Amino acid dipepetide frequency for Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.873AlaAla: 6.873 ± 0.692
1.635AlaCys: 1.635 ± 0.193
3.27AlaAsp: 3.27 ± 0.304
3.547AlaGlu: 3.547 ± 0.447
3.437AlaPhe: 3.437 ± 0.278
4.019AlaGly: 4.019 ± 0.384
1.968AlaHis: 1.968 ± 0.214
4.185AlaIle: 4.185 ± 0.406
2.134AlaLys: 2.134 ± 0.189
8.48AlaLeu: 8.48 ± 0.583
1.635AlaMet: 1.635 ± 0.209
2.716AlaAsn: 2.716 ± 0.263
3.298AlaPro: 3.298 ± 0.325
1.94AlaGln: 1.94 ± 0.194
5.016AlaArg: 5.016 ± 0.601
5.155AlaSer: 5.155 ± 0.361
5.155AlaThr: 5.155 ± 0.447
6.125AlaVal: 6.125 ± 0.54
0.776AlaTrp: 0.776 ± 0.176
2.938AlaTyr: 2.938 ± 0.294
0.0AlaXaa: 0.0 ± 0.0
Cys
1.552CysAla: 1.552 ± 0.261
0.443CysCys: 0.443 ± 0.115
0.97CysAsp: 0.97 ± 0.197
1.081CysGlu: 1.081 ± 0.136
1.136CysPhe: 1.136 ± 0.182
1.386CysGly: 1.386 ± 0.215
0.443CysHis: 0.443 ± 0.135
1.663CysIle: 1.663 ± 0.241
0.831CysLys: 0.831 ± 0.143
2.3CysLeu: 2.3 ± 0.275
0.554CysMet: 0.554 ± 0.123
0.942CysAsn: 0.942 ± 0.174
1.025CysPro: 1.025 ± 0.188
0.748CysGln: 0.748 ± 0.158
1.109CysArg: 1.109 ± 0.171
1.386CysSer: 1.386 ± 0.208
1.303CysThr: 1.303 ± 0.191
1.441CysVal: 1.441 ± 0.189
0.277CysTrp: 0.277 ± 0.101
0.859CysTyr: 0.859 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
3.935AspAla: 3.935 ± 0.398
1.053AspCys: 1.053 ± 0.185
3.298AspAsp: 3.298 ± 0.462
3.104AspGlu: 3.104 ± 0.288
1.801AspPhe: 1.801 ± 0.235
3.353AspGly: 3.353 ± 0.402
1.219AspHis: 1.219 ± 0.176
3.326AspIle: 3.326 ± 0.369
1.33AspLys: 1.33 ± 0.203
5.072AspLeu: 5.072 ± 0.323
1.358AspMet: 1.358 ± 0.206
1.774AspAsn: 1.774 ± 0.219
3.326AspPro: 3.326 ± 0.381
1.497AspGln: 1.497 ± 0.186
3.049AspArg: 3.049 ± 0.407
3.88AspSer: 3.88 ± 0.4
3.797AspThr: 3.797 ± 0.307
4.573AspVal: 4.573 ± 0.33
0.554AspTrp: 0.554 ± 0.12
1.247AspTyr: 1.247 ± 0.16
0.0AspXaa: 0.0 ± 0.0
Glu
4.988GluAla: 4.988 ± 0.442
0.998GluCys: 0.998 ± 0.191
3.243GluAsp: 3.243 ± 0.394
3.104GluGlu: 3.104 ± 0.404
1.358GluPhe: 1.358 ± 0.19
2.827GluGly: 2.827 ± 0.387
1.58GluHis: 1.58 ± 0.18
2.55GluIle: 2.55 ± 0.23
1.829GluLys: 1.829 ± 0.196
5.293GluLeu: 5.293 ± 0.362
0.887GluMet: 0.887 ± 0.161
2.411GluAsn: 2.411 ± 0.318
2.356GluPro: 2.356 ± 0.267
1.33GluGln: 1.33 ± 0.176
3.464GluArg: 3.464 ± 0.253
3.464GluSer: 3.464 ± 0.397
4.019GluThr: 4.019 ± 0.317
2.91GluVal: 2.91 ± 0.208
0.388GluTrp: 0.388 ± 0.085
1.912GluTyr: 1.912 ± 0.213
0.0GluXaa: 0.0 ± 0.0
Phe
2.799PheAla: 2.799 ± 0.224
0.97PheCys: 0.97 ± 0.167
2.522PheAsp: 2.522 ± 0.268
1.718PheGlu: 1.718 ± 0.208
2.162PhePhe: 2.162 ± 0.337
2.688PheGly: 2.688 ± 0.293
0.831PheHis: 0.831 ± 0.163
2.799PheIle: 2.799 ± 0.275
1.995PheLys: 1.995 ± 0.204
3.52PheLeu: 3.52 ± 0.321
1.053PheMet: 1.053 ± 0.162
1.995PheAsn: 1.995 ± 0.214
2.328PhePro: 2.328 ± 0.268
1.109PheGln: 1.109 ± 0.217
1.801PheArg: 1.801 ± 0.221
3.159PheSer: 3.159 ± 0.294
3.132PheThr: 3.132 ± 0.28
2.938PheVal: 2.938 ± 0.33
0.471PheTrp: 0.471 ± 0.11
1.58PheTyr: 1.58 ± 0.189
0.0PheXaa: 0.0 ± 0.0
Gly
3.769GlyAla: 3.769 ± 0.488
1.275GlyCys: 1.275 ± 0.175
3.492GlyAsp: 3.492 ± 0.358
3.908GlyGlu: 3.908 ± 0.47
3.243GlyPhe: 3.243 ± 0.267
3.797GlyGly: 3.797 ± 0.373
1.691GlyHis: 1.691 ± 0.178
3.603GlyIle: 3.603 ± 0.349
1.968GlyLys: 1.968 ± 0.261
6.291GlyLeu: 6.291 ± 0.375
1.247GlyMet: 1.247 ± 0.192
2.189GlyAsn: 2.189 ± 0.266
3.104GlyPro: 3.104 ± 0.415
2.162GlyGln: 2.162 ± 0.296
3.52GlyArg: 3.52 ± 0.402
4.213GlySer: 4.213 ± 0.38
3.908GlyThr: 3.908 ± 0.339
4.379GlyVal: 4.379 ± 0.344
0.61GlyTrp: 0.61 ± 0.107
1.94GlyTyr: 1.94 ± 0.248
0.0GlyXaa: 0.0 ± 0.0
His
2.328HisAla: 2.328 ± 0.328
0.333HisCys: 0.333 ± 0.093
0.942HisAsp: 0.942 ± 0.158
1.192HisGlu: 1.192 ± 0.164
1.136HisPhe: 1.136 ± 0.159
1.774HisGly: 1.774 ± 0.204
1.109HisHis: 1.109 ± 0.215
1.413HisIle: 1.413 ± 0.243
0.998HisLys: 0.998 ± 0.167
2.356HisLeu: 2.356 ± 0.286
0.721HisMet: 0.721 ± 0.138
0.998HisAsn: 0.998 ± 0.156
1.968HisPro: 1.968 ± 0.269
0.831HisGln: 0.831 ± 0.138
1.635HisArg: 1.635 ± 0.18
1.663HisSer: 1.663 ± 0.233
1.857HisThr: 1.857 ± 0.253
2.273HisVal: 2.273 ± 0.231
0.249HisTrp: 0.249 ± 0.071
0.61HisTyr: 0.61 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
3.825IleAla: 3.825 ± 0.32
1.441IleCys: 1.441 ± 0.234
2.882IleAsp: 2.882 ± 0.306
2.55IleGlu: 2.55 ± 0.313
2.189IlePhe: 2.189 ± 0.259
2.855IleGly: 2.855 ± 0.348
1.552IleHis: 1.552 ± 0.204
2.993IleIle: 2.993 ± 0.286
2.217IleLys: 2.217 ± 0.291
4.988IleLeu: 4.988 ± 0.349
1.219IleMet: 1.219 ± 0.188
2.799IleAsn: 2.799 ± 0.286
4.185IlePro: 4.185 ± 0.335
2.744IleGln: 2.744 ± 0.319
3.769IleArg: 3.769 ± 0.273
4.296IleSer: 4.296 ± 0.363
4.545IleThr: 4.545 ± 0.295
3.298IleVal: 3.298 ± 0.285
0.554IleTrp: 0.554 ± 0.14
2.051IleTyr: 2.051 ± 0.226
0.0IleXaa: 0.0 ± 0.0
Lys
2.356LysAla: 2.356 ± 0.266
0.61LysCys: 0.61 ± 0.125
1.801LysAsp: 1.801 ± 0.207
1.441LysGlu: 1.441 ± 0.188
1.497LysPhe: 1.497 ± 0.227
1.497LysGly: 1.497 ± 0.321
1.053LysHis: 1.053 ± 0.191
1.635LysIle: 1.635 ± 0.201
1.358LysLys: 1.358 ± 0.222
3.52LysLeu: 3.52 ± 0.494
0.859LysMet: 0.859 ± 0.17
1.774LysAsn: 1.774 ± 0.245
2.356LysPro: 2.356 ± 0.266
1.497LysGln: 1.497 ± 0.182
2.91LysArg: 2.91 ± 0.254
2.494LysSer: 2.494 ± 0.273
3.575LysThr: 3.575 ± 0.293
1.885LysVal: 1.885 ± 0.232
0.249LysTrp: 0.249 ± 0.085
1.275LysTyr: 1.275 ± 0.204
0.0LysXaa: 0.0 ± 0.0
Leu
6.956LeuAla: 6.956 ± 0.426
2.55LeuCys: 2.55 ± 0.229
4.462LeuAsp: 4.462 ± 0.286
4.711LeuGlu: 4.711 ± 0.323
4.323LeuPhe: 4.323 ± 0.389
5.099LeuGly: 5.099 ± 0.369
2.494LeuHis: 2.494 ± 0.239
5.737LeuIle: 5.737 ± 0.413
4.323LeuLys: 4.323 ± 0.372
10.919LeuLeu: 10.919 ± 0.6
2.328LeuMet: 2.328 ± 0.296
4.351LeuAsn: 4.351 ± 0.358
5.155LeuPro: 5.155 ± 0.45
4.213LeuGln: 4.213 ± 0.323
6.042LeuArg: 6.042 ± 0.412
7.372LeuSer: 7.372 ± 0.533
6.457LeuThr: 6.457 ± 0.387
4.961LeuVal: 4.961 ± 0.282
1.025LeuTrp: 1.025 ± 0.171
3.603LeuTyr: 3.603 ± 0.316
0.0LeuXaa: 0.0 ± 0.0
Met
1.968MetAla: 1.968 ± 0.227
0.333MetCys: 0.333 ± 0.099
1.607MetAsp: 1.607 ± 0.198
1.358MetGlu: 1.358 ± 0.198
1.164MetPhe: 1.164 ± 0.158
1.497MetGly: 1.497 ± 0.241
0.527MetHis: 0.527 ± 0.123
0.748MetIle: 0.748 ± 0.142
0.499MetLys: 0.499 ± 0.122
2.051MetLeu: 2.051 ± 0.268
0.443MetMet: 0.443 ± 0.11
0.831MetAsn: 0.831 ± 0.153
0.942MetPro: 0.942 ± 0.18
1.109MetGln: 1.109 ± 0.165
1.247MetArg: 1.247 ± 0.171
1.663MetSer: 1.663 ± 0.278
0.998MetThr: 0.998 ± 0.188
1.109MetVal: 1.109 ± 0.17
0.222MetTrp: 0.222 ± 0.071
0.97MetTyr: 0.97 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
2.965AsnAla: 2.965 ± 0.273
0.804AsnCys: 0.804 ± 0.173
1.829AsnAsp: 1.829 ± 0.209
1.718AsnGlu: 1.718 ± 0.247
1.829AsnPhe: 1.829 ± 0.258
2.661AsnGly: 2.661 ± 0.238
0.998AsnHis: 0.998 ± 0.184
2.467AsnIle: 2.467 ± 0.312
1.358AsnLys: 1.358 ± 0.194
4.074AsnLeu: 4.074 ± 0.394
0.748AsnMet: 0.748 ± 0.141
1.829AsnAsn: 1.829 ± 0.292
3.021AsnPro: 3.021 ± 0.359
1.219AsnGln: 1.219 ± 0.203
2.688AsnArg: 2.688 ± 0.265
2.965AsnSer: 2.965 ± 0.271
4.102AsnThr: 4.102 ± 0.328
3.132AsnVal: 3.132 ± 0.334
0.499AsnTrp: 0.499 ± 0.11
1.081AsnTyr: 1.081 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
4.129ProAla: 4.129 ± 0.506
1.136ProCys: 1.136 ± 0.184
3.381ProAsp: 3.381 ± 0.441
3.409ProGlu: 3.409 ± 0.268
1.912ProPhe: 1.912 ± 0.199
4.046ProGly: 4.046 ± 0.548
1.441ProHis: 1.441 ± 0.22
3.298ProIle: 3.298 ± 0.212
1.635ProLys: 1.635 ± 0.251
4.684ProLeu: 4.684 ± 0.364
0.831ProMet: 0.831 ± 0.15
2.55ProAsn: 2.55 ± 0.257
5.016ProPro: 5.016 ± 0.504
2.189ProGln: 2.189 ± 0.249
3.464ProArg: 3.464 ± 0.393
4.711ProSer: 4.711 ± 0.44
4.933ProThr: 4.933 ± 0.381
3.935ProVal: 3.935 ± 0.479
0.554ProTrp: 0.554 ± 0.101
1.607ProTyr: 1.607 ± 0.232
0.0ProXaa: 0.0 ± 0.0
Gln
2.494GlnAla: 2.494 ± 0.293
0.776GlnCys: 0.776 ± 0.15
1.58GlnAsp: 1.58 ± 0.194
1.552GlnGlu: 1.552 ± 0.181
1.58GlnPhe: 1.58 ± 0.237
1.635GlnGly: 1.635 ± 0.205
1.053GlnHis: 1.053 ± 0.158
1.691GlnIle: 1.691 ± 0.258
1.413GlnLys: 1.413 ± 0.235
3.492GlnLeu: 3.492 ± 0.312
0.998GlnMet: 0.998 ± 0.192
1.469GlnAsn: 1.469 ± 0.204
2.633GlnPro: 2.633 ± 0.358
1.691GlnGln: 1.691 ± 0.257
2.744GlnArg: 2.744 ± 0.336
2.411GlnSer: 2.411 ± 0.284
2.827GlnThr: 2.827 ± 0.261
1.691GlnVal: 1.691 ± 0.211
0.388GlnTrp: 0.388 ± 0.104
1.413GlnTyr: 1.413 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
4.601ArgAla: 4.601 ± 0.366
1.552ArgCys: 1.552 ± 0.228
3.852ArgAsp: 3.852 ± 0.362
3.187ArgGlu: 3.187 ± 0.356
2.356ArgPhe: 2.356 ± 0.349
4.296ArgGly: 4.296 ± 0.374
1.857ArgHis: 1.857 ± 0.22
3.575ArgIle: 3.575 ± 0.35
2.328ArgLys: 2.328 ± 0.271
6.236ArgLeu: 6.236 ± 0.46
1.053ArgMet: 1.053 ± 0.188
2.106ArgAsn: 2.106 ± 0.253
3.159ArgPro: 3.159 ± 0.283
2.439ArgGln: 2.439 ± 0.282
5.349ArgArg: 5.349 ± 0.418
3.908ArgSer: 3.908 ± 0.443
3.935ArgThr: 3.935 ± 0.318
5.404ArgVal: 5.404 ± 0.342
0.582ArgTrp: 0.582 ± 0.151
2.134ArgTyr: 2.134 ± 0.215
0.0ArgXaa: 0.0 ± 0.0
Ser
4.628SerAla: 4.628 ± 0.4
1.386SerCys: 1.386 ± 0.214
3.575SerAsp: 3.575 ± 0.325
4.046SerGlu: 4.046 ± 0.297
2.494SerPhe: 2.494 ± 0.214
5.072SerGly: 5.072 ± 0.352
2.106SerHis: 2.106 ± 0.276
4.517SerIle: 4.517 ± 0.356
2.661SerLys: 2.661 ± 0.305
6.069SerLeu: 6.069 ± 0.353
1.386SerMet: 1.386 ± 0.179
3.132SerAsn: 3.132 ± 0.255
4.933SerPro: 4.933 ± 0.42
2.134SerGln: 2.134 ± 0.235
4.407SerArg: 4.407 ± 0.372
6.624SerSer: 6.624 ± 0.546
5.626SerThr: 5.626 ± 0.358
5.681SerVal: 5.681 ± 0.413
0.804SerTrp: 0.804 ± 0.168
2.134SerTyr: 2.134 ± 0.242
0.0SerXaa: 0.0 ± 0.0
Thr
5.709ThrAla: 5.709 ± 0.358
1.358ThrCys: 1.358 ± 0.248
3.741ThrAsp: 3.741 ± 0.326
3.741ThrGlu: 3.741 ± 0.253
2.633ThrPhe: 2.633 ± 0.3
5.404ThrGly: 5.404 ± 0.351
1.885ThrHis: 1.885 ± 0.214
3.575ThrIle: 3.575 ± 0.353
2.3ThrLys: 2.3 ± 0.251
7.233ThrLeu: 7.233 ± 0.622
1.219ThrMet: 1.219 ± 0.187
2.55ThrAsn: 2.55 ± 0.235
4.878ThrPro: 4.878 ± 0.338
3.049ThrGln: 3.049 ± 0.267
5.044ThrArg: 5.044 ± 0.328
6.014ThrSer: 6.014 ± 0.546
5.543ThrThr: 5.543 ± 0.434
4.628ThrVal: 4.628 ± 0.355
0.998ThrTrp: 0.998 ± 0.182
2.716ThrTyr: 2.716 ± 0.356
0.0ThrXaa: 0.0 ± 0.0
Val
4.517ValAla: 4.517 ± 0.441
1.94ValCys: 1.94 ± 0.214
3.991ValAsp: 3.991 ± 0.337
3.243ValGlu: 3.243 ± 0.354
3.326ValPhe: 3.326 ± 0.356
3.52ValGly: 3.52 ± 0.279
1.33ValHis: 1.33 ± 0.168
3.935ValIle: 3.935 ± 0.368
2.439ValLys: 2.439 ± 0.231
6.845ValLeu: 6.845 ± 0.407
1.441ValMet: 1.441 ± 0.223
3.104ValAsn: 3.104 ± 0.294
3.326ValPro: 3.326 ± 0.352
2.522ValGln: 2.522 ± 0.284
4.102ValArg: 4.102 ± 0.319
5.487ValSer: 5.487 ± 0.402
4.795ValThr: 4.795 ± 0.339
5.127ValVal: 5.127 ± 0.441
0.721ValTrp: 0.721 ± 0.153
2.91ValTyr: 2.91 ± 0.312
0.0ValXaa: 0.0 ± 0.0
Trp
0.859TrpAla: 0.859 ± 0.142
0.249TrpCys: 0.249 ± 0.078
0.499TrpAsp: 0.499 ± 0.119
0.554TrpGlu: 0.554 ± 0.162
0.61TrpPhe: 0.61 ± 0.136
0.859TrpGly: 0.859 ± 0.169
0.305TrpHis: 0.305 ± 0.084
0.471TrpIle: 0.471 ± 0.098
0.527TrpLys: 0.527 ± 0.111
0.776TrpLeu: 0.776 ± 0.139
0.305TrpMet: 0.305 ± 0.092
0.637TrpAsn: 0.637 ± 0.155
0.554TrpPro: 0.554 ± 0.144
0.249TrpGln: 0.249 ± 0.083
0.61TrpArg: 0.61 ± 0.16
0.554TrpSer: 0.554 ± 0.124
1.053TrpThr: 1.053 ± 0.178
0.527TrpVal: 0.527 ± 0.118
0.139TrpTrp: 0.139 ± 0.057
0.249TrpTyr: 0.249 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.049TyrAla: 3.049 ± 0.296
0.637TyrCys: 0.637 ± 0.128
1.607TyrAsp: 1.607 ± 0.216
1.746TyrGlu: 1.746 ± 0.215
1.386TyrPhe: 1.386 ± 0.181
2.023TyrGly: 2.023 ± 0.247
0.942TyrHis: 0.942 ± 0.153
2.771TyrIle: 2.771 ± 0.319
1.497TyrLys: 1.497 ± 0.222
2.882TyrLeu: 2.882 ± 0.331
0.97TyrMet: 0.97 ± 0.149
1.829TyrAsn: 1.829 ± 0.197
1.303TyrPro: 1.303 ± 0.214
0.859TyrGln: 0.859 ± 0.137
1.94TyrArg: 1.94 ± 0.276
1.995TyrSer: 1.995 ± 0.223
2.661TyrThr: 2.661 ± 0.334
2.605TyrVal: 2.605 ± 0.24
0.527TyrTrp: 0.527 ± 0.114
1.219TyrTyr: 1.219 ± 0.168
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (36084 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski