Amino acid dipepetide frequency for Listeria phage LP-030-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.639AlaAla: 2.639 ± 0.788
0.34AlaCys: 0.34 ± 0.174
3.405AlaAsp: 3.405 ± 0.535
5.192AlaGlu: 5.192 ± 0.661
3.149AlaPhe: 3.149 ± 0.443
3.66AlaGly: 3.66 ± 0.681
0.936AlaHis: 0.936 ± 0.271
4.851AlaIle: 4.851 ± 0.548
5.958AlaLys: 5.958 ± 0.631
4.766AlaLeu: 4.766 ± 0.992
2.213AlaMet: 2.213 ± 0.466
4.171AlaAsn: 4.171 ± 0.645
1.617AlaPro: 1.617 ± 0.393
2.383AlaGln: 2.383 ± 0.568
2.383AlaArg: 2.383 ± 0.436
2.639AlaSer: 2.639 ± 0.536
4.596AlaThr: 4.596 ± 0.608
4.766AlaVal: 4.766 ± 0.73
1.617AlaTrp: 1.617 ± 0.43
1.958AlaTyr: 1.958 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
1.192CysAla: 1.192 ± 0.375
0.17CysCys: 0.17 ± 0.112
0.681CysAsp: 0.681 ± 0.226
0.936CysGlu: 0.936 ± 0.275
0.255CysPhe: 0.255 ± 0.144
1.106CysGly: 1.106 ± 0.409
0.17CysHis: 0.17 ± 0.118
0.085CysIle: 0.085 ± 0.073
0.681CysLys: 0.681 ± 0.282
0.255CysLeu: 0.255 ± 0.174
0.511CysMet: 0.511 ± 0.211
1.192CysAsn: 1.192 ± 0.266
0.255CysPro: 0.255 ± 0.143
0.255CysGln: 0.255 ± 0.156
0.17CysArg: 0.17 ± 0.109
0.426CysSer: 0.426 ± 0.204
0.255CysThr: 0.255 ± 0.154
0.936CysVal: 0.936 ± 0.35
0.0CysTrp: 0.0 ± 0.0
0.426CysTyr: 0.426 ± 0.186
0.0CysXaa: 0.0 ± 0.0
Asp
4.085AspAla: 4.085 ± 0.52
0.851AspCys: 0.851 ± 0.331
3.49AspAsp: 3.49 ± 0.438
5.873AspGlu: 5.873 ± 0.716
2.043AspPhe: 2.043 ± 0.351
4.426AspGly: 4.426 ± 0.518
0.596AspHis: 0.596 ± 0.217
5.107AspIle: 5.107 ± 0.716
5.447AspLys: 5.447 ± 0.578
5.447AspLeu: 5.447 ± 0.757
2.043AspMet: 2.043 ± 0.414
4.511AspAsn: 4.511 ± 0.562
1.106AspPro: 1.106 ± 0.306
0.936AspGln: 0.936 ± 0.305
1.958AspArg: 1.958 ± 0.332
3.319AspSer: 3.319 ± 0.477
2.809AspThr: 2.809 ± 0.562
4.596AspVal: 4.596 ± 0.577
0.851AspTrp: 0.851 ± 0.256
2.979AspTyr: 2.979 ± 0.523
0.0AspXaa: 0.0 ± 0.0
Glu
5.873GluAla: 5.873 ± 0.789
0.681GluCys: 0.681 ± 0.254
4.511GluAsp: 4.511 ± 0.638
6.384GluGlu: 6.384 ± 1.002
4.085GluPhe: 4.085 ± 0.713
4.341GluGly: 4.341 ± 0.7
1.532GluHis: 1.532 ± 0.38
7.064GluIle: 7.064 ± 0.882
6.724GluLys: 6.724 ± 0.541
7.916GluLeu: 7.916 ± 0.783
2.894GluMet: 2.894 ± 0.513
4.851GluAsn: 4.851 ± 0.579
1.447GluPro: 1.447 ± 0.328
3.915GluGln: 3.915 ± 0.506
3.49GluArg: 3.49 ± 0.562
3.915GluSer: 3.915 ± 0.515
4.426GluThr: 4.426 ± 0.493
5.022GluVal: 5.022 ± 0.687
0.936GluTrp: 0.936 ± 0.264
3.575GluTyr: 3.575 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
3.319PheAla: 3.319 ± 0.514
0.681PheCys: 0.681 ± 0.279
2.894PheAsp: 2.894 ± 0.39
3.575PheGlu: 3.575 ± 0.559
1.277PhePhe: 1.277 ± 0.273
1.958PheGly: 1.958 ± 0.354
1.021PheHis: 1.021 ± 0.225
2.894PheIle: 2.894 ± 0.47
3.66PheLys: 3.66 ± 0.545
3.745PheLeu: 3.745 ± 0.539
1.617PheMet: 1.617 ± 0.312
2.383PheAsn: 2.383 ± 0.483
1.277PhePro: 1.277 ± 0.322
1.021PheGln: 1.021 ± 0.233
1.958PheArg: 1.958 ± 0.347
2.809PheSer: 2.809 ± 0.407
3.319PheThr: 3.319 ± 0.511
2.979PheVal: 2.979 ± 0.495
0.511PheTrp: 0.511 ± 0.274
1.362PheTyr: 1.362 ± 0.323
0.0PheXaa: 0.0 ± 0.0
Gly
3.575GlyAla: 3.575 ± 0.714
0.426GlyCys: 0.426 ± 0.146
4.0GlyAsp: 4.0 ± 0.57
3.745GlyGlu: 3.745 ± 0.561
3.319GlyPhe: 3.319 ± 0.431
3.234GlyGly: 3.234 ± 0.466
0.681GlyHis: 0.681 ± 0.222
3.745GlyIle: 3.745 ± 0.696
5.958GlyLys: 5.958 ± 0.634
5.532GlyLeu: 5.532 ± 0.712
1.447GlyMet: 1.447 ± 0.349
2.979GlyAsn: 2.979 ± 0.582
1.021GlyPro: 1.021 ± 0.263
1.787GlyGln: 1.787 ± 0.388
1.958GlyArg: 1.958 ± 0.383
2.979GlySer: 2.979 ± 0.531
2.894GlyThr: 2.894 ± 0.687
3.319GlyVal: 3.319 ± 0.537
0.681GlyTrp: 0.681 ± 0.217
2.213GlyTyr: 2.213 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.22
0.255HisCys: 0.255 ± 0.128
1.106HisAsp: 1.106 ± 0.277
1.532HisGlu: 1.532 ± 0.413
0.511HisPhe: 0.511 ± 0.181
0.426HisGly: 0.426 ± 0.2
0.511HisHis: 0.511 ± 0.199
1.277HisIle: 1.277 ± 0.333
1.106HisLys: 1.106 ± 0.334
1.532HisLeu: 1.532 ± 0.448
0.085HisMet: 0.085 ± 0.081
0.936HisAsn: 0.936 ± 0.347
0.766HisPro: 0.766 ± 0.247
0.511HisGln: 0.511 ± 0.178
0.851HisArg: 0.851 ± 0.251
0.766HisSer: 0.766 ± 0.263
1.021HisThr: 1.021 ± 0.372
1.532HisVal: 1.532 ± 0.408
0.17HisTrp: 0.17 ± 0.111
1.277HisTyr: 1.277 ± 0.335
0.0HisXaa: 0.0 ± 0.0
Ile
5.107IleAla: 5.107 ± 0.715
1.021IleCys: 1.021 ± 0.346
5.532IleAsp: 5.532 ± 0.62
6.213IleGlu: 6.213 ± 0.774
3.405IlePhe: 3.405 ± 0.489
3.49IleGly: 3.49 ± 0.56
1.021IleHis: 1.021 ± 0.358
6.213IleIle: 6.213 ± 0.728
6.639IleLys: 6.639 ± 0.849
3.66IleLeu: 3.66 ± 0.497
0.851IleMet: 0.851 ± 0.297
5.277IleAsn: 5.277 ± 0.693
2.213IlePro: 2.213 ± 0.449
3.149IleGln: 3.149 ± 0.427
2.128IleArg: 2.128 ± 0.396
3.66IleSer: 3.66 ± 0.568
4.085IleThr: 4.085 ± 0.652
4.171IleVal: 4.171 ± 0.59
0.681IleTrp: 0.681 ± 0.232
2.468IleTyr: 2.468 ± 0.49
0.0IleXaa: 0.0 ± 0.0
Lys
5.362LysAla: 5.362 ± 0.57
0.681LysCys: 0.681 ± 0.295
4.426LysAsp: 4.426 ± 0.558
7.15LysGlu: 7.15 ± 0.679
3.49LysPhe: 3.49 ± 0.544
4.171LysGly: 4.171 ± 0.572
1.447LysHis: 1.447 ± 0.372
6.809LysIle: 6.809 ± 0.59
6.894LysLys: 6.894 ± 0.827
7.064LysLeu: 7.064 ± 0.866
3.745LysMet: 3.745 ± 0.46
7.064LysAsn: 7.064 ± 0.761
1.872LysPro: 1.872 ± 0.347
3.575LysGln: 3.575 ± 0.483
3.149LysArg: 3.149 ± 0.608
4.681LysSer: 4.681 ± 0.653
5.873LysThr: 5.873 ± 0.596
5.703LysVal: 5.703 ± 0.611
1.787LysTrp: 1.787 ± 0.398
4.937LysTyr: 4.937 ± 0.662
0.0LysXaa: 0.0 ± 0.0
Leu
4.511LeuAla: 4.511 ± 0.796
1.106LeuCys: 1.106 ± 0.344
6.213LeuAsp: 6.213 ± 0.768
7.575LeuGlu: 7.575 ± 0.756
3.064LeuPhe: 3.064 ± 0.509
3.575LeuGly: 3.575 ± 0.585
1.106LeuHis: 1.106 ± 0.353
4.851LeuIle: 4.851 ± 0.811
8.511LeuLys: 8.511 ± 0.95
6.128LeuLeu: 6.128 ± 0.862
2.213LeuMet: 2.213 ± 0.512
5.617LeuAsn: 5.617 ± 0.683
2.639LeuPro: 2.639 ± 0.48
2.979LeuGln: 2.979 ± 0.598
2.128LeuArg: 2.128 ± 0.474
5.277LeuSer: 5.277 ± 0.679
4.766LeuThr: 4.766 ± 0.612
4.085LeuVal: 4.085 ± 0.462
0.851LeuTrp: 0.851 ± 0.253
3.745LeuTyr: 3.745 ± 0.524
0.0LeuXaa: 0.0 ± 0.0
Met
1.362MetAla: 1.362 ± 0.359
0.17MetCys: 0.17 ± 0.119
1.532MetAsp: 1.532 ± 0.352
2.043MetGlu: 2.043 ± 0.569
1.362MetPhe: 1.362 ± 0.365
1.106MetGly: 1.106 ± 0.264
0.34MetHis: 0.34 ± 0.169
1.362MetIle: 1.362 ± 0.319
3.745MetLys: 3.745 ± 0.566
2.468MetLeu: 2.468 ± 0.426
0.511MetMet: 0.511 ± 0.241
1.958MetAsn: 1.958 ± 0.354
0.851MetPro: 0.851 ± 0.241
1.021MetGln: 1.021 ± 0.321
1.617MetArg: 1.617 ± 0.413
1.192MetSer: 1.192 ± 0.303
2.128MetThr: 2.128 ± 0.345
1.447MetVal: 1.447 ± 0.307
0.17MetTrp: 0.17 ± 0.138
1.532MetTyr: 1.532 ± 0.404
0.0MetXaa: 0.0 ± 0.0
Asn
3.49AsnAla: 3.49 ± 0.457
0.426AsnCys: 0.426 ± 0.214
3.234AsnAsp: 3.234 ± 0.561
6.128AsnGlu: 6.128 ± 1.011
2.468AsnPhe: 2.468 ± 0.474
5.362AsnGly: 5.362 ± 0.591
1.192AsnHis: 1.192 ± 0.296
5.022AsnIle: 5.022 ± 0.646
5.362AsnLys: 5.362 ± 0.646
4.596AsnLeu: 4.596 ± 0.525
1.872AsnMet: 1.872 ± 0.36
3.745AsnAsn: 3.745 ± 0.637
2.468AsnPro: 2.468 ± 0.397
2.043AsnGln: 2.043 ± 0.436
2.128AsnArg: 2.128 ± 0.371
4.171AsnSer: 4.171 ± 0.689
4.256AsnThr: 4.256 ± 0.594
4.0AsnVal: 4.0 ± 0.675
0.936AsnTrp: 0.936 ± 0.261
2.383AsnTyr: 2.383 ± 0.415
0.0AsnXaa: 0.0 ± 0.0
Pro
1.702ProAla: 1.702 ± 0.351
0.17ProCys: 0.17 ± 0.1
1.532ProAsp: 1.532 ± 0.4
2.553ProGlu: 2.553 ± 0.42
1.447ProPhe: 1.447 ± 0.294
1.277ProGly: 1.277 ± 0.292
0.681ProHis: 0.681 ± 0.212
1.787ProIle: 1.787 ± 0.368
1.617ProLys: 1.617 ± 0.36
2.213ProLeu: 2.213 ± 0.474
0.511ProMet: 0.511 ± 0.173
1.021ProAsn: 1.021 ± 0.3
1.106ProPro: 1.106 ± 0.378
0.851ProGln: 0.851 ± 0.253
0.681ProArg: 0.681 ± 0.207
1.532ProSer: 1.532 ± 0.295
1.872ProThr: 1.872 ± 0.35
2.894ProVal: 2.894 ± 0.478
0.0ProTrp: 0.0 ± 0.0
1.192ProTyr: 1.192 ± 0.292
0.0ProXaa: 0.0 ± 0.0
Gln
2.128GlnAla: 2.128 ± 0.358
0.255GlnCys: 0.255 ± 0.142
1.872GlnAsp: 1.872 ± 0.374
2.043GlnGlu: 2.043 ± 0.489
2.043GlnPhe: 2.043 ± 0.473
1.702GlnGly: 1.702 ± 0.342
0.936GlnHis: 0.936 ± 0.356
2.128GlnIle: 2.128 ± 0.335
2.809GlnLys: 2.809 ± 0.534
3.234GlnLeu: 3.234 ± 0.49
0.681GlnMet: 0.681 ± 0.276
1.958GlnAsn: 1.958 ± 0.455
0.851GlnPro: 0.851 ± 0.224
2.213GlnGln: 2.213 ± 0.586
1.447GlnArg: 1.447 ± 0.35
2.979GlnSer: 2.979 ± 0.498
1.617GlnThr: 1.617 ± 0.258
2.128GlnVal: 2.128 ± 0.342
0.34GlnTrp: 0.34 ± 0.15
1.617GlnTyr: 1.617 ± 0.391
0.0GlnXaa: 0.0 ± 0.0
Arg
1.532ArgAla: 1.532 ± 0.385
0.17ArgCys: 0.17 ± 0.122
2.298ArgAsp: 2.298 ± 0.473
2.298ArgGlu: 2.298 ± 0.343
1.702ArgPhe: 1.702 ± 0.486
1.702ArgGly: 1.702 ± 0.464
1.192ArgHis: 1.192 ± 0.326
2.468ArgIle: 2.468 ± 0.579
3.66ArgLys: 3.66 ± 0.636
3.745ArgLeu: 3.745 ± 0.508
1.532ArgMet: 1.532 ± 0.34
2.383ArgAsn: 2.383 ± 0.502
0.766ArgPro: 0.766 ± 0.279
1.447ArgGln: 1.447 ± 0.347
0.851ArgArg: 0.851 ± 0.242
1.787ArgSer: 1.787 ± 0.436
1.362ArgThr: 1.362 ± 0.304
1.702ArgVal: 1.702 ± 0.349
0.511ArgTrp: 0.511 ± 0.221
1.872ArgTyr: 1.872 ± 0.364
0.0ArgXaa: 0.0 ± 0.0
Ser
2.639SerAla: 2.639 ± 0.757
0.511SerCys: 0.511 ± 0.226
3.915SerAsp: 3.915 ± 0.638
5.873SerGlu: 5.873 ± 0.634
2.468SerPhe: 2.468 ± 0.437
3.405SerGly: 3.405 ± 0.432
1.021SerHis: 1.021 ± 0.33
4.766SerIle: 4.766 ± 0.839
5.362SerLys: 5.362 ± 0.659
4.426SerLeu: 4.426 ± 0.744
1.106SerMet: 1.106 ± 0.447
3.405SerAsn: 3.405 ± 0.436
1.021SerPro: 1.021 ± 0.306
1.362SerGln: 1.362 ± 0.347
2.128SerArg: 2.128 ± 0.419
4.0SerSer: 4.0 ± 0.634
3.405SerThr: 3.405 ± 0.532
3.575SerVal: 3.575 ± 0.487
0.936SerTrp: 0.936 ± 0.279
1.872SerTyr: 1.872 ± 0.485
0.0SerXaa: 0.0 ± 0.0
Thr
5.617ThrAla: 5.617 ± 0.848
0.511ThrCys: 0.511 ± 0.261
3.915ThrAsp: 3.915 ± 0.638
4.511ThrGlu: 4.511 ± 0.562
1.872ThrPhe: 1.872 ± 0.472
4.171ThrGly: 4.171 ± 0.726
0.17ThrHis: 0.17 ± 0.109
2.894ThrIle: 2.894 ± 0.415
5.532ThrLys: 5.532 ± 0.583
5.447ThrLeu: 5.447 ± 0.572
0.851ThrMet: 0.851 ± 0.23
3.405ThrAsn: 3.405 ± 0.575
2.043ThrPro: 2.043 ± 0.473
1.447ThrGln: 1.447 ± 0.293
1.362ThrArg: 1.362 ± 0.307
4.085ThrSer: 4.085 ± 0.463
2.639ThrThr: 2.639 ± 0.444
4.085ThrVal: 4.085 ± 0.571
0.681ThrTrp: 0.681 ± 0.236
1.532ThrTyr: 1.532 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
4.937ValAla: 4.937 ± 0.676
0.511ValCys: 0.511 ± 0.196
4.596ValAsp: 4.596 ± 0.624
6.213ValGlu: 6.213 ± 0.843
2.979ValPhe: 2.979 ± 0.476
3.66ValGly: 3.66 ± 0.594
1.106ValHis: 1.106 ± 0.339
3.66ValIle: 3.66 ± 0.406
4.937ValLys: 4.937 ± 0.601
4.0ValLeu: 4.0 ± 0.639
1.617ValMet: 1.617 ± 0.361
4.596ValAsn: 4.596 ± 0.656
2.043ValPro: 2.043 ± 0.351
1.958ValGln: 1.958 ± 0.464
2.979ValArg: 2.979 ± 0.474
3.66ValSer: 3.66 ± 0.66
3.234ValThr: 3.234 ± 0.517
2.724ValVal: 2.724 ± 0.486
1.021ValTrp: 1.021 ± 0.301
2.383ValTyr: 2.383 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
1.192TrpAla: 1.192 ± 0.335
0.426TrpCys: 0.426 ± 0.177
1.021TrpAsp: 1.021 ± 0.287
0.596TrpGlu: 0.596 ± 0.314
0.511TrpPhe: 0.511 ± 0.224
0.596TrpGly: 0.596 ± 0.193
0.596TrpHis: 0.596 ± 0.221
1.106TrpIle: 1.106 ± 0.322
0.851TrpLys: 0.851 ± 0.276
1.447TrpLeu: 1.447 ± 0.315
0.511TrpMet: 0.511 ± 0.194
0.851TrpAsn: 0.851 ± 0.32
0.0TrpPro: 0.0 ± 0.0
0.511TrpGln: 0.511 ± 0.24
0.34TrpArg: 0.34 ± 0.165
1.106TrpSer: 1.106 ± 0.289
0.511TrpThr: 0.511 ± 0.173
0.17TrpVal: 0.17 ± 0.119
0.17TrpTrp: 0.17 ± 0.107
0.936TrpTyr: 0.936 ± 0.423
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.298TyrAla: 2.298 ± 0.381
0.596TyrCys: 0.596 ± 0.237
2.298TyrAsp: 2.298 ± 0.386
3.149TyrGlu: 3.149 ± 0.552
2.809TyrPhe: 2.809 ± 0.512
2.128TyrGly: 2.128 ± 0.432
0.596TyrHis: 0.596 ± 0.207
2.979TyrIle: 2.979 ± 0.42
4.426TyrLys: 4.426 ± 0.6
3.319TyrLeu: 3.319 ± 0.494
1.021TyrMet: 1.021 ± 0.241
2.979TyrAsn: 2.979 ± 0.629
1.277TyrPro: 1.277 ± 0.407
1.617TyrGln: 1.617 ± 0.39
1.277TyrArg: 1.277 ± 0.305
2.213TyrSer: 2.213 ± 0.452
1.702TyrThr: 1.702 ± 0.385
2.979TyrVal: 2.979 ± 0.564
0.596TyrTrp: 0.596 ± 0.215
2.043TyrTyr: 2.043 ± 0.522
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (11750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski