Amino acid dipepetide frequency for Mycobacterium phage DreamTeam1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.786AlaAla: 12.786 ± 1.405
0.304AlaCys: 0.304 ± 0.136
5.114AlaAsp: 5.114 ± 0.534
7.367AlaGlu: 7.367 ± 1.017
3.653AlaPhe: 3.653 ± 0.493
8.037AlaGly: 8.037 ± 0.66
1.461AlaHis: 1.461 ± 0.274
4.932AlaIle: 4.932 ± 0.449
5.48AlaLys: 5.48 ± 0.533
9.377AlaLeu: 9.377 ± 0.777
2.923AlaMet: 2.923 ± 0.476
3.349AlaAsn: 3.349 ± 0.498
4.688AlaPro: 4.688 ± 0.828
4.445AlaGln: 4.445 ± 0.521
5.114AlaArg: 5.114 ± 0.664
5.602AlaSer: 5.602 ± 0.487
6.15AlaThr: 6.15 ± 0.682
7.428AlaVal: 7.428 ± 0.768
1.34AlaTrp: 1.34 ± 0.317
1.948AlaTyr: 1.948 ± 0.366
0.0AlaXaa: 0.0 ± 0.0
Cys
0.852CysAla: 0.852 ± 0.222
0.0CysCys: 0.0 ± 0.0
0.67CysAsp: 0.67 ± 0.199
0.548CysGlu: 0.548 ± 0.196
0.304CysPhe: 0.304 ± 0.139
0.67CysGly: 0.67 ± 0.197
0.183CysHis: 0.183 ± 0.107
0.487CysIle: 0.487 ± 0.178
0.304CysLys: 0.304 ± 0.133
0.426CysLeu: 0.426 ± 0.142
0.304CysMet: 0.304 ± 0.146
0.67CysAsn: 0.67 ± 0.179
0.487CysPro: 0.487 ± 0.189
0.244CysGln: 0.244 ± 0.122
0.426CysArg: 0.426 ± 0.153
0.67CysSer: 0.67 ± 0.211
0.487CysThr: 0.487 ± 0.17
0.609CysVal: 0.609 ± 0.205
0.304CysTrp: 0.304 ± 0.156
0.244CysTyr: 0.244 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
5.602AspAla: 5.602 ± 0.662
0.852AspCys: 0.852 ± 0.251
3.349AspAsp: 3.349 ± 0.429
4.384AspGlu: 4.384 ± 0.596
1.887AspPhe: 1.887 ± 0.397
5.906AspGly: 5.906 ± 0.578
1.583AspHis: 1.583 ± 0.372
3.653AspIle: 3.653 ± 0.476
2.131AspLys: 2.131 ± 0.428
6.454AspLeu: 6.454 ± 0.666
1.522AspMet: 1.522 ± 0.302
2.07AspAsn: 2.07 ± 0.375
4.384AspPro: 4.384 ± 0.586
1.887AspGln: 1.887 ± 0.304
3.41AspArg: 3.41 ± 0.591
3.105AspSer: 3.105 ± 0.378
3.41AspThr: 3.41 ± 0.491
4.14AspVal: 4.14 ± 0.504
1.157AspTrp: 1.157 ± 0.24
2.435AspTyr: 2.435 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
6.698GluAla: 6.698 ± 0.766
0.244GluCys: 0.244 ± 0.147
4.323GluAsp: 4.323 ± 0.591
4.445GluGlu: 4.445 ± 0.656
2.923GluPhe: 2.923 ± 0.414
5.723GluGly: 5.723 ± 0.596
1.157GluHis: 1.157 ± 0.287
3.471GluIle: 3.471 ± 0.493
2.496GluLys: 2.496 ± 0.375
5.784GluLeu: 5.784 ± 0.642
1.705GluMet: 1.705 ± 0.251
1.705GluAsn: 1.705 ± 0.373
3.166GluPro: 3.166 ± 0.425
1.887GluGln: 1.887 ± 0.293
4.749GluArg: 4.749 ± 0.62
3.044GluSer: 3.044 ± 0.408
3.227GluThr: 3.227 ± 0.439
4.81GluVal: 4.81 ± 0.494
1.4GluTrp: 1.4 ± 0.271
1.522GluTyr: 1.522 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
3.471PheAla: 3.471 ± 0.501
0.304PheCys: 0.304 ± 0.13
2.679PheAsp: 2.679 ± 0.461
2.983PheGlu: 2.983 ± 0.42
0.792PhePhe: 0.792 ± 0.218
3.349PheGly: 3.349 ± 0.426
0.609PheHis: 0.609 ± 0.229
1.644PheIle: 1.644 ± 0.32
1.218PheLys: 1.218 ± 0.312
2.314PheLeu: 2.314 ± 0.398
0.426PheMet: 0.426 ± 0.171
1.948PheAsn: 1.948 ± 0.331
1.461PhePro: 1.461 ± 0.252
1.157PheGln: 1.157 ± 0.294
2.009PheArg: 2.009 ± 0.341
2.192PheSer: 2.192 ± 0.345
2.74PheThr: 2.74 ± 0.462
1.948PheVal: 1.948 ± 0.348
0.609PheTrp: 0.609 ± 0.203
0.792PheTyr: 0.792 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
7.489GlyAla: 7.489 ± 0.87
0.913GlyCys: 0.913 ± 0.265
5.906GlyAsp: 5.906 ± 0.741
4.932GlyGlu: 4.932 ± 0.608
3.288GlyPhe: 3.288 ± 0.378
9.377GlyGly: 9.377 ± 1.372
1.948GlyHis: 1.948 ± 0.375
4.506GlyIle: 4.506 ± 0.559
5.054GlyLys: 5.054 ± 0.706
6.88GlyLeu: 6.88 ± 0.855
2.009GlyMet: 2.009 ± 0.334
3.531GlyAsn: 3.531 ± 0.477
3.471GlyPro: 3.471 ± 0.499
2.983GlyGln: 2.983 ± 0.502
3.836GlyArg: 3.836 ± 0.391
4.81GlySer: 4.81 ± 0.75
5.236GlyThr: 5.236 ± 0.624
5.784GlyVal: 5.784 ± 0.665
1.887GlyTrp: 1.887 ± 0.328
2.253GlyTyr: 2.253 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
1.157HisAla: 1.157 ± 0.244
0.122HisCys: 0.122 ± 0.078
1.522HisAsp: 1.522 ± 0.36
0.913HisGlu: 0.913 ± 0.261
0.67HisPhe: 0.67 ± 0.174
1.705HisGly: 1.705 ± 0.376
0.852HisHis: 0.852 ± 0.33
0.792HisIle: 0.792 ± 0.221
0.792HisLys: 0.792 ± 0.261
1.218HisLeu: 1.218 ± 0.279
0.487HisMet: 0.487 ± 0.208
0.609HisAsn: 0.609 ± 0.191
1.522HisPro: 1.522 ± 0.291
0.792HisGln: 0.792 ± 0.208
1.766HisArg: 1.766 ± 0.343
1.157HisSer: 1.157 ± 0.285
0.974HisThr: 0.974 ± 0.227
1.035HisVal: 1.035 ± 0.295
0.244HisTrp: 0.244 ± 0.128
0.609HisTyr: 0.609 ± 0.24
0.0HisXaa: 0.0 ± 0.0
Ile
4.384IleAla: 4.384 ± 0.502
0.548IleCys: 0.548 ± 0.184
3.836IleAsp: 3.836 ± 0.43
4.201IleGlu: 4.201 ± 0.518
1.705IlePhe: 1.705 ± 0.356
3.41IleGly: 3.41 ± 0.443
0.731IleHis: 0.731 ± 0.194
1.34IleIle: 1.34 ± 0.353
2.496IleLys: 2.496 ± 0.396
4.14IleLeu: 4.14 ± 0.434
0.609IleMet: 0.609 ± 0.167
2.375IleAsn: 2.375 ± 0.363
3.775IlePro: 3.775 ± 0.431
1.4IleGln: 1.4 ± 0.292
3.836IleArg: 3.836 ± 0.547
3.227IleSer: 3.227 ± 0.44
3.044IleThr: 3.044 ± 0.365
3.592IleVal: 3.592 ± 0.536
0.792IleTrp: 0.792 ± 0.228
0.852IleTyr: 0.852 ± 0.256
0.0IleXaa: 0.0 ± 0.0
Lys
4.932LysAla: 4.932 ± 0.531
0.365LysCys: 0.365 ± 0.137
2.557LysAsp: 2.557 ± 0.345
2.862LysGlu: 2.862 ± 0.472
1.279LysPhe: 1.279 ± 0.263
3.349LysGly: 3.349 ± 0.514
0.426LysHis: 0.426 ± 0.164
2.192LysIle: 2.192 ± 0.47
2.618LysLys: 2.618 ± 0.457
4.14LysLeu: 4.14 ± 0.516
1.279LysMet: 1.279 ± 0.318
1.279LysAsn: 1.279 ± 0.246
2.983LysPro: 2.983 ± 0.415
1.948LysGln: 1.948 ± 0.401
3.349LysArg: 3.349 ± 0.521
1.948LysSer: 1.948 ± 0.339
2.862LysThr: 2.862 ± 0.377
3.958LysVal: 3.958 ± 0.525
1.096LysTrp: 1.096 ± 0.265
1.34LysTyr: 1.34 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
9.559LeuAla: 9.559 ± 0.77
0.852LeuCys: 0.852 ± 0.213
4.201LeuAsp: 4.201 ± 0.525
5.419LeuGlu: 5.419 ± 0.515
2.74LeuPhe: 2.74 ± 0.364
6.819LeuGly: 6.819 ± 1.041
1.461LeuHis: 1.461 ± 0.288
4.627LeuIle: 4.627 ± 0.526
3.897LeuLys: 3.897 ± 0.524
5.906LeuLeu: 5.906 ± 0.637
2.07LeuMet: 2.07 ± 0.289
3.349LeuAsn: 3.349 ± 0.492
4.688LeuPro: 4.688 ± 0.513
2.192LeuGln: 2.192 ± 0.428
5.297LeuArg: 5.297 ± 0.549
5.175LeuSer: 5.175 ± 0.579
5.723LeuThr: 5.723 ± 0.63
5.054LeuVal: 5.054 ± 0.535
1.644LeuTrp: 1.644 ± 0.295
1.583LeuTyr: 1.583 ± 0.372
0.0LeuXaa: 0.0 ± 0.0
Met
2.74MetAla: 2.74 ± 0.36
0.183MetCys: 0.183 ± 0.111
0.974MetAsp: 0.974 ± 0.235
1.522MetGlu: 1.522 ± 0.307
0.609MetPhe: 0.609 ± 0.192
1.948MetGly: 1.948 ± 0.376
0.365MetHis: 0.365 ± 0.175
1.583MetIle: 1.583 ± 0.401
1.34MetLys: 1.34 ± 0.224
1.34MetLeu: 1.34 ± 0.272
0.365MetMet: 0.365 ± 0.172
0.426MetAsn: 0.426 ± 0.146
0.974MetPro: 0.974 ± 0.247
0.852MetGln: 0.852 ± 0.204
1.644MetArg: 1.644 ± 0.357
2.618MetSer: 2.618 ± 0.322
2.07MetThr: 2.07 ± 0.351
0.974MetVal: 0.974 ± 0.226
0.548MetTrp: 0.548 ± 0.171
0.609MetTyr: 0.609 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
4.566AsnAla: 4.566 ± 0.673
0.365AsnCys: 0.365 ± 0.124
1.827AsnAsp: 1.827 ± 0.347
1.827AsnGlu: 1.827 ± 0.36
1.157AsnPhe: 1.157 ± 0.319
3.105AsnGly: 3.105 ± 0.478
0.852AsnHis: 0.852 ± 0.201
1.218AsnIle: 1.218 ± 0.274
1.157AsnLys: 1.157 ± 0.2
3.349AsnLeu: 3.349 ± 0.528
0.852AsnMet: 0.852 ± 0.229
0.913AsnAsn: 0.913 ± 0.215
2.862AsnPro: 2.862 ± 0.447
0.852AsnGln: 0.852 ± 0.247
2.253AsnArg: 2.253 ± 0.415
2.131AsnSer: 2.131 ± 0.273
2.009AsnThr: 2.009 ± 0.329
2.983AsnVal: 2.983 ± 0.421
1.035AsnTrp: 1.035 ± 0.257
1.035AsnTyr: 1.035 ± 0.223
0.0AsnXaa: 0.0 ± 0.0
Pro
5.662ProAla: 5.662 ± 0.779
0.304ProCys: 0.304 ± 0.165
3.836ProAsp: 3.836 ± 0.504
4.079ProGlu: 4.079 ± 0.518
2.009ProPhe: 2.009 ± 0.351
4.993ProGly: 4.993 ± 0.754
0.974ProHis: 0.974 ± 0.241
3.227ProIle: 3.227 ± 0.426
2.862ProLys: 2.862 ± 0.44
3.775ProLeu: 3.775 ± 0.494
0.792ProMet: 0.792 ± 0.209
2.375ProAsn: 2.375 ± 0.472
2.07ProPro: 2.07 ± 0.467
1.583ProGln: 1.583 ± 0.276
2.679ProArg: 2.679 ± 0.459
2.557ProSer: 2.557 ± 0.384
3.227ProThr: 3.227 ± 0.425
4.262ProVal: 4.262 ± 0.473
0.792ProTrp: 0.792 ± 0.234
1.279ProTyr: 1.279 ± 0.22
0.0ProXaa: 0.0 ± 0.0
Gln
4.871GlnAla: 4.871 ± 0.656
0.183GlnCys: 0.183 ± 0.107
1.887GlnAsp: 1.887 ± 0.321
1.218GlnGlu: 1.218 ± 0.245
1.279GlnPhe: 1.279 ± 0.262
2.557GlnGly: 2.557 ± 0.369
0.852GlnHis: 0.852 ± 0.201
2.07GlnIle: 2.07 ± 0.279
1.157GlnLys: 1.157 ± 0.293
2.923GlnLeu: 2.923 ± 0.562
0.852GlnMet: 0.852 ± 0.264
1.035GlnAsn: 1.035 ± 0.268
1.096GlnPro: 1.096 ± 0.263
1.887GlnGln: 1.887 ± 0.365
2.618GlnArg: 2.618 ± 0.385
1.766GlnSer: 1.766 ± 0.304
1.644GlnThr: 1.644 ± 0.339
2.74GlnVal: 2.74 ± 0.395
0.852GlnTrp: 0.852 ± 0.189
1.279GlnTyr: 1.279 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
5.236ArgAla: 5.236 ± 0.676
0.67ArgCys: 0.67 ± 0.236
4.323ArgAsp: 4.323 ± 0.55
4.201ArgGlu: 4.201 ± 0.413
2.618ArgPhe: 2.618 ± 0.412
4.079ArgGly: 4.079 ± 0.535
1.157ArgHis: 1.157 ± 0.265
3.775ArgIle: 3.775 ± 0.595
2.618ArgLys: 2.618 ± 0.375
4.993ArgLeu: 4.993 ± 0.654
1.827ArgMet: 1.827 ± 0.362
2.375ArgAsn: 2.375 ± 0.376
2.983ArgPro: 2.983 ± 0.368
2.192ArgGln: 2.192 ± 0.318
4.384ArgArg: 4.384 ± 0.656
2.253ArgSer: 2.253 ± 0.342
3.105ArgThr: 3.105 ± 0.407
4.566ArgVal: 4.566 ± 0.546
1.766ArgTrp: 1.766 ± 0.284
2.192ArgTyr: 2.192 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
5.054SerAla: 5.054 ± 0.524
0.426SerCys: 0.426 ± 0.171
3.531SerAsp: 3.531 ± 0.445
2.801SerGlu: 2.801 ± 0.394
2.375SerPhe: 2.375 ± 0.47
5.541SerGly: 5.541 ± 0.76
0.731SerHis: 0.731 ± 0.227
2.679SerIle: 2.679 ± 0.458
2.983SerLys: 2.983 ± 0.448
4.14SerLeu: 4.14 ± 0.622
1.644SerMet: 1.644 ± 0.267
1.4SerAsn: 1.4 ± 0.33
2.801SerPro: 2.801 ± 0.361
1.827SerGln: 1.827 ± 0.33
3.897SerArg: 3.897 ± 0.443
2.74SerSer: 2.74 ± 0.47
3.044SerThr: 3.044 ± 0.395
3.592SerVal: 3.592 ± 0.459
1.218SerTrp: 1.218 ± 0.277
1.887SerTyr: 1.887 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
6.15ThrAla: 6.15 ± 0.66
0.792ThrCys: 0.792 ± 0.262
4.14ThrAsp: 4.14 ± 0.59
3.349ThrGlu: 3.349 ± 0.444
1.766ThrPhe: 1.766 ± 0.332
5.967ThrGly: 5.967 ± 0.635
1.218ThrHis: 1.218 ± 0.271
2.435ThrIle: 2.435 ± 0.435
2.74ThrLys: 2.74 ± 0.401
5.419ThrLeu: 5.419 ± 0.551
1.157ThrMet: 1.157 ± 0.265
2.314ThrAsn: 2.314 ± 0.385
4.14ThrPro: 4.14 ± 0.547
1.948ThrGln: 1.948 ± 0.311
3.105ThrArg: 3.105 ± 0.417
3.044ThrSer: 3.044 ± 0.517
3.105ThrThr: 3.105 ± 0.427
4.323ThrVal: 4.323 ± 0.491
0.852ThrTrp: 0.852 ± 0.2
2.557ThrTyr: 2.557 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
6.21ValAla: 6.21 ± 0.531
0.731ValCys: 0.731 ± 0.203
5.236ValAsp: 5.236 ± 0.527
4.201ValGlu: 4.201 ± 0.497
2.314ValPhe: 2.314 ± 0.433
5.662ValGly: 5.662 ± 0.504
1.583ValHis: 1.583 ± 0.353
3.653ValIle: 3.653 ± 0.491
3.653ValLys: 3.653 ± 0.419
5.48ValLeu: 5.48 ± 0.629
1.461ValMet: 1.461 ± 0.312
2.679ValAsn: 2.679 ± 0.44
3.653ValPro: 3.653 ± 0.487
2.314ValGln: 2.314 ± 0.387
4.079ValArg: 4.079 ± 0.433
3.897ValSer: 3.897 ± 0.467
5.175ValThr: 5.175 ± 0.562
5.114ValVal: 5.114 ± 0.466
1.705ValTrp: 1.705 ± 0.303
2.009ValTyr: 2.009 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
1.583TrpAla: 1.583 ± 0.355
0.487TrpCys: 0.487 ± 0.164
1.218TrpAsp: 1.218 ± 0.263
1.218TrpGlu: 1.218 ± 0.28
0.487TrpPhe: 0.487 ± 0.157
1.461TrpGly: 1.461 ± 0.39
0.548TrpHis: 0.548 ± 0.219
0.913TrpIle: 0.913 ± 0.181
0.913TrpLys: 0.913 ± 0.212
1.522TrpLeu: 1.522 ± 0.26
0.792TrpMet: 0.792 ± 0.219
0.852TrpAsn: 0.852 ± 0.235
0.913TrpPro: 0.913 ± 0.228
1.279TrpGln: 1.279 ± 0.267
1.157TrpArg: 1.157 ± 0.236
0.913TrpSer: 0.913 ± 0.21
1.522TrpThr: 1.522 ± 0.286
1.461TrpVal: 1.461 ± 0.283
0.365TrpTrp: 0.365 ± 0.15
0.365TrpTyr: 0.365 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.496TyrAla: 2.496 ± 0.425
0.244TyrCys: 0.244 ± 0.12
2.192TyrAsp: 2.192 ± 0.389
2.009TyrGlu: 2.009 ± 0.405
0.792TyrPhe: 0.792 ± 0.159
2.435TyrGly: 2.435 ± 0.335
0.244TyrHis: 0.244 ± 0.115
1.096TyrIle: 1.096 ± 0.243
0.852TyrLys: 0.852 ± 0.24
2.679TyrLeu: 2.679 ± 0.411
0.548TyrMet: 0.548 ± 0.213
1.096TyrAsn: 1.096 ± 0.211
1.218TyrPro: 1.218 ± 0.275
1.096TyrGln: 1.096 ± 0.235
1.705TyrArg: 1.705 ± 0.363
1.522TyrSer: 1.522 ± 0.254
1.766TyrThr: 1.766 ± 0.376
2.435TyrVal: 2.435 ± 0.379
0.365TyrTrp: 0.365 ± 0.131
0.974TyrTyr: 0.974 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 93 proteins (16425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski