Amino acid dipepetide frequency for Massilia psychrophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.034AlaAla: 18.034 ± 0.162	1.379AlaCys: 1.379 ± 0.035	6.674AlaAsp: 6.674 ± 0.082	5.994AlaGlu: 5.994 ± 0.081	4.042AlaPhe: 4.042 ± 0.059	11.053AlaGly: 11.053 ± 0.098	2.567AlaHis: 2.567 ± 0.047	6.151AlaIle: 6.151 ± 0.07	4.349AlaLys: 4.349 ± 0.079	14.37AlaLeu: 14.37 ± 0.137	3.654AlaMet: 3.654 ± 0.053	3.705AlaAsn: 3.705 ± 0.065	6.363AlaPro: 6.363 ± 0.091	5.075AlaGln: 5.075 ± 0.083	8.749AlaArg: 8.749 ± 0.097	7.224AlaSer: 7.224 ± 0.082	6.233AlaThr: 6.233 ± 0.091	8.554AlaVal: 8.554 ± 0.099	1.676AlaTrp: 1.676 ± 0.038	2.66AlaTyr: 2.66 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.388CysAla: 1.388 ± 0.039	0.135CysCys: 0.135 ± 0.012	0.537CysAsp: 0.537 ± 0.019	0.484CysGlu: 0.484 ± 0.018	0.349CysPhe: 0.349 ± 0.017	0.952CysGly: 0.952 ± 0.03	0.255CysHis: 0.255 ± 0.013	0.421CysIle: 0.421 ± 0.017	0.281CysLys: 0.281 ± 0.014	0.811CysLeu: 0.811 ± 0.024	0.219CysMet: 0.219 ± 0.013	0.262CysAsn: 0.262 ± 0.015	0.459CysPro: 0.459 ± 0.022	0.246CysGln: 0.246 ± 0.015	0.563CysArg: 0.563 ± 0.022	0.53CysSer: 0.53 ± 0.02	0.439CysThr: 0.439 ± 0.021	0.69CysVal: 0.69 ± 0.025	0.129CysTrp: 0.129 ± 0.011	0.225CysTyr: 0.225 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.98AspAla: 6.98 ± 0.092	0.5AspCys: 0.5 ± 0.019	2.966AspAsp: 2.966 ± 0.055	2.968AspGlu: 2.968 ± 0.049	2.164AspPhe: 2.164 ± 0.041	4.793AspGly: 4.793 ± 0.074	1.022AspHis: 1.022 ± 0.028	2.844AspIle: 2.844 ± 0.051	2.122AspLys: 2.122 ± 0.046	5.126AspLeu: 5.126 ± 0.06	1.346AspMet: 1.346 ± 0.033	1.594AspAsn: 1.594 ± 0.036	2.773AspPro: 2.773 ± 0.049	1.907AspGln: 1.907 ± 0.04	2.848AspArg: 2.848 ± 0.045	2.653AspSer: 2.653 ± 0.044	2.723AspThr: 2.723 ± 0.039	4.133AspVal: 4.133 ± 0.056	0.845AspTrp: 0.845 ± 0.026	1.566AspTyr: 1.566 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.92GluAla: 5.92 ± 0.073	0.383GluCys: 0.383 ± 0.018	1.876GluAsp: 1.876 ± 0.036	2.293GluGlu: 2.293 ± 0.05	1.79GluPhe: 1.79 ± 0.039	3.108GluGly: 3.108 ± 0.054	1.342GluHis: 1.342 ± 0.034	2.702GluIle: 2.702 ± 0.05	2.092GluLys: 2.092 ± 0.046	5.736GluLeu: 5.736 ± 0.079	1.357GluMet: 1.357 ± 0.03	1.443GluAsn: 1.443 ± 0.032	2.172GluPro: 2.172 ± 0.048	2.68GluGln: 2.68 ± 0.047	4.296GluArg: 4.296 ± 0.065	2.37GluSer: 2.37 ± 0.046	2.552GluThr: 2.552 ± 0.044	3.558GluVal: 3.558 ± 0.052	0.679GluTrp: 0.679 ± 0.023	1.085GluTyr: 1.085 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.431PheAla: 4.431 ± 0.064	0.438PheCys: 0.438 ± 0.019	2.709PheAsp: 2.709 ± 0.046	2.026PheGlu: 2.026 ± 0.04	1.457PhePhe: 1.457 ± 0.038	3.676PheGly: 3.676 ± 0.057	0.746PheHis: 0.746 ± 0.025	1.813PheIle: 1.813 ± 0.041	1.333PheLys: 1.333 ± 0.033	3.005PheLeu: 3.005 ± 0.056	0.855PheMet: 0.855 ± 0.028	1.367PheAsn: 1.367 ± 0.036	1.469PhePro: 1.469 ± 0.032	1.081PheGln: 1.081 ± 0.03	1.916PheArg: 1.916 ± 0.037	2.449PheSer: 2.449 ± 0.048	2.024PheThr: 2.024 ± 0.041	2.685PheVal: 2.685 ± 0.042	0.456PheTrp: 0.456 ± 0.019	1.058PheTyr: 1.058 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.166GlyAla: 10.166 ± 0.102	0.859GlyCys: 0.859 ± 0.025	4.051GlyAsp: 4.051 ± 0.059	4.104GlyGlu: 4.104 ± 0.05	3.414GlyPhe: 3.414 ± 0.053	6.638GlyGly: 6.638 ± 0.099	1.824GlyHis: 1.824 ± 0.035	4.178GlyIle: 4.178 ± 0.06	3.873GlyLys: 3.873 ± 0.067	7.794GlyLeu: 7.794 ± 0.085	2.488GlyMet: 2.488 ± 0.047	2.529GlyAsn: 2.529 ± 0.056	2.837GlyPro: 2.837 ± 0.052	3.208GlyGln: 3.208 ± 0.047	4.958GlyArg: 4.958 ± 0.063	4.76GlySer: 4.76 ± 0.064	4.2GlyThr: 4.2 ± 0.063	6.498GlyVal: 6.498 ± 0.068	1.235GlyTrp: 1.235 ± 0.037	2.33GlyTyr: 2.33 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.824HisAla: 2.824 ± 0.046	0.27HisCys: 0.27 ± 0.014	1.232HisAsp: 1.232 ± 0.036	1.043HisGlu: 1.043 ± 0.028	0.886HisPhe: 0.886 ± 0.028	1.967HisGly: 1.967 ± 0.042	0.667HisHis: 0.667 ± 0.028	1.051HisIle: 1.051 ± 0.03	0.658HisLys: 0.658 ± 0.022	2.083HisLeu: 2.083 ± 0.043	0.516HisMet: 0.516 ± 0.019	0.606HisAsn: 0.606 ± 0.02	1.313HisPro: 1.313 ± 0.034	0.832HisGln: 0.832 ± 0.024	1.266HisArg: 1.266 ± 0.034	1.083HisSer: 1.083 ± 0.027	1.046HisThr: 1.046 ± 0.027	1.545HisVal: 1.545 ± 0.032	0.331HisTrp: 0.331 ± 0.016	0.651HisTyr: 0.651 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.732IleAla: 6.732 ± 0.078	0.465IleCys: 0.465 ± 0.02	3.785IleAsp: 3.785 ± 0.055	3.233IleGlu: 3.233 ± 0.05	1.458IlePhe: 1.458 ± 0.035	4.932IleGly: 4.932 ± 0.058	0.942IleHis: 0.942 ± 0.028	2.099IleIle: 2.099 ± 0.044	1.906IleLys: 1.906 ± 0.044	3.868IleLeu: 3.868 ± 0.067	1.014IleMet: 1.014 ± 0.033	1.773IleAsn: 1.773 ± 0.046	2.02IlePro: 2.02 ± 0.039	1.146IleGln: 1.146 ± 0.029	2.65IleArg: 2.65 ± 0.044	2.764IleSer: 2.764 ± 0.042	2.598IleThr: 2.598 ± 0.049	3.931IleVal: 3.931 ± 0.061	0.49IleTrp: 0.49 ± 0.021	1.077IleTyr: 1.077 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.245LysAla: 4.245 ± 0.072	0.2LysCys: 0.2 ± 0.012	1.764LysAsp: 1.764 ± 0.041	1.657LysGlu: 1.657 ± 0.042	1.255LysPhe: 1.255 ± 0.039	2.551LysGly: 2.551 ± 0.054	0.752LysHis: 0.752 ± 0.027	1.949LysIle: 1.949 ± 0.047	1.743LysLys: 1.743 ± 0.054	4.172LysLeu: 4.172 ± 0.064	1.137LysMet: 1.137 ± 0.031	1.317LysAsn: 1.317 ± 0.031	2.249LysPro: 2.249 ± 0.049	1.512LysGln: 1.512 ± 0.039	2.412LysArg: 2.412 ± 0.046	2.099LysSer: 2.099 ± 0.044	2.148LysThr: 2.148 ± 0.044	2.768LysVal: 2.768 ± 0.057	0.412LysTrp: 0.412 ± 0.019	0.808LysTyr: 0.808 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.015LeuAla: 15.015 ± 0.159	0.969LeuCys: 0.969 ± 0.027	6.068LeuAsp: 6.068 ± 0.074	5.234LeuGlu: 5.234 ± 0.071	3.608LeuPhe: 3.608 ± 0.062	7.958LeuGly: 7.958 ± 0.094	2.205LeuHis: 2.205 ± 0.045	4.501LeuIle: 4.501 ± 0.072	3.754LeuLys: 3.754 ± 0.058	10.554LeuLeu: 10.554 ± 0.14	2.553LeuMet: 2.553 ± 0.046	2.952LeuAsn: 2.952 ± 0.048	5.622LeuPro: 5.622 ± 0.074	3.562LeuGln: 3.562 ± 0.06	7.106LeuArg: 7.106 ± 0.09	5.856LeuSer: 5.856 ± 0.081	5.434LeuThr: 5.434 ± 0.069	7.625LeuVal: 7.625 ± 0.092	1.121LeuTrp: 1.121 ± 0.034	2.22LeuTyr: 2.22 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.219MetAla: 3.219 ± 0.049	0.17MetCys: 0.17 ± 0.011	1.121MetAsp: 1.121 ± 0.024	1.066MetGlu: 1.066 ± 0.029	0.854MetPhe: 0.854 ± 0.028	1.776MetGly: 1.776 ± 0.04	0.623MetHis: 0.623 ± 0.021	1.249MetIle: 1.249 ± 0.032	1.205MetLys: 1.205 ± 0.037	3.075MetLeu: 3.075 ± 0.057	0.692MetMet: 0.692 ± 0.026	0.999MetAsn: 0.999 ± 0.027	1.513MetPro: 1.513 ± 0.038	1.212MetGln: 1.212 ± 0.03	1.788MetArg: 1.788 ± 0.038	1.625MetSer: 1.625 ± 0.035	1.653MetThr: 1.653 ± 0.034	1.848MetVal: 1.848 ± 0.039	0.227MetTrp: 0.227 ± 0.013	0.497MetTyr: 0.497 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.777AsnAla: 3.777 ± 0.058	0.34AsnCys: 0.34 ± 0.017	1.575AsnAsp: 1.575 ± 0.036	1.34AsnGlu: 1.34 ± 0.033	1.179AsnPhe: 1.179 ± 0.033	2.781AsnGly: 2.781 ± 0.049	0.625AsnHis: 0.625 ± 0.023	1.548AsnIle: 1.548 ± 0.037	1.1AsnLys: 1.1 ± 0.034	3.118AsnLeu: 3.118 ± 0.046	0.715AsnMet: 0.715 ± 0.021	1.094AsnAsn: 1.094 ± 0.04	1.992AsnPro: 1.992 ± 0.041	1.107AsnGln: 1.107 ± 0.034	1.92AsnArg: 1.92 ± 0.035	1.554AsnSer: 1.554 ± 0.036	1.632AsnThr: 1.632 ± 0.041	2.329AsnVal: 2.329 ± 0.046	0.44AsnTrp: 0.44 ± 0.021	0.89AsnTyr: 0.89 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.927ProAla: 6.927 ± 0.1	0.361ProCys: 0.361 ± 0.018	2.903ProAsp: 2.903 ± 0.046	2.639ProGlu: 2.639 ± 0.051	1.773ProPhe: 1.773 ± 0.036	4.416ProGly: 4.416 ± 0.064	1.087ProHis: 1.087 ± 0.03	2.013ProIle: 2.013 ± 0.039	1.617ProLys: 1.617 ± 0.039	4.957ProLeu: 4.957 ± 0.074	1.298ProMet: 1.298 ± 0.033	1.462ProAsn: 1.462 ± 0.034	2.294ProPro: 2.294 ± 0.053	1.917ProGln: 1.917 ± 0.039	2.529ProArg: 2.529 ± 0.041	2.612ProSer: 2.612 ± 0.05	2.347ProThr: 2.347 ± 0.044	4.042ProVal: 4.042 ± 0.059	0.596ProTrp: 0.596 ± 0.023	1.135ProTyr: 1.135 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.992GlnAla: 4.992 ± 0.069	0.3GlnCys: 0.3 ± 0.015	1.547GlnAsp: 1.547 ± 0.035	1.581GlnGlu: 1.581 ± 0.035	1.56GlnPhe: 1.56 ± 0.034	2.603GlnGly: 2.603 ± 0.047	0.885GlnHis: 0.885 ± 0.025	1.848GlnIle: 1.848 ± 0.041	1.293GlnLys: 1.293 ± 0.035	4.28GlnLeu: 4.28 ± 0.068	1.048GlnMet: 1.048 ± 0.03	1.034GlnAsn: 1.034 ± 0.033	1.913GlnPro: 1.913 ± 0.039	2.044GlnGln: 2.044 ± 0.055	2.855GlnArg: 2.855 ± 0.059	2.106GlnSer: 2.106 ± 0.043	1.702GlnThr: 1.702 ± 0.038	3.07GlnVal: 3.07 ± 0.047	0.527GlnTrp: 0.527 ± 0.019	0.907GlnTyr: 0.907 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.654ArgAla: 7.654 ± 0.089	0.549ArgCys: 0.549 ± 0.02	3.458ArgAsp: 3.458 ± 0.06	3.478ArgGlu: 3.478 ± 0.053	2.796ArgPhe: 2.796 ± 0.044	4.307ArgGly: 4.307 ± 0.062	1.77ArgHis: 1.77 ± 0.031	3.528ArgIle: 3.528 ± 0.05	2.243ArgLys: 2.243 ± 0.039	7.076ArgLeu: 7.076 ± 0.085	1.873ArgMet: 1.873 ± 0.038	2.024ArgAsn: 2.024 ± 0.042	2.841ArgPro: 2.841 ± 0.053	2.874ArgGln: 2.874 ± 0.052	4.437ArgArg: 4.437 ± 0.069	3.412ArgSer: 3.412 ± 0.05	2.983ArgThr: 2.983 ± 0.047	4.46ArgVal: 4.46 ± 0.06	0.909ArgTrp: 0.909 ± 0.025	1.829ArgTyr: 1.829 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.954SerAla: 6.954 ± 0.08	0.481SerCys: 0.481 ± 0.021	2.765SerAsp: 2.765 ± 0.049	2.476SerGlu: 2.476 ± 0.051	2.239SerPhe: 2.239 ± 0.044	5.363SerGly: 5.363 ± 0.071	1.251SerHis: 1.251 ± 0.029	2.765SerIle: 2.765 ± 0.044	1.929SerLys: 1.929 ± 0.04	5.788SerLeu: 5.788 ± 0.073	1.532SerMet: 1.532 ± 0.034	1.789SerAsn: 1.789 ± 0.042	2.596SerPro: 2.596 ± 0.05	1.844SerGln: 1.844 ± 0.037	3.347SerArg: 3.347 ± 0.05	3.415SerSer: 3.415 ± 0.058	3.037SerThr: 3.037 ± 0.051	4.139SerVal: 4.139 ± 0.061	0.71SerTrp: 0.71 ± 0.022	1.459SerTyr: 1.459 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.902ThrAla: 5.902 ± 0.064	0.452ThrCys: 0.452 ± 0.02	2.6ThrAsp: 2.6 ± 0.04	2.31ThrGlu: 2.31 ± 0.048	1.838ThrPhe: 1.838 ± 0.041	4.747ThrGly: 4.747 ± 0.065	1.052ThrHis: 1.052 ± 0.028	2.768ThrIle: 2.768 ± 0.05	1.47ThrLys: 1.47 ± 0.042	6.094ThrLeu: 6.094 ± 0.079	1.333ThrMet: 1.333 ± 0.033	1.489ThrAsn: 1.489 ± 0.038	3.118ThrPro: 3.118 ± 0.048	1.661ThrGln: 1.661 ± 0.037	3.187ThrArg: 3.187 ± 0.051	2.881ThrSer: 2.881 ± 0.045	2.815ThrThr: 2.815 ± 0.059	4.231ThrVal: 4.231 ± 0.061	0.625ThrTrp: 0.625 ± 0.024	1.202ThrTyr: 1.202 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.504ValAla: 9.504 ± 0.088	0.712ValCys: 0.712 ± 0.025	4.295ValAsp: 4.295 ± 0.058	3.904ValGlu: 3.904 ± 0.059	2.7ValPhe: 2.7 ± 0.047	5.452ValGly: 5.452 ± 0.062	1.456ValHis: 1.456 ± 0.036	3.811ValIle: 3.811 ± 0.05	2.851ValLys: 2.851 ± 0.052	7.777ValLeu: 7.777 ± 0.09	1.937ValMet: 1.937 ± 0.041	2.382ValAsn: 2.382 ± 0.049	3.54ValPro: 3.54 ± 0.049	2.479ValGln: 2.479 ± 0.04	4.754ValArg: 4.754 ± 0.066	4.254ValSer: 4.254 ± 0.062	4.328ValThr: 4.328 ± 0.068	5.807ValVal: 5.807 ± 0.073	0.804ValTrp: 0.804 ± 0.027	1.632ValTyr: 1.632 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.087TrpAla: 1.087 ± 0.034	0.147TrpCys: 0.147 ± 0.011	0.636TrpAsp: 0.636 ± 0.021	0.531TrpGlu: 0.531 ± 0.02	0.538TrpPhe: 0.538 ± 0.021	0.787TrpGly: 0.787 ± 0.025	0.314TrpHis: 0.314 ± 0.015	0.686TrpIle: 0.686 ± 0.022	0.474TrpLys: 0.474 ± 0.02	1.664TrpLeu: 1.664 ± 0.039	0.372TrpMet: 0.372 ± 0.018	0.463TrpAsn: 0.463 ± 0.019	0.589TrpPro: 0.589 ± 0.024	0.667TrpGln: 0.667 ± 0.023	1.078TrpArg: 1.078 ± 0.034	0.768TrpSer: 0.768 ± 0.026	0.643TrpThr: 0.643 ± 0.022	0.83TrpVal: 0.83 ± 0.027	0.221TrpTrp: 0.221 ± 0.013	0.316TrpTyr: 0.316 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.756TyrAla: 2.756 ± 0.044	0.263TyrCys: 0.263 ± 0.014	1.309TyrAsp: 1.309 ± 0.028	1.073TyrGlu: 1.073 ± 0.031	1.095TyrPhe: 1.095 ± 0.028	2.087TyrGly: 2.087 ± 0.046	0.484TyrHis: 0.484 ± 0.02	0.961TyrIle: 0.961 ± 0.029	0.855TyrLys: 0.855 ± 0.026	2.566TyrLeu: 2.566 ± 0.052	0.471TyrMet: 0.471 ± 0.02	0.773TyrAsn: 0.773 ± 0.027	1.254TyrPro: 1.254 ± 0.034	1.04TyrGln: 1.04 ± 0.024	1.844TyrArg: 1.844 ± 0.044	1.464TyrSer: 1.464 ± 0.035	1.24TyrThr: 1.24 ± 0.034	1.632TyrVal: 1.632 ± 0.036	0.378TyrTrp: 0.378 ± 0.018	0.675TyrTyr: 0.675 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4079 proteins (1339801 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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