Amino acid dipepetide frequency for Laceyella sacchari (Thermoactinomyces thalpophilus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.982AlaAla: 6.982 ± 0.123	0.885AlaCys: 0.885 ± 0.032	4.266AlaAsp: 4.266 ± 0.078	6.075AlaGlu: 6.075 ± 0.105	3.403AlaPhe: 3.403 ± 0.069	6.232AlaGly: 6.232 ± 0.096	1.863AlaHis: 1.863 ± 0.042	5.322AlaIle: 5.322 ± 0.088	4.82AlaLys: 4.82 ± 0.08	8.829AlaLeu: 8.829 ± 0.113	2.336AlaMet: 2.336 ± 0.055	2.54AlaAsn: 2.54 ± 0.053	2.87AlaPro: 2.87 ± 0.064	3.085AlaGln: 3.085 ± 0.058	4.277AlaArg: 4.277 ± 0.072	4.111AlaSer: 4.111 ± 0.069	3.988AlaThr: 3.988 ± 0.073	6.489AlaVal: 6.489 ± 0.098	1.115AlaTrp: 1.115 ± 0.04	2.676AlaTyr: 2.676 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.627CysAla: 0.627 ± 0.028	0.13CysCys: 0.13 ± 0.013	0.457CysAsp: 0.457 ± 0.022	0.515CysGlu: 0.515 ± 0.022	0.42CysPhe: 0.42 ± 0.023	0.83CysGly: 0.83 ± 0.03	0.279CysHis: 0.279 ± 0.019	0.494CysIle: 0.494 ± 0.022	0.403CysLys: 0.403 ± 0.022	0.965CysLeu: 0.965 ± 0.036	0.201CysMet: 0.201 ± 0.012	0.305CysAsn: 0.305 ± 0.02	0.496CysPro: 0.496 ± 0.027	0.369CysGln: 0.369 ± 0.02	0.575CysArg: 0.575 ± 0.026	0.504CysSer: 0.504 ± 0.023	0.451CysThr: 0.451 ± 0.021	0.602CysVal: 0.602 ± 0.026	0.143CysTrp: 0.143 ± 0.011	0.343CysTyr: 0.343 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.753AspAla: 3.753 ± 0.07	0.448AspCys: 0.448 ± 0.019	2.257AspAsp: 2.257 ± 0.058	4.173AspGlu: 4.173 ± 0.07	2.003AspPhe: 2.003 ± 0.046	3.7AspGly: 3.7 ± 0.07	1.243AspHis: 1.243 ± 0.04	3.003AspIle: 3.003 ± 0.064	2.655AspLys: 2.655 ± 0.065	4.997AspLeu: 4.997 ± 0.097	1.33AspMet: 1.33 ± 0.039	1.296AspAsn: 1.296 ± 0.042	2.425AspPro: 2.425 ± 0.054	2.193AspGln: 2.193 ± 0.048	3.015AspArg: 3.015 ± 0.069	2.049AspSer: 2.049 ± 0.049	2.139AspThr: 2.139 ± 0.055	3.898AspVal: 3.898 ± 0.07	0.877AspTrp: 0.877 ± 0.033	1.789AspTyr: 1.789 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.53GluAla: 6.53 ± 0.099	0.547GluCys: 0.547 ± 0.026	2.983GluAsp: 2.983 ± 0.067	6.542GluGlu: 6.542 ± 0.105	1.969GluPhe: 1.969 ± 0.043	4.384GluGly: 4.384 ± 0.076	1.653GluHis: 1.653 ± 0.054	4.556GluIle: 4.556 ± 0.077	4.953GluLys: 4.953 ± 0.085	7.347GluLeu: 7.347 ± 0.106	2.245GluMet: 2.245 ± 0.052	2.177GluAsn: 2.177 ± 0.048	2.389GluPro: 2.389 ± 0.053	4.095GluGln: 4.095 ± 0.08	5.249GluArg: 5.249 ± 0.102	2.927GluSer: 2.927 ± 0.057	3.507GluThr: 3.507 ± 0.067	5.343GluVal: 5.343 ± 0.078	1.157GluTrp: 1.157 ± 0.042	1.965GluTyr: 1.965 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.539PheAla: 3.539 ± 0.062	0.407PheCys: 0.407 ± 0.021	2.213PheAsp: 2.213 ± 0.058	2.161PheGlu: 2.161 ± 0.048	1.939PhePhe: 1.939 ± 0.055	2.972PheGly: 2.972 ± 0.064	1.066PheHis: 1.066 ± 0.037	2.644PheIle: 2.644 ± 0.06	1.648PheLys: 1.648 ± 0.044	3.883PheLeu: 3.883 ± 0.087	0.987PheMet: 0.987 ± 0.036	1.325PheAsn: 1.325 ± 0.045	1.769PhePro: 1.769 ± 0.047	1.488PheGln: 1.488 ± 0.04	1.936PheArg: 1.936 ± 0.05	2.479PheSer: 2.479 ± 0.056	2.3PheThr: 2.3 ± 0.059	3.001PheVal: 3.001 ± 0.063	0.5PheTrp: 0.5 ± 0.025	1.421PheTyr: 1.421 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.371GlyAla: 5.371 ± 0.08	0.768GlyCys: 0.768 ± 0.032	3.338GlyAsp: 3.338 ± 0.065	4.9GlyGlu: 4.9 ± 0.085	3.082GlyPhe: 3.082 ± 0.067	5.424GlyGly: 5.424 ± 0.104	1.55GlyHis: 1.55 ± 0.041	5.149GlyIle: 5.149 ± 0.08	4.908GlyLys: 4.908 ± 0.073	7.409GlyLeu: 7.409 ± 0.099	2.381GlyMet: 2.381 ± 0.047	2.248GlyAsn: 2.248 ± 0.066	2.018GlyPro: 2.018 ± 0.05	2.858GlyGln: 2.858 ± 0.058	3.911GlyArg: 3.911 ± 0.071	3.712GlySer: 3.712 ± 0.072	3.975GlyThr: 3.975 ± 0.083	5.813GlyVal: 5.813 ± 0.087	1.135GlyTrp: 1.135 ± 0.034	2.559GlyTyr: 2.559 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.97HisAla: 1.97 ± 0.052	0.259HisCys: 0.259 ± 0.018	1.093HisAsp: 1.093 ± 0.031	1.399HisGlu: 1.399 ± 0.039	1.083HisPhe: 1.083 ± 0.038	1.719HisGly: 1.719 ± 0.048	0.839HisHis: 0.839 ± 0.04	1.521HisIle: 1.521 ± 0.041	0.956HisLys: 0.956 ± 0.036	2.81HisLeu: 2.81 ± 0.068	0.61HisMet: 0.61 ± 0.024	0.631HisAsn: 0.631 ± 0.025	1.677HisPro: 1.677 ± 0.042	1.118HisGln: 1.118 ± 0.033	1.46HisArg: 1.46 ± 0.041	1.132HisSer: 1.132 ± 0.036	1.112HisThr: 1.112 ± 0.039	1.818HisVal: 1.818 ± 0.041	0.329HisTrp: 0.329 ± 0.019	0.853HisTyr: 0.853 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.643IleAla: 5.643 ± 0.091	0.657IleCys: 0.657 ± 0.025	3.61IleAsp: 3.61 ± 0.063	4.427IleGlu: 4.427 ± 0.078	2.216IlePhe: 2.216 ± 0.057	5.086IleGly: 5.086 ± 0.09	1.775IleHis: 1.775 ± 0.042	3.736IleIle: 3.736 ± 0.086	3.305IleLys: 3.305 ± 0.07	5.717IleLeu: 5.717 ± 0.102	1.393IleMet: 1.393 ± 0.04	2.242IleAsn: 2.242 ± 0.058	3.14IlePro: 3.14 ± 0.062	2.521IleGln: 2.521 ± 0.052	3.679IleArg: 3.679 ± 0.06	3.702IleSer: 3.702 ± 0.069	3.477IleThr: 3.477 ± 0.062	4.549IleVal: 4.549 ± 0.073	0.676IleTrp: 0.676 ± 0.028	1.955IleTyr: 1.955 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.44LysAla: 4.44 ± 0.081	0.368LysCys: 0.368 ± 0.019	2.548LysAsp: 2.548 ± 0.058	5.423LysGlu: 5.423 ± 0.084	1.372LysPhe: 1.372 ± 0.042	4.044LysGly: 4.044 ± 0.077	1.3LysHis: 1.3 ± 0.037	3.127LysIle: 3.127 ± 0.08	4.372LysLys: 4.372 ± 0.106	4.961LysLeu: 4.961 ± 0.085	1.758LysMet: 1.758 ± 0.042	1.946LysAsn: 1.946 ± 0.057	2.416LysPro: 2.416 ± 0.058	3.279LysGln: 3.279 ± 0.066	3.983LysArg: 3.983 ± 0.071	2.544LysSer: 2.544 ± 0.056	2.841LysThr: 2.841 ± 0.058	4.095LysVal: 4.095 ± 0.078	0.894LysTrp: 0.894 ± 0.034	1.591LysTyr: 1.591 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	9.466LeuAla: 9.466 ± 0.118	0.994LeuCys: 0.994 ± 0.036	5.245LeuAsp: 5.245 ± 0.086	6.705LeuGlu: 6.705 ± 0.098	4.608LeuPhe: 4.608 ± 0.097	7.103LeuGly: 7.103 ± 0.105	2.434LeuHis: 2.434 ± 0.048	6.477LeuIle: 6.477 ± 0.109	5.579LeuLys: 5.579 ± 0.088	10.43LeuLeu: 10.43 ± 0.14	2.558LeuMet: 2.558 ± 0.053	3.426LeuAsn: 3.426 ± 0.066	4.815LeuPro: 4.815 ± 0.084	3.745LeuGln: 3.745 ± 0.066	5.348LeuArg: 5.348 ± 0.089	6.666LeuSer: 6.666 ± 0.101	5.648LeuThr: 5.648 ± 0.076	6.998LeuVal: 6.998 ± 0.084	1.02LeuTrp: 1.02 ± 0.034	3.0LeuTyr: 3.0 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.391MetAla: 2.391 ± 0.055	0.192MetCys: 0.192 ± 0.014	1.423MetAsp: 1.423 ± 0.043	2.076MetGlu: 2.076 ± 0.046	0.947MetPhe: 0.947 ± 0.034	2.108MetGly: 2.108 ± 0.052	0.513MetHis: 0.513 ± 0.024	1.858MetIle: 1.858 ± 0.048	1.973MetLys: 1.973 ± 0.051	2.556MetLeu: 2.556 ± 0.063	0.9MetMet: 0.9 ± 0.031	1.157MetAsn: 1.157 ± 0.031	1.086MetPro: 1.086 ± 0.037	1.032MetGln: 1.032 ± 0.034	1.656MetArg: 1.656 ± 0.041	1.582MetSer: 1.582 ± 0.037	1.379MetThr: 1.379 ± 0.039	2.183MetVal: 2.183 ± 0.045	0.266MetTrp: 0.266 ± 0.016	0.662MetTyr: 0.662 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.285AsnAla: 2.285 ± 0.049	0.253AsnCys: 0.253 ± 0.017	1.469AsnAsp: 1.469 ± 0.044	2.291AsnGlu: 2.291 ± 0.055	1.015AsnPhe: 1.015 ± 0.037	2.515AsnGly: 2.515 ± 0.059	0.94AsnHis: 0.94 ± 0.03	2.054AsnIle: 2.054 ± 0.054	1.979AsnLys: 1.979 ± 0.058	3.012AsnLeu: 3.012 ± 0.064	0.938AsnMet: 0.938 ± 0.036	1.139AsnAsn: 1.139 ± 0.042	1.957AsnPro: 1.957 ± 0.046	1.807AsnGln: 1.807 ± 0.043	2.218AsnArg: 2.218 ± 0.05	1.408AsnSer: 1.408 ± 0.039	1.508AsnThr: 1.508 ± 0.042	2.119AsnVal: 2.119 ± 0.047	0.482AsnTrp: 0.482 ± 0.024	0.951AsnTyr: 0.951 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.349ProAla: 3.349 ± 0.071	0.307ProCys: 0.307 ± 0.021	2.668ProAsp: 2.668 ± 0.064	3.532ProGlu: 3.532 ± 0.07	2.026ProPhe: 2.026 ± 0.047	3.035ProGly: 3.035 ± 0.059	1.223ProHis: 1.223 ± 0.035	2.622ProIle: 2.622 ± 0.056	2.045ProLys: 2.045 ± 0.05	4.344ProLeu: 4.344 ± 0.072	1.002ProMet: 1.002 ± 0.036	1.441ProAsn: 1.441 ± 0.04	1.602ProPro: 1.602 ± 0.048	1.626ProGln: 1.626 ± 0.046	1.853ProArg: 1.853 ± 0.049	2.482ProSer: 2.482 ± 0.055	2.333ProThr: 2.333 ± 0.055	3.474ProVal: 3.474 ± 0.063	0.552ProTrp: 0.552 ± 0.027	1.513ProTyr: 1.513 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.276GlnAla: 4.276 ± 0.08	0.283GlnCys: 0.283 ± 0.021	1.663GlnAsp: 1.663 ± 0.048	3.169GlnGlu: 3.169 ± 0.066	1.528GlnPhe: 1.528 ± 0.041	2.799GlnGly: 2.799 ± 0.051	0.93GlnHis: 0.93 ± 0.031	2.543GlnIle: 2.543 ± 0.052	2.376GlnLys: 2.376 ± 0.048	4.805GlnLeu: 4.805 ± 0.069	1.301GlnMet: 1.301 ± 0.045	1.169GlnAsn: 1.169 ± 0.035	1.835GlnPro: 1.835 ± 0.052	2.13GlnGln: 2.13 ± 0.061	2.186GlnArg: 2.186 ± 0.056	2.063GlnSer: 2.063 ± 0.055	2.265GlnThr: 2.265 ± 0.054	3.485GlnVal: 3.485 ± 0.065	0.538GlnTrp: 0.538 ± 0.026	1.176GlnTyr: 1.176 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.786ArgAla: 3.786 ± 0.077	0.455ArgCys: 0.455 ± 0.022	2.732ArgAsp: 2.732 ± 0.056	4.461ArgGlu: 4.461 ± 0.082	2.569ArgPhe: 2.569 ± 0.046	3.376ArgGly: 3.376 ± 0.063	1.337ArgHis: 1.337 ± 0.041	3.818ArgIle: 3.818 ± 0.068	3.408ArgLys: 3.408 ± 0.067	6.648ArgLeu: 6.648 ± 0.108	1.907ArgMet: 1.907 ± 0.042	1.787ArgAsn: 1.787 ± 0.05	2.081ArgPro: 2.081 ± 0.05	2.6ArgGln: 2.6 ± 0.065	3.39ArgArg: 3.39 ± 0.067	2.721ArgSer: 2.721 ± 0.06	2.59ArgThr: 2.59 ± 0.064	4.332ArgVal: 4.332 ± 0.082	0.817ArgTrp: 0.817 ± 0.031	2.068ArgTyr: 2.068 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.942SerAla: 3.942 ± 0.077	0.488SerCys: 0.488 ± 0.024	2.362SerAsp: 2.362 ± 0.056	3.158SerGlu: 3.158 ± 0.062	2.579SerPhe: 2.579 ± 0.057	4.253SerGly: 4.253 ± 0.074	1.319SerHis: 1.319 ± 0.038	3.346SerIle: 3.346 ± 0.072	2.747SerLys: 2.747 ± 0.064	5.802SerLeu: 5.802 ± 0.091	1.523SerMet: 1.523 ± 0.041	1.683SerAsn: 1.683 ± 0.044	2.38SerPro: 2.38 ± 0.054	2.067SerGln: 2.067 ± 0.054	2.86SerArg: 2.86 ± 0.055	2.857SerSer: 2.857 ± 0.078	2.697SerThr: 2.697 ± 0.054	3.881SerVal: 3.881 ± 0.066	0.665SerTrp: 0.665 ± 0.028	1.768SerTyr: 1.768 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.211ThrAla: 4.211 ± 0.077	0.506ThrCys: 0.506 ± 0.025	2.516ThrAsp: 2.516 ± 0.061	3.292ThrGlu: 3.292 ± 0.074	2.104ThrPhe: 2.104 ± 0.048	4.275ThrGly: 4.275 ± 0.073	1.259ThrHis: 1.259 ± 0.038	3.386ThrIle: 3.386 ± 0.061	2.554ThrLys: 2.554 ± 0.055	5.226ThrLeu: 5.226 ± 0.077	1.321ThrMet: 1.321 ± 0.037	1.63ThrAsn: 1.63 ± 0.043	2.668ThrPro: 2.668 ± 0.057	1.761ThrGln: 1.761 ± 0.042	2.375ThrArg: 2.375 ± 0.058	2.765ThrSer: 2.765 ± 0.058	2.629ThrThr: 2.629 ± 0.059	4.278ThrVal: 4.278 ± 0.066	0.664ThrTrp: 0.664 ± 0.028	1.798ThrTyr: 1.798 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	6.399ValAla: 6.399 ± 0.098	0.739ValCys: 0.739 ± 0.035	4.018ValAsp: 4.018 ± 0.068	5.222ValGlu: 5.222 ± 0.083	2.881ValPhe: 2.881 ± 0.058	5.355ValGly: 5.355 ± 0.075	1.676ValHis: 1.676 ± 0.039	5.158ValIle: 5.158 ± 0.08	4.49ValLys: 4.49 ± 0.075	7.251ValLeu: 7.251 ± 0.083	1.955ValMet: 1.955 ± 0.041	2.685ValAsn: 2.685 ± 0.05	3.361ValPro: 3.361 ± 0.07	2.612ValGln: 2.612 ± 0.055	4.131ValArg: 4.131 ± 0.073	4.43ValSer: 4.43 ± 0.066	4.197ValThr: 4.197 ± 0.079	6.012ValVal: 6.012 ± 0.084	0.946ValTrp: 0.946 ± 0.033	2.186ValTyr: 2.186 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.853TrpAla: 0.853 ± 0.032	0.14TrpCys: 0.14 ± 0.012	0.634TrpAsp: 0.634 ± 0.024	0.914TrpGlu: 0.914 ± 0.032	0.595TrpPhe: 0.595 ± 0.028	0.891TrpGly: 0.891 ± 0.035	0.29TrpHis: 0.29 ± 0.019	0.926TrpIle: 0.926 ± 0.03	0.731TrpLys: 0.731 ± 0.029	1.759TrpLeu: 1.759 ± 0.052	0.512TrpMet: 0.512 ± 0.025	0.526TrpAsn: 0.526 ± 0.027	0.418TrpPro: 0.418 ± 0.022	0.57TrpGln: 0.57 ± 0.025	0.714TrpArg: 0.714 ± 0.032	0.735TrpSer: 0.735 ± 0.032	0.634TrpThr: 0.634 ± 0.027	0.987TrpVal: 0.987 ± 0.032	0.213TrpTrp: 0.213 ± 0.017	0.369TrpTyr: 0.369 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.351TyrAla: 2.351 ± 0.052	0.283TyrCys: 0.283 ± 0.017	1.744TyrAsp: 1.744 ± 0.059	2.081TyrGlu: 2.081 ± 0.048	1.34TyrPhe: 1.34 ± 0.041	2.411TyrGly: 2.411 ± 0.056	0.9TyrHis: 0.9 ± 0.036	1.766TyrIle: 1.766 ± 0.041	1.398TyrLys: 1.398 ± 0.04	3.519TyrLeu: 3.519 ± 0.072	0.783TyrMet: 0.783 ± 0.031	0.989TyrAsn: 0.989 ± 0.04	1.627TyrPro: 1.627 ± 0.048	1.564TyrGln: 1.564 ± 0.047	2.066TyrArg: 2.066 ± 0.052	1.506TyrSer: 1.506 ± 0.044	1.55TyrThr: 1.55 ± 0.043	2.346TyrVal: 2.346 ± 0.048	0.419TyrTrp: 0.419 ± 0.023	1.247TyrTyr: 1.247 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3145 proteins (918210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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