Amino acid dipepetide frequency for Inquilinus sp. KBS0705

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.071AlaAla: 7.071 ± 0.105	0.711AlaCys: 0.711 ± 0.025	5.122AlaAsp: 5.122 ± 0.06	4.413AlaGlu: 4.413 ± 0.073	3.705AlaPhe: 3.705 ± 0.058	6.149AlaGly: 6.149 ± 0.081	1.308AlaHis: 1.308 ± 0.031	5.943AlaIle: 5.943 ± 0.083	5.197AlaLys: 5.197 ± 0.071	7.312AlaLeu: 7.312 ± 0.084	1.778AlaMet: 1.778 ± 0.035	4.199AlaAsn: 4.199 ± 0.065	2.534AlaPro: 2.534 ± 0.054	3.108AlaGln: 3.108 ± 0.05	2.581AlaArg: 2.581 ± 0.041	4.322AlaSer: 4.322 ± 0.066	4.592AlaThr: 4.592 ± 0.081	5.176AlaVal: 5.176 ± 0.067	0.822AlaTrp: 0.822 ± 0.029	3.094AlaTyr: 3.094 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.549CysAla: 0.549 ± 0.021	0.129CysCys: 0.129 ± 0.012	0.403CysAsp: 0.403 ± 0.02	0.364CysGlu: 0.364 ± 0.017	0.432CysPhe: 0.432 ± 0.021	0.63CysGly: 0.63 ± 0.022	0.215CysHis: 0.215 ± 0.014	0.655CysIle: 0.655 ± 0.023	0.478CysLys: 0.478 ± 0.021	0.788CysLeu: 0.788 ± 0.023	0.178CysMet: 0.178 ± 0.012	0.381CysAsn: 0.381 ± 0.017	0.322CysPro: 0.322 ± 0.015	0.214CysGln: 0.214 ± 0.014	0.303CysArg: 0.303 ± 0.016	0.512CysSer: 0.512 ± 0.022	0.425CysThr: 0.425 ± 0.019	0.454CysVal: 0.454 ± 0.017	0.09CysTrp: 0.09 ± 0.008	0.321CysTyr: 0.321 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.397AspAla: 4.397 ± 0.064	0.392AspCys: 0.392 ± 0.017	3.017AspAsp: 3.017 ± 0.055	3.522AspGlu: 3.522 ± 0.058	2.93AspPhe: 2.93 ± 0.05	3.944AspGly: 3.944 ± 0.07	1.046AspHis: 1.046 ± 0.027	4.283AspIle: 4.283 ± 0.065	4.208AspLys: 4.208 ± 0.063	4.588AspLeu: 4.588 ± 0.066	1.376AspMet: 1.376 ± 0.033	3.091AspAsn: 3.091 ± 0.051	1.997AspPro: 1.997 ± 0.039	1.598AspGln: 1.598 ± 0.039	2.038AspArg: 2.038 ± 0.042	2.96AspSer: 2.96 ± 0.054	3.074AspThr: 3.074 ± 0.056	3.668AspVal: 3.668 ± 0.057	0.76AspTrp: 0.76 ± 0.024	2.547AspTyr: 2.547 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	3.91GluAla: 3.91 ± 0.074	0.318GluCys: 0.318 ± 0.016	2.644GluAsp: 2.644 ± 0.048	3.092GluGlu: 3.092 ± 0.061	2.328GluPhe: 2.328 ± 0.045	3.157GluGly: 3.157 ± 0.053	1.06GluHis: 1.06 ± 0.031	3.738GluIle: 3.738 ± 0.059	4.034GluLys: 4.034 ± 0.08	5.397GluLeu: 5.397 ± 0.082	1.352GluMet: 1.352 ± 0.037	2.746GluAsn: 2.746 ± 0.053	1.686GluPro: 1.686 ± 0.044	2.364GluGln: 2.364 ± 0.044	2.352GluArg: 2.352 ± 0.051	2.484GluSer: 2.484 ± 0.048	2.836GluThr: 2.836 ± 0.049	3.569GluVal: 3.569 ± 0.052	0.657GluTrp: 0.657 ± 0.025	2.051GluTyr: 2.051 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.627PheAla: 3.627 ± 0.058	0.44PheCys: 0.44 ± 0.017	2.929PheAsp: 2.929 ± 0.049	2.576PheGlu: 2.576 ± 0.051	2.367PhePhe: 2.367 ± 0.052	3.406PheGly: 3.406 ± 0.07	0.773PheHis: 0.773 ± 0.027	3.603PheIle: 3.603 ± 0.066	3.574PheLys: 3.574 ± 0.06	4.078PheLeu: 4.078 ± 0.072	1.093PheMet: 1.093 ± 0.027	3.108PheAsn: 3.108 ± 0.05	1.622PhePro: 1.622 ± 0.033	1.15PheGln: 1.15 ± 0.033	1.602PheArg: 1.602 ± 0.032	3.264PheSer: 3.264 ± 0.053	3.388PheThr: 3.388 ± 0.058	2.859PheVal: 2.859 ± 0.049	0.557PheTrp: 0.557 ± 0.021	2.112PheTyr: 2.112 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.896GlyAla: 4.896 ± 0.066	0.631GlyCys: 0.631 ± 0.027	3.643GlyAsp: 3.643 ± 0.067	3.173GlyGlu: 3.173 ± 0.056	3.674GlyPhe: 3.674 ± 0.053	5.075GlyGly: 5.075 ± 0.087	1.317GlyHis: 1.317 ± 0.036	5.45GlyIle: 5.45 ± 0.069	5.231GlyLys: 5.231 ± 0.066	6.423GlyLeu: 6.423 ± 0.071	1.699GlyMet: 1.699 ± 0.038	3.783GlyAsn: 3.783 ± 0.065	1.803GlyPro: 1.803 ± 0.04	2.307GlyGln: 2.307 ± 0.044	2.55GlyArg: 2.55 ± 0.046	4.21GlySer: 4.21 ± 0.067	4.311GlyThr: 4.311 ± 0.078	4.605GlyVal: 4.605 ± 0.059	0.96GlyTrp: 0.96 ± 0.033	3.216GlyTyr: 3.216 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.2HisAla: 1.2 ± 0.035	0.18HisCys: 0.18 ± 0.013	0.937HisAsp: 0.937 ± 0.028	0.951HisGlu: 0.951 ± 0.026	1.083HisPhe: 1.083 ± 0.033	1.175HisGly: 1.175 ± 0.031	0.526HisHis: 0.526 ± 0.024	1.435HisIle: 1.435 ± 0.032	1.063HisLys: 1.063 ± 0.032	1.949HisLeu: 1.949 ± 0.041	0.412HisMet: 0.412 ± 0.02	1.009HisAsn: 1.009 ± 0.026	1.045HisPro: 1.045 ± 0.029	0.817HisGln: 0.817 ± 0.026	0.726HisArg: 0.726 ± 0.021	1.001HisSer: 1.001 ± 0.031	1.122HisThr: 1.122 ± 0.03	1.046HisVal: 1.046 ± 0.027	0.25HisTrp: 0.25 ± 0.014	0.909HisTyr: 0.909 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.552IleAla: 6.552 ± 0.081	0.704IleCys: 0.704 ± 0.025	4.426IleAsp: 4.426 ± 0.047	3.861IleGlu: 3.861 ± 0.062	3.026IlePhe: 3.026 ± 0.055	4.93IleGly: 4.93 ± 0.066	1.22IleHis: 1.22 ± 0.029	5.427IleIle: 5.427 ± 0.073	5.422IleLys: 5.422 ± 0.07	6.148IleLeu: 6.148 ± 0.079	1.384IleMet: 1.384 ± 0.034	4.482IleAsn: 4.482 ± 0.068	3.055IlePro: 3.055 ± 0.054	2.286IleGln: 2.286 ± 0.049	2.819IleArg: 2.819 ± 0.04	4.878IleSer: 4.878 ± 0.065	5.066IleThr: 5.066 ± 0.08	4.393IleVal: 4.393 ± 0.055	0.721IleTrp: 0.721 ± 0.023	2.713IleTyr: 2.713 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.859LysAla: 5.859 ± 0.077	0.341LysCys: 0.341 ± 0.017	4.028LysAsp: 4.028 ± 0.065	3.984LysGlu: 3.984 ± 0.079	2.733LysPhe: 2.733 ± 0.048	4.537LysGly: 4.537 ± 0.063	1.352LysHis: 1.352 ± 0.036	4.856LysIle: 4.856 ± 0.066	5.333LysLys: 5.333 ± 0.062	6.52LysLeu: 6.52 ± 0.074	1.888LysMet: 1.888 ± 0.042	4.143LysAsn: 4.143 ± 0.057	3.01LysPro: 3.01 ± 0.053	3.16LysGln: 3.16 ± 0.047	2.752LysArg: 2.752 ± 0.052	3.79LysSer: 3.79 ± 0.056	4.279LysThr: 4.279 ± 0.063	4.573LysVal: 4.573 ± 0.062	0.788LysTrp: 0.788 ± 0.023	2.998LysTyr: 2.998 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.223LeuAla: 7.223 ± 0.087	0.833LeuCys: 0.833 ± 0.026	4.65LeuAsp: 4.65 ± 0.067	4.202LeuGlu: 4.202 ± 0.071	4.576LeuPhe: 4.576 ± 0.071	5.78LeuGly: 5.78 ± 0.071	1.756LeuHis: 1.756 ± 0.038	6.628LeuIle: 6.628 ± 0.091	7.168LeuLys: 7.168 ± 0.077	9.477LeuLeu: 9.477 ± 0.118	2.208LeuMet: 2.208 ± 0.048	5.569LeuAsn: 5.569 ± 0.068	4.121LeuPro: 4.121 ± 0.057	3.76LeuGln: 3.76 ± 0.06	3.485LeuArg: 3.485 ± 0.054	6.561LeuSer: 6.561 ± 0.079	5.636LeuThr: 5.636 ± 0.07	5.679LeuVal: 5.679 ± 0.075	0.92LeuTrp: 0.92 ± 0.029	3.382LeuTyr: 3.382 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.074MetAla: 2.074 ± 0.046	0.135MetCys: 0.135 ± 0.009	1.25MetAsp: 1.25 ± 0.033	1.232MetGlu: 1.232 ± 0.036	0.868MetPhe: 0.868 ± 0.028	1.626MetGly: 1.626 ± 0.038	0.461MetHis: 0.461 ± 0.015	1.429MetIle: 1.429 ± 0.035	1.845MetLys: 1.845 ± 0.037	2.351MetLeu: 2.351 ± 0.044	0.638MetMet: 0.638 ± 0.021	1.187MetAsn: 1.187 ± 0.031	1.126MetPro: 1.126 ± 0.027	1.046MetGln: 1.046 ± 0.031	0.96MetArg: 0.96 ± 0.026	1.291MetSer: 1.291 ± 0.033	0.985MetThr: 0.985 ± 0.031	1.554MetVal: 1.554 ± 0.039	0.159MetTrp: 0.159 ± 0.01	0.691MetTyr: 0.691 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.127AsnAla: 4.127 ± 0.06	0.396AsnCys: 0.396 ± 0.019	2.977AsnAsp: 2.977 ± 0.055	2.789AsnGlu: 2.789 ± 0.047	2.637AsnPhe: 2.637 ± 0.051	4.146AsnGly: 4.146 ± 0.066	1.068AsnHis: 1.068 ± 0.031	4.298AsnIle: 4.298 ± 0.064	3.884AsnLys: 3.884 ± 0.056	4.951AsnLeu: 4.951 ± 0.074	1.248AsnMet: 1.248 ± 0.027	3.626AsnAsn: 3.626 ± 0.069	2.654AsnPro: 2.654 ± 0.045	2.056AsnGln: 2.056 ± 0.045	2.284AsnArg: 2.284 ± 0.042	3.206AsnSer: 3.206 ± 0.052	3.509AsnThr: 3.509 ± 0.067	3.274AsnVal: 3.274 ± 0.053	0.781AsnTrp: 0.781 ± 0.026	2.786AsnTyr: 2.786 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.625ProAla: 3.625 ± 0.065	0.206ProCys: 0.206 ± 0.013	2.721ProAsp: 2.721 ± 0.05	2.605ProGlu: 2.605 ± 0.054	1.895ProPhe: 1.895 ± 0.033	2.935ProGly: 2.935 ± 0.052	0.705ProHis: 0.705 ± 0.028	2.429ProIle: 2.429 ± 0.045	2.329ProLys: 2.329 ± 0.049	3.335ProLeu: 3.335 ± 0.047	0.76ProMet: 0.76 ± 0.02	2.046ProAsn: 2.046 ± 0.038	1.129ProPro: 1.129 ± 0.036	1.514ProGln: 1.514 ± 0.037	1.062ProArg: 1.062 ± 0.026	2.025ProSer: 2.025 ± 0.045	2.021ProThr: 2.021 ± 0.046	3.378ProVal: 3.378 ± 0.05	0.416ProTrp: 0.416 ± 0.018	1.63ProTyr: 1.63 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.778GlnAla: 2.778 ± 0.046	0.196GlnCys: 0.196 ± 0.011	1.644GlnAsp: 1.644 ± 0.039	1.723GlnGlu: 1.723 ± 0.041	1.662GlnPhe: 1.662 ± 0.04	2.087GlnGly: 2.087 ± 0.043	0.825GlnHis: 0.825 ± 0.027	2.514GlnIle: 2.514 ± 0.04	2.739GlnLys: 2.739 ± 0.046	3.914GlnLeu: 3.914 ± 0.059	0.891GlnMet: 0.891 ± 0.029	2.057GlnAsn: 2.057 ± 0.043	1.615GlnPro: 1.615 ± 0.039	2.278GlnGln: 2.278 ± 0.049	1.486GlnArg: 1.486 ± 0.038	2.288GlnSer: 2.288 ± 0.051	2.252GlnThr: 2.252 ± 0.041	2.505GlnVal: 2.505 ± 0.045	0.423GlnTrp: 0.423 ± 0.02	1.595GlnTyr: 1.595 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.426ArgAla: 2.426 ± 0.048	0.236ArgCys: 0.236 ± 0.015	2.042ArgAsp: 2.042 ± 0.048	2.11ArgGlu: 2.11 ± 0.048	1.967ArgPhe: 1.967 ± 0.041	2.114ArgGly: 2.114 ± 0.048	0.727ArgHis: 0.727 ± 0.024	2.936ArgIle: 2.936 ± 0.048	2.706ArgLys: 2.706 ± 0.047	3.738ArgLeu: 3.738 ± 0.06	0.999ArgMet: 0.999 ± 0.029	2.073ArgAsn: 2.073 ± 0.042	1.388ArgPro: 1.388 ± 0.034	1.486ArgGln: 1.486 ± 0.034	1.568ArgArg: 1.568 ± 0.04	2.235ArgSer: 2.235 ± 0.047	1.922ArgThr: 1.922 ± 0.039	2.502ArgVal: 2.502 ± 0.048	0.457ArgTrp: 0.457 ± 0.019	1.737ArgTyr: 1.737 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.821SerAla: 4.821 ± 0.068	0.492SerCys: 0.492 ± 0.022	2.862SerAsp: 2.862 ± 0.049	2.622SerGlu: 2.622 ± 0.049	3.35SerPhe: 3.35 ± 0.056	4.71SerGly: 4.71 ± 0.077	1.106SerHis: 1.106 ± 0.026	4.536SerIle: 4.536 ± 0.067	3.79SerLys: 3.79 ± 0.053	5.711SerLeu: 5.711 ± 0.07	1.222SerMet: 1.222 ± 0.026	3.008SerAsn: 3.008 ± 0.05	2.393SerPro: 2.393 ± 0.045	1.995SerGln: 1.995 ± 0.038	2.271SerArg: 2.271 ± 0.043	3.647SerSer: 3.647 ± 0.062	3.483SerThr: 3.483 ± 0.058	4.142SerVal: 4.142 ± 0.064	0.7SerTrp: 0.7 ± 0.025	2.661SerTyr: 2.661 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.251ThrAla: 5.251 ± 0.08	0.419ThrCys: 0.419 ± 0.019	3.679ThrAsp: 3.679 ± 0.053	3.013ThrGlu: 3.013 ± 0.054	2.771ThrPhe: 2.771 ± 0.052	5.056ThrGly: 5.056 ± 0.075	1.089ThrHis: 1.089 ± 0.029	4.629ThrIle: 4.629 ± 0.08	3.351ThrLys: 3.351 ± 0.053	5.537ThrLeu: 5.537 ± 0.066	1.082ThrMet: 1.082 ± 0.032	3.067ThrAsn: 3.067 ± 0.062	2.763ThrPro: 2.763 ± 0.055	2.003ThrGln: 2.003 ± 0.04	2.019ThrArg: 2.019 ± 0.044	3.412ThrSer: 3.412 ± 0.07	3.797ThrThr: 3.797 ± 0.074	4.171ThrVal: 4.171 ± 0.09	0.671ThrTrp: 0.671 ± 0.024	2.605ThrTyr: 2.605 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.023ValAla: 5.023 ± 0.064	0.599ValCys: 0.599 ± 0.019	3.496ValAsp: 3.496 ± 0.062	3.114ValGlu: 3.114 ± 0.055	3.232ValPhe: 3.232 ± 0.047	3.832ValGly: 3.832 ± 0.054	1.052ValHis: 1.052 ± 0.028	5.122ValIle: 5.122 ± 0.067	4.896ValLys: 4.896 ± 0.062	6.196ValLeu: 6.196 ± 0.087	1.554ValMet: 1.554 ± 0.036	3.881ValAsn: 3.881 ± 0.061	2.398ValPro: 2.398 ± 0.043	2.038ValGln: 2.038 ± 0.036	2.181ValArg: 2.181 ± 0.042	4.247ValSer: 4.247 ± 0.058	4.316ValThr: 4.316 ± 0.09	4.537ValVal: 4.537 ± 0.063	0.702ValTrp: 0.702 ± 0.024	2.664ValTyr: 2.664 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.827TrpAla: 0.827 ± 0.025	0.11TrpCys: 0.11 ± 0.009	0.707TrpAsp: 0.707 ± 0.026	0.566TrpGlu: 0.566 ± 0.02	0.616TrpPhe: 0.616 ± 0.024	0.834TrpGly: 0.834 ± 0.035	0.302TrpHis: 0.302 ± 0.016	0.728TrpIle: 0.728 ± 0.025	0.766TrpLys: 0.766 ± 0.028	1.185TrpLeu: 1.185 ± 0.033	0.358TrpMet: 0.358 ± 0.019	0.588TrpAsn: 0.588 ± 0.022	0.364TrpPro: 0.364 ± 0.017	0.584TrpGln: 0.584 ± 0.02	0.481TrpArg: 0.481 ± 0.02	0.571TrpSer: 0.571 ± 0.023	0.573TrpThr: 0.573 ± 0.024	0.728TrpVal: 0.728 ± 0.027	0.192TrpTrp: 0.192 ± 0.015	0.449TrpTyr: 0.449 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.901TyrAla: 2.901 ± 0.051	0.374TyrCys: 0.374 ± 0.017	2.261TyrAsp: 2.261 ± 0.047	1.865TyrGlu: 1.865 ± 0.047	2.277TyrPhe: 2.277 ± 0.051	2.832TyrGly: 2.832 ± 0.045	0.926TyrHis: 0.926 ± 0.027	2.876TyrIle: 2.876 ± 0.052	2.906TyrLys: 2.906 ± 0.049	4.016TyrLeu: 4.016 ± 0.063	0.788TyrMet: 0.788 ± 0.024	2.649TyrAsn: 2.649 ± 0.052	1.741TyrPro: 1.741 ± 0.036	1.704TyrGln: 1.704 ± 0.04	1.851TyrArg: 1.851 ± 0.032	2.619TyrSer: 2.619 ± 0.052	2.798TyrThr: 2.798 ± 0.062	2.272TyrVal: 2.272 ± 0.045	0.506TyrTrp: 0.506 ± 0.019	1.946TyrTyr: 1.946 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3852 proteins (1306491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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