Amino acid dipepetide frequency for Mycoavidus cysteinexigens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.74AlaAla: 11.74 ± 0.203
1.092AlaCys: 1.092 ± 0.039
4.859AlaAsp: 4.859 ± 0.088
5.889AlaGlu: 5.889 ± 0.11
3.674AlaPhe: 3.674 ± 0.079
7.091AlaGly: 7.091 ± 0.134
2.865AlaHis: 2.865 ± 0.077
5.16AlaIle: 5.16 ± 0.095
4.309AlaLys: 4.309 ± 0.095
13.544AlaLeu: 13.544 ± 0.233
2.333AlaMet: 2.333 ± 0.056
3.35AlaAsn: 3.35 ± 0.062
4.538AlaPro: 4.538 ± 0.083
6.728AlaGln: 6.728 ± 0.129
6.564AlaArg: 6.564 ± 0.125
6.8AlaSer: 6.8 ± 0.115
4.807AlaThr: 4.807 ± 0.119
6.385AlaVal: 6.385 ± 0.109
1.497AlaTrp: 1.497 ± 0.052
3.004AlaTyr: 3.004 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.281CysAla: 1.281 ± 0.046
0.122CysCys: 0.122 ± 0.012
0.465CysAsp: 0.465 ± 0.024
0.515CysGlu: 0.515 ± 0.028
0.349CysPhe: 0.349 ± 0.024
0.773CysGly: 0.773 ± 0.033
0.259CysHis: 0.259 ± 0.02
0.48CysIle: 0.48 ± 0.03
0.319CysLys: 0.319 ± 0.019
1.041CysLeu: 1.041 ± 0.036
0.18CysMet: 0.18 ± 0.014
0.285CysAsn: 0.285 ± 0.022
0.41CysPro: 0.41 ± 0.023
0.421CysGln: 0.421 ± 0.022
0.569CysArg: 0.569 ± 0.029
0.485CysSer: 0.485 ± 0.027
0.471CysThr: 0.471 ± 0.025
0.666CysVal: 0.666 ± 0.037
0.131CysTrp: 0.131 ± 0.012
0.288CysTyr: 0.288 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.415AspAla: 5.415 ± 0.103
0.503AspCys: 0.503 ± 0.025
2.196AspAsp: 2.196 ± 0.058
3.553AspGlu: 3.553 ± 0.093
1.935AspPhe: 1.935 ± 0.053
3.634AspGly: 3.634 ± 0.092
0.994AspHis: 0.994 ± 0.04
2.562AspIle: 2.562 ± 0.059
2.695AspLys: 2.695 ± 0.081
5.273AspLeu: 5.273 ± 0.079
0.866AspMet: 0.866 ± 0.038
1.744AspAsn: 1.744 ± 0.059
2.156AspPro: 2.156 ± 0.059
2.06AspGln: 2.06 ± 0.067
2.509AspArg: 2.509 ± 0.056
2.615AspSer: 2.615 ± 0.079
2.448AspThr: 2.448 ± 0.057
2.776AspVal: 2.776 ± 0.064
0.962AspTrp: 0.962 ± 0.037
1.542AspTyr: 1.542 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
6.302GluAla: 6.302 ± 0.111
0.544GluCys: 0.544 ± 0.027
2.422GluAsp: 2.422 ± 0.084
3.395GluGlu: 3.395 ± 0.098
2.005GluPhe: 2.005 ± 0.061
3.811GluGly: 3.811 ± 0.105
1.512GluHis: 1.512 ± 0.049
4.033GluIle: 4.033 ± 0.083
3.297GluLys: 3.297 ± 0.088
6.411GluLeu: 6.411 ± 0.102
1.521GluMet: 1.521 ± 0.047
2.142GluAsn: 2.142 ± 0.062
2.211GluPro: 2.211 ± 0.054
3.443GluGln: 3.443 ± 0.073
4.459GluArg: 4.459 ± 0.081
3.287GluSer: 3.287 ± 0.082
3.163GluThr: 3.163 ± 0.076
3.94GluVal: 3.94 ± 0.076
0.764GluTrp: 0.764 ± 0.035
1.681GluTyr: 1.681 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.623PheAla: 3.623 ± 0.09
0.37PheCys: 0.37 ± 0.026
2.336PheAsp: 2.336 ± 0.045
2.401PheGlu: 2.401 ± 0.061
1.493PhePhe: 1.493 ± 0.048
2.603PheGly: 2.603 ± 0.062
0.65PheHis: 0.65 ± 0.031
2.189PheIle: 2.189 ± 0.046
1.761PheLys: 1.761 ± 0.05
3.214PheLeu: 3.214 ± 0.06
0.724PheMet: 0.724 ± 0.033
1.75PheAsn: 1.75 ± 0.045
1.169PhePro: 1.169 ± 0.043
1.058PheGln: 1.058 ± 0.039
1.466PheArg: 1.466 ± 0.047
3.16PheSer: 3.16 ± 0.101
1.852PheThr: 1.852 ± 0.046
2.277PheVal: 2.277 ± 0.062
0.497PheTrp: 0.497 ± 0.03
1.051PheTyr: 1.051 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.204GlyAla: 7.204 ± 0.133
0.748GlyCys: 0.748 ± 0.033
3.007GlyAsp: 3.007 ± 0.076
4.309GlyGlu: 4.309 ± 0.086
2.745GlyPhe: 2.745 ± 0.064
4.524GlyGly: 4.524 ± 0.114
2.693GlyHis: 2.693 ± 0.12
3.855GlyIle: 3.855 ± 0.073
3.603GlyLys: 3.603 ± 0.07
7.001GlyLeu: 7.001 ± 0.116
1.672GlyMet: 1.672 ± 0.054
2.026GlyAsn: 2.026 ± 0.052
1.908GlyPro: 1.908 ± 0.052
3.275GlyGln: 3.275 ± 0.075
3.796GlyArg: 3.796 ± 0.081
4.606GlySer: 4.606 ± 0.126
3.256GlyThr: 3.256 ± 0.066
5.085GlyVal: 5.085 ± 0.088
1.018GlyTrp: 1.018 ± 0.035
1.955GlyTyr: 1.955 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
2.551HisAla: 2.551 ± 0.066
0.278HisCys: 0.278 ± 0.02
1.061HisAsp: 1.061 ± 0.04
1.341HisGlu: 1.341 ± 0.048
0.973HisPhe: 0.973 ± 0.04
1.684HisGly: 1.684 ± 0.048
0.632HisHis: 0.632 ± 0.029
1.428HisIle: 1.428 ± 0.046
1.017HisLys: 1.017 ± 0.036
2.385HisLeu: 2.385 ± 0.06
0.421HisMet: 0.421 ± 0.025
0.767HisAsn: 0.767 ± 0.03
1.238HisPro: 1.238 ± 0.039
1.233HisGln: 1.233 ± 0.041
1.356HisArg: 1.356 ± 0.044
1.623HisSer: 1.623 ± 0.058
2.483HisThr: 2.483 ± 0.147
1.138HisVal: 1.138 ± 0.039
0.405HisTrp: 0.405 ± 0.022
0.944HisTyr: 0.944 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.538IleAla: 6.538 ± 0.095
0.601IleCys: 0.601 ± 0.029
3.134IleAsp: 3.134 ± 0.071
4.348IleGlu: 4.348 ± 0.092
1.859IlePhe: 1.859 ± 0.054
3.981IleGly: 3.981 ± 0.087
1.275IleHis: 1.275 ± 0.043
2.488IleIle: 2.488 ± 0.063
2.866IleLys: 2.866 ± 0.068
4.877IleLeu: 4.877 ± 0.096
0.929IleMet: 0.929 ± 0.033
2.111IleAsn: 2.111 ± 0.065
2.401IlePro: 2.401 ± 0.049
2.422IleGln: 2.422 ± 0.059
3.036IleArg: 3.036 ± 0.073
3.443IleSer: 3.443 ± 0.085
2.909IleThr: 2.909 ± 0.059
3.522IleVal: 3.522 ± 0.085
0.657IleTrp: 0.657 ± 0.029
1.438IleTyr: 1.438 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.425LysAla: 4.425 ± 0.084
0.29LysCys: 0.29 ± 0.021
2.17LysAsp: 2.17 ± 0.079
2.977LysGlu: 2.977 ± 0.082
1.38LysPhe: 1.38 ± 0.044
2.688LysGly: 2.688 ± 0.07
0.982LysHis: 0.982 ± 0.033
2.796LysIle: 2.796 ± 0.064
2.503LysLys: 2.503 ± 0.084
5.379LysLeu: 5.379 ± 0.104
1.084LysMet: 1.084 ± 0.04
1.955LysAsn: 1.955 ± 0.062
2.073LysPro: 2.073 ± 0.056
2.441LysGln: 2.441 ± 0.083
2.893LysArg: 2.893 ± 0.06
2.763LysSer: 2.763 ± 0.075
3.056LysThr: 3.056 ± 0.075
2.806LysVal: 2.806 ± 0.073
0.602LysTrp: 0.602 ± 0.035
1.037LysTyr: 1.037 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
13.233LeuAla: 13.233 ± 0.176
1.067LeuCys: 1.067 ± 0.037
5.625LeuAsp: 5.625 ± 0.08
7.154LeuGlu: 7.154 ± 0.111
3.312LeuPhe: 3.312 ± 0.083
7.028LeuGly: 7.028 ± 0.127
2.425LeuHis: 2.425 ± 0.059
5.786LeuIle: 5.786 ± 0.098
5.642LeuLys: 5.642 ± 0.107
10.826LeuLeu: 10.826 ± 0.154
2.339LeuMet: 2.339 ± 0.065
4.22LeuAsn: 4.22 ± 0.068
5.345LeuPro: 5.345 ± 0.11
4.573LeuGln: 4.573 ± 0.093
6.678LeuArg: 6.678 ± 0.104
7.818LeuSer: 7.818 ± 0.128
6.323LeuThr: 6.323 ± 0.116
6.07LeuVal: 6.07 ± 0.087
2.305LeuTrp: 2.305 ± 0.124
2.597LeuTyr: 2.597 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.211MetAla: 2.211 ± 0.056
0.137MetCys: 0.137 ± 0.014
0.889MetAsp: 0.889 ± 0.036
0.928MetGlu: 0.928 ± 0.036
0.598MetPhe: 0.598 ± 0.028
1.278MetGly: 1.278 ± 0.047
0.588MetHis: 0.588 ± 0.028
1.052MetIle: 1.052 ± 0.043
0.984MetLys: 0.984 ± 0.037
2.513MetLeu: 2.513 ± 0.067
0.522MetMet: 0.522 ± 0.031
0.861MetAsn: 0.861 ± 0.03
1.17MetPro: 1.17 ± 0.041
1.262MetGln: 1.262 ± 0.051
1.507MetArg: 1.507 ± 0.053
1.383MetSer: 1.383 ± 0.043
1.216MetThr: 1.216 ± 0.038
1.348MetVal: 1.348 ± 0.041
0.153MetTrp: 0.153 ± 0.013
0.437MetTyr: 0.437 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.674AsnAla: 3.674 ± 0.086
0.294AsnCys: 0.294 ± 0.019
1.584AsnAsp: 1.584 ± 0.051
1.984AsnGlu: 1.984 ± 0.07
1.265AsnPhe: 1.265 ± 0.045
2.562AsnGly: 2.562 ± 0.065
0.866AsnHis: 0.866 ± 0.036
1.816AsnIle: 1.816 ± 0.057
1.563AsnLys: 1.563 ± 0.044
3.938AsnLeu: 3.938 ± 0.072
0.72AsnMet: 0.72 ± 0.038
1.35AsnAsn: 1.35 ± 0.068
1.996AsnPro: 1.996 ± 0.055
1.922AsnGln: 1.922 ± 0.057
1.985AsnArg: 1.985 ± 0.043
2.16AsnSer: 2.16 ± 0.071
2.054AsnThr: 2.054 ± 0.057
2.039AsnVal: 2.039 ± 0.055
0.607AsnTrp: 0.607 ± 0.029
1.009AsnTyr: 1.009 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.572ProAla: 4.572 ± 0.103
0.346ProCys: 0.346 ± 0.022
2.421ProAsp: 2.421 ± 0.061
2.909ProGlu: 2.909 ± 0.061
1.776ProPhe: 1.776 ± 0.039
2.747ProGly: 2.747 ± 0.07
1.101ProHis: 1.101 ± 0.04
2.425ProIle: 2.425 ± 0.061
1.837ProLys: 1.837 ± 0.06
4.948ProLeu: 4.948 ± 0.081
0.812ProMet: 0.812 ± 0.036
1.829ProAsn: 1.829 ± 0.052
1.917ProPro: 1.917 ± 0.073
1.834ProGln: 1.834 ± 0.059
2.138ProArg: 2.138 ± 0.06
3.304ProSer: 3.304 ± 0.092
2.38ProThr: 2.38 ± 0.055
2.993ProVal: 2.993 ± 0.068
0.485ProTrp: 0.485 ± 0.025
1.144ProTyr: 1.144 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
5.883GlnAla: 5.883 ± 0.122
0.405GlnCys: 0.405 ± 0.026
1.937GlnAsp: 1.937 ± 0.063
2.459GlnGlu: 2.459 ± 0.074
1.754GlnPhe: 1.754 ± 0.053
2.849GlnGly: 2.849 ± 0.058
1.262GlnHis: 1.262 ± 0.037
3.485GlnIle: 3.485 ± 0.091
2.294GlnLys: 2.294 ± 0.06
5.739GlnLeu: 5.739 ± 0.106
1.109GlnMet: 1.109 ± 0.042
1.637GlnAsn: 1.637 ± 0.054
2.192GlnPro: 2.192 ± 0.057
2.837GlnGln: 2.837 ± 0.085
3.409GlnArg: 3.409 ± 0.067
2.763GlnSer: 2.763 ± 0.074
2.722GlnThr: 2.722 ± 0.072
2.957GlnVal: 2.957 ± 0.071
0.766GlnTrp: 0.766 ± 0.043
1.239GlnTyr: 1.239 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
6.157ArgAla: 6.157 ± 0.115
0.573ArgCys: 0.573 ± 0.032
2.768ArgAsp: 2.768 ± 0.062
3.653ArgGlu: 3.653 ± 0.07
2.642ArgPhe: 2.642 ± 0.063
3.7ArgGly: 3.7 ± 0.08
1.559ArgHis: 1.559 ± 0.043
3.588ArgIle: 3.588 ± 0.076
2.402ArgLys: 2.402 ± 0.059
7.285ArgLeu: 7.285 ± 0.125
1.33ArgMet: 1.33 ± 0.044
1.931ArgAsn: 1.931 ± 0.05
2.485ArgPro: 2.485 ± 0.059
3.09ArgGln: 3.09 ± 0.078
3.61ArgArg: 3.61 ± 0.084
3.334ArgSer: 3.334 ± 0.074
3.023ArgThr: 3.023 ± 0.06
3.84ArgVal: 3.84 ± 0.084
0.923ArgTrp: 0.923 ± 0.036
2.044ArgTyr: 2.044 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.385SerAla: 6.385 ± 0.113
0.597SerCys: 0.597 ± 0.027
3.182SerAsp: 3.182 ± 0.091
3.643SerGlu: 3.643 ± 0.085
2.175SerPhe: 2.175 ± 0.057
6.83SerGly: 6.83 ± 0.269
1.364SerHis: 1.364 ± 0.041
3.359SerIle: 3.359 ± 0.072
2.63SerLys: 2.63 ± 0.063
6.201SerLeu: 6.201 ± 0.099
1.224SerMet: 1.224 ± 0.043
2.298SerAsn: 2.298 ± 0.066
3.384SerPro: 3.384 ± 0.122
2.739SerGln: 2.739 ± 0.08
3.06SerArg: 3.06 ± 0.066
4.3SerSer: 4.3 ± 0.102
3.199SerThr: 3.199 ± 0.064
5.266SerVal: 5.266 ± 0.16
0.934SerTrp: 0.934 ± 0.039
1.676SerTyr: 1.676 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.954ThrAla: 4.954 ± 0.089
0.444ThrCys: 0.444 ± 0.023
2.719ThrAsp: 2.719 ± 0.062
2.841ThrGlu: 2.841 ± 0.062
1.81ThrPhe: 1.81 ± 0.051
3.879ThrGly: 3.879 ± 0.09
1.525ThrHis: 1.525 ± 0.05
2.816ThrIle: 2.816 ± 0.065
1.639ThrLys: 1.639 ± 0.054
7.565ThrLeu: 7.565 ± 0.118
0.95ThrMet: 0.95 ± 0.038
1.477ThrAsn: 1.477 ± 0.054
3.082ThrPro: 3.082 ± 0.069
2.856ThrGln: 2.856 ± 0.056
2.942ThrArg: 2.942 ± 0.064
3.056ThrSer: 3.056 ± 0.078
2.727ThrThr: 2.727 ± 0.09
4.44ThrVal: 4.44 ± 0.101
0.528ThrTrp: 0.528 ± 0.025
1.365ThrTyr: 1.365 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
6.487ValAla: 6.487 ± 0.119
0.681ValCys: 0.681 ± 0.03
2.84ValAsp: 2.84 ± 0.064
3.723ValGlu: 3.723 ± 0.066
2.219ValPhe: 2.219 ± 0.054
3.928ValGly: 3.928 ± 0.079
1.454ValHis: 1.454 ± 0.058
3.527ValIle: 3.527 ± 0.071
3.281ValLys: 3.281 ± 0.087
6.894ValLeu: 6.894 ± 0.101
1.564ValMet: 1.564 ± 0.048
2.488ValAsn: 2.488 ± 0.067
2.487ValPro: 2.487 ± 0.065
2.994ValGln: 2.994 ± 0.072
4.919ValArg: 4.919 ± 0.124
4.039ValSer: 4.039 ± 0.084
3.534ValThr: 3.534 ± 0.077
4.602ValVal: 4.602 ± 0.107
0.919ValTrp: 0.919 ± 0.044
2.099ValTyr: 2.099 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.997TrpAla: 0.997 ± 0.037
0.136TrpCys: 0.136 ± 0.013
1.329TrpAsp: 1.329 ± 0.091
0.778TrpGlu: 0.778 ± 0.04
0.51TrpPhe: 0.51 ± 0.027
0.783TrpGly: 0.783 ± 0.035
0.378TrpHis: 0.378 ± 0.022
0.675TrpIle: 0.675 ± 0.031
0.556TrpLys: 0.556 ± 0.026
2.145TrpLeu: 2.145 ± 0.07
0.317TrpMet: 0.317 ± 0.022
0.448TrpAsn: 0.448 ± 0.027
0.591TrpPro: 0.591 ± 0.027
0.937TrpGln: 0.937 ± 0.038
1.194TrpArg: 1.194 ± 0.043
0.975TrpSer: 0.975 ± 0.054
0.544TrpThr: 0.544 ± 0.029
0.939TrpVal: 0.939 ± 0.04
0.2TrpTrp: 0.2 ± 0.015
0.29TrpTyr: 0.29 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.598TyrAla: 2.598 ± 0.062
0.284TyrCys: 0.284 ± 0.016
1.495TyrAsp: 1.495 ± 0.051
1.544TyrGlu: 1.544 ± 0.041
1.167TyrPhe: 1.167 ± 0.038
1.912TyrGly: 1.912 ± 0.055
0.573TyrHis: 0.573 ± 0.025
1.316TyrIle: 1.316 ± 0.037
1.1TyrLys: 1.1 ± 0.039
3.19TyrLeu: 3.19 ± 0.07
0.42TyrMet: 0.42 ± 0.023
0.722TyrAsn: 0.722 ± 0.035
1.163TyrPro: 1.163 ± 0.04
1.569TyrGln: 1.569 ± 0.047
1.848TyrArg: 1.848 ± 0.052
2.532TyrSer: 2.532 ± 0.122
1.451TyrThr: 1.451 ± 0.05
1.591TyrVal: 1.591 ± 0.046
0.368TyrTrp: 0.368 ± 0.02
0.8TyrTyr: 0.8 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2280 proteins (795496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski