Amino acid dipepetide frequency for Uukuniemi virus (strain S23) (Uuk)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.849AlaAla: 3.849 ± 1.176
1.65AlaCys: 1.65 ± 1.384
2.75AlaAsp: 2.75 ± 1.228
1.925AlaGlu: 1.925 ± 0.533
1.925AlaPhe: 1.925 ± 0.51
3.024AlaGly: 3.024 ± 1.259
1.375AlaHis: 1.375 ± 0.854
4.124AlaIle: 4.124 ± 1.069
2.75AlaLys: 2.75 ± 1.713
5.224AlaLeu: 5.224 ± 1.785
1.65AlaMet: 1.65 ± 0.406
2.475AlaAsn: 2.475 ± 0.694
1.65AlaPro: 1.65 ± 0.795
1.925AlaGln: 1.925 ± 0.51
2.75AlaArg: 2.75 ± 0.393
4.124AlaSer: 4.124 ± 0.853
3.299AlaThr: 3.299 ± 0.359
3.849AlaVal: 3.849 ± 1.528
0.825AlaTrp: 0.825 ± 0.486
1.375AlaTyr: 1.375 ± 0.349
0.0AlaXaa: 0.0 ± 0.0
Cys
0.55CysAla: 0.55 ± 0.596
0.0CysCys: 0.0 ± 0.0
0.825CysAsp: 0.825 ± 0.486
1.1CysGlu: 1.1 ± 1.193
2.2CysPhe: 2.2 ± 1.208
1.375CysGly: 1.375 ± 0.438
0.825CysHis: 0.825 ± 0.246
2.475CysIle: 2.475 ± 0.863
1.65CysLys: 1.65 ± 0.661
3.299CysLeu: 3.299 ± 1.501
1.375CysMet: 1.375 ± 0.471
1.375CysAsn: 1.375 ± 1.196
1.375CysPro: 1.375 ± 1.087
1.375CysGln: 1.375 ± 0.711
1.375CysArg: 1.375 ± 0.828
3.024CysSer: 3.024 ± 2.08
0.825CysThr: 0.825 ± 0.499
0.55CysVal: 0.55 ± 0.596
0.55CysTrp: 0.55 ± 0.22
0.55CysTyr: 0.55 ± 0.596
0.0CysXaa: 0.0 ± 0.0
Asp
4.399AspAla: 4.399 ± 1.563
1.65AspCys: 1.65 ± 1.789
3.849AspAsp: 3.849 ± 0.803
3.574AspGlu: 3.574 ± 0.939
3.024AspPhe: 3.024 ± 1.131
4.674AspGly: 4.674 ± 0.826
1.925AspHis: 1.925 ± 0.927
3.024AspIle: 3.024 ± 0.959
3.849AspLys: 3.849 ± 0.804
6.049AspLeu: 6.049 ± 1.918
1.375AspMet: 1.375 ± 0.696
0.825AspAsn: 0.825 ± 0.486
1.925AspPro: 1.925 ± 0.648
2.2AspGln: 2.2 ± 0.612
1.65AspArg: 1.65 ± 0.451
4.399AspSer: 4.399 ± 1.713
3.024AspThr: 3.024 ± 1.063
2.75AspVal: 2.75 ± 0.916
0.825AspTrp: 0.825 ± 0.59
1.925AspTyr: 1.925 ± 0.589
0.0AspXaa: 0.0 ± 0.0
Glu
4.674GluAla: 4.674 ± 0.962
1.925GluCys: 1.925 ± 1.289
3.574GluAsp: 3.574 ± 1.092
7.699GluGlu: 7.699 ± 1.698
4.124GluPhe: 4.124 ± 1.048
3.024GluGly: 3.024 ± 0.923
1.375GluHis: 1.375 ± 0.48
2.475GluIle: 2.475 ± 1.208
3.024GluLys: 3.024 ± 0.959
3.024GluLeu: 3.024 ± 0.548
1.65GluMet: 1.65 ± 1.18
1.375GluAsn: 1.375 ± 0.349
1.65GluPro: 1.65 ± 0.795
2.2GluGln: 2.2 ± 0.419
4.124GluArg: 4.124 ± 1.295
5.499GluSer: 5.499 ± 0.691
3.574GluThr: 3.574 ± 0.769
3.574GluVal: 3.574 ± 0.974
1.375GluTrp: 1.375 ± 0.438
2.2GluTyr: 2.2 ± 0.952
0.0GluXaa: 0.0 ± 0.0
Phe
2.2PheAla: 2.2 ± 1.381
1.375PheCys: 1.375 ± 0.438
1.65PheAsp: 1.65 ± 0.644
2.475PheGlu: 2.475 ± 1.154
2.75PhePhe: 2.75 ± 1.067
3.024PheGly: 3.024 ± 0.417
1.65PheHis: 1.65 ± 0.641
2.475PheIle: 2.475 ± 1.033
5.774PheLys: 5.774 ± 1.435
3.849PheLeu: 3.849 ± 0.903
1.65PheMet: 1.65 ± 0.451
4.124PheAsn: 4.124 ± 1.23
2.475PhePro: 2.475 ± 1.178
1.925PheGln: 1.925 ± 0.873
2.2PheArg: 2.2 ± 0.984
4.399PheSer: 4.399 ± 0.968
3.574PheThr: 3.574 ± 1.977
1.65PheVal: 1.65 ± 0.641
1.925PheTrp: 1.925 ± 0.648
1.1PheTyr: 1.1 ± 0.44
0.0PheXaa: 0.0 ± 0.0
Gly
2.475GlyAla: 2.475 ± 0.738
0.825GlyCys: 0.825 ± 0.246
1.925GlyAsp: 1.925 ± 0.533
1.925GlyGlu: 1.925 ± 0.927
3.024GlyPhe: 3.024 ± 1.257
2.2GlyGly: 2.2 ± 0.707
0.55GlyHis: 0.55 ± 0.22
1.65GlyIle: 1.65 ± 0.641
3.849GlyLys: 3.849 ± 0.607
6.324GlyLeu: 6.324 ± 1.479
2.475GlyMet: 2.475 ± 0.715
1.925GlyAsn: 1.925 ± 0.982
2.2GlyPro: 2.2 ± 0.881
1.375GlyGln: 1.375 ± 0.48
2.2GlyArg: 2.2 ± 0.881
5.499GlySer: 5.499 ± 1.039
2.475GlyThr: 2.475 ± 1.399
4.674GlyVal: 4.674 ± 0.81
1.65GlyTrp: 1.65 ± 1.231
1.65GlyTyr: 1.65 ± 0.374
0.0GlyXaa: 0.0 ± 0.0
His
0.55HisAla: 0.55 ± 0.324
0.825HisCys: 0.825 ± 0.499
1.1HisAsp: 1.1 ± 0.625
1.375HisGlu: 1.375 ± 0.711
1.1HisPhe: 1.1 ± 0.44
2.75HisGly: 2.75 ± 0.828
1.925HisHis: 1.925 ± 0.796
2.2HisIle: 2.2 ± 0.419
1.375HisLys: 1.375 ± 0.492
3.574HisLeu: 3.574 ± 1.507
0.55HisMet: 0.55 ± 0.599
1.65HisAsn: 1.65 ± 0.7
1.1HisPro: 1.1 ± 0.625
0.0HisGln: 0.0 ± 0.0
2.2HisArg: 2.2 ± 0.726
1.925HisSer: 1.925 ± 0.648
1.375HisThr: 1.375 ± 0.471
2.475HisVal: 2.475 ± 0.863
0.825HisTrp: 0.825 ± 0.59
1.1HisTyr: 1.1 ± 0.354
0.0HisXaa: 0.0 ± 0.0
Ile
3.024IleAla: 3.024 ± 0.808
1.375IleCys: 1.375 ± 0.492
3.574IleAsp: 3.574 ± 0.246
2.75IleGlu: 2.75 ± 0.988
1.925IlePhe: 1.925 ± 0.51
3.299IleGly: 3.299 ± 0.476
1.375IleHis: 1.375 ± 0.438
4.674IleIle: 4.674 ± 0.81
3.299IleLys: 3.299 ± 0.647
6.874IleLeu: 6.874 ± 0.92
1.375IleMet: 1.375 ± 0.677
1.65IleAsn: 1.65 ± 1.261
3.024IlePro: 3.024 ± 0.417
2.2IleGln: 2.2 ± 0.419
5.499IleArg: 5.499 ± 0.756
5.499IleSer: 5.499 ± 1.806
3.299IleThr: 3.299 ± 1.182
2.2IleVal: 2.2 ± 1.0
0.55IleTrp: 0.55 ± 0.596
1.65IleTyr: 1.65 ± 0.662
0.0IleXaa: 0.0 ± 0.0
Lys
4.399LysAla: 4.399 ± 1.988
1.1LysCys: 1.1 ± 0.791
2.75LysAsp: 2.75 ± 0.961
4.124LysGlu: 4.124 ± 1.018
2.75LysPhe: 2.75 ± 0.828
2.2LysGly: 2.2 ± 0.675
1.65LysHis: 1.65 ± 0.644
3.849LysIle: 3.849 ± 0.767
5.774LysLys: 5.774 ± 1.821
6.324LysLeu: 6.324 ± 0.757
2.2LysMet: 2.2 ± 0.338
1.925LysAsn: 1.925 ± 1.004
1.925LysPro: 1.925 ± 0.587
1.65LysGln: 1.65 ± 0.971
5.499LysArg: 5.499 ± 2.254
4.674LysSer: 4.674 ± 1.405
2.75LysThr: 2.75 ± 0.547
4.124LysVal: 4.124 ± 0.853
1.1LysTrp: 1.1 ± 0.648
2.2LysTyr: 2.2 ± 1.295
0.0LysXaa: 0.0 ± 0.0
Leu
4.399LeuAla: 4.399 ± 0.458
3.299LeuCys: 3.299 ± 1.501
7.699LeuAsp: 7.699 ± 2.172
8.249LeuGlu: 8.249 ± 0.636
4.674LeuPhe: 4.674 ± 1.199
5.774LeuGly: 5.774 ± 1.263
3.849LeuHis: 3.849 ± 0.378
4.949LeuIle: 4.949 ± 1.54
4.674LeuLys: 4.674 ± 0.553
10.173LeuLeu: 10.173 ± 0.503
2.75LeuMet: 2.75 ± 0.472
4.124LeuAsn: 4.124 ± 0.705
2.475LeuPro: 2.475 ± 0.996
3.299LeuGln: 3.299 ± 0.935
6.874LeuArg: 6.874 ± 1.868
10.998LeuSer: 10.998 ± 2.6
6.324LeuThr: 6.324 ± 1.495
5.499LeuVal: 5.499 ± 1.75
1.375LeuTrp: 1.375 ± 0.419
1.375LeuTyr: 1.375 ± 0.717
0.0LeuXaa: 0.0 ± 0.0
Met
1.375MetAla: 1.375 ± 0.471
0.55MetCys: 0.55 ± 0.324
2.2MetAsp: 2.2 ± 0.984
1.925MetGlu: 1.925 ± 0.982
2.475MetPhe: 2.475 ± 0.776
1.1MetGly: 1.1 ± 0.44
1.1MetHis: 1.1 ± 0.363
1.925MetIle: 1.925 ± 0.911
1.65MetLys: 1.65 ± 1.034
3.299MetLeu: 3.299 ± 0.174
2.2MetMet: 2.2 ± 0.612
0.825MetAsn: 0.825 ± 0.59
1.65MetPro: 1.65 ± 0.708
0.55MetGln: 0.55 ± 0.324
1.1MetArg: 1.1 ± 0.448
1.375MetSer: 1.375 ± 1.088
1.1MetThr: 1.1 ± 0.354
0.825MetVal: 0.825 ± 0.499
0.0MetTrp: 0.0 ± 0.0
0.55MetTyr: 0.55 ± 0.324
0.0MetXaa: 0.0 ± 0.0
Asn
1.65AsnAla: 1.65 ± 0.803
1.925AsnCys: 1.925 ± 0.927
1.375AsnAsp: 1.375 ± 0.471
2.75AsnGlu: 2.75 ± 0.349
2.2AsnPhe: 2.2 ± 1.0
1.375AsnGly: 1.375 ± 0.717
1.65AsnHis: 1.65 ± 0.492
1.375AsnIle: 1.375 ± 0.438
2.2AsnLys: 2.2 ± 1.185
4.399AsnLeu: 4.399 ± 2.113
0.825AsnMet: 0.825 ± 0.246
1.65AsnAsn: 1.65 ± 0.492
1.925AsnPro: 1.925 ± 0.533
1.65AsnGln: 1.65 ± 0.661
2.475AsnArg: 2.475 ± 0.425
2.475AsnSer: 2.475 ± 0.738
1.65AsnThr: 1.65 ± 0.641
2.75AsnVal: 2.75 ± 0.483
1.375AsnTrp: 1.375 ± 0.349
0.275AsnTyr: 0.275 ± 0.649
0.0AsnXaa: 0.0 ± 0.0
Pro
1.925ProAla: 1.925 ± 0.648
0.825ProCys: 0.825 ± 0.527
3.024ProAsp: 3.024 ± 1.08
3.574ProGlu: 3.574 ± 0.696
3.024ProPhe: 3.024 ± 0.917
1.375ProGly: 1.375 ± 0.492
0.55ProHis: 0.55 ± 0.638
2.2ProIle: 2.2 ± 1.295
3.024ProLys: 3.024 ± 0.417
3.299ProLeu: 3.299 ± 0.903
0.55ProMet: 0.55 ± 0.22
1.1ProAsn: 1.1 ± 0.44
1.65ProPro: 1.65 ± 0.641
1.375ProGln: 1.375 ± 0.82
2.475ProArg: 2.475 ± 0.35
3.849ProSer: 3.849 ± 0.738
1.65ProThr: 1.65 ± 1.231
1.375ProVal: 1.375 ± 0.848
0.825ProTrp: 0.825 ± 0.486
0.275ProTyr: 0.275 ± 0.162
0.0ProXaa: 0.0 ± 0.0
Gln
2.2GlnAla: 2.2 ± 1.029
1.375GlnCys: 1.375 ± 0.711
0.55GlnAsp: 0.55 ± 0.22
2.2GlnGlu: 2.2 ± 0.952
1.1GlnPhe: 1.1 ± 0.44
1.65GlnGly: 1.65 ± 0.832
1.65GlnHis: 1.65 ± 0.661
0.825GlnIle: 0.825 ± 0.486
3.574GlnLys: 3.574 ± 1.092
2.2GlnLeu: 2.2 ± 0.388
0.825GlnMet: 0.825 ± 0.468
1.65GlnAsn: 1.65 ± 1.735
1.65GlnPro: 1.65 ± 0.661
1.1GlnGln: 1.1 ± 0.363
3.299GlnArg: 3.299 ± 0.833
2.75GlnSer: 2.75 ± 0.828
2.475GlnThr: 2.475 ± 0.841
1.65GlnVal: 1.65 ± 0.975
0.275GlnTrp: 0.275 ± 0.513
0.275GlnTyr: 0.275 ± 0.513
0.0GlnXaa: 0.0 ± 0.0
Arg
4.674ArgAla: 4.674 ± 0.776
2.75ArgCys: 2.75 ± 1.787
4.399ArgAsp: 4.399 ± 1.277
2.475ArgGlu: 2.475 ± 0.658
3.299ArgPhe: 3.299 ± 0.961
3.024ArgGly: 3.024 ± 1.006
0.825ArgHis: 0.825 ± 0.499
4.124ArgIle: 4.124 ± 1.156
2.2ArgLys: 2.2 ± 0.896
6.599ArgLeu: 6.599 ± 1.551
2.475ArgMet: 2.475 ± 1.931
2.2ArgAsn: 2.2 ± 0.419
3.024ArgPro: 3.024 ± 0.856
1.375ArgGln: 1.375 ± 0.492
3.299ArgArg: 3.299 ± 0.987
5.499ArgSer: 5.499 ± 1.343
3.849ArgThr: 3.849 ± 0.83
2.75ArgVal: 2.75 ± 0.349
0.55ArgTrp: 0.55 ± 0.324
1.65ArgTyr: 1.65 ± 0.832
0.0ArgXaa: 0.0 ± 0.0
Ser
4.124SerAla: 4.124 ± 1.48
1.375SerCys: 1.375 ± 1.491
6.049SerAsp: 6.049 ± 0.71
4.399SerGlu: 4.399 ± 0.905
3.574SerPhe: 3.574 ± 1.115
4.399SerGly: 4.399 ± 1.351
2.475SerHis: 2.475 ± 0.863
6.049SerIle: 6.049 ± 0.91
6.324SerLys: 6.324 ± 1.274
10.723SerLeu: 10.723 ± 0.605
0.825SerMet: 0.825 ± 0.438
2.75SerAsn: 2.75 ± 0.876
3.849SerPro: 3.849 ± 1.541
3.299SerGln: 3.299 ± 0.877
6.599SerArg: 6.599 ± 2.267
7.699SerSer: 7.699 ± 1.66
5.224SerThr: 5.224 ± 0.955
5.774SerVal: 5.774 ± 2.184
1.375SerTrp: 1.375 ± 0.711
1.925SerTyr: 1.925 ± 0.908
0.0SerXaa: 0.0 ± 0.0
Thr
2.475ThrAla: 2.475 ± 0.504
1.925ThrCys: 1.925 ± 0.968
2.2ThrAsp: 2.2 ± 0.419
3.299ThrGlu: 3.299 ± 0.528
3.849ThrPhe: 3.849 ± 1.267
4.124ThrGly: 4.124 ± 1.173
2.2ThrHis: 2.2 ± 1.208
4.674ThrIle: 4.674 ± 2.656
2.475ThrLys: 2.475 ± 0.35
7.149ThrLeu: 7.149 ± 0.714
0.825ThrMet: 0.825 ± 0.894
2.2ThrAsn: 2.2 ± 0.952
1.65ThrPro: 1.65 ± 0.406
1.375ThrGln: 1.375 ± 0.81
3.574ThrArg: 3.574 ± 0.642
4.399ThrSer: 4.399 ± 1.414
3.299ThrThr: 3.299 ± 0.903
4.124ThrVal: 4.124 ± 0.139
0.55ThrTrp: 0.55 ± 0.596
1.925ThrTyr: 1.925 ± 0.317
0.0ThrXaa: 0.0 ± 0.0
Val
2.2ValAla: 2.2 ± 0.507
1.1ValCys: 1.1 ± 0.592
4.949ValAsp: 4.949 ± 1.362
3.849ValGlu: 3.849 ± 1.174
1.65ValPhe: 1.65 ± 0.641
1.65ValGly: 1.65 ± 1.231
1.925ValHis: 1.925 ± 0.317
3.849ValIle: 3.849 ± 1.332
3.574ValLys: 3.574 ± 0.667
4.124ValLeu: 4.124 ± 1.046
1.1ValMet: 1.1 ± 0.354
2.2ValAsn: 2.2 ± 0.472
1.1ValPro: 1.1 ± 0.44
2.75ValGln: 2.75 ± 0.393
1.925ValArg: 1.925 ± 1.374
7.974ValSer: 7.974 ± 1.519
4.399ValThr: 4.399 ± 0.925
4.124ValVal: 4.124 ± 0.518
0.825ValTrp: 0.825 ± 0.486
1.375ValTyr: 1.375 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.499
0.55TrpCys: 0.55 ± 0.324
0.825TrpAsp: 0.825 ± 0.499
0.825TrpGlu: 0.825 ± 0.888
1.925TrpPhe: 1.925 ± 0.648
0.55TrpGly: 0.55 ± 0.22
0.0TrpHis: 0.0 ± 0.0
1.65TrpIle: 1.65 ± 0.374
0.55TrpLys: 0.55 ± 0.22
2.475TrpLeu: 2.475 ± 0.776
0.0TrpMet: 0.0 ± 0.0
0.55TrpAsn: 0.55 ± 0.324
0.825TrpPro: 0.825 ± 1.252
0.55TrpGln: 0.55 ± 0.22
0.825TrpArg: 0.825 ± 0.486
1.1TrpSer: 1.1 ± 0.791
1.375TrpThr: 1.375 ± 0.492
1.1TrpVal: 1.1 ± 0.363
0.275TrpTrp: 0.275 ± 0.298
0.55TrpTyr: 0.55 ± 0.324
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.55TyrAla: 0.55 ± 0.22
0.275TyrCys: 0.275 ± 0.298
1.65TyrAsp: 1.65 ± 1.054
1.65TyrGlu: 1.65 ± 0.374
1.65TyrPhe: 1.65 ± 1.054
0.55TyrGly: 0.55 ± 0.599
1.1TyrHis: 1.1 ± 0.648
0.55TyrIle: 0.55 ± 0.324
1.375TyrLys: 1.375 ± 0.81
3.849TyrLeu: 3.849 ± 0.763
0.825TyrMet: 0.825 ± 0.246
1.375TyrAsn: 1.375 ± 0.438
0.825TyrPro: 0.825 ± 0.441
1.1TyrGln: 1.1 ± 0.93
1.1TyrArg: 1.1 ± 0.354
1.65TyrSer: 1.65 ± 0.661
2.75TyrThr: 2.75 ± 0.349
0.825TyrVal: 0.825 ± 0.486
0.275TyrTrp: 0.275 ± 0.298
0.825TyrTyr: 0.825 ± 0.246
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski