Amino acid dipepetide frequency for Corynebacterium sp. DNF00584

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.356AlaAla: 18.356 ± 0.25
0.932AlaCys: 0.932 ± 0.035
7.403AlaAsp: 7.403 ± 0.107
8.083AlaGlu: 8.083 ± 0.116
3.934AlaPhe: 3.934 ± 0.065
10.458AlaGly: 10.458 ± 0.125
2.687AlaHis: 2.687 ± 0.055
5.305AlaIle: 5.305 ± 0.095
3.843AlaLys: 3.843 ± 0.068
12.434AlaLeu: 12.434 ± 0.186
2.796AlaMet: 2.796 ± 0.057
2.799AlaAsn: 2.799 ± 0.07
5.91AlaPro: 5.91 ± 0.104
4.866AlaGln: 4.866 ± 0.094
7.742AlaArg: 7.742 ± 0.126
6.208AlaSer: 6.208 ± 0.104
7.314AlaThr: 7.314 ± 0.107
9.756AlaVal: 9.756 ± 0.128
1.817AlaTrp: 1.817 ± 0.059
2.431AlaTyr: 2.431 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.845CysAla: 0.845 ± 0.037
0.069CysCys: 0.069 ± 0.01
0.415CysAsp: 0.415 ± 0.023
0.393CysGlu: 0.393 ± 0.025
0.251CysPhe: 0.251 ± 0.019
0.708CysGly: 0.708 ± 0.029
0.157CysHis: 0.157 ± 0.016
0.301CysIle: 0.301 ± 0.019
0.124CysLys: 0.124 ± 0.014
0.513CysLeu: 0.513 ± 0.026
0.147CysMet: 0.147 ± 0.013
0.156CysAsn: 0.156 ± 0.014
0.397CysPro: 0.397 ± 0.024
0.201CysGln: 0.201 ± 0.015
0.351CysArg: 0.351 ± 0.025
0.468CysSer: 0.468 ± 0.024
0.43CysThr: 0.43 ± 0.022
0.555CysVal: 0.555 ± 0.025
0.072CysTrp: 0.072 ± 0.011
0.157CysTyr: 0.157 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.923AspAla: 7.923 ± 0.131
0.399AspCys: 0.399 ± 0.024
3.467AspAsp: 3.467 ± 0.082
4.249AspGlu: 4.249 ± 0.074
2.282AspPhe: 2.282 ± 0.048
5.207AspGly: 5.207 ± 0.087
1.285AspHis: 1.285 ± 0.041
3.244AspIle: 3.244 ± 0.07
2.067AspLys: 2.067 ± 0.057
5.292AspLeu: 5.292 ± 0.083
1.318AspMet: 1.318 ± 0.043
1.753AspAsn: 1.753 ± 0.057
3.508AspPro: 3.508 ± 0.068
1.546AspGln: 1.546 ± 0.044
3.257AspArg: 3.257 ± 0.073
3.032AspSer: 3.032 ± 0.063
3.275AspThr: 3.275 ± 0.067
4.774AspVal: 4.774 ± 0.081
0.856AspTrp: 0.856 ± 0.031
1.583AspTyr: 1.583 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
7.013GluAla: 7.013 ± 0.102
0.359GluCys: 0.359 ± 0.026
3.836GluAsp: 3.836 ± 0.069
4.386GluGlu: 4.386 ± 0.092
2.199GluPhe: 2.199 ± 0.053
4.636GluGly: 4.636 ± 0.079
1.703GluHis: 1.703 ± 0.055
3.043GluIle: 3.043 ± 0.068
2.436GluLys: 2.436 ± 0.061
7.106GluLeu: 7.106 ± 0.109
1.338GluMet: 1.338 ± 0.045
1.792GluAsn: 1.792 ± 0.052
2.962GluPro: 2.962 ± 0.073
2.249GluGln: 2.249 ± 0.057
4.134GluArg: 4.134 ± 0.079
3.287GluSer: 3.287 ± 0.06
3.445GluThr: 3.445 ± 0.078
4.779GluVal: 4.779 ± 0.085
0.909GluTrp: 0.909 ± 0.041
1.413GluTyr: 1.413 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
4.091PheAla: 4.091 ± 0.077
0.274PheCys: 0.274 ± 0.019
2.474PheAsp: 2.474 ± 0.058
1.97PheGlu: 1.97 ± 0.052
1.393PhePhe: 1.393 ± 0.057
3.48PheGly: 3.48 ± 0.071
0.727PheHis: 0.727 ± 0.03
1.778PheIle: 1.778 ± 0.051
0.95PheLys: 0.95 ± 0.038
3.099PheLeu: 3.099 ± 0.073
0.75PheMet: 0.75 ± 0.032
1.049PheAsn: 1.049 ± 0.039
1.441PhePro: 1.441 ± 0.047
0.884PheGln: 0.884 ± 0.032
1.711PheArg: 1.711 ± 0.049
1.96PheSer: 1.96 ± 0.05
2.123PheThr: 2.123 ± 0.056
2.687PheVal: 2.687 ± 0.063
0.467PheTrp: 0.467 ± 0.026
0.837PheTyr: 0.837 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
9.278GlyAla: 9.278 ± 0.131
0.611GlyCys: 0.611 ± 0.031
4.493GlyAsp: 4.493 ± 0.084
5.292GlyGlu: 5.292 ± 0.102
3.264GlyPhe: 3.264 ± 0.059
6.737GlyGly: 6.737 ± 0.121
1.95GlyHis: 1.95 ± 0.049
4.612GlyIle: 4.612 ± 0.064
3.119GlyLys: 3.119 ± 0.078
8.357GlyLeu: 8.357 ± 0.121
2.138GlyMet: 2.138 ± 0.057
2.207GlyAsn: 2.207 ± 0.055
3.342GlyPro: 3.342 ± 0.072
2.712GlyGln: 2.712 ± 0.072
4.789GlyArg: 4.789 ± 0.086
4.82GlySer: 4.82 ± 0.084
5.644GlyThr: 5.644 ± 0.098
6.932GlyVal: 6.932 ± 0.106
1.451GlyTrp: 1.451 ± 0.05
2.215GlyTyr: 2.215 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.558HisAla: 2.558 ± 0.065
0.192HisCys: 0.192 ± 0.015
1.263HisAsp: 1.263 ± 0.05
1.354HisGlu: 1.354 ± 0.043
0.694HisPhe: 0.694 ± 0.031
2.005HisGly: 2.005 ± 0.056
0.551HisHis: 0.551 ± 0.032
1.076HisIle: 1.076 ± 0.039
0.536HisLys: 0.536 ± 0.027
1.999HisLeu: 1.999 ± 0.049
0.453HisMet: 0.453 ± 0.022
0.633HisAsn: 0.633 ± 0.031
1.434HisPro: 1.434 ± 0.043
0.586HisGln: 0.586 ± 0.03
1.396HisArg: 1.396 ± 0.048
1.165HisSer: 1.165 ± 0.041
1.308HisThr: 1.308 ± 0.044
1.684HisVal: 1.684 ± 0.051
0.292HisTrp: 0.292 ± 0.021
0.607HisTyr: 0.607 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.541IleAla: 6.541 ± 0.083
0.383IleCys: 0.383 ± 0.022
3.387IleAsp: 3.387 ± 0.064
3.001IleGlu: 3.001 ± 0.066
1.608IlePhe: 1.608 ± 0.052
4.136IleGly: 4.136 ± 0.069
0.986IleHis: 0.986 ± 0.039
2.709IleIle: 2.709 ± 0.061
1.447IleLys: 1.447 ± 0.048
4.072IleLeu: 4.072 ± 0.079
1.044IleMet: 1.044 ± 0.034
1.542IleAsn: 1.542 ± 0.047
2.546IlePro: 2.546 ± 0.06
1.278IleGln: 1.278 ± 0.038
2.401IleArg: 2.401 ± 0.06
2.576IleSer: 2.576 ± 0.065
2.996IleThr: 2.996 ± 0.065
4.415IleVal: 4.415 ± 0.083
0.462IleTrp: 0.462 ± 0.026
1.053IleTyr: 1.053 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.734LysAla: 3.734 ± 0.073
0.131LysCys: 0.131 ± 0.012
2.166LysAsp: 2.166 ± 0.065
2.044LysGlu: 2.044 ± 0.058
0.979LysPhe: 0.979 ± 0.035
2.234LysGly: 2.234 ± 0.067
0.675LysHis: 0.675 ± 0.027
1.569LysIle: 1.569 ± 0.047
1.813LysLys: 1.813 ± 0.061
3.097LysLeu: 3.097 ± 0.065
0.789LysMet: 0.789 ± 0.034
1.099LysAsn: 1.099 ± 0.043
1.635LysPro: 1.635 ± 0.06
1.122LysGln: 1.122 ± 0.039
2.021LysArg: 2.021 ± 0.055
1.658LysSer: 1.658 ± 0.052
1.844LysThr: 1.844 ± 0.052
2.497LysVal: 2.497 ± 0.075
0.38LysTrp: 0.38 ± 0.022
0.753LysTyr: 0.753 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
13.012LeuAla: 13.012 ± 0.168
0.656LeuCys: 0.656 ± 0.03
6.114LeuAsp: 6.114 ± 0.105
5.378LeuGlu: 5.378 ± 0.086
2.884LeuPhe: 2.884 ± 0.069
8.635LeuGly: 8.635 ± 0.1
1.987LeuHis: 1.987 ± 0.059
4.84LeuIle: 4.84 ± 0.088
2.767LeuLys: 2.767 ± 0.067
8.787LeuLeu: 8.787 ± 0.152
2.005LeuMet: 2.005 ± 0.058
2.452LeuAsn: 2.452 ± 0.055
5.248LeuPro: 5.248 ± 0.099
2.45LeuGln: 2.45 ± 0.058
6.22LeuArg: 6.22 ± 0.101
5.507LeuSer: 5.507 ± 0.09
6.271LeuThr: 6.271 ± 0.087
7.822LeuVal: 7.822 ± 0.11
1.16LeuTrp: 1.16 ± 0.044
1.839LeuTyr: 1.839 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.689MetAla: 2.689 ± 0.061
0.153MetCys: 0.153 ± 0.015
1.146MetAsp: 1.146 ± 0.038
1.124MetGlu: 1.124 ± 0.038
0.702MetPhe: 0.702 ± 0.03
1.839MetGly: 1.839 ± 0.057
0.477MetHis: 0.477 ± 0.027
0.991MetIle: 0.991 ± 0.039
0.793MetLys: 0.793 ± 0.033
2.157MetLeu: 2.157 ± 0.061
0.545MetMet: 0.545 ± 0.027
0.695MetAsn: 0.695 ± 0.032
1.226MetPro: 1.226 ± 0.045
0.641MetGln: 0.641 ± 0.032
1.384MetArg: 1.384 ± 0.039
1.667MetSer: 1.667 ± 0.038
1.732MetThr: 1.732 ± 0.048
1.726MetVal: 1.726 ± 0.053
0.325MetTrp: 0.325 ± 0.018
0.385MetTyr: 0.385 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.194AsnAla: 3.194 ± 0.062
0.172AsnCys: 0.172 ± 0.014
1.54AsnAsp: 1.54 ± 0.049
1.66AsnGlu: 1.66 ± 0.049
1.047AsnPhe: 1.047 ± 0.035
2.353AsnGly: 2.353 ± 0.068
0.562AsnHis: 0.562 ± 0.027
1.278AsnIle: 1.278 ± 0.04
0.909AsnLys: 0.909 ± 0.039
2.5AsnLeu: 2.5 ± 0.056
0.59AsnMet: 0.59 ± 0.027
0.902AsnAsn: 0.902 ± 0.036
2.028AsnPro: 2.028 ± 0.06
0.88AsnGln: 0.88 ± 0.037
1.473AsnArg: 1.473 ± 0.054
1.54AsnSer: 1.54 ± 0.046
1.54AsnThr: 1.54 ± 0.047
2.098AsnVal: 2.098 ± 0.052
0.413AsnTrp: 0.413 ± 0.026
0.807AsnTyr: 0.807 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
6.51ProAla: 6.51 ± 0.107
0.222ProCys: 0.222 ± 0.018
3.291ProAsp: 3.291 ± 0.078
4.288ProGlu: 4.288 ± 0.087
1.58ProPhe: 1.58 ± 0.046
4.579ProGly: 4.579 ± 0.103
1.094ProHis: 1.094 ± 0.039
1.978ProIle: 1.978 ± 0.051
1.541ProLys: 1.541 ± 0.052
4.412ProLeu: 4.412 ± 0.087
0.996ProMet: 0.996 ± 0.035
1.419ProAsn: 1.419 ± 0.048
1.62ProPro: 1.62 ± 0.052
1.815ProGln: 1.815 ± 0.056
2.895ProArg: 2.895 ± 0.066
2.919ProSer: 2.919 ± 0.064
3.249ProThr: 3.249 ± 0.075
4.261ProVal: 4.261 ± 0.079
0.714ProTrp: 0.714 ± 0.03
1.103ProTyr: 1.103 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.926GlnAla: 3.926 ± 0.069
0.159GlnCys: 0.159 ± 0.014
1.625GlnAsp: 1.625 ± 0.047
1.766GlnGlu: 1.766 ± 0.042
1.014GlnPhe: 1.014 ± 0.039
2.206GlnGly: 2.206 ± 0.062
0.673GlnHis: 0.673 ± 0.029
1.608GlnIle: 1.608 ± 0.046
1.02GlnLys: 1.02 ± 0.037
3.677GlnLeu: 3.677 ± 0.075
0.764GlnMet: 0.764 ± 0.031
0.781GlnAsn: 0.781 ± 0.03
1.742GlnPro: 1.742 ± 0.064
1.295GlnGln: 1.295 ± 0.048
2.353GlnArg: 2.353 ± 0.057
1.578GlnSer: 1.578 ± 0.048
1.539GlnThr: 1.539 ± 0.04
2.475GlnVal: 2.475 ± 0.065
0.506GlnTrp: 0.506 ± 0.028
0.684GlnTyr: 0.684 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
7.076ArgAla: 7.076 ± 0.114
0.348ArgCys: 0.348 ± 0.025
3.672ArgAsp: 3.672 ± 0.073
4.277ArgGlu: 4.277 ± 0.083
2.092ArgPhe: 2.092 ± 0.051
4.674ArgGly: 4.674 ± 0.079
1.347ArgHis: 1.347 ± 0.046
2.771ArgIle: 2.771 ± 0.066
1.879ArgLys: 1.879 ± 0.054
5.69ArgLeu: 5.69 ± 0.093
1.562ArgMet: 1.562 ± 0.045
1.621ArgAsn: 1.621 ± 0.047
2.84ArgPro: 2.84 ± 0.062
1.827ArgGln: 1.827 ± 0.049
4.71ArgArg: 4.71 ± 0.112
3.147ArgSer: 3.147 ± 0.063
3.796ArgThr: 3.796 ± 0.068
4.823ArgVal: 4.823 ± 0.09
0.892ArgTrp: 0.892 ± 0.034
1.51ArgTyr: 1.51 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.483SerAla: 6.483 ± 0.102
0.351SerCys: 0.351 ± 0.021
3.115SerAsp: 3.115 ± 0.07
3.142SerGlu: 3.142 ± 0.068
2.052SerPhe: 2.052 ± 0.056
5.034SerGly: 5.034 ± 0.083
1.195SerHis: 1.195 ± 0.042
2.499SerIle: 2.499 ± 0.062
1.713SerLys: 1.713 ± 0.051
5.342SerLeu: 5.342 ± 0.086
1.398SerMet: 1.398 ± 0.044
1.542SerAsn: 1.542 ± 0.042
2.795SerPro: 2.795 ± 0.063
1.871SerGln: 1.871 ± 0.054
3.23SerArg: 3.23 ± 0.067
3.726SerSer: 3.726 ± 0.089
3.708SerThr: 3.708 ± 0.075
4.224SerVal: 4.224 ± 0.076
0.787SerTrp: 0.787 ± 0.032
1.342SerTyr: 1.342 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
7.404ThrAla: 7.404 ± 0.113
0.41ThrCys: 0.41 ± 0.026
3.467ThrAsp: 3.467 ± 0.088
3.48ThrGlu: 3.48 ± 0.078
1.994ThrPhe: 1.994 ± 0.059
5.474ThrGly: 5.474 ± 0.093
1.337ThrHis: 1.337 ± 0.037
3.071ThrIle: 3.071 ± 0.063
1.874ThrLys: 1.874 ± 0.056
5.837ThrLeu: 5.837 ± 0.093
1.289ThrMet: 1.289 ± 0.044
1.682ThrAsn: 1.682 ± 0.055
3.898ThrPro: 3.898 ± 0.076
1.901ThrGln: 1.901 ± 0.057
3.378ThrArg: 3.378 ± 0.065
3.426ThrSer: 3.426 ± 0.069
4.225ThrThr: 4.225 ± 0.101
5.733ThrVal: 5.733 ± 0.103
0.951ThrTrp: 0.951 ± 0.032
1.434ThrTyr: 1.434 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
10.323ValAla: 10.323 ± 0.139
0.605ValCys: 0.605 ± 0.027
5.243ValAsp: 5.243 ± 0.082
5.069ValGlu: 5.069 ± 0.098
2.648ValPhe: 2.648 ± 0.062
6.525ValGly: 6.525 ± 0.104
1.618ValHis: 1.618 ± 0.045
4.262ValIle: 4.262 ± 0.069
2.289ValLys: 2.289 ± 0.059
7.842ValLeu: 7.842 ± 0.112
1.702ValMet: 1.702 ± 0.045
2.147ValAsn: 2.147 ± 0.061
4.121ValPro: 4.121 ± 0.078
1.993ValGln: 1.993 ± 0.046
4.687ValArg: 4.687 ± 0.069
4.692ValSer: 4.692 ± 0.074
5.542ValThr: 5.542 ± 0.108
7.087ValVal: 7.087 ± 0.121
1.05ValTrp: 1.05 ± 0.044
1.652ValTyr: 1.652 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.584TrpAla: 1.584 ± 0.057
0.115TrpCys: 0.115 ± 0.012
0.757TrpAsp: 0.757 ± 0.031
0.763TrpGlu: 0.763 ± 0.033
0.577TrpPhe: 0.577 ± 0.028
1.027TrpGly: 1.027 ± 0.037
0.321TrpHis: 0.321 ± 0.018
0.693TrpIle: 0.693 ± 0.031
0.463TrpLys: 0.463 ± 0.024
1.55TrpLeu: 1.55 ± 0.054
0.369TrpMet: 0.369 ± 0.018
0.476TrpAsn: 0.476 ± 0.025
0.643TrpPro: 0.643 ± 0.03
0.545TrpGln: 0.545 ± 0.028
0.939TrpArg: 0.939 ± 0.039
0.784TrpSer: 0.784 ± 0.032
0.887TrpThr: 0.887 ± 0.04
1.084TrpVal: 1.084 ± 0.039
0.33TrpTrp: 0.33 ± 0.027
0.281TrpTyr: 0.281 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.536TyrAla: 2.536 ± 0.059
0.167TyrCys: 0.167 ± 0.014
1.442TyrAsp: 1.442 ± 0.042
1.304TyrGlu: 1.304 ± 0.041
0.951TyrPhe: 0.951 ± 0.035
2.018TyrGly: 2.018 ± 0.053
0.454TyrHis: 0.454 ± 0.025
0.956TyrIle: 0.956 ± 0.034
0.658TyrLys: 0.658 ± 0.031
2.269TyrLeu: 2.269 ± 0.055
0.402TyrMet: 0.402 ± 0.02
0.737TyrAsn: 0.737 ± 0.029
1.152TyrPro: 1.152 ± 0.041
0.729TyrGln: 0.729 ± 0.03
1.483TyrArg: 1.483 ± 0.04
1.389TyrSer: 1.389 ± 0.038
1.398TyrThr: 1.398 ± 0.041
1.685TyrVal: 1.685 ± 0.052
0.354TyrTrp: 0.354 ± 0.022
0.625TyrTyr: 0.625 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2623 proteins (796831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski