Amino acid dipepetide frequency for Levilactobacillus suantsaii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.997AlaAla: 9.997 ± 0.218
0.362AlaCys: 0.362 ± 0.024
6.072AlaAsp: 6.072 ± 0.116
4.308AlaGlu: 4.308 ± 0.099
3.372AlaPhe: 3.372 ± 0.086
6.835AlaGly: 6.835 ± 0.118
2.264AlaHis: 2.264 ± 0.061
5.745AlaIle: 5.745 ± 0.092
5.569AlaLys: 5.569 ± 0.109
9.355AlaLeu: 9.355 ± 0.128
2.372AlaMet: 2.372 ± 0.058
3.914AlaAsn: 3.914 ± 0.085
3.167AlaPro: 3.167 ± 0.077
5.213AlaGln: 5.213 ± 0.128
3.429AlaArg: 3.429 ± 0.076
5.077AlaSer: 5.077 ± 0.258
7.359AlaThr: 7.359 ± 0.162
6.871AlaVal: 6.871 ± 0.114
0.912AlaTrp: 0.912 ± 0.042
2.943AlaTyr: 2.943 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.367CysAla: 0.367 ± 0.024
0.032CysCys: 0.032 ± 0.006
0.255CysAsp: 0.255 ± 0.02
0.165CysGlu: 0.165 ± 0.016
0.191CysPhe: 0.191 ± 0.017
0.499CysGly: 0.499 ± 0.03
0.168CysHis: 0.168 ± 0.019
0.195CysIle: 0.195 ± 0.018
0.109CysLys: 0.109 ± 0.014
0.523CysLeu: 0.523 ± 0.03
0.077CysMet: 0.077 ± 0.011
0.123CysAsn: 0.123 ± 0.014
0.223CysPro: 0.223 ± 0.021
0.221CysGln: 0.221 ± 0.018
0.194CysArg: 0.194 ± 0.019
0.25CysSer: 0.25 ± 0.022
0.241CysThr: 0.241 ± 0.02
0.288CysVal: 0.288 ± 0.024
0.071CysTrp: 0.071 ± 0.01
0.186CysTyr: 0.186 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.898AspAla: 4.898 ± 0.12
0.224AspCys: 0.224 ± 0.018
3.864AspAsp: 3.864 ± 0.096
3.234AspGlu: 3.234 ± 0.088
2.631AspPhe: 2.631 ± 0.076
3.581AspGly: 3.581 ± 0.091
1.828AspHis: 1.828 ± 0.065
2.966AspIle: 2.966 ± 0.075
2.749AspLys: 2.749 ± 0.084
6.287AspLeu: 6.287 ± 0.112
1.446AspMet: 1.446 ± 0.047
2.123AspAsn: 2.123 ± 0.07
2.629AspPro: 2.629 ± 0.068
3.905AspGln: 3.905 ± 0.099
2.796AspArg: 2.796 ± 0.066
2.707AspSer: 2.707 ± 0.088
3.181AspThr: 3.181 ± 0.089
4.111AspVal: 4.111 ± 0.094
0.855AspTrp: 0.855 ± 0.037
2.488AspTyr: 2.488 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
3.993GluAla: 3.993 ± 0.094
0.149GluCys: 0.149 ± 0.018
2.367GluAsp: 2.367 ± 0.071
2.044GluGlu: 2.044 ± 0.07
1.668GluPhe: 1.668 ± 0.054
2.185GluGly: 2.185 ± 0.061
1.059GluHis: 1.059 ± 0.038
2.846GluIle: 2.846 ± 0.077
2.56GluLys: 2.56 ± 0.073
4.749GluLeu: 4.749 ± 0.102
1.273GluMet: 1.273 ± 0.046
1.969GluAsn: 1.969 ± 0.053
1.606GluPro: 1.606 ± 0.053
2.276GluGln: 2.276 ± 0.066
2.425GluArg: 2.425 ± 0.065
2.255GluSer: 2.255 ± 0.064
2.987GluThr: 2.987 ± 0.069
2.935GluVal: 2.935 ± 0.083
0.503GluTrp: 0.503 ± 0.028
1.252GluTyr: 1.252 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.298PheAla: 3.298 ± 0.072
0.253PheCys: 0.253 ± 0.021
2.582PheAsp: 2.582 ± 0.07
1.606PheGlu: 1.606 ± 0.047
1.729PhePhe: 1.729 ± 0.055
3.051PheGly: 3.051 ± 0.078
0.883PheHis: 0.883 ± 0.036
2.329PheIle: 2.329 ± 0.069
1.962PheLys: 1.962 ± 0.06
3.588PheLeu: 3.588 ± 0.1
0.923PheMet: 0.923 ± 0.041
1.858PheAsn: 1.858 ± 0.059
1.502PhePro: 1.502 ± 0.049
1.581PheGln: 1.581 ± 0.044
1.441PheArg: 1.441 ± 0.046
2.497PheSer: 2.497 ± 0.07
2.641PheThr: 2.641 ± 0.058
2.71PheVal: 2.71 ± 0.075
0.638PheTrp: 0.638 ± 0.034
1.494PheTyr: 1.494 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.465GlyAla: 5.465 ± 0.105
0.402GlyCys: 0.402 ± 0.023
3.778GlyAsp: 3.778 ± 0.091
3.058GlyGlu: 3.058 ± 0.07
2.8GlyPhe: 2.8 ± 0.064
4.63GlyGly: 4.63 ± 0.114
1.905GlyHis: 1.905 ± 0.052
4.94GlyIle: 4.94 ± 0.112
3.931GlyLys: 3.931 ± 0.072
7.344GlyLeu: 7.344 ± 0.113
1.899GlyMet: 1.899 ± 0.073
2.569GlyAsn: 2.569 ± 0.059
1.908GlyPro: 1.908 ± 0.049
3.637GlyGln: 3.637 ± 0.084
2.897GlyArg: 2.897 ± 0.072
4.036GlySer: 4.036 ± 0.085
4.893GlyThr: 4.893 ± 0.096
5.358GlyVal: 5.358 ± 0.109
0.97GlyTrp: 0.97 ± 0.04
2.928GlyTyr: 2.928 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
2.009HisAla: 2.009 ± 0.059
0.112HisCys: 0.112 ± 0.012
1.668HisAsp: 1.668 ± 0.053
1.2HisGlu: 1.2 ± 0.05
1.079HisPhe: 1.079 ± 0.041
1.787HisGly: 1.787 ± 0.052
0.99HisHis: 0.99 ± 0.045
1.079HisIle: 1.079 ± 0.043
0.908HisLys: 0.908 ± 0.04
2.729HisLeu: 2.729 ± 0.079
0.529HisMet: 0.529 ± 0.029
0.915HisAsn: 0.915 ± 0.038
1.393HisPro: 1.393 ± 0.05
1.646HisGln: 1.646 ± 0.05
1.523HisArg: 1.523 ± 0.059
1.185HisSer: 1.185 ± 0.038
1.271HisThr: 1.271 ± 0.046
1.847HisVal: 1.847 ± 0.055
0.433HisTrp: 0.433 ± 0.026
1.15HisTyr: 1.15 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.462IleAla: 5.462 ± 0.093
0.362IleCys: 0.362 ± 0.024
3.707IleAsp: 3.707 ± 0.078
2.576IleGlu: 2.576 ± 0.074
2.346IlePhe: 2.346 ± 0.071
4.59IleGly: 4.59 ± 0.103
1.323IleHis: 1.323 ± 0.045
3.557IleIle: 3.557 ± 0.1
2.86IleLys: 2.86 ± 0.085
5.759IleLeu: 5.759 ± 0.131
1.45IleMet: 1.45 ± 0.05
2.417IleAsn: 2.417 ± 0.059
2.423IlePro: 2.423 ± 0.056
2.382IleGln: 2.382 ± 0.06
2.503IleArg: 2.503 ± 0.065
3.466IleSer: 3.466 ± 0.075
4.084IleThr: 4.084 ± 0.084
4.445IleVal: 4.445 ± 0.091
0.606IleTrp: 0.606 ± 0.035
1.799IleTyr: 1.799 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.574LysAla: 4.574 ± 0.1
0.135LysCys: 0.135 ± 0.012
2.769LysAsp: 2.769 ± 0.079
2.167LysGlu: 2.167 ± 0.061
1.625LysPhe: 1.625 ± 0.057
2.794LysGly: 2.794 ± 0.077
1.215LysHis: 1.215 ± 0.039
2.997LysIle: 2.997 ± 0.076
3.405LysLys: 3.405 ± 0.099
4.969LysLeu: 4.969 ± 0.1
1.628LysMet: 1.628 ± 0.049
2.293LysAsn: 2.293 ± 0.075
2.012LysPro: 2.012 ± 0.059
2.987LysGln: 2.987 ± 0.077
3.041LysArg: 3.041 ± 0.067
2.761LysSer: 2.761 ± 0.08
3.998LysThr: 3.998 ± 0.085
3.595LysVal: 3.595 ± 0.075
0.555LysTrp: 0.555 ± 0.033
1.762LysTyr: 1.762 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
11.063LeuAla: 11.063 ± 0.17
0.5LeuCys: 0.5 ± 0.03
5.54LeuAsp: 5.54 ± 0.118
3.745LeuGlu: 3.745 ± 0.083
3.879LeuPhe: 3.879 ± 0.102
7.644LeuGly: 7.644 ± 0.154
2.187LeuHis: 2.187 ± 0.056
5.921LeuIle: 5.921 ± 0.134
5.398LeuLys: 5.398 ± 0.094
9.755LeuLeu: 9.755 ± 0.212
2.475LeuMet: 2.475 ± 0.065
4.349LeuAsn: 4.349 ± 0.088
4.734LeuPro: 4.734 ± 0.082
4.181LeuGln: 4.181 ± 0.074
4.534LeuArg: 4.534 ± 0.09
6.181LeuSer: 6.181 ± 0.126
8.742LeuThr: 8.742 ± 0.146
7.763LeuVal: 7.763 ± 0.136
1.034LeuTrp: 1.034 ± 0.045
2.716LeuTyr: 2.716 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.702MetAla: 2.702 ± 0.066
0.108MetCys: 0.108 ± 0.013
1.182MetAsp: 1.182 ± 0.041
0.896MetGlu: 0.896 ± 0.041
0.774MetPhe: 0.774 ± 0.039
1.843MetGly: 1.843 ± 0.059
0.456MetHis: 0.456 ± 0.026
1.571MetIle: 1.571 ± 0.061
1.343MetLys: 1.343 ± 0.048
2.166MetLeu: 2.166 ± 0.069
0.705MetMet: 0.705 ± 0.03
1.053MetAsn: 1.053 ± 0.042
1.12MetPro: 1.12 ± 0.042
1.138MetGln: 1.138 ± 0.04
1.17MetArg: 1.17 ± 0.044
1.52MetSer: 1.52 ± 0.091
2.234MetThr: 2.234 ± 0.063
1.797MetVal: 1.797 ± 0.053
0.202MetTrp: 0.202 ± 0.018
0.573MetTyr: 0.573 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.522AsnAla: 3.522 ± 0.071
0.165AsnCys: 0.165 ± 0.016
2.42AsnAsp: 2.42 ± 0.06
1.765AsnGlu: 1.765 ± 0.059
1.606AsnPhe: 1.606 ± 0.047
3.178AsnGly: 3.178 ± 0.077
1.167AsnHis: 1.167 ± 0.049
1.973AsnIle: 1.973 ± 0.059
1.728AsnLys: 1.728 ± 0.053
4.128AsnLeu: 4.128 ± 0.084
0.949AsnMet: 0.949 ± 0.042
1.664AsnAsn: 1.664 ± 0.062
2.053AsnPro: 2.053 ± 0.053
2.466AsnGln: 2.466 ± 0.066
2.111AsnArg: 2.111 ± 0.059
2.02AsnSer: 2.02 ± 0.076
2.272AsnThr: 2.272 ± 0.071
3.004AsnVal: 3.004 ± 0.075
0.615AsnTrp: 0.615 ± 0.034
1.499AsnTyr: 1.499 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
4.205ProAla: 4.205 ± 0.093
0.106ProCys: 0.106 ± 0.013
2.802ProAsp: 2.802 ± 0.08
2.491ProGlu: 2.491 ± 0.064
1.576ProPhe: 1.576 ± 0.052
2.657ProGly: 2.657 ± 0.059
1.012ProHis: 1.012 ± 0.046
2.279ProIle: 2.279 ± 0.063
2.206ProLys: 2.206 ± 0.054
3.94ProLeu: 3.94 ± 0.075
0.824ProMet: 0.824 ± 0.034
1.662ProAsn: 1.662 ± 0.049
0.683ProPro: 0.683 ± 0.034
2.325ProGln: 2.325 ± 0.062
1.509ProArg: 1.509 ± 0.048
2.006ProSer: 2.006 ± 0.053
3.181ProThr: 3.181 ± 0.086
3.408ProVal: 3.408 ± 0.087
0.467ProTrp: 0.467 ± 0.029
1.32ProTyr: 1.32 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.624GlnAla: 5.624 ± 0.114
0.139GlnCys: 0.139 ± 0.018
2.528GlnAsp: 2.528 ± 0.062
1.956GlnGlu: 1.956 ± 0.052
1.8GlnPhe: 1.8 ± 0.055
2.784GlnGly: 2.784 ± 0.065
1.497GlnHis: 1.497 ± 0.048
2.835GlnIle: 2.835 ± 0.074
2.525GlnLys: 2.525 ± 0.068
6.207GlnLeu: 6.207 ± 0.124
1.208GlnMet: 1.208 ± 0.048
1.976GlnAsn: 1.976 ± 0.057
2.394GlnPro: 2.394 ± 0.068
3.314GlnGln: 3.314 ± 0.11
3.261GlnArg: 3.261 ± 0.088
2.472GlnSer: 2.472 ± 0.102
3.929GlnThr: 3.929 ± 0.093
4.001GlnVal: 4.001 ± 0.091
0.599GlnTrp: 0.599 ± 0.032
1.602GlnTyr: 1.602 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.667ArgAla: 3.667 ± 0.076
0.188ArgCys: 0.188 ± 0.017
2.582ArgAsp: 2.582 ± 0.069
2.285ArgGlu: 2.285 ± 0.06
1.929ArgPhe: 1.929 ± 0.051
2.717ArgGly: 2.717 ± 0.065
1.464ArgHis: 1.464 ± 0.056
2.653ArgIle: 2.653 ± 0.065
2.255ArgLys: 2.255 ± 0.053
5.277ArgLeu: 5.277 ± 0.108
1.12ArgMet: 1.12 ± 0.041
1.731ArgAsn: 1.731 ± 0.056
1.906ArgPro: 1.906 ± 0.05
3.191ArgGln: 3.191 ± 0.086
2.769ArgArg: 2.769 ± 0.082
2.116ArgSer: 2.116 ± 0.065
2.679ArgThr: 2.679 ± 0.073
3.352ArgVal: 3.352 ± 0.082
0.62ArgTrp: 0.62 ± 0.034
1.962ArgTyr: 1.962 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.134SerAla: 5.134 ± 0.157
0.227SerCys: 0.227 ± 0.017
3.295SerAsp: 3.295 ± 0.117
2.293SerGlu: 2.293 ± 0.137
2.272SerPhe: 2.272 ± 0.068
4.551SerGly: 4.551 ± 0.099
1.276SerHis: 1.276 ± 0.048
2.934SerIle: 2.934 ± 0.065
2.591SerLys: 2.591 ± 0.077
5.765SerLeu: 5.765 ± 0.131
1.358SerMet: 1.358 ± 0.088
1.988SerAsn: 1.988 ± 0.065
2.067SerPro: 2.067 ± 0.061
2.914SerGln: 2.914 ± 0.123
2.464SerArg: 2.464 ± 0.065
3.992SerSer: 3.992 ± 0.191
3.745SerThr: 3.745 ± 0.122
3.917SerVal: 3.917 ± 0.107
0.7SerTrp: 0.7 ± 0.033
1.914SerTyr: 1.914 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
7.445ThrAla: 7.445 ± 0.152
0.276ThrCys: 0.276 ± 0.025
4.12ThrAsp: 4.12 ± 0.089
2.705ThrGlu: 2.705 ± 0.069
2.6ThrPhe: 2.6 ± 0.063
5.431ThrGly: 5.431 ± 0.103
1.705ThrHis: 1.705 ± 0.047
4.322ThrIle: 4.322 ± 0.077
3.613ThrLys: 3.613 ± 0.08
7.189ThrLeu: 7.189 ± 0.112
1.518ThrMet: 1.518 ± 0.052
2.867ThrAsn: 2.867 ± 0.077
3.851ThrPro: 3.851 ± 0.089
3.307ThrGln: 3.307 ± 0.091
2.675ThrArg: 2.675 ± 0.07
4.116ThrSer: 4.116 ± 0.137
6.209ThrThr: 6.209 ± 0.173
5.824ThrVal: 5.824 ± 0.108
0.847ThrTrp: 0.847 ± 0.038
2.493ThrTyr: 2.493 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
8.018ValAla: 8.018 ± 0.122
0.376ValCys: 0.376 ± 0.025
4.413ValAsp: 4.413 ± 0.097
2.916ValGlu: 2.916 ± 0.086
2.599ValPhe: 2.599 ± 0.074
5.271ValGly: 5.271 ± 0.103
1.543ValHis: 1.543 ± 0.048
4.777ValIle: 4.777 ± 0.107
3.911ValLys: 3.911 ± 0.086
6.907ValLeu: 6.907 ± 0.121
1.884ValMet: 1.884 ± 0.057
3.058ValAsn: 3.058 ± 0.068
3.116ValPro: 3.116 ± 0.076
2.819ValGln: 2.819 ± 0.07
2.896ValArg: 2.896 ± 0.072
4.336ValSer: 4.336 ± 0.095
6.606ValThr: 6.606 ± 0.128
6.015ValVal: 6.015 ± 0.104
0.724ValTrp: 0.724 ± 0.037
2.256ValTyr: 2.256 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.915TrpAla: 0.915 ± 0.042
0.088TrpCys: 0.088 ± 0.013
0.533TrpAsp: 0.533 ± 0.031
0.426TrpGlu: 0.426 ± 0.023
0.529TrpPhe: 0.529 ± 0.032
0.882TrpGly: 0.882 ± 0.038
0.394TrpHis: 0.394 ± 0.027
0.646TrpIle: 0.646 ± 0.034
0.358TrpLys: 0.358 ± 0.024
1.69TrpLeu: 1.69 ± 0.059
0.27TrpMet: 0.27 ± 0.019
0.467TrpAsn: 0.467 ± 0.029
0.453TrpPro: 0.453 ± 0.025
0.83TrpGln: 0.83 ± 0.038
0.72TrpArg: 0.72 ± 0.037
0.664TrpSer: 0.664 ± 0.034
0.724TrpThr: 0.724 ± 0.035
0.859TrpVal: 0.859 ± 0.037
0.261TrpTrp: 0.261 ± 0.021
0.385TrpTyr: 0.385 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.779TyrAla: 2.779 ± 0.066
0.174TyrCys: 0.174 ± 0.016
2.025TyrAsp: 2.025 ± 0.069
1.264TyrGlu: 1.264 ± 0.049
1.561TyrPhe: 1.561 ± 0.053
2.44TyrGly: 2.44 ± 0.059
1.118TyrHis: 1.118 ± 0.049
1.55TyrIle: 1.55 ± 0.051
1.302TyrLys: 1.302 ± 0.054
4.014TyrLeu: 4.014 ± 0.088
0.644TyrMet: 0.644 ± 0.03
1.308TyrAsn: 1.308 ± 0.047
1.42TyrPro: 1.42 ± 0.048
2.32TyrGln: 2.32 ± 0.063
2.105TyrArg: 2.105 ± 0.057
1.741TyrSer: 1.741 ± 0.05
2.137TyrThr: 2.137 ± 0.063
2.338TyrVal: 2.338 ± 0.057
0.482TyrTrp: 0.482 ± 0.031
1.382TyrTyr: 1.382 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2163 proteins (659888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski