Amino acid dipepetide frequency for Salmonella phage LPSE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.264AlaAla: 12.264 ± 1.613
1.418AlaCys: 1.418 ± 0.405
5.924AlaAsp: 5.924 ± 0.858
7.008AlaGlu: 7.008 ± 1.072
4.005AlaPhe: 4.005 ± 0.603
7.592AlaGly: 7.592 ± 0.866
1.752AlaHis: 1.752 ± 0.362
3.671AlaIle: 3.671 ± 0.677
4.756AlaLys: 4.756 ± 0.786
7.258AlaLeu: 7.258 ± 1.084
2.586AlaMet: 2.586 ± 0.561
3.588AlaAsn: 3.588 ± 0.399
3.754AlaPro: 3.754 ± 0.525
3.337AlaGln: 3.337 ± 0.6
5.006AlaArg: 5.006 ± 0.706
6.758AlaSer: 6.758 ± 0.989
5.673AlaThr: 5.673 ± 0.629
7.342AlaVal: 7.342 ± 0.79
1.418AlaTrp: 1.418 ± 0.401
3.588AlaTyr: 3.588 ± 0.396
0.0AlaXaa: 0.0 ± 0.0
Cys
1.001CysAla: 1.001 ± 0.282
0.334CysCys: 0.334 ± 0.184
1.001CysAsp: 1.001 ± 0.342
1.168CysGlu: 1.168 ± 0.344
0.167CysPhe: 0.167 ± 0.093
0.834CysGly: 0.834 ± 0.241
0.083CysHis: 0.083 ± 0.101
0.083CysIle: 0.083 ± 0.069
0.584CysLys: 0.584 ± 0.213
0.667CysLeu: 0.667 ± 0.265
0.083CysMet: 0.083 ± 0.077
0.501CysAsn: 0.501 ± 0.208
0.25CysPro: 0.25 ± 0.161
0.334CysGln: 0.334 ± 0.165
0.501CysArg: 0.501 ± 0.197
0.334CysSer: 0.334 ± 0.208
0.417CysThr: 0.417 ± 0.154
0.584CysVal: 0.584 ± 0.207
0.167CysTrp: 0.167 ± 0.097
0.25CysTyr: 0.25 ± 0.108
0.0CysXaa: 0.0 ± 0.0
Asp
7.342AspAla: 7.342 ± 0.826
0.667AspCys: 0.667 ± 0.228
3.588AspAsp: 3.588 ± 0.416
3.754AspGlu: 3.754 ± 0.633
3.004AspPhe: 3.004 ± 0.486
5.84AspGly: 5.84 ± 0.852
0.667AspHis: 0.667 ± 0.24
3.504AspIle: 3.504 ± 0.481
3.754AspLys: 3.754 ± 0.459
4.505AspLeu: 4.505 ± 0.405
1.669AspMet: 1.669 ± 0.267
2.837AspAsn: 2.837 ± 0.607
1.585AspPro: 1.585 ± 0.337
0.417AspGln: 0.417 ± 0.184
2.586AspArg: 2.586 ± 0.427
3.254AspSer: 3.254 ± 0.443
4.672AspThr: 4.672 ± 0.547
3.838AspVal: 3.838 ± 0.529
0.667AspTrp: 0.667 ± 0.22
1.835AspTyr: 1.835 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
6.508GluAla: 6.508 ± 0.886
0.167GluCys: 0.167 ± 0.136
3.838GluAsp: 3.838 ± 0.629
4.589GluGlu: 4.589 ± 1.074
3.087GluPhe: 3.087 ± 0.65
5.173GluGly: 5.173 ± 0.787
1.085GluHis: 1.085 ± 0.277
3.588GluIle: 3.588 ± 0.38
4.088GluLys: 4.088 ± 0.638
5.84GluLeu: 5.84 ± 0.849
2.586GluMet: 2.586 ± 0.376
2.586GluAsn: 2.586 ± 0.44
2.086GluPro: 2.086 ± 0.544
3.754GluGln: 3.754 ± 0.526
3.921GluArg: 3.921 ± 0.682
3.754GluSer: 3.754 ± 0.556
3.671GluThr: 3.671 ± 0.562
4.422GluVal: 4.422 ± 0.554
0.834GluTrp: 0.834 ± 0.346
1.919GluTyr: 1.919 ± 0.416
0.0GluXaa: 0.0 ± 0.0
Phe
2.753PheAla: 2.753 ± 0.501
0.417PheCys: 0.417 ± 0.179
3.004PheAsp: 3.004 ± 0.465
3.17PheGlu: 3.17 ± 0.493
1.085PhePhe: 1.085 ± 0.233
3.087PheGly: 3.087 ± 0.471
1.001PheHis: 1.001 ± 0.263
2.586PheIle: 2.586 ± 0.505
1.669PheLys: 1.669 ± 0.389
1.919PheLeu: 1.919 ± 0.405
0.667PheMet: 0.667 ± 0.209
1.669PheAsn: 1.669 ± 0.45
1.335PhePro: 1.335 ± 0.404
1.335PheGln: 1.335 ± 0.278
1.919PheArg: 1.919 ± 0.313
3.17PheSer: 3.17 ± 0.564
3.087PheThr: 3.087 ± 0.529
2.586PheVal: 2.586 ± 0.617
0.834PheTrp: 0.834 ± 0.294
1.085PheTyr: 1.085 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
7.509GlyAla: 7.509 ± 0.942
0.417GlyCys: 0.417 ± 0.172
4.255GlyAsp: 4.255 ± 0.553
6.174GlyGlu: 6.174 ± 0.734
2.419GlyPhe: 2.419 ± 0.425
6.257GlyGly: 6.257 ± 1.167
1.502GlyHis: 1.502 ± 0.462
3.671GlyIle: 3.671 ± 0.565
4.922GlyLys: 4.922 ± 0.558
5.173GlyLeu: 5.173 ± 0.556
2.336GlyMet: 2.336 ± 0.651
4.005GlyAsn: 4.005 ± 0.572
1.669GlyPro: 1.669 ± 0.397
3.004GlyGln: 3.004 ± 0.521
4.422GlyArg: 4.422 ± 0.517
5.34GlySer: 5.34 ± 0.739
3.838GlyThr: 3.838 ± 0.626
5.924GlyVal: 5.924 ± 0.654
1.168GlyTrp: 1.168 ± 0.323
2.67GlyTyr: 2.67 ± 0.546
0.0GlyXaa: 0.0 ± 0.0
His
1.085HisAla: 1.085 ± 0.339
0.25HisCys: 0.25 ± 0.131
0.918HisAsp: 0.918 ± 0.261
0.584HisGlu: 0.584 ± 0.244
0.751HisPhe: 0.751 ± 0.262
1.085HisGly: 1.085 ± 0.373
0.667HisHis: 0.667 ± 0.235
0.584HisIle: 0.584 ± 0.211
1.251HisLys: 1.251 ± 0.288
0.751HisLeu: 0.751 ± 0.292
0.751HisMet: 0.751 ± 0.246
0.667HisAsn: 0.667 ± 0.224
0.667HisPro: 0.667 ± 0.211
1.001HisGln: 1.001 ± 0.274
1.001HisArg: 1.001 ± 0.297
1.168HisSer: 1.168 ± 0.312
0.667HisThr: 0.667 ± 0.307
1.001HisVal: 1.001 ± 0.267
0.0HisTrp: 0.0 ± 0.0
1.085HisTyr: 1.085 ± 0.388
0.0HisXaa: 0.0 ± 0.0
Ile
4.255IleAla: 4.255 ± 0.701
0.25IleCys: 0.25 ± 0.132
3.671IleAsp: 3.671 ± 0.544
2.586IleGlu: 2.586 ± 0.582
1.502IlePhe: 1.502 ± 0.37
2.92IleGly: 2.92 ± 0.511
0.667IleHis: 0.667 ± 0.237
2.336IleIle: 2.336 ± 0.501
2.419IleLys: 2.419 ± 0.409
3.337IleLeu: 3.337 ± 0.533
1.001IleMet: 1.001 ± 0.322
2.336IleAsn: 2.336 ± 0.438
2.753IlePro: 2.753 ± 0.398
1.835IleGln: 1.835 ± 0.418
2.419IleArg: 2.419 ± 0.342
2.92IleSer: 2.92 ± 0.482
4.589IleThr: 4.589 ± 0.555
3.504IleVal: 3.504 ± 0.483
0.751IleTrp: 0.751 ± 0.22
1.335IleTyr: 1.335 ± 0.433
0.0IleXaa: 0.0 ± 0.0
Lys
5.423LysAla: 5.423 ± 0.832
0.751LysCys: 0.751 ± 0.244
2.92LysAsp: 2.92 ± 0.491
4.088LysGlu: 4.088 ± 0.634
1.835LysPhe: 1.835 ± 0.3
3.421LysGly: 3.421 ± 0.432
1.085LysHis: 1.085 ± 0.262
1.669LysIle: 1.669 ± 0.476
3.17LysLys: 3.17 ± 0.562
4.922LysLeu: 4.922 ± 0.617
2.67LysMet: 2.67 ± 0.583
2.419LysAsn: 2.419 ± 0.4
2.586LysPro: 2.586 ± 0.648
2.67LysGln: 2.67 ± 0.529
4.172LysArg: 4.172 ± 0.731
2.753LysSer: 2.753 ± 0.609
3.588LysThr: 3.588 ± 0.402
3.17LysVal: 3.17 ± 0.55
0.584LysTrp: 0.584 ± 0.196
2.586LysTyr: 2.586 ± 0.487
0.0LysXaa: 0.0 ± 0.0
Leu
6.841LeuAla: 6.841 ± 0.644
0.667LeuCys: 0.667 ± 0.276
3.588LeuAsp: 3.588 ± 0.437
4.839LeuGlu: 4.839 ± 0.87
1.835LeuPhe: 1.835 ± 0.401
4.756LeuGly: 4.756 ± 0.536
1.418LeuHis: 1.418 ± 0.37
4.172LeuIle: 4.172 ± 0.509
4.756LeuLys: 4.756 ± 0.826
6.007LeuLeu: 6.007 ± 0.808
1.752LeuMet: 1.752 ± 0.35
4.839LeuAsn: 4.839 ± 0.727
3.337LeuPro: 3.337 ± 0.516
2.67LeuGln: 2.67 ± 0.437
4.922LeuArg: 4.922 ± 0.71
4.839LeuSer: 4.839 ± 0.696
5.423LeuThr: 5.423 ± 0.444
6.09LeuVal: 6.09 ± 0.534
1.335LeuTrp: 1.335 ± 0.371
2.253LeuTyr: 2.253 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
2.503MetAla: 2.503 ± 0.343
0.25MetCys: 0.25 ± 0.143
1.168MetAsp: 1.168 ± 0.335
1.168MetGlu: 1.168 ± 0.271
0.918MetPhe: 0.918 ± 0.293
1.835MetGly: 1.835 ± 0.361
0.25MetHis: 0.25 ± 0.124
1.251MetIle: 1.251 ± 0.339
1.502MetLys: 1.502 ± 0.384
1.835MetLeu: 1.835 ± 0.367
0.584MetMet: 0.584 ± 0.212
0.834MetAsn: 0.834 ± 0.227
1.335MetPro: 1.335 ± 0.357
1.001MetGln: 1.001 ± 0.247
1.585MetArg: 1.585 ± 0.247
2.086MetSer: 2.086 ± 0.333
2.169MetThr: 2.169 ± 0.437
2.336MetVal: 2.336 ± 0.367
0.501MetTrp: 0.501 ± 0.179
0.501MetTyr: 0.501 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
4.505AsnAla: 4.505 ± 0.6
0.584AsnCys: 0.584 ± 0.192
2.837AsnAsp: 2.837 ± 0.418
2.503AsnGlu: 2.503 ± 0.526
1.835AsnPhe: 1.835 ± 0.421
4.255AsnGly: 4.255 ± 0.584
0.501AsnHis: 0.501 ± 0.173
2.837AsnIle: 2.837 ± 0.487
2.169AsnLys: 2.169 ± 0.419
4.005AsnLeu: 4.005 ± 0.45
0.667AsnMet: 0.667 ± 0.322
2.169AsnAsn: 2.169 ± 0.472
1.835AsnPro: 1.835 ± 0.403
1.669AsnGln: 1.669 ± 0.462
2.419AsnArg: 2.419 ± 0.339
2.253AsnSer: 2.253 ± 0.388
1.919AsnThr: 1.919 ± 0.435
4.255AsnVal: 4.255 ± 0.458
1.085AsnTrp: 1.085 ± 0.27
1.335AsnTyr: 1.335 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
3.254ProAla: 3.254 ± 0.564
0.25ProCys: 0.25 ± 0.131
2.92ProAsp: 2.92 ± 0.612
3.838ProGlu: 3.838 ± 0.463
2.002ProPhe: 2.002 ± 0.4
2.837ProGly: 2.837 ± 0.476
0.417ProHis: 0.417 ± 0.145
1.335ProIle: 1.335 ± 0.372
2.336ProLys: 2.336 ± 0.45
3.254ProLeu: 3.254 ± 0.439
1.001ProMet: 1.001 ± 0.231
1.669ProAsn: 1.669 ± 0.569
1.251ProPro: 1.251 ± 0.355
1.251ProGln: 1.251 ± 0.337
2.086ProArg: 2.086 ± 0.429
2.169ProSer: 2.169 ± 0.406
1.502ProThr: 1.502 ± 0.235
3.921ProVal: 3.921 ± 0.715
0.417ProTrp: 0.417 ± 0.25
1.502ProTyr: 1.502 ± 0.4
0.0ProXaa: 0.0 ± 0.0
Gln
4.756GlnAla: 4.756 ± 0.624
0.417GlnCys: 0.417 ± 0.184
1.752GlnAsp: 1.752 ± 0.32
2.086GlnGlu: 2.086 ± 0.566
1.335GlnPhe: 1.335 ± 0.384
2.503GlnGly: 2.503 ± 0.421
0.918GlnHis: 0.918 ± 0.298
1.585GlnIle: 1.585 ± 0.312
2.086GlnLys: 2.086 ± 0.428
3.588GlnLeu: 3.588 ± 0.506
1.168GlnMet: 1.168 ± 0.355
2.086GlnAsn: 2.086 ± 0.364
1.919GlnPro: 1.919 ± 0.311
2.336GlnGln: 2.336 ± 0.639
1.835GlnArg: 1.835 ± 0.373
2.002GlnSer: 2.002 ± 0.342
1.752GlnThr: 1.752 ± 0.42
2.92GlnVal: 2.92 ± 0.456
0.667GlnTrp: 0.667 ± 0.21
1.335GlnTyr: 1.335 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
4.172ArgAla: 4.172 ± 0.534
0.334ArgCys: 0.334 ± 0.156
3.337ArgAsp: 3.337 ± 0.395
3.588ArgGlu: 3.588 ± 0.607
1.919ArgPhe: 1.919 ± 0.399
3.588ArgGly: 3.588 ± 0.355
0.667ArgHis: 0.667 ± 0.261
3.254ArgIle: 3.254 ± 0.534
3.671ArgLys: 3.671 ± 0.623
4.505ArgLeu: 4.505 ± 0.571
2.169ArgMet: 2.169 ± 0.363
3.421ArgAsn: 3.421 ± 0.514
1.919ArgPro: 1.919 ± 0.403
3.421ArgGln: 3.421 ± 0.509
4.088ArgArg: 4.088 ± 0.672
2.336ArgSer: 2.336 ± 0.464
2.67ArgThr: 2.67 ± 0.456
4.505ArgVal: 4.505 ± 0.526
1.085ArgTrp: 1.085 ± 0.296
1.585ArgTyr: 1.585 ± 0.341
0.0ArgXaa: 0.0 ± 0.0
Ser
6.925SerAla: 6.925 ± 1.048
0.417SerCys: 0.417 ± 0.337
3.671SerAsp: 3.671 ± 0.568
3.588SerGlu: 3.588 ± 0.529
2.92SerPhe: 2.92 ± 0.491
6.758SerGly: 6.758 ± 0.804
0.918SerHis: 0.918 ± 0.256
2.419SerIle: 2.419 ± 0.526
2.086SerLys: 2.086 ± 0.509
4.922SerLeu: 4.922 ± 0.518
0.751SerMet: 0.751 ± 0.267
2.67SerAsn: 2.67 ± 0.456
2.586SerPro: 2.586 ± 0.493
2.336SerGln: 2.336 ± 0.425
3.004SerArg: 3.004 ± 0.592
3.004SerSer: 3.004 ± 0.681
4.172SerThr: 4.172 ± 0.644
5.673SerVal: 5.673 ± 0.692
0.834SerTrp: 0.834 ± 0.246
1.502SerTyr: 1.502 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
6.257ThrAla: 6.257 ± 0.655
0.334ThrCys: 0.334 ± 0.144
3.921ThrAsp: 3.921 ± 0.644
3.087ThrGlu: 3.087 ± 0.534
2.753ThrPhe: 2.753 ± 0.538
5.84ThrGly: 5.84 ± 0.857
0.751ThrHis: 0.751 ± 0.267
3.004ThrIle: 3.004 ± 0.431
2.92ThrLys: 2.92 ± 0.477
5.757ThrLeu: 5.757 ± 0.709
0.501ThrMet: 0.501 ± 0.214
2.002ThrAsn: 2.002 ± 0.462
4.172ThrPro: 4.172 ± 0.457
2.002ThrGln: 2.002 ± 0.391
3.337ThrArg: 3.337 ± 0.459
4.589ThrSer: 4.589 ± 0.632
4.088ThrThr: 4.088 ± 0.551
4.255ThrVal: 4.255 ± 0.697
0.834ThrTrp: 0.834 ± 0.226
2.586ThrTyr: 2.586 ± 0.505
0.0ThrXaa: 0.0 ± 0.0
Val
7.342ValAla: 7.342 ± 1.035
1.085ValCys: 1.085 ± 0.309
4.005ValAsp: 4.005 ± 0.545
6.257ValGlu: 6.257 ± 0.746
2.586ValPhe: 2.586 ± 0.46
4.338ValGly: 4.338 ± 0.595
0.751ValHis: 0.751 ± 0.222
3.921ValIle: 3.921 ± 0.511
5.256ValLys: 5.256 ± 0.668
4.589ValLeu: 4.589 ± 0.708
1.502ValMet: 1.502 ± 0.338
3.254ValAsn: 3.254 ± 0.457
2.503ValPro: 2.503 ± 0.72
2.837ValGln: 2.837 ± 0.445
3.671ValArg: 3.671 ± 0.501
6.09ValSer: 6.09 ± 0.81
5.924ValThr: 5.924 ± 0.641
6.174ValVal: 6.174 ± 0.719
0.751ValTrp: 0.751 ± 0.266
2.837ValTyr: 2.837 ± 0.451
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.257
0.083TrpCys: 0.083 ± 0.088
1.168TrpAsp: 1.168 ± 0.294
0.667TrpGlu: 0.667 ± 0.248
1.085TrpPhe: 1.085 ± 0.368
1.001TrpGly: 1.001 ± 0.289
0.334TrpHis: 0.334 ± 0.173
0.417TrpIle: 0.417 ± 0.18
0.417TrpLys: 0.417 ± 0.193
1.502TrpLeu: 1.502 ± 0.42
0.501TrpMet: 0.501 ± 0.197
0.667TrpAsn: 0.667 ± 0.24
0.501TrpPro: 0.501 ± 0.2
0.501TrpGln: 0.501 ± 0.206
1.001TrpArg: 1.001 ± 0.321
0.584TrpSer: 0.584 ± 0.209
0.584TrpThr: 0.584 ± 0.211
1.418TrpVal: 1.418 ± 0.287
0.25TrpTrp: 0.25 ± 0.13
0.417TrpTyr: 0.417 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.92TyrAla: 2.92 ± 0.528
0.25TyrCys: 0.25 ± 0.142
2.503TyrAsp: 2.503 ± 0.585
2.753TyrGlu: 2.753 ± 0.447
1.335TyrPhe: 1.335 ± 0.321
2.753TyrGly: 2.753 ± 0.517
0.501TyrHis: 0.501 ± 0.183
1.502TyrIle: 1.502 ± 0.363
2.67TyrLys: 2.67 ± 0.437
2.002TyrLeu: 2.002 ± 0.36
0.584TyrMet: 0.584 ± 0.219
1.418TyrAsn: 1.418 ± 0.308
1.168TyrPro: 1.168 ± 0.352
1.335TyrGln: 1.335 ± 0.325
2.336TyrArg: 2.336 ± 0.517
1.835TyrSer: 1.835 ± 0.386
2.586TyrThr: 2.586 ± 0.507
1.752TyrVal: 1.752 ± 0.358
0.0TyrTrp: 0.0 ± 0.0
1.335TyrTyr: 1.335 ± 0.288
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (11987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski