Amino acid dipepetide frequency for Actinophytocola xanthii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.108AlaAla: 21.108 ± 0.154
0.966AlaCys: 0.966 ± 0.021
8.321AlaAsp: 8.321 ± 0.069
9.272AlaGlu: 9.272 ± 0.08
3.415AlaPhe: 3.415 ± 0.042
13.43AlaGly: 13.43 ± 0.088
2.57AlaHis: 2.57 ± 0.037
3.59AlaIle: 3.59 ± 0.044
2.102AlaLys: 2.102 ± 0.036
14.203AlaLeu: 14.203 ± 0.118
2.521AlaMet: 2.521 ± 0.034
2.318AlaAsn: 2.318 ± 0.037
6.406AlaPro: 6.406 ± 0.054
3.304AlaGln: 3.304 ± 0.04
10.322AlaArg: 10.322 ± 0.079
5.837AlaSer: 5.837 ± 0.056
7.798AlaThr: 7.798 ± 0.074
13.071AlaVal: 13.071 ± 0.094
1.867AlaTrp: 1.867 ± 0.029
2.279AlaTyr: 2.279 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.037CysAla: 1.037 ± 0.023
0.085CysCys: 0.085 ± 0.006
0.452CysAsp: 0.452 ± 0.015
0.385CysGlu: 0.385 ± 0.013
0.203CysPhe: 0.203 ± 0.009
0.918CysGly: 0.918 ± 0.023
0.192CysHis: 0.192 ± 0.008
0.129CysIle: 0.129 ± 0.008
0.087CysLys: 0.087 ± 0.006
0.742CysLeu: 0.742 ± 0.017
0.11CysMet: 0.11 ± 0.006
0.117CysAsn: 0.117 ± 0.007
0.476CysPro: 0.476 ± 0.013
0.19CysGln: 0.19 ± 0.009
0.627CysArg: 0.627 ± 0.017
0.434CysSer: 0.434 ± 0.016
0.47CysThr: 0.47 ± 0.018
0.698CysVal: 0.698 ± 0.016
0.134CysTrp: 0.134 ± 0.008
0.167CysTyr: 0.167 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.129AspAla: 7.129 ± 0.06
0.384AspCys: 0.384 ± 0.015
3.524AspAsp: 3.524 ± 0.044
4.085AspGlu: 4.085 ± 0.042
1.486AspPhe: 1.486 ± 0.026
6.248AspGly: 6.248 ± 0.063
1.463AspHis: 1.463 ± 0.027
1.718AspIle: 1.718 ± 0.031
0.845AspLys: 0.845 ± 0.022
6.742AspLeu: 6.742 ± 0.058
0.72AspMet: 0.72 ± 0.017
1.065AspAsn: 1.065 ± 0.022
4.74AspPro: 4.74 ± 0.056
1.84AspGln: 1.84 ± 0.024
5.455AspArg: 5.455 ± 0.053
2.419AspSer: 2.419 ± 0.032
3.213AspThr: 3.213 ± 0.041
5.181AspVal: 5.181 ± 0.052
0.984AspTrp: 0.984 ± 0.021
1.232AspTyr: 1.232 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
6.637GluAla: 6.637 ± 0.068
0.366GluCys: 0.366 ± 0.012
2.94GluAsp: 2.94 ± 0.041
3.199GluGlu: 3.199 ± 0.046
1.687GluPhe: 1.687 ± 0.03
3.771GluGly: 3.771 ± 0.041
1.697GluHis: 1.697 ± 0.028
2.209GluIle: 2.209 ± 0.035
0.955GluLys: 0.955 ± 0.022
7.799GluLeu: 7.799 ± 0.07
0.824GluMet: 0.824 ± 0.021
1.044GluAsn: 1.044 ± 0.022
3.735GluPro: 3.735 ± 0.046
2.304GluGln: 2.304 ± 0.035
5.763GluArg: 5.763 ± 0.059
2.572GluSer: 2.572 ± 0.038
2.704GluThr: 2.704 ± 0.03
5.5GluVal: 5.5 ± 0.047
0.816GluTrp: 0.816 ± 0.019
1.072GluTyr: 1.072 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.891PheAla: 3.891 ± 0.038
0.249PheCys: 0.249 ± 0.011
2.162PheAsp: 2.162 ± 0.031
1.419PheGlu: 1.419 ± 0.023
0.798PhePhe: 0.798 ± 0.018
3.171PheGly: 3.171 ± 0.034
0.59PheHis: 0.59 ± 0.016
0.599PheIle: 0.599 ± 0.016
0.297PheLys: 0.297 ± 0.011
2.58PheLeu: 2.58 ± 0.037
0.344PheMet: 0.344 ± 0.013
0.546PheAsn: 0.546 ± 0.016
1.383PhePro: 1.383 ± 0.025
0.644PheGln: 0.644 ± 0.016
1.913PheArg: 1.913 ± 0.03
1.418PheSer: 1.418 ± 0.025
2.04PheThr: 2.04 ± 0.032
2.537PheVal: 2.537 ± 0.031
0.407PheTrp: 0.407 ± 0.013
0.583PheTyr: 0.583 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
10.482GlyAla: 10.482 ± 0.068
0.842GlyCys: 0.842 ± 0.02
5.141GlyAsp: 5.141 ± 0.047
5.575GlyGlu: 5.575 ± 0.047
2.853GlyPhe: 2.853 ± 0.033
8.615GlyGly: 8.615 ± 0.089
2.167GlyHis: 2.167 ± 0.031
3.114GlyIle: 3.114 ± 0.038
1.735GlyLys: 1.735 ± 0.032
9.335GlyLeu: 9.335 ± 0.075
2.094GlyMet: 2.094 ± 0.032
1.88GlyAsn: 1.88 ± 0.04
4.918GlyPro: 4.918 ± 0.051
2.708GlyGln: 2.708 ± 0.04
7.856GlyArg: 7.856 ± 0.068
5.057GlySer: 5.057 ± 0.059
6.135GlyThr: 6.135 ± 0.069
8.3GlyVal: 8.3 ± 0.072
1.755GlyTrp: 1.755 ± 0.028
2.263GlyTyr: 2.263 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.613HisAla: 2.613 ± 0.034
0.198HisCys: 0.198 ± 0.009
1.335HisAsp: 1.335 ± 0.022
1.227HisGlu: 1.227 ± 0.023
0.548HisPhe: 0.548 ± 0.016
2.23HisGly: 2.23 ± 0.036
0.659HisHis: 0.659 ± 0.017
0.507HisIle: 0.507 ± 0.016
0.245HisLys: 0.245 ± 0.011
2.452HisLeu: 2.452 ± 0.038
0.251HisMet: 0.251 ± 0.011
0.418HisAsn: 0.418 ± 0.015
1.717HisPro: 1.717 ± 0.029
0.653HisGln: 0.653 ± 0.018
2.116HisArg: 2.116 ± 0.033
0.925HisSer: 0.925 ± 0.025
1.206HisThr: 1.206 ± 0.023
1.886HisVal: 1.886 ± 0.031
0.354HisTrp: 0.354 ± 0.014
0.456HisTyr: 0.456 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.413IleAla: 4.413 ± 0.047
0.244IleCys: 0.244 ± 0.011
2.168IleAsp: 2.168 ± 0.034
1.905IleGlu: 1.905 ± 0.031
0.625IlePhe: 0.625 ± 0.017
3.258IleGly: 3.258 ± 0.045
0.515IleHis: 0.515 ± 0.015
0.813IleIle: 0.813 ± 0.02
0.49IleLys: 0.49 ± 0.015
2.199IleLeu: 2.199 ± 0.037
0.407IleMet: 0.407 ± 0.013
0.649IleAsn: 0.649 ± 0.018
1.612IlePro: 1.612 ± 0.026
0.651IleGln: 0.651 ± 0.016
2.164IleArg: 2.164 ± 0.033
1.616IleSer: 1.616 ± 0.027
2.096IleThr: 2.096 ± 0.038
2.663IleVal: 2.663 ± 0.038
0.356IleTrp: 0.356 ± 0.014
0.518IleTyr: 0.518 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
1.883LysAla: 1.883 ± 0.036
0.085LysCys: 0.085 ± 0.007
0.751LysAsp: 0.751 ± 0.02
0.738LysGlu: 0.738 ± 0.018
0.348LysPhe: 0.348 ± 0.012
1.057LysGly: 1.057 ± 0.026
0.316LysHis: 0.316 ± 0.01
0.672LysIle: 0.672 ± 0.02
0.367LysLys: 0.367 ± 0.016
1.572LysLeu: 1.572 ± 0.031
0.244LysMet: 0.244 ± 0.01
0.312LysAsn: 0.312 ± 0.012
0.991LysPro: 0.991 ± 0.023
0.478LysGln: 0.478 ± 0.014
1.127LysArg: 1.127 ± 0.024
0.766LysSer: 0.766 ± 0.02
0.881LysThr: 0.881 ± 0.02
1.447LysVal: 1.447 ± 0.027
0.206LysTrp: 0.206 ± 0.01
0.302LysTyr: 0.302 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
16.821LeuAla: 16.821 ± 0.139
0.809LeuCys: 0.809 ± 0.02
7.055LeuAsp: 7.055 ± 0.062
4.834LeuGlu: 4.834 ± 0.056
2.697LeuPhe: 2.697 ± 0.035
9.574LeuGly: 9.574 ± 0.076
2.203LeuHis: 2.203 ± 0.034
2.598LeuIle: 2.598 ± 0.045
1.121LeuLys: 1.121 ± 0.027
11.363LeuLeu: 11.363 ± 0.108
1.395LeuMet: 1.395 ± 0.026
1.656LeuAsn: 1.656 ± 0.029
6.438LeuPro: 6.438 ± 0.059
1.754LeuGln: 1.754 ± 0.029
9.401LeuArg: 9.401 ± 0.08
5.456LeuSer: 5.456 ± 0.05
6.831LeuThr: 6.831 ± 0.06
11.006LeuVal: 11.006 ± 0.086
1.298LeuTrp: 1.298 ± 0.025
1.694LeuTyr: 1.694 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.092MetAla: 2.092 ± 0.03
0.12MetCys: 0.12 ± 0.008
0.844MetAsp: 0.844 ± 0.018
0.572MetGlu: 0.572 ± 0.016
0.493MetPhe: 0.493 ± 0.016
1.16MetGly: 1.16 ± 0.025
0.336MetHis: 0.336 ± 0.013
0.641MetIle: 0.641 ± 0.017
0.261MetLys: 0.261 ± 0.011
1.772MetLeu: 1.772 ± 0.03
0.262MetMet: 0.262 ± 0.011
0.383MetAsn: 0.383 ± 0.013
1.06MetPro: 1.06 ± 0.027
0.331MetGln: 0.331 ± 0.012
1.565MetArg: 1.565 ± 0.028
1.275MetSer: 1.275 ± 0.022
1.438MetThr: 1.438 ± 0.023
1.44MetVal: 1.44 ± 0.025
0.198MetTrp: 0.198 ± 0.009
0.263MetTyr: 0.263 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.264AsnAla: 2.264 ± 0.027
0.17AsnCys: 0.17 ± 0.008
1.013AsnAsp: 1.013 ± 0.023
0.891AsnGlu: 0.891 ± 0.02
0.491AsnPhe: 0.491 ± 0.016
2.045AsnGly: 2.045 ± 0.038
0.404AsnHis: 0.404 ± 0.014
0.632AsnIle: 0.632 ± 0.016
0.295AsnLys: 0.295 ± 0.01
1.844AsnLeu: 1.844 ± 0.03
0.261AsnMet: 0.261 ± 0.011
0.484AsnAsn: 0.484 ± 0.019
1.485AsnPro: 1.485 ± 0.029
0.614AsnGln: 0.614 ± 0.018
1.479AsnArg: 1.479 ± 0.027
0.912AsnSer: 0.912 ± 0.021
1.178AsnThr: 1.178 ± 0.027
1.435AsnVal: 1.435 ± 0.029
0.288AsnTrp: 0.288 ± 0.012
0.445AsnTyr: 0.445 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
8.665ProAla: 8.665 ± 0.086
0.343ProCys: 0.343 ± 0.012
4.604ProAsp: 4.604 ± 0.051
4.164ProGlu: 4.164 ± 0.049
1.571ProPhe: 1.571 ± 0.025
6.375ProGly: 6.375 ± 0.065
1.221ProHis: 1.221 ± 0.025
1.414ProIle: 1.414 ± 0.023
0.865ProLys: 0.865 ± 0.018
5.104ProLeu: 5.104 ± 0.059
1.0ProMet: 1.0 ± 0.021
1.145ProAsn: 1.145 ± 0.027
4.104ProPro: 4.104 ± 0.069
1.32ProGln: 1.32 ± 0.025
4.143ProArg: 4.143 ± 0.044
3.111ProSer: 3.111 ± 0.04
3.684ProThr: 3.684 ± 0.046
5.803ProVal: 5.803 ± 0.059
0.914ProTrp: 0.914 ± 0.02
1.077ProTyr: 1.077 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.459GlnAla: 3.459 ± 0.047
0.169GlnCys: 0.169 ± 0.009
1.266GlnAsp: 1.266 ± 0.025
1.214GlnGlu: 1.214 ± 0.023
0.682GlnPhe: 0.682 ± 0.018
1.935GlnGly: 1.935 ± 0.033
0.604GlnHis: 0.604 ± 0.019
0.878GlnIle: 0.878 ± 0.021
0.392GlnLys: 0.392 ± 0.014
3.213GlnLeu: 3.213 ± 0.043
0.373GlnMet: 0.373 ± 0.011
0.517GlnAsn: 0.517 ± 0.017
1.725GlnPro: 1.725 ± 0.028
1.075GlnGln: 1.075 ± 0.026
2.519GlnArg: 2.519 ± 0.037
1.075GlnSer: 1.075 ± 0.021
1.271GlnThr: 1.271 ± 0.023
2.647GlnVal: 2.647 ± 0.036
0.427GlnTrp: 0.427 ± 0.014
0.519GlnTyr: 0.519 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
10.366ArgAla: 10.366 ± 0.085
0.681ArgCys: 0.681 ± 0.017
4.549ArgAsp: 4.549 ± 0.045
5.047ArgGlu: 5.047 ± 0.049
2.707ArgPhe: 2.707 ± 0.037
6.198ArgGly: 6.198 ± 0.051
2.1ArgHis: 2.1 ± 0.035
2.961ArgIle: 2.961 ± 0.035
1.227ArgLys: 1.227 ± 0.029
9.329ArgLeu: 9.329 ± 0.082
1.88ArgMet: 1.88 ± 0.028
1.443ArgAsn: 1.443 ± 0.026
5.088ArgPro: 5.088 ± 0.054
2.459ArgGln: 2.459 ± 0.039
8.492ArgArg: 8.492 ± 0.081
4.128ArgSer: 4.128 ± 0.043
5.174ArgThr: 5.174 ± 0.052
7.1ArgVal: 7.1 ± 0.055
1.604ArgTrp: 1.604 ± 0.03
1.955ArgTyr: 1.955 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.651SerAla: 6.651 ± 0.055
0.41SerCys: 0.41 ± 0.016
2.596SerAsp: 2.596 ± 0.035
2.295SerGlu: 2.295 ± 0.033
1.495SerPhe: 1.495 ± 0.026
5.691SerGly: 5.691 ± 0.057
0.916SerHis: 0.916 ± 0.021
1.511SerIle: 1.511 ± 0.029
0.704SerLys: 0.704 ± 0.021
4.586SerLeu: 4.586 ± 0.044
1.074SerMet: 1.074 ± 0.023
0.916SerAsn: 0.916 ± 0.021
3.107SerPro: 3.107 ± 0.04
1.144SerGln: 1.144 ± 0.024
3.787SerArg: 3.787 ± 0.037
2.867SerSer: 2.867 ± 0.046
3.452SerThr: 3.452 ± 0.049
4.514SerVal: 4.514 ± 0.048
1.007SerTrp: 1.007 ± 0.022
1.089SerTyr: 1.089 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
8.507ThrAla: 8.507 ± 0.086
0.467ThrCys: 0.467 ± 0.014
3.583ThrAsp: 3.583 ± 0.048
3.531ThrGlu: 3.531 ± 0.041
1.743ThrPhe: 1.743 ± 0.032
6.541ThrGly: 6.541 ± 0.07
1.145ThrHis: 1.145 ± 0.023
1.885ThrIle: 1.885 ± 0.035
0.91ThrLys: 0.91 ± 0.024
5.77ThrLeu: 5.77 ± 0.05
1.028ThrMet: 1.028 ± 0.022
1.175ThrAsn: 1.175 ± 0.028
3.971ThrPro: 3.971 ± 0.051
1.314ThrGln: 1.314 ± 0.026
4.263ThrArg: 4.263 ± 0.041
3.272ThrSer: 3.272 ± 0.045
4.17ThrThr: 4.17 ± 0.072
6.42ThrVal: 6.42 ± 0.091
0.961ThrTrp: 0.961 ± 0.022
1.251ThrTyr: 1.251 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
12.794ValAla: 12.794 ± 0.097
0.729ValCys: 0.729 ± 0.019
6.146ValAsp: 6.146 ± 0.059
5.522ValGlu: 5.522 ± 0.049
2.552ValPhe: 2.552 ± 0.037
7.659ValGly: 7.659 ± 0.065
2.078ValHis: 2.078 ± 0.029
2.662ValIle: 2.662 ± 0.042
1.19ValLys: 1.19 ± 0.025
11.163ValLeu: 11.163 ± 0.088
1.266ValMet: 1.266 ± 0.025
1.808ValAsn: 1.808 ± 0.034
5.658ValPro: 5.658 ± 0.064
1.962ValGln: 1.962 ± 0.029
7.945ValArg: 7.945 ± 0.063
4.745ValSer: 4.745 ± 0.048
5.964ValThr: 5.964 ± 0.072
9.941ValVal: 9.941 ± 0.085
1.138ValTrp: 1.138 ± 0.023
1.514ValTyr: 1.514 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.638TrpAla: 1.638 ± 0.029
0.156TrpCys: 0.156 ± 0.007
0.764TrpAsp: 0.764 ± 0.02
0.672TrpGlu: 0.672 ± 0.016
0.548TrpPhe: 0.548 ± 0.016
1.046TrpGly: 1.046 ± 0.026
0.377TrpHis: 0.377 ± 0.015
0.461TrpIle: 0.461 ± 0.014
0.219TrpLys: 0.219 ± 0.01
1.931TrpLeu: 1.931 ± 0.027
0.261TrpMet: 0.261 ± 0.011
0.367TrpAsn: 0.367 ± 0.014
0.898TrpPro: 0.898 ± 0.019
0.585TrpGln: 0.585 ± 0.017
1.546TrpArg: 1.546 ± 0.029
0.965TrpSer: 0.965 ± 0.022
1.099TrpThr: 1.099 ± 0.025
1.222TrpVal: 1.222 ± 0.023
0.369TrpTrp: 0.369 ± 0.013
0.314TrpTyr: 0.314 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.25TyrAla: 2.25 ± 0.032
0.179TyrCys: 0.179 ± 0.009
1.261TyrAsp: 1.261 ± 0.029
1.046TyrGlu: 1.046 ± 0.023
0.63TyrPhe: 0.63 ± 0.019
1.902TyrGly: 1.902 ± 0.032
0.445TyrHis: 0.445 ± 0.014
0.367TyrIle: 0.367 ± 0.013
0.234TyrLys: 0.234 ± 0.011
2.307TyrLeu: 2.307 ± 0.032
0.189TyrMet: 0.189 ± 0.008
0.387TyrAsn: 0.387 ± 0.013
1.114TyrPro: 1.114 ± 0.024
0.633TyrGln: 0.633 ± 0.017
2.001TyrArg: 2.001 ± 0.032
0.965TyrSer: 0.965 ± 0.023
1.105TyrThr: 1.105 ± 0.027
1.621TyrVal: 1.621 ± 0.029
0.355TyrTrp: 0.355 ± 0.012
0.482TyrTyr: 0.482 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7316 proteins (2454192 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski