Amino acid dipepetide frequency for Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.346AlaAla: 13.346 ± 0.173	1.297AlaCys: 1.297 ± 0.047	6.766AlaAsp: 6.766 ± 0.104	6.266AlaGlu: 6.266 ± 0.1	2.965AlaPhe: 2.965 ± 0.065	9.828AlaGly: 9.828 ± 0.155	2.639AlaHis: 2.639 ± 0.055	5.596AlaIle: 5.596 ± 0.099	3.492AlaLys: 3.492 ± 0.078	10.367AlaLeu: 10.367 ± 0.126	3.106AlaMet: 3.106 ± 0.074	2.581AlaAsn: 2.581 ± 0.054	4.754AlaPro: 4.754 ± 0.094	3.555AlaGln: 3.555 ± 0.073	7.297AlaArg: 7.297 ± 0.109	6.649AlaSer: 6.649 ± 0.098	6.792AlaThr: 6.792 ± 0.101	9.447AlaVal: 9.447 ± 0.135	1.751AlaTrp: 1.751 ± 0.05	1.931AlaTyr: 1.931 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.039	0.183CysCys: 0.183 ± 0.016	0.691CysAsp: 0.691 ± 0.032	0.545CysGlu: 0.545 ± 0.025	0.313CysPhe: 0.313 ± 0.017	1.204CysGly: 1.204 ± 0.048	0.338CysHis: 0.338 ± 0.02	0.396CysIle: 0.396 ± 0.023	0.196CysLys: 0.196 ± 0.017	1.038CysLeu: 1.038 ± 0.036	0.219CysMet: 0.219 ± 0.018	0.231CysAsn: 0.231 ± 0.017	0.714CysPro: 0.714 ± 0.035	0.398CysGln: 0.398 ± 0.024	0.781CysArg: 0.781 ± 0.031	0.739CysSer: 0.739 ± 0.031	0.587CysThr: 0.587 ± 0.03	0.831CysVal: 0.831 ± 0.038	0.184CysTrp: 0.184 ± 0.016	0.239CysTyr: 0.239 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.608AspAla: 6.608 ± 0.104	0.474AspCys: 0.474 ± 0.025	4.503AspAsp: 4.503 ± 0.091	4.306AspGlu: 4.306 ± 0.084	1.607AspPhe: 1.607 ± 0.046	5.408AspGly: 5.408 ± 0.107	1.76AspHis: 1.76 ± 0.046	2.767AspIle: 2.767 ± 0.067	1.715AspLys: 1.715 ± 0.05	6.365AspLeu: 6.365 ± 0.097	1.28AspMet: 1.28 ± 0.042	1.354AspAsn: 1.354 ± 0.039	4.156AspPro: 4.156 ± 0.089	1.877AspGln: 1.877 ± 0.051	4.111AspArg: 4.111 ± 0.09	3.207AspSer: 3.207 ± 0.054	3.016AspThr: 3.016 ± 0.063	5.465AspVal: 5.465 ± 0.09	0.849AspTrp: 0.849 ± 0.036	1.31AspTyr: 1.31 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.065GluAla: 6.065 ± 0.098	0.428GluCys: 0.428 ± 0.023	2.774GluAsp: 2.774 ± 0.062	3.066GluGlu: 3.066 ± 0.078	1.597GluPhe: 1.597 ± 0.049	3.88GluGly: 3.88 ± 0.068	1.393GluHis: 1.393 ± 0.049	2.765GluIle: 2.765 ± 0.069	1.848GluLys: 1.848 ± 0.047	5.357GluLeu: 5.357 ± 0.099	1.271GluMet: 1.271 ± 0.04	1.312GluAsn: 1.312 ± 0.043	2.756GluPro: 2.756 ± 0.064	1.911GluGln: 1.911 ± 0.053	3.669GluArg: 3.669 ± 0.08	2.915GluSer: 2.915 ± 0.061	2.789GluThr: 2.789 ± 0.058	4.758GluVal: 4.758 ± 0.092	0.79GluTrp: 0.79 ± 0.03	1.1GluTyr: 1.1 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.115PheAla: 3.115 ± 0.066	0.38PheCys: 0.38 ± 0.024	2.088PheAsp: 2.088 ± 0.057	1.247PheGlu: 1.247 ± 0.042	1.034PhePhe: 1.034 ± 0.05	2.941PheGly: 2.941 ± 0.071	0.701PheHis: 0.701 ± 0.033	1.471PheIle: 1.471 ± 0.046	0.682PheLys: 0.682 ± 0.031	2.673PheLeu: 2.673 ± 0.071	0.681PheMet: 0.681 ± 0.029	0.89PheAsn: 0.89 ± 0.033	1.283PhePro: 1.283 ± 0.041	0.779PheGln: 0.779 ± 0.031	1.54PheArg: 1.54 ± 0.04	1.983PheSer: 1.983 ± 0.052	1.945PheThr: 1.945 ± 0.057	2.573PheVal: 2.573 ± 0.055	0.465PheTrp: 0.465 ± 0.029	0.618PheTyr: 0.618 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.33GlyAla: 8.33 ± 0.119	1.058GlyCys: 1.058 ± 0.043	4.503GlyAsp: 4.503 ± 0.078	4.08GlyGlu: 4.08 ± 0.087	2.905GlyPhe: 2.905 ± 0.067	6.507GlyGly: 6.507 ± 0.115	2.416GlyHis: 2.416 ± 0.058	4.634GlyIle: 4.634 ± 0.086	2.97GlyLys: 2.97 ± 0.059	8.38GlyLeu: 8.38 ± 0.112	2.354GlyMet: 2.354 ± 0.06	2.179GlyAsn: 2.179 ± 0.055	3.819GlyPro: 3.819 ± 0.085	2.893GlyGln: 2.893 ± 0.065	6.038GlyArg: 6.038 ± 0.11	5.448GlySer: 5.448 ± 0.094	5.184GlyThr: 5.184 ± 0.08	7.481GlyVal: 7.481 ± 0.093	1.808GlyTrp: 1.808 ± 0.06	2.19GlyTyr: 2.19 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.347HisAla: 2.347 ± 0.058	0.283HisCys: 0.283 ± 0.021	1.845HisAsp: 1.845 ± 0.051	1.363HisGlu: 1.363 ± 0.047	0.655HisPhe: 0.655 ± 0.029	2.241HisGly: 2.241 ± 0.054	0.874HisHis: 0.874 ± 0.039	1.137HisIle: 1.137 ± 0.039	0.589HisLys: 0.589 ± 0.029	2.371HisLeu: 2.371 ± 0.061	0.547HisMet: 0.547 ± 0.024	0.653HisAsn: 0.653 ± 0.03	1.815HisPro: 1.815 ± 0.052	0.873HisGln: 0.873 ± 0.037	1.965HisArg: 1.965 ± 0.052	1.398HisSer: 1.398 ± 0.042	1.415HisThr: 1.415 ± 0.045	2.044HisVal: 2.044 ± 0.055	0.355HisTrp: 0.355 ± 0.021	0.531HisTyr: 0.531 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.826IleAla: 5.826 ± 0.094	0.648IleCys: 0.648 ± 0.03	3.782IleAsp: 3.782 ± 0.073	2.613IleGlu: 2.613 ± 0.066	1.45IlePhe: 1.45 ± 0.054	4.796IleGly: 4.796 ± 0.095	1.075IleHis: 1.075 ± 0.036	2.632IleIle: 2.632 ± 0.069	1.337IleLys: 1.337 ± 0.042	4.115IleLeu: 4.115 ± 0.078	1.117IleMet: 1.117 ± 0.036	1.377IleAsn: 1.377 ± 0.05	2.713IlePro: 2.713 ± 0.052	1.07IleGln: 1.07 ± 0.034	2.768IleArg: 2.768 ± 0.061	2.979IleSer: 2.979 ± 0.062	3.295IleThr: 3.295 ± 0.067	4.742IleVal: 4.742 ± 0.089	0.559IleTrp: 0.559 ± 0.029	0.892IleTyr: 0.892 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.772LysAla: 3.772 ± 0.082	0.179LysCys: 0.179 ± 0.016	1.614LysAsp: 1.614 ± 0.049	1.446LysGlu: 1.446 ± 0.051	0.71LysPhe: 0.71 ± 0.033	2.18LysGly: 2.18 ± 0.058	0.612LysHis: 0.612 ± 0.03	1.575LysIle: 1.575 ± 0.05	1.306LysLys: 1.306 ± 0.054	2.571LysLeu: 2.571 ± 0.067	0.672LysMet: 0.672 ± 0.03	0.787LysAsn: 0.787 ± 0.039	1.739LysPro: 1.739 ± 0.058	0.886LysGln: 0.886 ± 0.034	1.908LysArg: 1.908 ± 0.053	1.705LysSer: 1.705 ± 0.051	1.759LysThr: 1.759 ± 0.057	2.847LysVal: 2.847 ± 0.059	0.34LysTrp: 0.34 ± 0.021	0.662LysTyr: 0.662 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.826LeuAla: 11.826 ± 0.139	1.008LeuCys: 1.008 ± 0.035	6.343LeuAsp: 6.343 ± 0.107	4.463LeuGlu: 4.463 ± 0.082	2.554LeuPhe: 2.554 ± 0.06	8.216LeuGly: 8.216 ± 0.114	2.008LeuHis: 2.008 ± 0.054	4.345LeuIle: 4.345 ± 0.085	2.355LeuLys: 2.355 ± 0.061	8.476LeuLeu: 8.476 ± 0.124	2.044LeuMet: 2.044 ± 0.06	2.284LeuAsn: 2.284 ± 0.061	5.123LeuPro: 5.123 ± 0.086	2.096LeuGln: 2.096 ± 0.058	5.996LeuArg: 5.996 ± 0.112	6.125LeuSer: 6.125 ± 0.09	6.282LeuThr: 6.282 ± 0.089	8.992LeuVal: 8.992 ± 0.122	1.195LeuTrp: 1.195 ± 0.042	1.501LeuTyr: 1.501 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.263MetAla: 3.263 ± 0.069	0.283MetCys: 0.283 ± 0.018	1.195MetAsp: 1.195 ± 0.047	0.957MetGlu: 0.957 ± 0.039	0.658MetPhe: 0.658 ± 0.032	2.016MetGly: 2.016 ± 0.059	0.482MetHis: 0.482 ± 0.029	1.212MetIle: 1.212 ± 0.038	0.773MetLys: 0.773 ± 0.035	2.045MetLeu: 2.045 ± 0.055	0.548MetMet: 0.548 ± 0.027	0.708MetAsn: 0.708 ± 0.031	1.366MetPro: 1.366 ± 0.039	0.553MetGln: 0.553 ± 0.027	1.548MetArg: 1.548 ± 0.045	2.115MetSer: 2.115 ± 0.055	2.138MetThr: 2.138 ± 0.054	2.069MetVal: 2.069 ± 0.055	0.381MetTrp: 0.381 ± 0.024	0.398MetTyr: 0.398 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.608AsnAla: 2.608 ± 0.059	0.248AsnCys: 0.248 ± 0.017	1.601AsnAsp: 1.601 ± 0.05	1.258AsnGlu: 1.258 ± 0.039	0.748AsnPhe: 0.748 ± 0.031	2.318AsnGly: 2.318 ± 0.053	0.765AsnHis: 0.765 ± 0.032	1.126AsnIle: 1.126 ± 0.042	0.756AsnLys: 0.756 ± 0.031	2.449AsnLeu: 2.449 ± 0.064	0.489AsnMet: 0.489 ± 0.024	0.719AsnAsn: 0.719 ± 0.03	2.012AsnPro: 2.012 ± 0.053	0.861AsnGln: 0.861 ± 0.034	1.64AsnArg: 1.64 ± 0.046	1.437AsnSer: 1.437 ± 0.048	1.479AsnThr: 1.479 ± 0.042	1.881AsnVal: 1.881 ± 0.055	0.36AsnTrp: 0.36 ± 0.023	0.644AsnTyr: 0.644 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.517ProAla: 5.517 ± 0.091	0.498ProCys: 0.498 ± 0.028	3.951ProAsp: 3.951 ± 0.072	3.48ProGlu: 3.48 ± 0.077	1.494ProPhe: 1.494 ± 0.045	4.842ProGly: 4.842 ± 0.083	1.437ProHis: 1.437 ± 0.043	2.241ProIle: 2.241 ± 0.049	1.55ProLys: 1.55 ± 0.048	4.354ProLeu: 4.354 ± 0.083	1.196ProMet: 1.196 ± 0.041	1.387ProAsn: 1.387 ± 0.038	2.004ProPro: 2.004 ± 0.065	1.862ProGln: 1.862 ± 0.062	3.334ProArg: 3.334 ± 0.08	3.496ProSer: 3.496 ± 0.08	3.647ProThr: 3.647 ± 0.083	4.662ProVal: 4.662 ± 0.081	0.954ProTrp: 0.954 ± 0.032	1.092ProTyr: 1.092 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.786GlnAla: 3.786 ± 0.079	0.28GlnCys: 0.28 ± 0.019	1.355GlnAsp: 1.355 ± 0.043	1.377GlnGlu: 1.377 ± 0.04	0.825GlnPhe: 0.825 ± 0.036	2.3GlnGly: 2.3 ± 0.062	0.702GlnHis: 0.702 ± 0.03	1.747GlnIle: 1.747 ± 0.049	0.766GlnLys: 0.766 ± 0.03	3.148GlnLeu: 3.148 ± 0.067	0.846GlnMet: 0.846 ± 0.032	0.736GlnAsn: 0.736 ± 0.031	1.638GlnPro: 1.638 ± 0.053	1.163GlnGln: 1.163 ± 0.044	2.385GlnArg: 2.385 ± 0.064	1.547GlnSer: 1.547 ± 0.047	1.795GlnThr: 1.795 ± 0.047	2.935GlnVal: 2.935 ± 0.061	0.585GlnTrp: 0.585 ± 0.027	0.651GlnTyr: 0.651 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.64ArgAla: 6.64 ± 0.109	0.811ArgCys: 0.811 ± 0.034	3.881ArgAsp: 3.881 ± 0.083	3.617ArgGlu: 3.617 ± 0.081	1.949ArgPhe: 1.949 ± 0.052	4.888ArgGly: 4.888 ± 0.1	2.169ArgHis: 2.169 ± 0.059	3.752ArgIle: 3.752 ± 0.068	1.982ArgLys: 1.982 ± 0.062	6.261ArgLeu: 6.261 ± 0.11	1.949ArgMet: 1.949 ± 0.052	1.789ArgAsn: 1.789 ± 0.051	3.508ArgPro: 3.508 ± 0.073	2.439ArgGln: 2.439 ± 0.061	6.507ArgArg: 6.507 ± 0.122	4.085ArgSer: 4.085 ± 0.075	4.187ArgThr: 4.187 ± 0.086	5.126ArgVal: 5.126 ± 0.084	1.256ArgTrp: 1.256 ± 0.042	1.485ArgTyr: 1.485 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.412SerAla: 6.412 ± 0.104	0.635SerCys: 0.635 ± 0.027	3.485SerAsp: 3.485 ± 0.062	2.894SerGlu: 2.894 ± 0.063	1.861SerPhe: 1.861 ± 0.05	6.009SerGly: 6.009 ± 0.098	1.699SerHis: 1.699 ± 0.047	2.63SerIle: 2.63 ± 0.067	1.736SerLys: 1.736 ± 0.059	5.528SerLeu: 5.528 ± 0.086	1.747SerMet: 1.747 ± 0.046	1.467SerAsn: 1.467 ± 0.042	3.395SerPro: 3.395 ± 0.079	2.23SerGln: 2.23 ± 0.058	4.484SerArg: 4.484 ± 0.077	4.303SerSer: 4.303 ± 0.093	4.022SerThr: 4.022 ± 0.095	4.96SerVal: 4.96 ± 0.083	1.288SerTrp: 1.288 ± 0.036	1.299SerTyr: 1.299 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.669ThrAla: 6.669 ± 0.101	0.679ThrCys: 0.679 ± 0.03	3.768ThrAsp: 3.768 ± 0.064	2.907ThrGlu: 2.907 ± 0.065	1.958ThrPhe: 1.958 ± 0.052	5.507ThrGly: 5.507 ± 0.08	1.451ThrHis: 1.451 ± 0.041	3.388ThrIle: 3.388 ± 0.071	1.824ThrLys: 1.824 ± 0.051	5.481ThrLeu: 5.481 ± 0.099	1.603ThrMet: 1.603 ± 0.043	1.59ThrAsn: 1.59 ± 0.046	3.822ThrPro: 3.822 ± 0.077	1.632ThrGln: 1.632 ± 0.05	3.872ThrArg: 3.872 ± 0.07	4.147ThrSer: 4.147 ± 0.065	4.591ThrThr: 4.591 ± 0.085	5.93ThrVal: 5.93 ± 0.091	1.195ThrTrp: 1.195 ± 0.036	1.264ThrTyr: 1.264 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.786ValAla: 9.786 ± 0.139	1.076ValCys: 1.076 ± 0.039	5.82ValAsp: 5.82 ± 0.087	4.997ValGlu: 4.997 ± 0.095	2.479ValPhe: 2.479 ± 0.068	7.083ValGly: 7.083 ± 0.112	1.856ValHis: 1.856 ± 0.051	4.823ValIle: 4.823 ± 0.088	2.481ValLys: 2.481 ± 0.05	8.293ValLeu: 8.293 ± 0.104	2.272ValMet: 2.272 ± 0.053	2.376ValAsn: 2.376 ± 0.063	4.494ValPro: 4.494 ± 0.066	2.033ValGln: 2.033 ± 0.052	5.495ValArg: 5.495 ± 0.096	5.477ValSer: 5.477 ± 0.088	6.218ValThr: 6.218 ± 0.092	8.878ValVal: 8.878 ± 0.146	1.216ValTrp: 1.216 ± 0.045	1.412ValTyr: 1.412 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.511TrpAla: 1.511 ± 0.052	0.242TrpCys: 0.242 ± 0.019	0.787TrpAsp: 0.787 ± 0.034	0.586TrpGlu: 0.586 ± 0.028	0.653TrpPhe: 0.653 ± 0.031	1.199TrpGly: 1.199 ± 0.042	0.444TrpHis: 0.444 ± 0.024	0.848TrpIle: 0.848 ± 0.036	0.446TrpLys: 0.446 ± 0.023	1.744TrpLeu: 1.744 ± 0.054	0.407TrpMet: 0.407 ± 0.025	0.477TrpAsn: 0.477 ± 0.026	0.758TrpPro: 0.758 ± 0.032	0.72TrpGln: 0.72 ± 0.024	1.292TrpArg: 1.292 ± 0.045	1.095TrpSer: 1.095 ± 0.043	1.012TrpThr: 1.012 ± 0.039	1.325TrpVal: 1.325 ± 0.051	0.436TrpTrp: 0.436 ± 0.023	0.343TrpTyr: 0.343 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.906TyrAla: 1.906 ± 0.052	0.227TyrCys: 0.227 ± 0.017	1.385TyrAsp: 1.385 ± 0.045	0.977TyrGlu: 0.977 ± 0.039	0.676TyrPhe: 0.676 ± 0.03	1.812TyrGly: 1.812 ± 0.049	0.48TyrHis: 0.48 ± 0.028	0.702TyrIle: 0.702 ± 0.03	0.465TyrLys: 0.465 ± 0.025	2.216TyrLeu: 2.216 ± 0.058	0.359TyrMet: 0.359 ± 0.023	0.499TyrAsn: 0.499 ± 0.026	1.132TyrPro: 1.132 ± 0.041	0.735TyrGln: 0.735 ± 0.033	1.651TyrArg: 1.651 ± 0.056	1.237TyrSer: 1.237 ± 0.042	1.125TyrThr: 1.125 ± 0.039	1.621TyrVal: 1.621 ± 0.046	0.359TyrTrp: 0.359 ± 0.022	0.457TyrTyr: 0.457 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2294 proteins (760875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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