Amino acid dipepetide frequency for Klebsiella phage ST512-KPC3phi13.5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.53AlaAla: 10.53 ± 1.374
1.04AlaCys: 1.04 ± 0.364
6.89AlaAsp: 6.89 ± 1.052
6.63AlaGlu: 6.63 ± 1.303
2.99AlaPhe: 2.99 ± 0.542
7.93AlaGly: 7.93 ± 1.048
1.43AlaHis: 1.43 ± 0.403
7.02AlaIle: 7.02 ± 1.345
6.11AlaLys: 6.11 ± 0.773
7.41AlaLeu: 7.41 ± 0.958
2.47AlaMet: 2.47 ± 0.544
3.12AlaAsn: 3.12 ± 0.522
2.73AlaPro: 2.73 ± 0.675
2.34AlaGln: 2.34 ± 0.537
4.55AlaArg: 4.55 ± 0.718
5.07AlaSer: 5.07 ± 0.946
5.46AlaThr: 5.46 ± 0.967
5.46AlaVal: 5.46 ± 0.98
0.78AlaTrp: 0.78 ± 0.27
2.6AlaTyr: 2.6 ± 0.574
0.0AlaXaa: 0.0 ± 0.0
Cys
1.56CysAla: 1.56 ± 0.39
0.26CysCys: 0.26 ± 0.173
0.78CysAsp: 0.78 ± 0.293
0.65CysGlu: 0.65 ± 0.284
0.52CysPhe: 0.52 ± 0.296
0.91CysGly: 0.91 ± 0.522
0.39CysHis: 0.39 ± 0.234
0.91CysIle: 0.91 ± 0.425
0.78CysLys: 0.78 ± 0.382
0.91CysLeu: 0.91 ± 0.348
0.13CysMet: 0.13 ± 0.16
0.13CysAsn: 0.13 ± 0.141
1.04CysPro: 1.04 ± 0.388
0.13CysGln: 0.13 ± 0.122
0.78CysArg: 0.78 ± 0.381
0.52CysSer: 0.52 ± 0.353
0.52CysThr: 0.52 ± 0.308
0.26CysVal: 0.26 ± 0.164
0.52CysTrp: 0.52 ± 0.247
0.65CysTyr: 0.65 ± 0.314
0.0CysXaa: 0.0 ± 0.0
Asp
6.24AspAla: 6.24 ± 0.882
0.65AspCys: 0.65 ± 0.267
3.51AspAsp: 3.51 ± 0.583
3.77AspGlu: 3.77 ± 0.699
2.08AspPhe: 2.08 ± 0.409
5.2AspGly: 5.2 ± 0.759
0.52AspHis: 0.52 ± 0.283
3.25AspIle: 3.25 ± 0.469
3.38AspLys: 3.38 ± 0.513
5.33AspLeu: 5.33 ± 0.932
1.56AspMet: 1.56 ± 0.38
1.82AspAsn: 1.82 ± 0.457
1.69AspPro: 1.69 ± 0.356
1.95AspGln: 1.95 ± 0.662
3.38AspArg: 3.38 ± 0.591
4.68AspSer: 4.68 ± 0.695
3.12AspThr: 3.12 ± 0.623
4.42AspVal: 4.42 ± 0.758
1.04AspTrp: 1.04 ± 0.383
1.3AspTyr: 1.3 ± 0.391
0.0AspXaa: 0.0 ± 0.0
Glu
6.24GluAla: 6.24 ± 1.086
0.91GluCys: 0.91 ± 0.397
2.99GluAsp: 2.99 ± 0.475
4.68GluGlu: 4.68 ± 1.113
3.12GluPhe: 3.12 ± 0.771
3.38GluGly: 3.38 ± 0.558
0.39GluHis: 0.39 ± 0.235
3.77GluIle: 3.77 ± 0.629
3.9GluLys: 3.9 ± 0.732
5.59GluLeu: 5.59 ± 0.929
2.21GluMet: 2.21 ± 0.562
1.69GluAsn: 1.69 ± 0.51
2.34GluPro: 2.34 ± 0.618
2.47GluGln: 2.47 ± 0.525
4.42GluArg: 4.42 ± 0.657
2.99GluSer: 2.99 ± 0.672
3.51GluThr: 3.51 ± 0.836
2.99GluVal: 2.99 ± 0.914
0.91GluTrp: 0.91 ± 0.339
1.69GluTyr: 1.69 ± 0.39
0.0GluXaa: 0.0 ± 0.0
Phe
2.47PheAla: 2.47 ± 0.561
0.65PheCys: 0.65 ± 0.273
2.34PheAsp: 2.34 ± 0.509
2.08PheGlu: 2.08 ± 0.541
1.56PhePhe: 1.56 ± 0.372
2.47PheGly: 2.47 ± 0.576
0.13PheHis: 0.13 ± 0.134
1.82PheIle: 1.82 ± 0.551
2.08PheLys: 2.08 ± 0.454
2.73PheLeu: 2.73 ± 0.649
0.78PheMet: 0.78 ± 0.316
1.95PheAsn: 1.95 ± 0.519
2.21PhePro: 2.21 ± 0.564
0.91PheGln: 0.91 ± 0.344
2.47PheArg: 2.47 ± 0.518
2.34PheSer: 2.34 ± 0.548
2.08PheThr: 2.08 ± 0.501
2.47PheVal: 2.47 ± 0.586
0.91PheTrp: 0.91 ± 0.333
1.17PheTyr: 1.17 ± 0.268
0.0PheXaa: 0.0 ± 0.0
Gly
5.85GlyAla: 5.85 ± 0.999
0.26GlyCys: 0.26 ± 0.18
5.46GlyAsp: 5.46 ± 1.064
3.51GlyGlu: 3.51 ± 0.715
3.77GlyPhe: 3.77 ± 0.627
3.64GlyGly: 3.64 ± 0.634
1.17GlyHis: 1.17 ± 0.396
5.46GlyIle: 5.46 ± 0.849
4.94GlyLys: 4.94 ± 0.71
7.41GlyLeu: 7.41 ± 0.893
2.99GlyMet: 2.99 ± 0.622
2.6GlyAsn: 2.6 ± 0.554
2.21GlyPro: 2.21 ± 0.557
2.47GlyGln: 2.47 ± 0.551
5.07GlyArg: 5.07 ± 0.618
2.86GlySer: 2.86 ± 0.62
4.55GlyThr: 4.55 ± 0.806
5.98GlyVal: 5.98 ± 0.779
1.04GlyTrp: 1.04 ± 0.325
2.99GlyTyr: 2.99 ± 0.57
0.0GlyXaa: 0.0 ± 0.0
His
1.3HisAla: 1.3 ± 0.54
0.39HisCys: 0.39 ± 0.23
0.91HisAsp: 0.91 ± 0.42
1.43HisGlu: 1.43 ± 0.401
0.26HisPhe: 0.26 ± 0.182
1.69HisGly: 1.69 ± 0.366
0.26HisHis: 0.26 ± 0.154
1.69HisIle: 1.69 ± 0.476
0.52HisLys: 0.52 ± 0.266
1.43HisLeu: 1.43 ± 0.357
0.26HisMet: 0.26 ± 0.179
0.65HisAsn: 0.65 ± 0.263
1.04HisPro: 1.04 ± 0.377
0.91HisGln: 0.91 ± 0.328
1.43HisArg: 1.43 ± 0.446
0.91HisSer: 0.91 ± 0.343
0.13HisThr: 0.13 ± 0.117
0.52HisVal: 0.52 ± 0.255
0.13HisTrp: 0.13 ± 0.131
0.91HisTyr: 0.91 ± 0.341
0.0HisXaa: 0.0 ± 0.0
Ile
4.94IleAla: 4.94 ± 0.64
1.17IleCys: 1.17 ± 0.467
2.99IleAsp: 2.99 ± 0.521
5.72IleGlu: 5.72 ± 0.973
2.47IlePhe: 2.47 ± 0.39
5.07IleGly: 5.07 ± 0.494
1.04IleHis: 1.04 ± 0.341
2.86IleIle: 2.86 ± 0.515
2.86IleLys: 2.86 ± 0.693
3.51IleLeu: 3.51 ± 0.636
1.69IleMet: 1.69 ± 0.437
3.64IleAsn: 3.64 ± 0.638
2.73IlePro: 2.73 ± 0.505
3.77IleGln: 3.77 ± 0.637
4.29IleArg: 4.29 ± 0.637
4.55IleSer: 4.55 ± 0.674
3.64IleThr: 3.64 ± 0.521
3.38IleVal: 3.38 ± 0.687
0.78IleTrp: 0.78 ± 0.306
1.17IleTyr: 1.17 ± 0.318
0.0IleXaa: 0.0 ± 0.0
Lys
5.98LysAla: 5.98 ± 1.046
0.78LysCys: 0.78 ± 0.315
2.34LysAsp: 2.34 ± 0.622
2.6LysGlu: 2.6 ± 0.406
1.95LysPhe: 1.95 ± 0.415
2.99LysGly: 2.99 ± 0.658
2.08LysHis: 2.08 ± 0.529
3.77LysIle: 3.77 ± 0.957
3.25LysLys: 3.25 ± 0.504
4.55LysLeu: 4.55 ± 0.713
1.69LysMet: 1.69 ± 0.575
3.12LysAsn: 3.12 ± 0.584
3.64LysPro: 3.64 ± 0.775
2.08LysGln: 2.08 ± 0.471
4.29LysArg: 4.29 ± 0.818
3.12LysSer: 3.12 ± 0.736
3.9LysThr: 3.9 ± 0.68
2.73LysVal: 2.73 ± 0.628
0.91LysTrp: 0.91 ± 0.377
1.3LysTyr: 1.3 ± 0.381
0.0LysXaa: 0.0 ± 0.0
Leu
9.1LeuAla: 9.1 ± 1.257
0.52LeuCys: 0.52 ± 0.273
4.03LeuAsp: 4.03 ± 0.803
3.64LeuGlu: 3.64 ± 0.924
2.6LeuPhe: 2.6 ± 0.599
4.68LeuGly: 4.68 ± 0.679
1.3LeuHis: 1.3 ± 0.438
6.11LeuIle: 6.11 ± 1.241
4.29LeuLys: 4.29 ± 0.74
7.15LeuLeu: 7.15 ± 0.877
1.56LeuMet: 1.56 ± 0.461
4.03LeuAsn: 4.03 ± 0.844
3.77LeuPro: 3.77 ± 0.791
3.51LeuGln: 3.51 ± 0.608
6.24LeuArg: 6.24 ± 1.007
6.24LeuSer: 6.24 ± 0.828
5.46LeuThr: 5.46 ± 0.84
5.59LeuVal: 5.59 ± 0.755
1.17LeuTrp: 1.17 ± 0.42
2.21LeuTyr: 2.21 ± 0.571
0.0LeuXaa: 0.0 ± 0.0
Met
3.12MetAla: 3.12 ± 0.555
0.13MetCys: 0.13 ± 0.117
0.65MetAsp: 0.65 ± 0.257
1.17MetGlu: 1.17 ± 0.328
0.52MetPhe: 0.52 ± 0.267
1.04MetGly: 1.04 ± 0.358
0.78MetHis: 0.78 ± 0.28
1.43MetIle: 1.43 ± 0.523
3.25MetLys: 3.25 ± 0.799
2.47MetLeu: 2.47 ± 0.631
1.17MetMet: 1.17 ± 0.4
1.04MetAsn: 1.04 ± 0.317
1.17MetPro: 1.17 ± 0.441
0.65MetGln: 0.65 ± 0.24
1.43MetArg: 1.43 ± 0.392
2.08MetSer: 2.08 ± 0.62
2.47MetThr: 2.47 ± 0.515
1.3MetVal: 1.3 ± 0.425
0.0MetTrp: 0.0 ± 0.0
0.78MetTyr: 0.78 ± 0.348
0.0MetXaa: 0.0 ± 0.0
Asn
3.51AsnAla: 3.51 ± 0.66
0.39AsnCys: 0.39 ± 0.233
1.95AsnAsp: 1.95 ± 0.501
1.3AsnGlu: 1.3 ± 0.483
1.69AsnPhe: 1.69 ± 0.464
4.29AsnGly: 4.29 ± 0.702
0.65AsnHis: 0.65 ± 0.282
2.34AsnIle: 2.34 ± 0.506
2.73AsnLys: 2.73 ± 0.848
3.12AsnLeu: 3.12 ± 0.623
1.04AsnMet: 1.04 ± 0.307
2.21AsnAsn: 2.21 ± 0.593
2.47AsnPro: 2.47 ± 0.484
1.69AsnGln: 1.69 ± 0.327
2.21AsnArg: 2.21 ± 0.459
2.21AsnSer: 2.21 ± 0.592
2.34AsnThr: 2.34 ± 0.475
3.38AsnVal: 3.38 ± 0.851
1.17AsnTrp: 1.17 ± 0.379
1.43AsnTyr: 1.43 ± 0.39
0.0AsnXaa: 0.0 ± 0.0
Pro
2.73ProAla: 2.73 ± 0.645
0.52ProCys: 0.52 ± 0.329
2.86ProAsp: 2.86 ± 0.582
4.29ProGlu: 4.29 ± 0.915
1.43ProPhe: 1.43 ± 0.432
3.64ProGly: 3.64 ± 0.973
0.91ProHis: 0.91 ± 0.353
2.21ProIle: 2.21 ± 0.468
1.82ProLys: 1.82 ± 0.532
3.38ProLeu: 3.38 ± 0.959
0.78ProMet: 0.78 ± 0.368
2.21ProAsn: 2.21 ± 0.477
3.12ProPro: 3.12 ± 0.671
2.47ProGln: 2.47 ± 0.542
1.17ProArg: 1.17 ± 0.424
1.82ProSer: 1.82 ± 0.502
3.77ProThr: 3.77 ± 0.73
4.42ProVal: 4.42 ± 0.744
0.13ProTrp: 0.13 ± 0.146
1.17ProTyr: 1.17 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
4.94GlnAla: 4.94 ± 0.784
0.26GlnCys: 0.26 ± 0.171
1.17GlnAsp: 1.17 ± 0.381
1.82GlnGlu: 1.82 ± 0.446
1.56GlnPhe: 1.56 ± 0.492
2.99GlnGly: 2.99 ± 0.856
0.78GlnHis: 0.78 ± 0.337
2.47GlnIle: 2.47 ± 0.572
1.82GlnLys: 1.82 ± 0.488
3.9GlnLeu: 3.9 ± 0.567
1.17GlnMet: 1.17 ± 0.458
1.69GlnAsn: 1.69 ± 0.38
1.17GlnPro: 1.17 ± 0.364
1.43GlnGln: 1.43 ± 0.438
2.34GlnArg: 2.34 ± 0.885
2.47GlnSer: 2.47 ± 0.48
1.69GlnThr: 1.69 ± 0.373
2.99GlnVal: 2.99 ± 0.781
0.65GlnTrp: 0.65 ± 0.311
1.69GlnTyr: 1.69 ± 0.497
0.0GlnXaa: 0.0 ± 0.0
Arg
4.55ArgAla: 4.55 ± 0.913
0.91ArgCys: 0.91 ± 0.521
4.03ArgAsp: 4.03 ± 0.693
4.16ArgGlu: 4.16 ± 0.712
2.99ArgPhe: 2.99 ± 0.642
4.03ArgGly: 4.03 ± 0.643
1.82ArgHis: 1.82 ± 0.4
3.64ArgIle: 3.64 ± 0.591
3.64ArgLys: 3.64 ± 0.757
5.59ArgLeu: 5.59 ± 0.816
2.21ArgMet: 2.21 ± 0.473
2.34ArgAsn: 2.34 ± 0.571
2.47ArgPro: 2.47 ± 0.615
2.86ArgGln: 2.86 ± 0.496
4.68ArgArg: 4.68 ± 0.851
2.86ArgSer: 2.86 ± 0.59
2.34ArgThr: 2.34 ± 0.531
2.99ArgVal: 2.99 ± 0.675
2.47ArgTrp: 2.47 ± 0.537
2.08ArgTyr: 2.08 ± 0.649
0.0ArgXaa: 0.0 ± 0.0
Ser
6.37SerAla: 6.37 ± 0.918
1.04SerCys: 1.04 ± 0.465
3.38SerAsp: 3.38 ± 0.75
3.51SerGlu: 3.51 ± 0.897
1.56SerPhe: 1.56 ± 0.345
6.11SerGly: 6.11 ± 0.814
0.91SerHis: 0.91 ± 0.374
3.25SerIle: 3.25 ± 0.63
3.51SerLys: 3.51 ± 0.588
4.94SerLeu: 4.94 ± 0.757
1.43SerMet: 1.43 ± 0.383
2.47SerAsn: 2.47 ± 0.512
2.73SerPro: 2.73 ± 0.696
1.56SerGln: 1.56 ± 0.499
4.42SerArg: 4.42 ± 0.751
4.03SerSer: 4.03 ± 1.004
3.38SerThr: 3.38 ± 0.521
3.77SerVal: 3.77 ± 0.631
0.91SerTrp: 0.91 ± 0.288
1.56SerTyr: 1.56 ± 0.454
0.0SerXaa: 0.0 ± 0.0
Thr
4.81ThrAla: 4.81 ± 0.83
0.39ThrCys: 0.39 ± 0.48
4.29ThrAsp: 4.29 ± 0.768
2.47ThrGlu: 2.47 ± 0.47
1.95ThrPhe: 1.95 ± 0.402
4.94ThrGly: 4.94 ± 0.994
0.78ThrHis: 0.78 ± 0.278
3.25ThrIle: 3.25 ± 0.527
2.99ThrLys: 2.99 ± 0.741
5.59ThrLeu: 5.59 ± 0.996
0.78ThrMet: 0.78 ± 0.265
2.86ThrAsn: 2.86 ± 0.728
3.77ThrPro: 3.77 ± 0.654
2.73ThrGln: 2.73 ± 0.757
1.95ThrArg: 1.95 ± 0.487
4.16ThrSer: 4.16 ± 0.726
3.38ThrThr: 3.38 ± 0.548
5.07ThrVal: 5.07 ± 0.738
0.78ThrTrp: 0.78 ± 0.369
2.21ThrTyr: 2.21 ± 0.625
0.0ThrXaa: 0.0 ± 0.0
Val
5.59ValAla: 5.59 ± 0.761
1.17ValCys: 1.17 ± 0.454
4.81ValAsp: 4.81 ± 0.618
4.42ValGlu: 4.42 ± 0.893
1.3ValPhe: 1.3 ± 0.344
5.33ValGly: 5.33 ± 1.068
0.52ValHis: 0.52 ± 0.205
5.33ValIle: 5.33 ± 0.822
3.12ValLys: 3.12 ± 0.681
4.16ValLeu: 4.16 ± 0.812
1.3ValMet: 1.3 ± 0.314
2.6ValAsn: 2.6 ± 0.69
2.47ValPro: 2.47 ± 0.758
1.95ValGln: 1.95 ± 0.574
3.77ValArg: 3.77 ± 0.73
4.29ValSer: 4.29 ± 0.817
5.07ValThr: 5.07 ± 0.873
3.51ValVal: 3.51 ± 0.772
0.52ValTrp: 0.52 ± 0.222
2.99ValTyr: 2.99 ± 0.818
0.0ValXaa: 0.0 ± 0.0
Trp
1.04TrpAla: 1.04 ± 0.468
0.65TrpCys: 0.65 ± 0.311
0.78TrpAsp: 0.78 ± 0.349
0.91TrpGlu: 0.91 ± 0.304
0.52TrpPhe: 0.52 ± 0.223
0.65TrpGly: 0.65 ± 0.268
0.13TrpHis: 0.13 ± 0.136
1.04TrpIle: 1.04 ± 0.312
0.78TrpLys: 0.78 ± 0.341
1.82TrpLeu: 1.82 ± 0.502
0.52TrpMet: 0.52 ± 0.215
1.04TrpAsn: 1.04 ± 0.38
0.26TrpPro: 0.26 ± 0.164
0.65TrpGln: 0.65 ± 0.281
1.17TrpArg: 1.17 ± 0.416
1.17TrpSer: 1.17 ± 0.306
1.17TrpThr: 1.17 ± 0.322
0.78TrpVal: 0.78 ± 0.354
0.39TrpTrp: 0.39 ± 0.193
0.52TrpTyr: 0.52 ± 0.257
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.69TyrAla: 1.69 ± 0.468
0.26TyrCys: 0.26 ± 0.229
2.73TyrAsp: 2.73 ± 0.608
1.56TyrGlu: 1.56 ± 0.415
0.78TyrPhe: 0.78 ± 0.314
3.25TyrGly: 3.25 ± 0.556
0.78TyrHis: 0.78 ± 0.294
0.65TyrIle: 0.65 ± 0.312
1.3TyrLys: 1.3 ± 0.346
2.21TyrLeu: 2.21 ± 0.682
0.78TyrMet: 0.78 ± 0.34
0.91TyrAsn: 0.91 ± 0.366
1.82TyrPro: 1.82 ± 0.513
2.47TyrGln: 2.47 ± 0.589
2.6TyrArg: 2.6 ± 0.617
2.47TyrSer: 2.47 ± 0.577
1.17TyrThr: 1.17 ± 0.368
2.21TyrVal: 2.21 ± 0.65
0.78TyrTrp: 0.78 ± 0.306
0.91TyrTyr: 0.91 ± 0.348
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (7693 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski