Amino acid dipepetide frequency for Bradymonadales bacterium V1718

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.132AlaAla: 9.132 ± 0.094	1.581AlaCys: 1.581 ± 0.049	5.28AlaAsp: 5.28 ± 0.066	7.127AlaGlu: 7.127 ± 0.079	3.686AlaPhe: 3.686 ± 0.046	7.12AlaGly: 7.12 ± 0.082	1.897AlaHis: 1.897 ± 0.033	4.878AlaIle: 4.878 ± 0.058	3.795AlaLys: 3.795 ± 0.053	10.242AlaLeu: 10.242 ± 0.102	2.265AlaMet: 2.265 ± 0.039	2.943AlaAsn: 2.943 ± 0.047	4.428AlaPro: 4.428 ± 0.057	3.805AlaGln: 3.805 ± 0.045	5.91AlaArg: 5.91 ± 0.078	5.817AlaSer: 5.817 ± 0.057	4.856AlaThr: 4.856 ± 0.059	5.836AlaVal: 5.836 ± 0.064	1.345AlaTrp: 1.345 ± 0.033	2.175AlaTyr: 2.175 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.323CysAla: 1.323 ± 0.046	0.141CysCys: 0.141 ± 0.011	1.164CysAsp: 1.164 ± 0.054	1.042CysGlu: 1.042 ± 0.033	0.405CysPhe: 0.405 ± 0.018	1.462CysGly: 1.462 ± 0.063	0.239CysHis: 0.239 ± 0.016	0.454CysIle: 0.454 ± 0.019	0.268CysLys: 0.268 ± 0.012	0.978CysLeu: 0.978 ± 0.03	0.182CysMet: 0.182 ± 0.01	0.426CysAsn: 0.426 ± 0.027	0.846CysPro: 0.846 ± 0.042	0.485CysGln: 0.485 ± 0.025	0.613CysArg: 0.613 ± 0.021	0.958CysSer: 0.958 ± 0.04	0.925CysThr: 0.925 ± 0.043	1.148CysVal: 1.148 ± 0.043	0.185CysTrp: 0.185 ± 0.019	0.229CysTyr: 0.229 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.251AspAla: 6.251 ± 0.071	0.889AspCys: 0.889 ± 0.047	3.758AspAsp: 3.758 ± 0.06	4.924AspGlu: 4.924 ± 0.055	2.796AspPhe: 2.796 ± 0.046	5.638AspGly: 5.638 ± 0.108	1.176AspHis: 1.176 ± 0.025	3.066AspIle: 3.066 ± 0.048	1.705AspLys: 1.705 ± 0.034	6.159AspLeu: 6.159 ± 0.057	1.446AspMet: 1.446 ± 0.035	1.574AspAsn: 1.574 ± 0.051	3.661AspPro: 3.661 ± 0.052	2.046AspGln: 2.046 ± 0.038	3.145AspArg: 3.145 ± 0.041	3.706AspSer: 3.706 ± 0.054	2.927AspThr: 2.927 ± 0.047	4.679AspVal: 4.679 ± 0.057	0.886AspTrp: 0.886 ± 0.025	1.527AspTyr: 1.527 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.3GluAla: 7.3 ± 0.074	1.041GluCys: 1.041 ± 0.041	4.374GluAsp: 4.374 ± 0.051	5.648GluGlu: 5.648 ± 0.088	3.24GluPhe: 3.24 ± 0.044	5.212GluGly: 5.212 ± 0.063	1.505GluHis: 1.505 ± 0.031	4.362GluIle: 4.362 ± 0.051	3.169GluLys: 3.169 ± 0.053	8.207GluLeu: 8.207 ± 0.094	1.681GluMet: 1.681 ± 0.032	2.452GluAsn: 2.452 ± 0.038	3.617GluPro: 3.617 ± 0.063	2.116GluGln: 2.116 ± 0.036	5.028GluArg: 5.028 ± 0.071	4.757GluSer: 4.757 ± 0.061	3.809GluThr: 3.809 ± 0.045	5.896GluVal: 5.896 ± 0.057	1.015GluTrp: 1.015 ± 0.026	1.616GluTyr: 1.616 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.638PheAla: 3.638 ± 0.052	0.508PheCys: 0.508 ± 0.02	3.001PheAsp: 3.001 ± 0.044	3.653PheGlu: 3.653 ± 0.048	1.684PhePhe: 1.684 ± 0.034	3.829PheGly: 3.829 ± 0.053	0.805PheHis: 0.805 ± 0.022	1.647PheIle: 1.647 ± 0.034	1.501PheLys: 1.501 ± 0.034	3.653PheLeu: 3.653 ± 0.049	0.884PheMet: 0.884 ± 0.021	1.252PheAsn: 1.252 ± 0.024	1.609PhePro: 1.609 ± 0.033	1.362PheGln: 1.362 ± 0.027	2.229PheArg: 2.229 ± 0.039	2.7PheSer: 2.7 ± 0.04	1.913PheThr: 1.913 ± 0.04	3.142PheVal: 3.142 ± 0.042	0.648PheTrp: 0.648 ± 0.022	1.068PheTyr: 1.068 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.248GlyAla: 7.248 ± 0.077	1.242GlyCys: 1.242 ± 0.035	4.569GlyAsp: 4.569 ± 0.078	5.482GlyGlu: 5.482 ± 0.066	3.642GlyPhe: 3.642 ± 0.053	5.92GlyGly: 5.92 ± 0.093	1.531GlyHis: 1.531 ± 0.035	4.106GlyIle: 4.106 ± 0.05	3.064GlyLys: 3.064 ± 0.044	7.87GlyLeu: 7.87 ± 0.081	1.814GlyMet: 1.814 ± 0.033	2.409GlyAsn: 2.409 ± 0.05	3.292GlyPro: 3.292 ± 0.053	2.947GlyGln: 2.947 ± 0.047	4.361GlyArg: 4.361 ± 0.055	4.673GlySer: 4.673 ± 0.064	4.703GlyThr: 4.703 ± 0.062	6.281GlyVal: 6.281 ± 0.08	1.212GlyTrp: 1.212 ± 0.027	2.067GlyTyr: 2.067 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	1.815HisAla: 1.815 ± 0.035	0.207HisCys: 0.207 ± 0.011	1.129HisAsp: 1.129 ± 0.028	1.371HisGlu: 1.371 ± 0.027	0.939HisPhe: 0.939 ± 0.026	1.519HisGly: 1.519 ± 0.03	0.588HisHis: 0.588 ± 0.021	0.988HisIle: 0.988 ± 0.026	0.63HisLys: 0.63 ± 0.018	2.005HisLeu: 2.005 ± 0.04	0.405HisMet: 0.405 ± 0.014	0.522HisAsn: 0.522 ± 0.016	1.222HisPro: 1.222 ± 0.03	0.748HisGln: 0.748 ± 0.021	1.334HisArg: 1.334 ± 0.031	1.047HisSer: 1.047 ± 0.023	1.019HisThr: 1.019 ± 0.026	1.522HisVal: 1.522 ± 0.033	0.326HisTrp: 0.326 ± 0.013	0.559HisTyr: 0.559 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.818IleAla: 4.818 ± 0.061	0.652IleCys: 0.652 ± 0.023	3.267IleAsp: 3.267 ± 0.053	4.216IleGlu: 4.216 ± 0.06	1.954IlePhe: 1.954 ± 0.036	3.894IleGly: 3.894 ± 0.049	1.047IleHis: 1.047 ± 0.026	2.099IleIle: 2.099 ± 0.043	1.784IleLys: 1.784 ± 0.035	4.858IleLeu: 4.858 ± 0.06	0.846IleMet: 0.846 ± 0.025	1.486IleAsn: 1.486 ± 0.032	2.617IlePro: 2.617 ± 0.037	1.841IleGln: 1.841 ± 0.032	2.996IleArg: 2.996 ± 0.041	3.314IleSer: 3.314 ± 0.046	2.458IleThr: 2.458 ± 0.043	3.606IleVal: 3.606 ± 0.039	0.711IleTrp: 0.711 ± 0.021	1.216IleTyr: 1.216 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.879LysAla: 3.879 ± 0.062	0.272LysCys: 0.272 ± 0.014	2.264LysAsp: 2.264 ± 0.039	2.74LysGlu: 2.74 ± 0.048	1.408LysPhe: 1.408 ± 0.03	2.639LysGly: 2.639 ± 0.049	0.829LysHis: 0.829 ± 0.026	2.132LysIle: 2.132 ± 0.037	1.983LysLys: 1.983 ± 0.054	3.798LysLeu: 3.798 ± 0.055	0.921LysMet: 0.921 ± 0.027	1.27LysAsn: 1.27 ± 0.025	2.073LysPro: 2.073 ± 0.045	1.006LysGln: 1.006 ± 0.027	2.545LysArg: 2.545 ± 0.045	2.557LysSer: 2.557 ± 0.043	2.387LysThr: 2.387 ± 0.042	3.028LysVal: 3.028 ± 0.048	0.477LysTrp: 0.477 ± 0.016	0.913LysTyr: 0.913 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	9.621LeuAla: 9.621 ± 0.08	0.893LeuCys: 0.893 ± 0.022	6.274LeuAsp: 6.274 ± 0.072	8.204LeuGlu: 8.204 ± 0.101	3.527LeuPhe: 3.527 ± 0.053	8.184LeuGly: 8.184 ± 0.084	1.832LeuHis: 1.832 ± 0.035	4.534LeuIle: 4.534 ± 0.058	4.703LeuLys: 4.703 ± 0.063	8.995LeuLeu: 8.995 ± 0.109	2.174LeuMet: 2.174 ± 0.041	3.411LeuAsn: 3.411 ± 0.05	4.332LeuPro: 4.332 ± 0.054	3.012LeuGln: 3.012 ± 0.044	6.05LeuArg: 6.05 ± 0.074	6.743LeuSer: 6.743 ± 0.076	4.872LeuThr: 4.872 ± 0.056	7.615LeuVal: 7.615 ± 0.065	1.138LeuTrp: 1.138 ± 0.025	2.093LeuTyr: 2.093 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.224MetAla: 2.224 ± 0.044	0.215MetCys: 0.215 ± 0.011	1.19MetAsp: 1.19 ± 0.026	1.344MetGlu: 1.344 ± 0.025	0.706MetPhe: 0.706 ± 0.019	1.764MetGly: 1.764 ± 0.037	0.388MetHis: 0.388 ± 0.015	1.068MetIle: 1.068 ± 0.025	1.295MetLys: 1.295 ± 0.029	1.988MetLeu: 1.988 ± 0.037	0.617MetMet: 0.617 ± 0.018	0.861MetAsn: 0.861 ± 0.022	1.175MetPro: 1.175 ± 0.023	0.666MetGln: 0.666 ± 0.018	1.508MetArg: 1.508 ± 0.031	1.602MetSer: 1.602 ± 0.033	1.305MetThr: 1.305 ± 0.029	1.672MetVal: 1.672 ± 0.035	0.219MetTrp: 0.219 ± 0.011	0.388MetTyr: 0.388 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.083AsnAla: 3.083 ± 0.041	0.493AsnCys: 0.493 ± 0.033	1.892AsnAsp: 1.892 ± 0.038	1.978AsnGlu: 1.978 ± 0.038	1.301AsnPhe: 1.301 ± 0.03	2.663AsnGly: 2.663 ± 0.053	0.677AsnHis: 0.677 ± 0.021	1.606AsnIle: 1.606 ± 0.031	0.846AsnLys: 0.846 ± 0.023	3.179AsnLeu: 3.179 ± 0.05	0.602AsnMet: 0.602 ± 0.019	1.355AsnAsn: 1.355 ± 0.05	2.355AsnPro: 2.355 ± 0.035	1.314AsnGln: 1.314 ± 0.028	1.762AsnArg: 1.762 ± 0.026	1.978AsnSer: 1.978 ± 0.036	1.952AsnThr: 1.952 ± 0.039	2.339AsnVal: 2.339 ± 0.034	0.432AsnTrp: 0.432 ± 0.017	0.827AsnTyr: 0.827 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.352ProAla: 4.352 ± 0.066	0.506ProCys: 0.506 ± 0.022	3.747ProAsp: 3.747 ± 0.053	4.829ProGlu: 4.829 ± 0.062	1.881ProPhe: 1.881 ± 0.032	3.919ProGly: 3.919 ± 0.054	0.92ProHis: 0.92 ± 0.024	2.324ProIle: 2.324 ± 0.041	2.18ProLys: 2.18 ± 0.047	4.054ProLeu: 4.054 ± 0.051	1.091ProMet: 1.091 ± 0.024	1.92ProAsn: 1.92 ± 0.041	2.355ProPro: 2.355 ± 0.047	1.703ProGln: 1.703 ± 0.034	2.362ProArg: 2.362 ± 0.04	3.215ProSer: 3.215 ± 0.045	2.828ProThr: 2.828 ± 0.047	3.527ProVal: 3.527 ± 0.04	0.67ProTrp: 0.67 ± 0.021	1.077ProTyr: 1.077 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.047	0.467GlnCys: 0.467 ± 0.027	2.125GlnAsp: 2.125 ± 0.032	2.457GlnGlu: 2.457 ± 0.033	1.163GlnPhe: 1.163 ± 0.031	2.443GlnGly: 2.443 ± 0.037	0.612GlnHis: 0.612 ± 0.019	2.037GlnIle: 2.037 ± 0.037	1.531GlnLys: 1.531 ± 0.032	2.953GlnLeu: 2.953 ± 0.043	0.826GlnMet: 0.826 ± 0.021	1.36GlnAsn: 1.36 ± 0.031	1.564GlnPro: 1.564 ± 0.031	0.852GlnGln: 0.852 ± 0.021	2.227GlnArg: 2.227 ± 0.04	2.117GlnSer: 2.117 ± 0.037	2.272GlnThr: 2.272 ± 0.034	2.547GlnVal: 2.547 ± 0.04	0.454GlnTrp: 0.454 ± 0.016	0.669GlnTyr: 0.669 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.642ArgAla: 5.642 ± 0.073	0.653ArgCys: 0.653 ± 0.024	3.563ArgAsp: 3.563 ± 0.045	4.421ArgGlu: 4.421 ± 0.056	2.604ArgPhe: 2.604 ± 0.036	3.924ArgGly: 3.924 ± 0.054	1.27ArgHis: 1.27 ± 0.026	3.339ArgIle: 3.339 ± 0.042	2.237ArgLys: 2.237 ± 0.041	6.244ArgLeu: 6.244 ± 0.072	1.419ArgMet: 1.419 ± 0.029	1.786ArgAsn: 1.786 ± 0.032	2.71ArgPro: 2.71 ± 0.041	2.02ArgGln: 2.02 ± 0.035	3.955ArgArg: 3.955 ± 0.064	3.268ArgSer: 3.268 ± 0.046	2.836ArgThr: 2.836 ± 0.04	5.079ArgVal: 5.079 ± 0.057	0.897ArgTrp: 0.897 ± 0.024	1.682ArgTyr: 1.682 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.033SerAla: 6.033 ± 0.061	1.029SerCys: 1.029 ± 0.045	4.003SerAsp: 4.003 ± 0.051	4.424SerGlu: 4.424 ± 0.056	2.586SerPhe: 2.586 ± 0.044	5.593SerGly: 5.593 ± 0.072	1.192SerHis: 1.192 ± 0.025	2.923SerIle: 2.923 ± 0.039	2.533SerLys: 2.533 ± 0.039	5.974SerLeu: 5.974 ± 0.062	1.407SerMet: 1.407 ± 0.027	2.19SerAsn: 2.19 ± 0.041	3.136SerPro: 3.136 ± 0.046	2.123SerGln: 2.123 ± 0.034	3.465SerArg: 3.465 ± 0.052	4.147SerSer: 4.147 ± 0.051	3.575SerThr: 3.575 ± 0.059	4.707SerVal: 4.707 ± 0.054	0.937SerTrp: 0.937 ± 0.024	1.461SerTyr: 1.461 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.059ThrAla: 4.059 ± 0.052	1.068ThrCys: 1.068 ± 0.051	3.072ThrAsp: 3.072 ± 0.051	3.278ThrGlu: 3.278 ± 0.04	2.237ThrPhe: 2.237 ± 0.04	4.204ThrGly: 4.204 ± 0.063	1.143ThrHis: 1.143 ± 0.026	2.847ThrIle: 2.847 ± 0.039	1.831ThrLys: 1.831 ± 0.035	5.735ThrLeu: 5.735 ± 0.055	1.137ThrMet: 1.137 ± 0.03	1.905ThrAsn: 1.905 ± 0.039	3.389ThrPro: 3.389 ± 0.051	2.096ThrGln: 2.096 ± 0.033	3.104ThrArg: 3.104 ± 0.047	3.497ThrSer: 3.497 ± 0.05	3.187ThrThr: 3.187 ± 0.052	3.554ThrVal: 3.554 ± 0.058	0.843ThrTrp: 0.843 ± 0.024	1.514ThrTyr: 1.514 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.063ValAla: 7.063 ± 0.058	1.131ValCys: 1.131 ± 0.044	5.016ValAsp: 5.016 ± 0.061	6.172ValGlu: 6.172 ± 0.068	3.209ValPhe: 3.209 ± 0.046	5.679ValGly: 5.679 ± 0.064	1.468ValHis: 1.468 ± 0.029	3.612ValIle: 3.612 ± 0.045	2.7ValLys: 2.7 ± 0.048	7.454ValLeu: 7.454 ± 0.071	1.561ValMet: 1.561 ± 0.036	2.305ValAsn: 2.305 ± 0.04	3.463ValPro: 3.463 ± 0.05	2.53ValGln: 2.53 ± 0.035	4.352ValArg: 4.352 ± 0.054	4.888ValSer: 4.888 ± 0.051	3.64ValThr: 3.64 ± 0.058	6.328ValVal: 6.328 ± 0.074	1.041ValTrp: 1.041 ± 0.024	1.757ValTyr: 1.757 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.199TrpAla: 1.199 ± 0.023	0.152TrpCys: 0.152 ± 0.009	0.816TrpAsp: 0.816 ± 0.023	1.016TrpGlu: 1.016 ± 0.026	0.533TrpPhe: 0.533 ± 0.017	0.991TrpGly: 0.991 ± 0.026	0.267TrpHis: 0.267 ± 0.012	0.663TrpIle: 0.663 ± 0.019	0.584TrpLys: 0.584 ± 0.018	1.419TrpLeu: 1.419 ± 0.031	0.405TrpMet: 0.405 ± 0.015	0.469TrpAsn: 0.469 ± 0.017	0.545TrpPro: 0.545 ± 0.017	0.481TrpGln: 0.481 ± 0.016	0.949TrpArg: 0.949 ± 0.023	0.937TrpSer: 0.937 ± 0.028	0.875TrpThr: 0.875 ± 0.026	1.188TrpVal: 1.188 ± 0.029	0.24TrpTrp: 0.24 ± 0.012	0.316TrpTyr: 0.316 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.008TyrAla: 2.008 ± 0.038	0.332TyrCys: 0.332 ± 0.016	1.454TyrAsp: 1.454 ± 0.031	1.718TyrGlu: 1.718 ± 0.036	1.224TyrPhe: 1.224 ± 0.029	1.839TyrGly: 1.839 ± 0.032	0.511TyrHis: 0.511 ± 0.017	0.996TyrIle: 0.996 ± 0.029	0.784TyrLys: 0.784 ± 0.023	2.442TyrLeu: 2.442 ± 0.036	0.512TyrMet: 0.512 ± 0.019	0.737TyrAsn: 0.737 ± 0.02	1.071TyrPro: 1.071 ± 0.026	0.951TyrGln: 0.951 ± 0.024	1.654TyrArg: 1.654 ± 0.036	1.517TyrSer: 1.517 ± 0.029	1.363TyrThr: 1.363 ± 0.031	1.67TyrVal: 1.67 ± 0.03	0.37TyrTrp: 0.37 ± 0.015	0.706TyrTyr: 0.706 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4727 proteins (1827870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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