Amino acid dipepetide frequency for Sphingopyxis granuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.722AlaAla: 21.722 ± 0.242	1.037AlaCys: 1.037 ± 0.032	8.55AlaAsp: 8.55 ± 0.089	7.885AlaGlu: 7.885 ± 0.102	4.541AlaPhe: 4.541 ± 0.058	12.178AlaGly: 12.178 ± 0.156	2.465AlaHis: 2.465 ± 0.053	7.058AlaIle: 7.058 ± 0.08	4.04AlaLys: 4.04 ± 0.068	14.23AlaLeu: 14.23 ± 0.163	3.998AlaMet: 3.998 ± 0.064	3.143AlaAsn: 3.143 ± 0.052	6.939AlaPro: 6.939 ± 0.1	4.282AlaGln: 4.282 ± 0.062	10.402AlaArg: 10.402 ± 0.138	6.737AlaSer: 6.737 ± 0.083	6.852AlaThr: 6.852 ± 0.099	8.903AlaVal: 8.903 ± 0.092	1.775AlaTrp: 1.775 ± 0.04	2.722AlaTyr: 2.722 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.029	0.116CysCys: 0.116 ± 0.009	0.527CysAsp: 0.527 ± 0.022	0.394CysGlu: 0.394 ± 0.021	0.302CysPhe: 0.302 ± 0.016	0.818CysGly: 0.818 ± 0.028	0.204CysHis: 0.204 ± 0.017	0.344CysIle: 0.344 ± 0.016	0.155CysLys: 0.155 ± 0.009	0.644CysLeu: 0.644 ± 0.025	0.138CysMet: 0.138 ± 0.012	0.191CysAsn: 0.191 ± 0.013	0.459CysPro: 0.459 ± 0.019	0.217CysGln: 0.217 ± 0.012	0.595CysArg: 0.595 ± 0.024	0.424CysSer: 0.424 ± 0.018	0.372CysThr: 0.372 ± 0.016	0.508CysVal: 0.508 ± 0.021	0.113CysTrp: 0.113 ± 0.009	0.166CysTyr: 0.166 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.583AspAla: 8.583 ± 0.104	0.473AspCys: 0.473 ± 0.022	3.554AspAsp: 3.554 ± 0.058	3.391AspGlu: 3.391 ± 0.062	2.193AspPhe: 2.193 ± 0.04	6.066AspGly: 6.066 ± 0.099	1.346AspHis: 1.346 ± 0.033	2.995AspIle: 2.995 ± 0.05	1.643AspLys: 1.643 ± 0.037	5.786AspLeu: 5.786 ± 0.065	1.455AspMet: 1.455 ± 0.028	1.35AspAsn: 1.35 ± 0.038	4.055AspPro: 4.055 ± 0.054	1.639AspGln: 1.639 ± 0.033	5.422AspArg: 5.422 ± 0.071	2.565AspSer: 2.565 ± 0.056	2.578AspThr: 2.578 ± 0.048	4.033AspVal: 4.033 ± 0.061	1.144AspTrp: 1.144 ± 0.031	1.724AspTyr: 1.724 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.03GluAla: 8.03 ± 0.115	0.302GluCys: 0.302 ± 0.016	2.557GluAsp: 2.557 ± 0.05	2.798GluGlu: 2.798 ± 0.061	1.394GluPhe: 1.394 ± 0.032	4.396GluGly: 4.396 ± 0.071	1.043GluHis: 1.043 ± 0.029	2.908GluIle: 2.908 ± 0.051	1.798GluLys: 1.798 ± 0.044	4.93GluLeu: 4.93 ± 0.074	1.389GluMet: 1.389 ± 0.034	1.288GluAsn: 1.288 ± 0.031	2.508GluPro: 2.508 ± 0.045	1.934GluGln: 1.934 ± 0.041	5.153GluArg: 5.153 ± 0.084	2.275GluSer: 2.275 ± 0.04	2.981GluThr: 2.981 ± 0.044	3.451GluVal: 3.451 ± 0.062	0.781GluTrp: 0.781 ± 0.023	1.024GluTyr: 1.024 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.905PheAla: 4.905 ± 0.063	0.307PheCys: 0.307 ± 0.015	2.824PheAsp: 2.824 ± 0.057	1.993PheGlu: 1.993 ± 0.037	1.257PhePhe: 1.257 ± 0.033	3.704PheGly: 3.704 ± 0.056	0.692PheHis: 0.692 ± 0.024	1.407PheIle: 1.407 ± 0.033	0.723PheLys: 0.723 ± 0.023	3.047PheLeu: 3.047 ± 0.048	0.707PheMet: 0.707 ± 0.025	1.009PheAsn: 1.009 ± 0.034	1.513PhePro: 1.513 ± 0.031	0.867PheGln: 0.867 ± 0.027	2.328PheArg: 2.328 ± 0.043	1.93PheSer: 1.93 ± 0.046	1.942PheThr: 1.942 ± 0.051	2.589PheVal: 2.589 ± 0.046	0.476PheTrp: 0.476 ± 0.021	0.847PheTyr: 0.847 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.72GlyAla: 10.72 ± 0.134	0.84GlyCys: 0.84 ± 0.028	5.337GlyAsp: 5.337 ± 0.072	5.007GlyGlu: 5.007 ± 0.063	3.58GlyPhe: 3.58 ± 0.062	8.629GlyGly: 8.629 ± 0.139	1.902GlyHis: 1.902 ± 0.039	4.537GlyIle: 4.537 ± 0.06	3.078GlyLys: 3.078 ± 0.055	8.576GlyLeu: 8.576 ± 0.09	2.259GlyMet: 2.259 ± 0.04	2.184GlyAsn: 2.184 ± 0.056	3.726GlyPro: 3.726 ± 0.054	2.942GlyGln: 2.942 ± 0.048	6.883GlyArg: 6.883 ± 0.079	4.88GlySer: 4.88 ± 0.075	4.897GlyThr: 4.897 ± 0.123	6.234GlyVal: 6.234 ± 0.073	1.612GlyTrp: 1.612 ± 0.038	2.373GlyTyr: 2.373 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.496HisAla: 2.496 ± 0.053	0.248HisCys: 0.248 ± 0.015	1.272HisAsp: 1.272 ± 0.034	0.92HisGlu: 0.92 ± 0.032	0.799HisPhe: 0.799 ± 0.025	1.987HisGly: 1.987 ± 0.041	0.578HisHis: 0.578 ± 0.024	0.933HisIle: 0.933 ± 0.027	0.412HisLys: 0.412 ± 0.018	1.84HisLeu: 1.84 ± 0.045	0.443HisMet: 0.443 ± 0.019	0.405HisAsn: 0.405 ± 0.017	1.281HisPro: 1.281 ± 0.031	0.54HisGln: 0.54 ± 0.019	1.521HisArg: 1.521 ± 0.035	0.945HisSer: 0.945 ± 0.031	0.596HisThr: 0.596 ± 0.022	1.535HisVal: 1.535 ± 0.041	0.365HisTrp: 0.365 ± 0.017	0.584HisTyr: 0.584 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.147IleAla: 8.147 ± 0.094	0.413IleCys: 0.413 ± 0.016	4.133IleAsp: 4.133 ± 0.064	3.454IleGlu: 3.454 ± 0.051	1.548IlePhe: 1.548 ± 0.033	5.013IleGly: 5.013 ± 0.072	0.874IleHis: 0.874 ± 0.027	1.928IleIle: 1.928 ± 0.042	1.079IleLys: 1.079 ± 0.028	4.057IleLeu: 4.057 ± 0.061	0.78IleMet: 0.78 ± 0.026	1.236IleAsn: 1.236 ± 0.032	2.19IlePro: 2.19 ± 0.04	1.079IleGln: 1.079 ± 0.032	3.375IleArg: 3.375 ± 0.051	2.345IleSer: 2.345 ± 0.048	2.217IleThr: 2.217 ± 0.05	4.285IleVal: 4.285 ± 0.057	0.596IleTrp: 0.596 ± 0.022	0.988IleTyr: 0.988 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.003LysAla: 4.003 ± 0.066	0.135LysCys: 0.135 ± 0.01	1.505LysAsp: 1.505 ± 0.035	1.202LysGlu: 1.202 ± 0.035	0.766LysPhe: 0.766 ± 0.024	2.487LysGly: 2.487 ± 0.051	0.486LysHis: 0.486 ± 0.017	1.307LysIle: 1.307 ± 0.033	0.971LysLys: 0.971 ± 0.033	2.889LysLeu: 2.889 ± 0.051	0.637LysMet: 0.637 ± 0.023	0.623LysAsn: 0.623 ± 0.021	1.783LysPro: 1.783 ± 0.039	0.888LysGln: 0.888 ± 0.025	2.207LysArg: 2.207 ± 0.046	1.433LysSer: 1.433 ± 0.035	1.533LysThr: 1.533 ± 0.037	2.0LysVal: 2.0 ± 0.041	0.392LysTrp: 0.392 ± 0.017	0.505LysTyr: 0.505 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.799LeuAla: 14.799 ± 0.168	0.772LeuCys: 0.772 ± 0.028	6.236LeuAsp: 6.236 ± 0.082	4.292LeuGlu: 4.292 ± 0.066	3.734LeuPhe: 3.734 ± 0.056	8.204LeuGly: 8.204 ± 0.08	1.764LeuHis: 1.764 ± 0.037	4.733LeuIle: 4.733 ± 0.052	2.705LeuLys: 2.705 ± 0.051	9.532LeuLeu: 9.532 ± 0.125	2.043LeuMet: 2.043 ± 0.043	2.232LeuAsn: 2.232 ± 0.042	5.612LeuPro: 5.612 ± 0.07	2.324LeuGln: 2.324 ± 0.044	7.112LeuArg: 7.112 ± 0.08	5.805LeuSer: 5.805 ± 0.07	5.559LeuThr: 5.559 ± 0.077	7.083LeuVal: 7.083 ± 0.086	1.291LeuTrp: 1.291 ± 0.036	2.008LeuTyr: 2.008 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.239MetAla: 3.239 ± 0.057	0.157MetCys: 0.157 ± 0.011	1.08MetAsp: 1.08 ± 0.028	1.059MetGlu: 1.059 ± 0.031	0.641MetPhe: 0.641 ± 0.021	1.811MetGly: 1.811 ± 0.043	0.423MetHis: 0.423 ± 0.017	1.312MetIle: 1.312 ± 0.03	0.853MetLys: 0.853 ± 0.028	2.594MetLeu: 2.594 ± 0.049	0.638MetMet: 0.638 ± 0.024	0.614MetAsn: 0.614 ± 0.02	1.381MetPro: 1.381 ± 0.032	0.699MetGln: 0.699 ± 0.024	1.852MetArg: 1.852 ± 0.035	1.282MetSer: 1.282 ± 0.035	1.966MetThr: 1.966 ± 0.037	1.546MetVal: 1.546 ± 0.034	0.214MetTrp: 0.214 ± 0.014	0.245MetTyr: 0.245 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.113AsnAla: 3.113 ± 0.051	0.23AsnCys: 0.23 ± 0.013	1.347AsnAsp: 1.347 ± 0.036	1.057AsnGlu: 1.057 ± 0.029	0.942AsnPhe: 0.942 ± 0.028	2.346AsnGly: 2.346 ± 0.056	0.44AsnHis: 0.44 ± 0.019	1.302AsnIle: 1.302 ± 0.029	0.553AsnLys: 0.553 ± 0.019	2.359AsnLeu: 2.359 ± 0.044	0.508AsnMet: 0.508 ± 0.023	0.626AsnAsn: 0.626 ± 0.035	1.684AsnPro: 1.684 ± 0.043	0.703AsnGln: 0.703 ± 0.024	1.929AsnArg: 1.929 ± 0.041	1.238AsnSer: 1.238 ± 0.037	0.933AsnThr: 0.933 ± 0.032	1.666AsnVal: 1.666 ± 0.04	0.41AsnTrp: 0.41 ± 0.018	0.673AsnTyr: 0.673 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.703ProAla: 7.703 ± 0.092	0.323ProCys: 0.323 ± 0.016	4.024ProAsp: 4.024 ± 0.056	3.373ProGlu: 3.373 ± 0.05	1.848ProPhe: 1.848 ± 0.039	5.053ProGly: 5.053 ± 0.065	1.056ProHis: 1.056 ± 0.027	2.379ProIle: 2.379 ± 0.039	1.426ProLys: 1.426 ± 0.038	5.002ProLeu: 5.002 ± 0.07	1.228ProMet: 1.228 ± 0.029	1.166ProAsn: 1.166 ± 0.035	3.116ProPro: 3.116 ± 0.077	1.66ProGln: 1.66 ± 0.039	3.25ProArg: 3.25 ± 0.057	2.584ProSer: 2.584 ± 0.05	2.623ProThr: 2.623 ± 0.051	4.363ProVal: 4.363 ± 0.059	0.699ProTrp: 0.699 ± 0.022	1.088ProTyr: 1.088 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.103GlnAla: 4.103 ± 0.064	0.219GlnCys: 0.219 ± 0.015	1.355GlnAsp: 1.355 ± 0.036	1.194GlnGlu: 1.194 ± 0.034	1.06GlnPhe: 1.06 ± 0.03	2.439GlnGly: 2.439 ± 0.041	0.529GlnHis: 0.529 ± 0.021	1.715GlnIle: 1.715 ± 0.034	0.87GlnLys: 0.87 ± 0.025	3.018GlnLeu: 3.018 ± 0.045	0.769GlnMet: 0.769 ± 0.023	0.711GlnAsn: 0.711 ± 0.023	1.728GlnPro: 1.728 ± 0.036	1.18GlnGln: 1.18 ± 0.036	2.499GlnArg: 2.499 ± 0.048	1.605GlnSer: 1.605 ± 0.034	1.548GlnThr: 1.548 ± 0.036	2.062GlnVal: 2.062 ± 0.039	0.445GlnTrp: 0.445 ± 0.02	0.62GlnTyr: 0.62 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.579ArgAla: 9.579 ± 0.123	0.51ArgCys: 0.51 ± 0.022	4.629ArgAsp: 4.629 ± 0.069	4.081ArgGlu: 4.081 ± 0.068	3.228ArgPhe: 3.228 ± 0.056	5.467ArgGly: 5.467 ± 0.066	1.831ArgHis: 1.831 ± 0.04	4.395ArgIle: 4.395 ± 0.071	2.125ArgLys: 2.125 ± 0.044	8.585ArgLeu: 8.585 ± 0.086	1.96ArgMet: 1.96 ± 0.037	1.746ArgAsn: 1.746 ± 0.041	3.963ArgPro: 3.963 ± 0.055	2.538ArgGln: 2.538 ± 0.05	6.27ArgArg: 6.27 ± 0.103	3.783ArgSer: 3.783 ± 0.057	3.837ArgThr: 3.837 ± 0.054	4.887ArgVal: 4.887 ± 0.062	1.326ArgTrp: 1.326 ± 0.034	1.972ArgTyr: 1.972 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.372SerAla: 6.372 ± 0.076	0.404SerCys: 0.404 ± 0.017	3.245SerAsp: 3.245 ± 0.044	2.507SerGlu: 2.507 ± 0.04	2.201SerPhe: 2.201 ± 0.053	5.397SerGly: 5.397 ± 0.101	0.961SerHis: 0.961 ± 0.03	2.608SerIle: 2.608 ± 0.045	1.268SerLys: 1.268 ± 0.033	5.031SerLeu: 5.031 ± 0.065	1.153SerMet: 1.153 ± 0.031	1.348SerAsn: 1.348 ± 0.035	2.705SerPro: 2.705 ± 0.046	1.505SerGln: 1.505 ± 0.034	3.435SerArg: 3.435 ± 0.046	2.566SerSer: 2.566 ± 0.052	2.404SerThr: 2.404 ± 0.049	3.586SerVal: 3.586 ± 0.054	0.779SerTrp: 0.779 ± 0.023	1.308SerTyr: 1.308 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.63ThrAla: 6.63 ± 0.088	0.339ThrCys: 0.339 ± 0.017	2.968ThrAsp: 2.968 ± 0.057	2.245ThrGlu: 2.245 ± 0.044	1.577ThrPhe: 1.577 ± 0.038	5.357ThrGly: 5.357 ± 0.103	0.946ThrHis: 0.946 ± 0.027	2.92ThrIle: 2.92 ± 0.057	1.19ThrLys: 1.19 ± 0.032	5.881ThrLeu: 5.881 ± 0.087	1.202ThrMet: 1.202 ± 0.031	1.285ThrAsn: 1.285 ± 0.046	3.451ThrPro: 3.451 ± 0.055	1.359ThrGln: 1.359 ± 0.033	3.592ThrArg: 3.592 ± 0.052	2.557ThrSer: 2.557 ± 0.058	2.567ThrThr: 2.567 ± 0.068	3.976ThrVal: 3.976 ± 0.081	0.597ThrTrp: 0.597 ± 0.021	1.122ThrTyr: 1.122 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.195ValAla: 10.195 ± 0.108	0.504ValCys: 0.504 ± 0.021	4.438ValAsp: 4.438 ± 0.064	4.403ValGlu: 4.403 ± 0.061	2.09ValPhe: 2.09 ± 0.045	5.717ValGly: 5.717 ± 0.066	1.335ValHis: 1.335 ± 0.032	3.369ValIle: 3.369 ± 0.051	1.86ValLys: 1.86 ± 0.042	5.929ValLeu: 5.929 ± 0.071	1.526ValMet: 1.526 ± 0.036	1.846ValAsn: 1.846 ± 0.043	4.084ValPro: 4.084 ± 0.06	1.978ValGln: 1.978 ± 0.036	5.456ValArg: 5.456 ± 0.062	3.721ValSer: 3.721 ± 0.053	4.379ValThr: 4.379 ± 0.091	5.191ValVal: 5.191 ± 0.077	0.859ValTrp: 0.859 ± 0.029	1.376ValTyr: 1.376 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.402TrpAla: 1.402 ± 0.034	0.135TrpCys: 0.135 ± 0.012	0.79TrpAsp: 0.79 ± 0.025	0.605TrpGlu: 0.605 ± 0.025	0.554TrpPhe: 0.554 ± 0.021	0.969TrpGly: 0.969 ± 0.025	0.326TrpHis: 0.326 ± 0.016	0.726TrpIle: 0.726 ± 0.024	0.449TrpLys: 0.449 ± 0.018	1.795TrpLeu: 1.795 ± 0.043	0.331TrpMet: 0.331 ± 0.017	0.45TrpAsn: 0.45 ± 0.018	0.708TrpPro: 0.708 ± 0.022	0.615TrpGln: 0.615 ± 0.02	1.381TrpArg: 1.381 ± 0.036	0.947TrpSer: 0.947 ± 0.028	0.924TrpThr: 0.924 ± 0.033	0.826TrpVal: 0.826 ± 0.026	0.239TrpTrp: 0.239 ± 0.014	0.318TrpTyr: 0.318 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.724TyrAla: 2.724 ± 0.044	0.219TyrCys: 0.219 ± 0.013	1.626TyrAsp: 1.626 ± 0.038	1.078TyrGlu: 1.078 ± 0.027	0.808TyrPhe: 0.808 ± 0.026	2.156TyrGly: 2.156 ± 0.042	0.497TyrHis: 0.497 ± 0.021	0.863TyrIle: 0.863 ± 0.025	0.553TyrLys: 0.553 ± 0.024	2.114TyrLeu: 2.114 ± 0.043	0.441TyrMet: 0.441 ± 0.019	0.607TyrAsn: 0.607 ± 0.024	1.077TyrPro: 1.077 ± 0.029	0.721TyrGln: 0.721 ± 0.024	2.051TyrArg: 2.051 ± 0.043	1.162TyrSer: 1.162 ± 0.037	1.054TyrThr: 1.054 ± 0.033	1.534TyrVal: 1.534 ± 0.041	0.376TyrTrp: 0.376 ± 0.019	0.682TyrTyr: 0.682 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4159 proteins (1379132 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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