0.039
2.387GluTyr: 2.387 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.489PheAla: 3.489 ± 0.083
0.652PheCys: 0.652 ± 0.036
2.925PheAsp: 2.925 ± 0.068
2.387PheGlu: 2.387 ± 0.068
2.485PhePhe: 2.485 ± 0.081
3.48PheGly: 3.48 ± 0.076
0.889PheHis: 0.889 ± 0.039
2.748PheIle: 2.748 ± 0.077
1.792PheLys: 1.792 ± 0.056
4.277PheLeu: 4.277 ± 0.085
1.085PheMet: 1.085 ± 0.046
1.661PheAsn: 1.661 ± 0.057
1.836PhePro: 1.836 ± 0.048
1.008PheGln: 1.008 ± 0.041
2.779PheArg: 2.779 ± 0.071
3.518PheSer: 3.518 ± 0.083
2.181PheThr: 2.181 ± 0.06
3.178PheVal: 3.178 ± 0.08
0.492PheTrp: 0.492 ± 0.032
1.624PheTyr: 1.624 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
5.022GlyAla: 5.022 ± 0.095
0.982GlyCys: 0.982 ± 0.044
3.336GlyAsp: 3.336 ± 0.078
4.318GlyGlu: 4.318 ± 0.09
3.224GlyPhe: 3.224 ± 0.07
5.13GlyGly: 5.13 ± 0.105
1.572GlyHis: 1.572 ± 0.058
5.258GlyIle: 5.258 ± 0.09
4.603GlyLys: 4.603 ± 0.091
6.461GlyLeu: 6.461 ± 0.112
2.221GlyMet: 2.221 ± 0.07
2.869GlyAsn: 2.869 ± 0.08
1.354GlyPro: 1.354 ± 0.054
2.282GlyGln: 2.282 ± 0.064
4.136GlyArg: 4.136 ± 0.087
4.388GlySer: 4.388 ± 0.088
3.749GlyThr: 3.749 ± 0.11
4.658GlyVal: 4.658 ± 0.095
0.789GlyTrp: 0.789 ± 0.039
3.116GlyTyr: 3.116 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.37HisAla: 1.37 ± 0.05
0.327HisCys: 0.327 ± 0.024
1.008HisAsp: 1.008 ± 0.04
1.142HisGlu: 1.142 ± 0.048
1.09HisPhe: 1.09 ± 0.037
1.376HisGly: 1.376 ± 0.053
0.609HisHis: 0.609 ± 0.033
1.59HisIle: 1.59 ± 0.051
1.015HisLys: 1.015 ± 0.04
2.184HisLeu: 2.184 ± 0.066
0.369HisMet: 0.369 ± 0.025
0.922HisAsn: 0.922 ± 0.035
1.305HisPro: 1.305 ± 0.05
0.609HisGln: 0.609 ± 0.036
1.425HisArg: 1.425 ± 0.052
1.33HisSer: 1.33 ± 0.04
1.185HisThr: 1.185 ± 0.046
1.087HisVal: 1.087 ± 0.041
0.247HisTrp: 0.247 ± 0.021
0.921HisTyr: 0.921 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.985IleAla: 5.985 ± 0.115
0.879IleCys: 0.879 ± 0.041
4.211IleAsp: 4.211 ± 0.093
4.555IleGlu: 4.555 ± 0.097
2.678IlePhe: 2.678 ± 0.074
5.06IleGly: 5.06 ± 0.098
1.329IleHis: 1.329 ± 0.051
4.442IleIle: 4.442 ± 0.099
3.483IleLys: 3.483 ± 0.098
6.199IleLeu: 6.199 ± 0.131
1.427IleMet: 1.427 ± 0.048
2.548IleAsn: 2.548 ± 0.066
3.222IlePro: 3.222 ± 0.075
1.909IleGln: 1.909 ± 0.061
4.546IleArg: 4.546 ± 0.089
4.353IleSer: 4.353 ± 0.092
3.53IleThr: 3.53 ± 0.08
4.554IleVal: 4.554 ± 0.106
0.514IleTrp: 0.514 ± 0.029
2.256IleTyr: 2.256 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.554LysAla: 4.554 ± 0.104
0.384LysCys: 0.384 ± 0.027
3.016LysAsp: 3.016 ± 0.079
4.673LysGlu: 4.673 ± 0.11
1.593LysPhe: 1.593 ± 0.05
3.984LysGly: 3.984 ± 0.083
1.139LysHis: 1.139 ± 0.04
3.319LysIle: 3.319 ± 0.087
3.997LysLys: 3.997 ± 0.116
4.812LysLeu: 4.812 ± 0.109
1.878LysMet: 1.878 ± 0.057
2.45LysAsn: 2.45 ± 0.07
2.271LysPro: 2.271 ± 0.066
2.29LysGln: 2.29 ± 0.067
3.641LysArg: 3.641 ± 0.08
3.097LysSer: 3.097 ± 0.071
3.096LysThr: 3.096 ± 0.072
3.436LysVal: 3.436 ± 0.09
0.514LysTrp: 0.514 ± 0.032
2.074LysTyr: 2.074 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
7.335LeuAla: 7.335 ± 0.138
1.367LeuCys: 1.367 ± 0.05
4.646LeuAsp: 4.646 ± 0.09
5.199LeuGlu: 5.199 ± 0.116
4.938LeuPhe: 4.938 ± 0.107
5.995LeuGly: 5.995 ± 0.109
2.303LeuHis: 2.303 ± 0.07
6.158LeuIle: 6.158 ± 0.103
5.009LeuLys: 5.009 ± 0.087
10.569LeuLeu: 10.569 ± 0.166
2.687LeuMet: 2.687 ± 0.067
3.937LeuAsn: 3.937 ± 0.091
5.009LeuPro: 5.009 ± 0.091
3.126LeuGln: 3.126 ± 0.07
6.164LeuArg: 6.164 ± 0.112
8.02LeuSer: 8.02 ± 0.148
5.383LeuThr: 5.383 ± 0.119
5.443LeuVal: 5.443 ± 0.105
0.928LeuTrp: 0.928 ± 0.041
3.603LeuTyr: 3.603 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.064
0.236MetCys: 0.236 ± 0.021
1.5MetAsp: 1.5 ± 0.046
1.887MetGlu: 1.887 ± 0.049
0.778MetPhe: 0.778 ± 0.035
1.972MetGly: 1.972 ± 0.06
0.55MetHis: 0.55 ± 0.029
1.711MetIle: 1.711 ± 0.053
2.037MetLys: 2.037 ± 0.071
2.749MetLeu: 2.749 ± 0.071
0.813MetMet: 0.813 ± 0.039
1.384MetAsn: 1.384 ± 0.042
1.269MetPro: 1.269 ± 0.047
1.223MetGln: 1.223 ± 0.042
1.602MetArg: 1.602 ± 0.043
1.613MetSer: 1.613 ± 0.052
1.488MetThr: 1.488 ± 0.048
1.542MetVal: 1.542 ± 0.054
0.199MetTrp: 0.199 ± 0.021
0.718MetTyr: 0.718 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.898AsnAla: 2.898 ± 0.072
0.427AsnCys: 0.427 ± 0.027
2.044AsnAsp: 2.044 ± 0.052
2.502AsnGlu: 2.502 ± 0.059
1.792AsnPhe: 1.792 ± 0.053
2.986AsnGly: 2.986 ± 0.092
0.747AsnHis: 0.747 ± 0.041
2.768AsnIle: 2.768 ± 0.08
2.403AsnLys: 2.403 ± 0.069
3.754AsnLeu: 3.754 ± 0.089
1.158AsnMet: 1.158 ± 0.046
1.833AsnAsn: 1.833 ± 0.072
2.366AsnPro: 2.366 ± 0.068
1.156AsnGln: 1.156 ± 0.053
2.442AsnArg: 2.442 ± 0.067
2.241AsnSer: 2.241 ± 0.064
2.219AsnThr: 2.219 ± 0.071
2.482AsnVal: 2.482 ± 0.075
0.399AsnTrp: 0.399 ± 0.03
1.697AsnTyr: 1.697 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.279ProAla: 3.279 ± 0.086
0.388ProCys: 0.388 ± 0.026
2.914ProAsp: 2.914 ± 0.065
3.505ProGlu: 3.505 ± 0.083
1.96ProPhe: 1.96 ± 0.061
2.355ProGly: 2.355 ± 0.068
0.957ProHis: 0.957 ± 0.042
2.694ProIle: 2.694 ± 0.063
1.995ProLys: 1.995 ± 0.059
3.75ProLeu: 3.75 ± 0.084
1.09ProMet: 1.09 ± 0.04
1.666ProAsn: 1.666 ± 0.064
1.193ProPro: 1.193 ± 0.044
1.471ProGln: 1.471 ± 0.049
1.727ProArg: 1.727 ± 0.056
2.668ProSer: 2.668 ± 0.079
2.275ProThr: 2.275 ± 0.058
3.015ProVal: 3.015 ± 0.077
0.438ProTrp: 0.438 ± 0.027
1.618ProTyr: 1.618 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
2.74GlnAla: 2.74 ± 0.074
0.263GlnCys: 0.263 ± 0.023
1.632GlnAsp: 1.632 ± 0.054
2.309GlnGlu: 2.309 ± 0.074
1.09GlnPhe: 1.09 ± 0.04
2.245GlnGly: 2.245 ± 0.06
0.607GlnHis: 0.607 ± 0.033
2.412GlnIle: 2.412 ± 0.078
1.987GlnLys: 1.987 ± 0.066
3.04GlnLeu: 3.04 ± 0.079
0.976GlnMet: 0.976 ± 0.038
1.338GlnAsn: 1.338 ± 0.049
1.221GlnPro: 1.221 ± 0.044
1.401GlnGln: 1.401 ± 0.056
1.857GlnArg: 1.857 ± 0.057
2.036GlnSer: 2.036 ± 0.058
1.971GlnThr: 1.971 ± 0.06
2.067GlnVal: 2.067 ± 0.058
0.413GlnTrp: 0.413 ± 0.027
1.27GlnTyr: 1.27 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
3.839ArgAla: 3.839 ± 0.088
0.546ArgCys: 0.546 ± 0.028
2.649ArgAsp: 2.649 ± 0.062
4.182ArgGlu: 4.182 ± 0.098
2.895ArgPhe: 2.895 ± 0.069
3.296ArgGly: 3.296 ± 0.074
1.598ArgHis: 1.598 ± 0.054
4.617ArgIle: 4.617 ± 0.09
3.769ArgLys: 3.769 ± 0.086
6.591ArgLeu: 6.591 ± 0.127
2.004ArgMet: 2.004 ± 0.054
2.482ArgAsn: 2.482 ± 0.069
2.417ArgPro: 2.417 ± 0.062
2.381ArgGln: 2.381 ± 0.075
3.983ArgArg: 3.983 ± 0.1
3.548ArgSer: 3.548 ± 0.082
3.054ArgThr: 3.054 ± 0.073
3.26ArgVal: 3.26 ± 0.073
0.688ArgTrp: 0.688 ± 0.036
2.578ArgTyr: 2.578 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.873SerAla: 4.873 ± 0.1
0.786SerCys: 0.786 ± 0.034
3.535SerAsp: 3.535 ± 0.083
3.905SerGlu: 3.905 ± 0.087
3.459SerPhe: 3.459 ± 0.087
4.967SerGly: 4.967 ± 0.093
1.321SerHis: 1.321 ± 0.048
4.462SerIle: 4.462 ± 0.081
3.073SerLys: 3.073 ± 0.072
6.662SerLeu: 6.662 ± 0.126
1.745SerMet: 1.745 ± 0.059
2.289SerAsn: 2.289 ± 0.06
2.729SerPro: 2.729 ± 0.078
1.672SerGln: 1.672 ± 0.059
3.69SerArg: 3.69 ± 0.089
4.285SerSer: 4.285 ± 0.09
3.119SerThr: 3.119 ± 0.079
4.217SerVal: 4.217 ± 0.097
0.696SerTrp: 0.696 ± 0.031
2.642SerTyr: 2.642 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
4.434ThrAla: 4.434 ± 0.102
0.456ThrCys: 0.456 ± 0.027
3.263ThrAsp: 3.263 ± 0.068
3.458ThrGlu: 3.458 ± 0.07
2.379ThrPhe: 2.379 ± 0.063
4.2ThrGly: 4.2 ± 0.088
1.077ThrHis: 1.077 ± 0.041
3.801ThrIle: 3.801 ± 0.09
2.561ThrLys: 2.561 ± 0.075
5.376ThrLeu: 5.376 ± 0.089
1.18ThrMet: 1.18 ± 0.042
2.023ThrAsn: 2.023 ± 0.071
2.766ThrPro: 2.766 ± 0.078
1.536ThrGln: 1.536 ± 0.046
2.306ThrArg: 2.306 ± 0.07
2.929ThrSer: 2.929 ± 0.069
3.005ThrThr: 3.005 ± 0.078
3.701ThrVal: 3.701 ± 0.091
0.465ThrTrp: 0.465 ± 0.03
1.9ThrTyr: 1.9 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.087ValAla: 5.087 ± 0.104
0.982ValCys: 0.982 ± 0.037
3.401ValAsp: 3.401 ± 0.079
4.258ValGlu: 4.258 ± 0.087
2.952ValPhe: 2.952 ± 0.086
4.536ValGly: 4.536 ± 0.103
1.213ValHis: 1.213 ± 0.044
3.994ValIle: 3.994 ± 0.089
3.22ValLys: 3.22 ± 0.078
6.096ValLeu: 6.096 ± 0.115
1.711ValMet: 1.711 ± 0.053
2.444ValAsn: 2.444 ± 0.065
2.61ValPro: 2.61 ± 0.063
1.916ValGln: 1.916 ± 0.06
3.959ValArg: 3.959 ± 0.085
4.666ValSer: 4.666 ± 0.104
3.173ValThr: 3.173 ± 0.094
4.674ValVal: 4.674 ± 0.108
0.66ValTrp: 0.66 ± 0.041
2.349ValTyr: 2.349 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.633TrpAla: 0.633 ± 0.031
0.165TrpCys: 0.165 ± 0.017
0.565TrpAsp: 0.565 ± 0.029
0.612TrpGlu: 0.612 ± 0.037
0.432TrpPhe: 0.432 ± 0.026
0.764TrpGly: 0.764 ± 0.036
0.274TrpHis: 0.274 ± 0.023
0.661TrpIle: 0.661 ± 0.037
0.641TrpLys: 0.641 ± 0.032
1.071TrpLeu: 1.071 ± 0.047
0.361TrpMet: 0.361 ± 0.021
0.457TrpAsn: 0.457 ± 0.027
0.272TrpPro: 0.272 ± 0.021
0.547TrpGln: 0.547 ± 0.029
0.639TrpArg: 0.639 ± 0.032
0.56TrpSer: 0.56 ± 0.036
0.516TrpThr: 0.516 ± 0.032
0.596TrpVal: 0.596 ± 0.03
0.134TrpTrp: 0.134 ± 0.016
0.383TrpTyr: 0.383 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.994TyrAla: 2.994 ± 0.08
0.55TyrCys: 0.55 ± 0.033
2.262TyrAsp: 2.262 ± 0.071
2.222TyrGlu: 2.222 ± 0.055
1.737TyrPhe: 1.737 ± 0.06
2.634TyrGly: 2.634 ± 0.068
0.791TyrHis: 0.791 ± 0.036
2.449TyrIle: 2.449 ± 0.074
1.916TyrLys: 1.916 ± 0.055
3.595TyrLeu: 3.595 ± 0.082
0.837TyrMet: 0.837 ± 0.039
1.887TyrAsn: 1.887 ± 0.062
1.779TyrPro: 1.779 ± 0.059
1.156TyrGln: 1.156 ± 0.045
2.86TyrArg: 2.86 ± 0.078
2.537TyrSer: 2.537 ± 0.07
2.3TyrThr: 2.3 ± 0.072
2.279TyrVal: 2.279 ± 0.065
0.449TyrTrp: 0.449 ± 0.025
1.734TyrTyr: 1.734 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1863 proteins (632208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski