Amino acid dipepetide frequency for Dante Muikkunen virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.659AlaAla: 1.659 ± 0.663
0.0AlaCys: 0.0 ± 0.0
0.664AlaAsp: 0.664 ± 0.36
2.323AlaGlu: 2.323 ± 0.542
1.659AlaPhe: 1.659 ± 0.506
2.987AlaGly: 2.987 ± 0.719
1.328AlaHis: 1.328 ± 0.45
3.319AlaIle: 3.319 ± 1.367
3.983AlaLys: 3.983 ± 2.157
6.306AlaLeu: 6.306 ± 1.346
0.0AlaMet: 0.0 ± 0.0
1.659AlaAsn: 1.659 ± 0.558
0.664AlaPro: 0.664 ± 0.36
1.328AlaGln: 1.328 ± 0.386
1.328AlaArg: 1.328 ± 0.386
2.987AlaSer: 2.987 ± 1.371
2.323AlaThr: 2.323 ± 0.816
1.328AlaVal: 1.328 ± 0.853
0.332AlaTrp: 0.332 ± 0.18
1.328AlaTyr: 1.328 ± 0.45
0.0AlaXaa: 0.0 ± 0.0
Cys
1.659CysAla: 1.659 ± 0.663
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.991CysGlu: 1.991 ± 0.653
1.328CysPhe: 1.328 ± 0.386
0.332CysGly: 0.332 ± 0.516
0.664CysHis: 0.664 ± 0.359
1.991CysIle: 1.991 ± 0.696
1.659CysLys: 1.659 ± 0.683
2.323CysLeu: 2.323 ± 0.249
0.332CysMet: 0.332 ± 0.18
1.991CysAsn: 1.991 ± 0.975
0.996CysPro: 0.996 ± 0.928
0.996CysGln: 0.996 ± 0.928
0.664CysArg: 0.664 ± 0.425
2.987CysSer: 2.987 ± 1.57
0.332CysThr: 0.332 ± 0.516
0.664CysVal: 0.664 ± 0.36
0.332CysTrp: 0.332 ± 0.18
1.328CysTyr: 1.328 ± 0.721
0.0CysXaa: 0.0 ± 0.0
Asp
1.991AspAla: 1.991 ± 0.52
0.664AspCys: 0.664 ± 0.359
1.659AspAsp: 1.659 ± 0.901
3.983AspGlu: 3.983 ± 1.306
2.323AspPhe: 2.323 ± 0.249
1.328AspGly: 1.328 ± 0.386
0.996AspHis: 0.996 ± 0.54
3.983AspIle: 3.983 ± 0.59
1.991AspLys: 1.991 ± 0.655
6.97AspLeu: 6.97 ± 0.874
1.328AspMet: 1.328 ± 0.438
2.987AspAsn: 2.987 ± 0.267
2.655AspPro: 2.655 ± 1.441
1.991AspGln: 1.991 ± 0.52
1.991AspArg: 1.991 ± 0.653
2.987AspSer: 2.987 ± 1.462
2.323AspThr: 2.323 ± 0.542
3.319AspVal: 3.319 ± 1.325
0.664AspTrp: 0.664 ± 0.359
2.655AspTyr: 2.655 ± 0.27
0.0AspXaa: 0.0 ± 0.0
Glu
3.651GluAla: 3.651 ± 1.072
1.328GluCys: 1.328 ± 0.849
3.651GluAsp: 3.651 ± 1.303
5.974GluGlu: 5.974 ± 0.708
3.983GluPhe: 3.983 ± 0.786
2.323GluGly: 2.323 ± 1.015
0.664GluHis: 0.664 ± 0.36
5.974GluIle: 5.974 ± 1.726
8.297GluLys: 8.297 ± 1.112
9.293GluLeu: 9.293 ± 2.214
2.655GluMet: 2.655 ± 0.27
3.319GluAsn: 3.319 ± 1.801
1.991GluPro: 1.991 ± 0.655
4.315GluGln: 4.315 ± 1.468
2.323GluArg: 2.323 ± 0.816
4.978GluSer: 4.978 ± 2.05
4.315GluThr: 4.315 ± 0.582
2.987GluVal: 2.987 ± 0.882
0.996GluTrp: 0.996 ± 0.399
2.323GluTyr: 2.323 ± 0.85
0.0GluXaa: 0.0 ± 0.0
Phe
0.996PheAla: 0.996 ± 0.54
0.996PheCys: 0.996 ± 1.027
2.987PheAsp: 2.987 ± 0.267
2.655PheGlu: 2.655 ± 0.425
1.991PhePhe: 1.991 ± 1.294
2.987PheGly: 2.987 ± 1.155
0.332PheHis: 0.332 ± 0.465
1.991PheIle: 1.991 ± 0.655
4.647PheLys: 4.647 ± 0.185
4.978PheLeu: 4.978 ± 2.64
0.996PheMet: 0.996 ± 0.327
5.31PheAsn: 5.31 ± 1.43
1.991PhePro: 1.991 ± 0.655
2.655PheGln: 2.655 ± 0.425
0.996PheArg: 0.996 ± 0.487
3.983PheSer: 3.983 ± 0.186
2.655PheThr: 2.655 ± 0.772
3.319PheVal: 3.319 ± 0.778
0.664PheTrp: 0.664 ± 0.425
2.323PheTyr: 2.323 ± 1.261
0.0PheXaa: 0.0 ± 0.0
Gly
0.996GlyAla: 0.996 ± 0.487
0.996GlyCys: 0.996 ± 0.487
1.328GlyAsp: 1.328 ± 0.386
1.328GlyGlu: 1.328 ± 0.849
4.647GlyPhe: 4.647 ± 0.185
3.319GlyGly: 3.319 ± 1.367
0.664GlyHis: 0.664 ± 0.359
1.991GlyIle: 1.991 ± 0.655
3.319GlyLys: 3.319 ± 0.629
4.647GlyLeu: 4.647 ± 1.064
0.996GlyMet: 0.996 ± 0.591
2.987GlyAsn: 2.987 ± 0.964
1.991GlyPro: 1.991 ± 0.696
0.996GlyGln: 0.996 ± 0.54
1.659GlyArg: 1.659 ± 0.142
1.991GlySer: 1.991 ± 0.651
1.991GlyThr: 1.991 ± 1.078
1.659GlyVal: 1.659 ± 0.663
1.328GlyTrp: 1.328 ± 0.31
0.664GlyTyr: 0.664 ± 0.666
0.0GlyXaa: 0.0 ± 0.0
His
0.332HisAla: 0.332 ± 0.18
0.332HisCys: 0.332 ± 0.465
0.996HisAsp: 0.996 ± 0.487
0.332HisGlu: 0.332 ± 0.465
1.328HisPhe: 1.328 ± 0.386
2.323HisGly: 2.323 ± 1.879
0.664HisHis: 0.664 ± 0.425
0.332HisIle: 0.332 ± 0.516
0.996HisLys: 0.996 ± 0.399
3.651HisLeu: 3.651 ± 0.65
0.996HisMet: 0.996 ± 1.382
2.323HisAsn: 2.323 ± 1.402
0.664HisPro: 0.664 ± 0.36
0.332HisGln: 0.332 ± 0.18
0.332HisArg: 0.332 ± 0.516
1.991HisSer: 1.991 ± 0.653
1.659HisThr: 1.659 ± 0.142
1.328HisVal: 1.328 ± 0.45
0.0HisTrp: 0.0 ± 0.0
2.323HisTyr: 2.323 ± 1.402
0.0HisXaa: 0.0 ± 0.0
Ile
1.991IleAla: 1.991 ± 0.093
0.996IleCys: 0.996 ± 0.54
1.659IleAsp: 1.659 ± 1.348
7.634IleGlu: 7.634 ± 1.459
2.323IlePhe: 2.323 ± 0.977
0.664IleGly: 0.664 ± 0.425
1.328IleHis: 1.328 ± 0.31
4.647IleIle: 4.647 ± 0.992
7.634IleLys: 7.634 ± 1.629
7.302IleLeu: 7.302 ± 2.108
1.328IleMet: 1.328 ± 0.45
4.647IleAsn: 4.647 ± 0.747
1.659IlePro: 1.659 ± 0.901
2.323IleGln: 2.323 ± 0.373
4.978IleArg: 4.978 ± 0.562
4.978IleSer: 4.978 ± 0.425
2.987IleThr: 2.987 ± 1.304
3.983IleVal: 3.983 ± 0.876
0.996IleTrp: 0.996 ± 0.54
1.659IleTyr: 1.659 ± 0.901
0.0IleXaa: 0.0 ± 0.0
Lys
3.983LysAla: 3.983 ± 1.35
2.323LysCys: 2.323 ± 1.222
6.306LysAsp: 6.306 ± 1.339
5.642LysGlu: 5.642 ± 1.167
4.315LysPhe: 4.315 ± 0.649
1.659LysGly: 1.659 ± 0.804
3.983LysHis: 3.983 ± 1.543
4.315LysIle: 4.315 ± 1.264
7.965LysLys: 7.965 ± 1.113
13.276LysLeu: 13.276 ± 1.447
1.328LysMet: 1.328 ± 0.721
7.634LysAsn: 7.634 ± 1.097
1.991LysPro: 1.991 ± 0.653
4.315LysGln: 4.315 ± 1.642
3.983LysArg: 3.983 ± 0.669
5.974LysSer: 5.974 ± 1.482
5.642LysThr: 5.642 ± 1.701
1.991LysVal: 1.991 ± 0.975
1.328LysTrp: 1.328 ± 0.45
2.987LysTyr: 2.987 ± 0.719
0.0LysXaa: 0.0 ± 0.0
Leu
1.991LeuAla: 1.991 ± 0.655
4.978LeuCys: 4.978 ± 1.09
6.306LeuAsp: 6.306 ± 0.617
6.638LeuGlu: 6.638 ± 1.18
4.315LeuPhe: 4.315 ± 0.845
1.991LeuGly: 1.991 ± 0.696
2.655LeuHis: 2.655 ± 1.438
9.625LeuIle: 9.625 ± 2.931
12.944LeuLys: 12.944 ± 2.834
9.293LeuLeu: 9.293 ± 1.393
2.323LeuMet: 2.323 ± 0.249
6.97LeuAsn: 6.97 ± 0.748
3.319LeuPro: 3.319 ± 0.629
3.651LeuGln: 3.651 ± 1.074
6.97LeuArg: 6.97 ± 0.23
9.293LeuSer: 9.293 ± 1.468
8.961LeuThr: 8.961 ± 2.361
5.31LeuVal: 5.31 ± 1.672
1.328LeuTrp: 1.328 ± 0.31
1.328LeuTyr: 1.328 ± 0.721
0.0LeuXaa: 0.0 ± 0.0
Met
0.664MetAla: 0.664 ± 0.359
1.328MetCys: 1.328 ± 0.31
0.664MetAsp: 0.664 ± 0.36
2.323MetGlu: 2.323 ± 1.261
0.664MetPhe: 0.664 ± 0.36
1.328MetGly: 1.328 ± 0.849
0.664MetHis: 0.664 ± 0.666
0.664MetIle: 0.664 ± 0.931
0.664MetLys: 0.664 ± 0.425
0.996MetLeu: 0.996 ± 0.327
0.664MetMet: 0.664 ± 0.36
2.987MetAsn: 2.987 ± 0.603
0.664MetPro: 0.664 ± 0.425
0.664MetGln: 0.664 ± 0.36
1.659MetArg: 1.659 ± 0.142
2.987MetSer: 2.987 ± 0.267
2.655MetThr: 2.655 ± 0.27
0.0MetVal: 0.0 ± 0.0
0.332MetTrp: 0.332 ± 0.18
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.323AsnAla: 2.323 ± 1.261
3.319AsnCys: 3.319 ± 1.47
3.651AsnAsp: 3.651 ± 0.65
6.97AsnGlu: 6.97 ± 0.874
2.323AsnPhe: 2.323 ± 0.692
1.328AsnGly: 1.328 ± 0.853
1.328AsnHis: 1.328 ± 1.58
5.31AsnIle: 5.31 ± 0.706
7.302AsnLys: 7.302 ± 0.922
8.961AsnLeu: 8.961 ± 1.663
1.991AsnMet: 1.991 ± 1.081
3.651AsnAsn: 3.651 ± 0.869
1.328AsnPro: 1.328 ± 0.721
3.319AsnGln: 3.319 ± 0.9
1.991AsnArg: 1.991 ± 1.078
5.31AsnSer: 5.31 ± 0.633
1.991AsnThr: 1.991 ± 0.653
0.996AsnVal: 0.996 ± 0.327
0.664AsnTrp: 0.664 ± 0.36
2.655AsnTyr: 2.655 ± 0.479
0.0AsnXaa: 0.0 ± 0.0
Pro
0.332ProAla: 0.332 ± 0.18
0.0ProCys: 0.0 ± 0.0
2.987ProAsp: 2.987 ± 0.98
0.664ProGlu: 0.664 ± 0.36
1.659ProPhe: 1.659 ± 0.683
1.659ProGly: 1.659 ± 0.901
1.659ProHis: 1.659 ± 0.142
3.983ProIle: 3.983 ± 1.699
0.996ProLys: 0.996 ± 1.027
1.991ProLeu: 1.991 ± 0.696
0.996ProMet: 0.996 ± 0.399
1.659ProAsn: 1.659 ± 0.142
0.664ProPro: 0.664 ± 0.359
0.664ProGln: 0.664 ± 0.36
0.664ProArg: 0.664 ± 0.36
2.323ProSer: 2.323 ± 0.816
1.991ProThr: 1.991 ± 0.696
2.323ProVal: 2.323 ± 0.977
0.0ProTrp: 0.0 ± 0.0
1.991ProTyr: 1.991 ± 0.696
0.0ProXaa: 0.0 ± 0.0
Gln
2.323GlnAla: 2.323 ± 0.977
0.664GlnCys: 0.664 ± 0.36
0.996GlnAsp: 0.996 ± 0.54
3.983GlnGlu: 3.983 ± 1.309
0.996GlnPhe: 0.996 ± 0.327
1.659GlnGly: 1.659 ± 0.506
0.996GlnHis: 0.996 ± 0.487
1.991GlnIle: 1.991 ± 0.696
2.987GlnLys: 2.987 ± 0.998
4.647GlnLeu: 4.647 ± 0.905
1.328GlnMet: 1.328 ± 0.721
3.983GlnAsn: 3.983 ± 0.786
0.332GlnPro: 0.332 ± 0.18
1.991GlnGln: 1.991 ± 0.093
1.659GlnArg: 1.659 ± 0.506
5.31GlnSer: 5.31 ± 2.843
2.655GlnThr: 2.655 ± 1.055
2.987GlnVal: 2.987 ± 0.719
0.0GlnTrp: 0.0 ± 0.0
1.328GlnTyr: 1.328 ± 0.721
0.0GlnXaa: 0.0 ± 0.0
Arg
2.655ArgAla: 2.655 ± 0.839
0.332ArgCys: 0.332 ± 0.465
2.655ArgAsp: 2.655 ± 0.27
3.319ArgGlu: 3.319 ± 0.629
0.664ArgPhe: 0.664 ± 0.359
2.987ArgGly: 2.987 ± 0.603
0.664ArgHis: 0.664 ± 0.425
1.328ArgIle: 1.328 ± 0.721
3.319ArgLys: 3.319 ± 1.329
4.647ArgLeu: 4.647 ± 2.522
1.659ArgMet: 1.659 ± 1.285
3.319ArgAsn: 3.319 ± 0.283
0.0ArgPro: 0.0 ± 0.0
2.655ArgGln: 2.655 ± 0.9
0.996ArgArg: 0.996 ± 1.396
1.659ArgSer: 1.659 ± 0.142
1.991ArgThr: 1.991 ± 0.975
2.655ArgVal: 2.655 ± 0.479
0.996ArgTrp: 0.996 ± 0.928
0.996ArgTyr: 0.996 ± 0.54
0.0ArgXaa: 0.0 ± 0.0
Ser
2.323SerAla: 2.323 ± 1.584
1.991SerCys: 1.991 ± 0.093
2.655SerAsp: 2.655 ± 0.27
6.638SerGlu: 6.638 ± 0.832
3.319SerPhe: 3.319 ± 1.329
4.647SerGly: 4.647 ± 1.701
1.328SerHis: 1.328 ± 0.849
5.642SerIle: 5.642 ± 0.94
7.634SerLys: 7.634 ± 1.038
7.634SerLeu: 7.634 ± 0.836
1.328SerMet: 1.328 ± 0.386
3.983SerAsn: 3.983 ± 0.436
1.659SerPro: 1.659 ± 1.166
2.655SerGln: 2.655 ± 0.479
2.655SerArg: 2.655 ± 1.013
9.957SerSer: 9.957 ± 1.39
5.642SerThr: 5.642 ± 0.94
5.31SerVal: 5.31 ± 1.573
0.332SerTrp: 0.332 ± 0.18
3.319SerTyr: 3.319 ± 0.9
0.0SerXaa: 0.0 ± 0.0
Thr
2.323ThrAla: 2.323 ± 0.977
0.332ThrCys: 0.332 ± 0.18
2.655ThrAsp: 2.655 ± 0.772
3.651ThrGlu: 3.651 ± 1.504
3.651ThrPhe: 3.651 ± 1.433
2.987ThrGly: 2.987 ± 2.131
1.328ThrHis: 1.328 ± 0.849
5.642ThrIle: 5.642 ± 0.529
6.638ThrLys: 6.638 ± 2.061
2.323ThrLeu: 2.323 ± 0.85
0.332ThrMet: 0.332 ± 0.516
4.978ThrAsn: 4.978 ± 1.789
1.659ThrPro: 1.659 ± 0.787
2.655ThrGln: 2.655 ± 0.27
1.991ThrArg: 1.991 ± 0.653
4.315ThrSer: 4.315 ± 0.918
6.306ThrThr: 6.306 ± 1.728
2.655ThrVal: 2.655 ± 0.479
0.332ThrTrp: 0.332 ± 0.18
2.655ThrTyr: 2.655 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
3.651ValAla: 3.651 ± 1.433
1.328ValCys: 1.328 ± 0.719
4.978ValAsp: 4.978 ± 1.988
4.978ValGlu: 4.978 ± 0.873
4.978ValPhe: 4.978 ± 1.701
0.996ValGly: 0.996 ± 0.54
0.332ValHis: 0.332 ± 0.18
0.996ValIle: 0.996 ± 0.487
2.655ValLys: 2.655 ± 1.977
4.647ValLeu: 4.647 ± 1.064
0.664ValMet: 0.664 ± 0.359
1.659ValAsn: 1.659 ± 1.348
2.323ValPro: 2.323 ± 0.816
3.651ValGln: 3.651 ± 1.387
1.328ValArg: 1.328 ± 0.45
2.655ValSer: 2.655 ± 0.479
0.996ValThr: 0.996 ± 0.54
1.991ValVal: 1.991 ± 0.651
0.664ValTrp: 0.664 ± 0.425
2.323ValTyr: 2.323 ± 0.977
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.18
0.332TrpCys: 0.332 ± 0.18
0.664TrpAsp: 0.664 ± 0.36
1.991TrpGlu: 1.991 ± 0.798
0.664TrpPhe: 0.664 ± 0.425
0.664TrpGly: 0.664 ± 0.36
0.332TrpHis: 0.332 ± 0.18
0.332TrpIle: 0.332 ± 0.18
2.323TrpLys: 2.323 ± 1.402
1.328TrpLeu: 1.328 ± 0.721
0.664TrpMet: 0.664 ± 0.359
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.664TrpGln: 0.664 ± 0.359
0.664TrpArg: 0.664 ± 0.425
0.664TrpSer: 0.664 ± 0.36
0.332TrpThr: 0.332 ± 0.516
0.332TrpVal: 0.332 ± 0.18
0.332TrpTrp: 0.332 ± 0.516
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.328TyrAla: 1.328 ± 0.721
0.332TyrCys: 0.332 ± 0.18
1.328TyrAsp: 1.328 ± 0.45
2.323TyrGlu: 2.323 ± 0.692
2.323TyrPhe: 2.323 ± 0.249
1.659TyrGly: 1.659 ± 1.738
1.328TyrHis: 1.328 ± 0.938
1.659TyrIle: 1.659 ± 0.506
2.987TyrLys: 2.987 ± 1.181
4.978TyrLeu: 4.978 ± 0.673
0.332TyrMet: 0.332 ± 0.18
0.664TyrAsn: 0.664 ± 0.425
2.655TyrPro: 2.655 ± 1.055
0.996TyrGln: 0.996 ± 0.54
0.664TyrArg: 0.664 ± 0.36
3.319TyrSer: 3.319 ± 1.116
1.659TyrThr: 1.659 ± 1.348
2.655TyrVal: 2.655 ± 0.27
0.996TyrTrp: 0.996 ± 0.327
1.328TyrTyr: 1.328 ± 0.938
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski