Amino acid dipepetide frequency for Arthrobacter phage Yang

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.185AlaAla: 19.185 ± 2.0
0.595AlaCys: 0.595 ± 0.233
9.593AlaAsp: 9.593 ± 0.871
7.808AlaGlu: 7.808 ± 0.79
3.495AlaPhe: 3.495 ± 0.551
9.369AlaGly: 9.369 ± 1.1
2.826AlaHis: 2.826 ± 0.485
5.131AlaIle: 5.131 ± 0.612
6.469AlaLys: 6.469 ± 0.807
14.203AlaLeu: 14.203 ± 1.176
3.198AlaMet: 3.198 ± 0.512
2.751AlaAsn: 2.751 ± 0.56
6.172AlaPro: 6.172 ± 0.806
4.313AlaGln: 4.313 ± 0.735
9.89AlaArg: 9.89 ± 1.3
7.064AlaSer: 7.064 ± 0.715
7.362AlaThr: 7.362 ± 0.911
9.146AlaVal: 9.146 ± 0.789
1.859AlaTrp: 1.859 ± 0.31
3.569AlaTyr: 3.569 ± 0.464
0.0AlaXaa: 0.0 ± 0.0
Cys
0.521CysAla: 0.521 ± 0.208
0.074CysCys: 0.074 ± 0.077
0.297CysAsp: 0.297 ± 0.17
0.744CysGlu: 0.744 ± 0.287
0.074CysPhe: 0.074 ± 0.066
0.669CysGly: 0.669 ± 0.259
0.074CysHis: 0.074 ± 0.079
0.074CysIle: 0.074 ± 0.08
0.223CysLys: 0.223 ± 0.127
0.074CysLeu: 0.074 ± 0.077
0.0CysMet: 0.0 ± 0.0
0.149CysAsn: 0.149 ± 0.107
0.595CysPro: 0.595 ± 0.209
0.446CysGln: 0.446 ± 0.182
1.041CysArg: 1.041 ± 0.355
0.223CysSer: 0.223 ± 0.169
0.372CysThr: 0.372 ± 0.166
0.149CysVal: 0.149 ± 0.105
0.074CysTrp: 0.074 ± 0.079
0.074CysTyr: 0.074 ± 0.086
0.0CysXaa: 0.0 ± 0.0
Asp
9.741AspAla: 9.741 ± 0.843
0.297AspCys: 0.297 ± 0.146
4.09AspAsp: 4.09 ± 0.522
3.718AspGlu: 3.718 ± 0.749
2.751AspPhe: 2.751 ± 0.419
7.436AspGly: 7.436 ± 0.773
1.041AspHis: 1.041 ± 0.336
1.562AspIle: 1.562 ± 0.322
1.859AspLys: 1.859 ± 0.494
7.436AspLeu: 7.436 ± 1.117
0.297AspMet: 0.297 ± 0.128
1.19AspAsn: 1.19 ± 0.336
3.495AspPro: 3.495 ± 0.605
1.562AspGln: 1.562 ± 0.315
3.123AspArg: 3.123 ± 0.654
4.164AspSer: 4.164 ± 0.521
3.867AspThr: 3.867 ± 0.567
5.28AspVal: 5.28 ± 0.654
1.115AspTrp: 1.115 ± 0.266
1.859AspTyr: 1.859 ± 0.42
0.0AspXaa: 0.0 ± 0.0
Glu
8.403GluAla: 8.403 ± 1.059
0.223GluCys: 0.223 ± 0.12
3.941GluAsp: 3.941 ± 0.619
4.685GluGlu: 4.685 ± 0.601
1.19GluPhe: 1.19 ± 0.324
4.239GluGly: 4.239 ± 0.492
1.338GluHis: 1.338 ± 0.322
3.495GluIle: 3.495 ± 0.503
2.305GluLys: 2.305 ± 0.491
5.726GluLeu: 5.726 ± 0.765
0.669GluMet: 0.669 ± 0.195
1.041GluAsn: 1.041 ± 0.309
2.528GluPro: 2.528 ± 0.537
0.744GluGln: 0.744 ± 0.241
4.759GluArg: 4.759 ± 0.922
2.305GluSer: 2.305 ± 0.479
3.941GluThr: 3.941 ± 0.64
4.61GluVal: 4.61 ± 0.575
1.785GluTrp: 1.785 ± 0.295
1.264GluTyr: 1.264 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
2.974PheAla: 2.974 ± 0.431
0.297PheCys: 0.297 ± 0.159
2.454PheAsp: 2.454 ± 0.506
1.933PheGlu: 1.933 ± 0.346
0.892PhePhe: 0.892 ± 0.228
2.9PheGly: 2.9 ± 0.383
0.669PheHis: 0.669 ± 0.182
0.967PheIle: 0.967 ± 0.32
1.041PheLys: 1.041 ± 0.243
2.751PheLeu: 2.751 ± 0.549
0.669PheMet: 0.669 ± 0.179
0.521PheAsn: 0.521 ± 0.203
1.562PhePro: 1.562 ± 0.304
1.785PheGln: 1.785 ± 0.405
1.636PheArg: 1.636 ± 0.359
1.562PheSer: 1.562 ± 0.338
2.528PheThr: 2.528 ± 0.482
2.082PheVal: 2.082 ± 0.446
0.297PheTrp: 0.297 ± 0.138
0.892PheTyr: 0.892 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
10.262GlyAla: 10.262 ± 0.779
0.372GlyCys: 0.372 ± 0.189
5.8GlyAsp: 5.8 ± 0.71
5.28GlyGlu: 5.28 ± 0.496
2.9GlyPhe: 2.9 ± 0.441
6.395GlyGly: 6.395 ± 1.043
1.785GlyHis: 1.785 ± 0.332
4.313GlyIle: 4.313 ± 0.894
4.685GlyLys: 4.685 ± 0.655
6.544GlyLeu: 6.544 ± 0.678
1.562GlyMet: 1.562 ± 0.301
2.231GlyAsn: 2.231 ± 0.463
3.644GlyPro: 3.644 ± 0.625
2.454GlyGln: 2.454 ± 0.515
6.246GlyArg: 6.246 ± 0.808
4.387GlySer: 4.387 ± 0.862
4.313GlyThr: 4.313 ± 0.922
6.618GlyVal: 6.618 ± 0.759
2.231GlyTrp: 2.231 ± 0.463
3.272GlyTyr: 3.272 ± 0.477
0.0GlyXaa: 0.0 ± 0.0
His
1.859HisAla: 1.859 ± 0.377
0.074HisCys: 0.074 ± 0.066
1.487HisAsp: 1.487 ± 0.418
0.967HisGlu: 0.967 ± 0.249
0.967HisPhe: 0.967 ± 0.363
1.636HisGly: 1.636 ± 0.318
0.669HisHis: 0.669 ± 0.275
0.521HisIle: 0.521 ± 0.176
0.521HisLys: 0.521 ± 0.196
1.71HisLeu: 1.71 ± 0.441
0.372HisMet: 0.372 ± 0.174
0.446HisAsn: 0.446 ± 0.2
1.487HisPro: 1.487 ± 0.296
0.446HisGln: 0.446 ± 0.187
1.264HisArg: 1.264 ± 0.292
1.19HisSer: 1.19 ± 0.352
1.115HisThr: 1.115 ± 0.259
0.967HisVal: 0.967 ± 0.294
0.223HisTrp: 0.223 ± 0.154
0.372HisTyr: 0.372 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
4.685IleAla: 4.685 ± 0.482
0.149IleCys: 0.149 ± 0.108
2.528IleAsp: 2.528 ± 0.462
2.603IleGlu: 2.603 ± 0.477
0.892IlePhe: 0.892 ± 0.294
4.164IleGly: 4.164 ± 0.701
1.041IleHis: 1.041 ± 0.243
1.636IleIle: 1.636 ± 0.399
1.859IleLys: 1.859 ± 0.333
3.049IleLeu: 3.049 ± 0.495
0.372IleMet: 0.372 ± 0.154
0.892IleAsn: 0.892 ± 0.264
2.826IlePro: 2.826 ± 0.508
1.859IleGln: 1.859 ± 0.413
3.867IleArg: 3.867 ± 0.453
2.156IleSer: 2.156 ± 0.441
2.974IleThr: 2.974 ± 0.429
2.751IleVal: 2.751 ± 0.643
0.521IleTrp: 0.521 ± 0.203
0.818IleTyr: 0.818 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
6.544LysAla: 6.544 ± 0.834
0.595LysCys: 0.595 ± 0.35
1.933LysAsp: 1.933 ± 0.436
2.826LysGlu: 2.826 ± 0.52
0.744LysPhe: 0.744 ± 0.264
4.015LysGly: 4.015 ± 0.577
0.818LysHis: 0.818 ± 0.273
2.082LysIle: 2.082 ± 0.435
1.785LysLys: 1.785 ± 0.369
2.974LysLeu: 2.974 ± 0.394
0.892LysMet: 0.892 ± 0.223
0.967LysAsn: 0.967 ± 0.281
1.933LysPro: 1.933 ± 0.353
0.892LysGln: 0.892 ± 0.299
3.123LysArg: 3.123 ± 0.494
1.71LysSer: 1.71 ± 0.336
2.082LysThr: 2.082 ± 0.386
2.9LysVal: 2.9 ± 0.463
0.521LysTrp: 0.521 ± 0.216
0.521LysTyr: 0.521 ± 0.234
0.0LysXaa: 0.0 ± 0.0
Leu
12.418LeuAla: 12.418 ± 1.36
0.595LeuCys: 0.595 ± 0.228
6.692LeuAsp: 6.692 ± 0.825
3.272LeuGlu: 3.272 ± 0.573
2.156LeuPhe: 2.156 ± 0.434
6.99LeuGly: 6.99 ± 0.816
1.71LeuHis: 1.71 ± 0.472
3.644LeuIle: 3.644 ± 0.449
1.785LeuLys: 1.785 ± 0.376
6.841LeuLeu: 6.841 ± 0.702
1.19LeuMet: 1.19 ± 0.344
2.677LeuAsn: 2.677 ± 0.375
4.164LeuPro: 4.164 ± 0.577
4.387LeuGln: 4.387 ± 0.7
7.659LeuArg: 7.659 ± 0.779
5.503LeuSer: 5.503 ± 0.491
5.8LeuThr: 5.8 ± 0.692
5.354LeuVal: 5.354 ± 0.442
1.71LeuTrp: 1.71 ± 0.302
1.562LeuTyr: 1.562 ± 0.363
0.0LeuXaa: 0.0 ± 0.0
Met
2.603MetAla: 2.603 ± 0.475
0.074MetCys: 0.074 ± 0.068
1.19MetAsp: 1.19 ± 0.287
0.595MetGlu: 0.595 ± 0.162
0.372MetPhe: 0.372 ± 0.182
1.115MetGly: 1.115 ± 0.322
0.074MetHis: 0.074 ± 0.054
0.818MetIle: 0.818 ± 0.243
0.967MetLys: 0.967 ± 0.294
1.338MetLeu: 1.338 ± 0.304
0.372MetMet: 0.372 ± 0.167
0.297MetAsn: 0.297 ± 0.117
1.115MetPro: 1.115 ± 0.247
0.074MetGln: 0.074 ± 0.077
1.264MetArg: 1.264 ± 0.299
2.231MetSer: 2.231 ± 0.364
1.636MetThr: 1.636 ± 0.358
1.041MetVal: 1.041 ± 0.257
0.0MetTrp: 0.0 ± 0.0
0.223MetTyr: 0.223 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
3.049AsnAla: 3.049 ± 0.628
0.0AsnCys: 0.0 ± 0.0
1.264AsnAsp: 1.264 ± 0.302
0.669AsnGlu: 0.669 ± 0.198
0.818AsnPhe: 0.818 ± 0.231
3.346AsnGly: 3.346 ± 0.588
0.149AsnHis: 0.149 ± 0.096
0.297AsnIle: 0.297 ± 0.14
0.744AsnLys: 0.744 ± 0.227
1.933AsnLeu: 1.933 ± 0.414
0.297AsnMet: 0.297 ± 0.147
0.595AsnAsn: 0.595 ± 0.198
1.71AsnPro: 1.71 ± 0.371
0.595AsnGln: 0.595 ± 0.256
1.115AsnArg: 1.115 ± 0.248
1.115AsnSer: 1.115 ± 0.259
1.338AsnThr: 1.338 ± 0.344
2.38AsnVal: 2.38 ± 0.673
0.521AsnTrp: 0.521 ± 0.149
0.595AsnTyr: 0.595 ± 0.175
0.0AsnXaa: 0.0 ± 0.0
Pro
7.064ProAla: 7.064 ± 1.042
0.446ProCys: 0.446 ± 0.174
3.421ProAsp: 3.421 ± 0.552
3.644ProGlu: 3.644 ± 0.623
2.231ProPhe: 2.231 ± 0.418
4.462ProGly: 4.462 ± 0.525
0.669ProHis: 0.669 ± 0.25
1.71ProIle: 1.71 ± 0.252
2.38ProLys: 2.38 ± 0.472
4.015ProLeu: 4.015 ± 0.646
1.19ProMet: 1.19 ± 0.334
1.115ProAsn: 1.115 ± 0.255
1.71ProPro: 1.71 ± 0.508
1.859ProGln: 1.859 ± 0.372
2.826ProArg: 2.826 ± 0.504
2.231ProSer: 2.231 ± 0.446
3.644ProThr: 3.644 ± 0.617
4.164ProVal: 4.164 ± 0.589
1.041ProTrp: 1.041 ± 0.356
0.892ProTyr: 0.892 ± 0.276
0.0ProXaa: 0.0 ± 0.0
Gln
4.164GlnAla: 4.164 ± 0.59
0.149GlnCys: 0.149 ± 0.1
2.008GlnAsp: 2.008 ± 0.348
1.636GlnGlu: 1.636 ± 0.302
0.446GlnPhe: 0.446 ± 0.188
2.38GlnGly: 2.38 ± 0.425
0.521GlnHis: 0.521 ± 0.162
2.826GlnIle: 2.826 ± 0.391
1.71GlnLys: 1.71 ± 0.363
1.413GlnLeu: 1.413 ± 0.348
0.892GlnMet: 0.892 ± 0.238
0.446GlnAsn: 0.446 ± 0.153
1.338GlnPro: 1.338 ± 0.33
0.446GlnGln: 0.446 ± 0.204
2.231GlnArg: 2.231 ± 0.431
1.71GlnSer: 1.71 ± 0.431
2.9GlnThr: 2.9 ± 0.567
1.859GlnVal: 1.859 ± 0.377
0.372GlnTrp: 0.372 ± 0.179
0.521GlnTyr: 0.521 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
10.039ArgAla: 10.039 ± 1.464
0.744ArgCys: 0.744 ± 0.339
4.462ArgAsp: 4.462 ± 0.839
4.759ArgGlu: 4.759 ± 0.624
2.603ArgPhe: 2.603 ± 0.357
4.462ArgGly: 4.462 ± 0.536
1.562ArgHis: 1.562 ± 0.333
3.049ArgIle: 3.049 ± 0.503
2.751ArgLys: 2.751 ± 0.514
7.51ArgLeu: 7.51 ± 1.03
1.71ArgMet: 1.71 ± 0.328
1.71ArgAsn: 1.71 ± 0.404
3.123ArgPro: 3.123 ± 0.594
2.38ArgGln: 2.38 ± 0.499
7.436ArgArg: 7.436 ± 1.289
4.313ArgSer: 4.313 ± 0.561
3.941ArgThr: 3.941 ± 0.68
5.131ArgVal: 5.131 ± 0.699
1.338ArgTrp: 1.338 ± 0.301
2.156ArgTyr: 2.156 ± 0.429
0.0ArgXaa: 0.0 ± 0.0
Ser
7.362SerAla: 7.362 ± 0.713
0.223SerCys: 0.223 ± 0.136
2.9SerAsp: 2.9 ± 0.403
3.346SerGlu: 3.346 ± 0.517
1.859SerPhe: 1.859 ± 0.346
6.767SerGly: 6.767 ± 0.839
0.521SerHis: 0.521 ± 0.251
2.305SerIle: 2.305 ± 0.329
2.38SerLys: 2.38 ± 0.433
3.495SerLeu: 3.495 ± 0.482
0.967SerMet: 0.967 ± 0.281
1.636SerAsn: 1.636 ± 0.481
3.346SerPro: 3.346 ± 0.456
1.19SerGln: 1.19 ± 0.309
3.198SerArg: 3.198 ± 0.484
2.603SerSer: 2.603 ± 0.506
4.982SerThr: 4.982 ± 0.861
4.015SerVal: 4.015 ± 0.599
1.264SerTrp: 1.264 ± 0.286
1.785SerTyr: 1.785 ± 0.446
0.0SerXaa: 0.0 ± 0.0
Thr
8.626ThrAla: 8.626 ± 1.541
0.297ThrCys: 0.297 ± 0.173
3.569ThrAsp: 3.569 ± 0.514
3.421ThrGlu: 3.421 ± 0.644
2.528ThrPhe: 2.528 ± 0.449
6.023ThrGly: 6.023 ± 0.652
0.818ThrHis: 0.818 ± 0.23
2.677ThrIle: 2.677 ± 0.516
1.859ThrLys: 1.859 ± 0.346
5.874ThrLeu: 5.874 ± 0.569
0.818ThrMet: 0.818 ± 0.227
0.744ThrAsn: 0.744 ± 0.227
4.387ThrPro: 4.387 ± 0.533
1.338ThrGln: 1.338 ± 0.359
4.387ThrArg: 4.387 ± 0.648
4.387ThrSer: 4.387 ± 0.601
5.651ThrThr: 5.651 ± 0.975
5.8ThrVal: 5.8 ± 0.716
0.521ThrTrp: 0.521 ± 0.169
1.933ThrTyr: 1.933 ± 0.372
0.0ThrXaa: 0.0 ± 0.0
Val
9.444ValAla: 9.444 ± 0.915
0.521ValCys: 0.521 ± 0.216
5.651ValAsp: 5.651 ± 0.684
3.941ValGlu: 3.941 ± 0.636
2.305ValPhe: 2.305 ± 0.454
4.982ValGly: 4.982 ± 0.642
1.19ValHis: 1.19 ± 0.333
3.272ValIle: 3.272 ± 0.592
2.082ValLys: 2.082 ± 0.381
6.841ValLeu: 6.841 ± 0.751
1.338ValMet: 1.338 ± 0.272
1.859ValAsn: 1.859 ± 0.517
3.792ValPro: 3.792 ± 0.492
2.305ValGln: 2.305 ± 0.424
6.023ValArg: 6.023 ± 0.729
4.462ValSer: 4.462 ± 0.55
3.792ValThr: 3.792 ± 0.688
5.651ValVal: 5.651 ± 0.821
1.562ValTrp: 1.562 ± 0.423
1.785ValTyr: 1.785 ± 0.26
0.0ValXaa: 0.0 ± 0.0
Trp
1.487TrpAla: 1.487 ± 0.289
0.149TrpCys: 0.149 ± 0.104
1.19TrpAsp: 1.19 ± 0.26
1.859TrpGlu: 1.859 ± 0.351
0.149TrpPhe: 0.149 ± 0.097
1.338TrpGly: 1.338 ± 0.295
0.446TrpHis: 0.446 ± 0.203
0.744TrpIle: 0.744 ± 0.266
0.967TrpLys: 0.967 ± 0.242
0.818TrpLeu: 0.818 ± 0.31
0.149TrpMet: 0.149 ± 0.091
0.744TrpAsn: 0.744 ± 0.223
0.446TrpPro: 0.446 ± 0.165
0.595TrpGln: 0.595 ± 0.182
2.305TrpArg: 2.305 ± 0.417
1.264TrpSer: 1.264 ± 0.289
1.562TrpThr: 1.562 ± 0.385
0.818TrpVal: 0.818 ± 0.215
0.223TrpTrp: 0.223 ± 0.13
0.595TrpTyr: 0.595 ± 0.218
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.569TyrAla: 3.569 ± 0.51
0.074TyrCys: 0.074 ± 0.068
1.413TyrAsp: 1.413 ± 0.355
1.562TyrGlu: 1.562 ± 0.445
1.041TyrPhe: 1.041 ± 0.275
2.603TyrGly: 2.603 ± 0.414
0.372TyrHis: 0.372 ± 0.201
0.521TyrIle: 0.521 ± 0.184
1.487TyrLys: 1.487 ± 0.358
1.562TyrLeu: 1.562 ± 0.3
0.372TyrMet: 0.372 ± 0.151
0.521TyrAsn: 0.521 ± 0.185
1.338TyrPro: 1.338 ± 0.295
0.297TyrGln: 0.297 ± 0.153
1.785TyrArg: 1.785 ± 0.318
1.562TyrSer: 1.562 ± 0.45
1.859TyrThr: 1.859 ± 0.322
2.082TyrVal: 2.082 ± 0.403
0.669TyrTrp: 0.669 ± 0.195
0.446TyrTyr: 0.446 ± 0.273
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (13449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski