Amino acid dipepetide frequency for Gordonia phage Yeezy

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.12AlaAla: 18.12 ± 2.07
0.951AlaCys: 0.951 ± 0.29
9.209AlaAsp: 9.209 ± 0.67
8.615AlaGlu: 8.615 ± 0.818
2.971AlaPhe: 2.971 ± 0.447
9.387AlaGly: 9.387 ± 0.771
2.258AlaHis: 2.258 ± 0.4
4.99AlaIle: 4.99 ± 0.47
4.693AlaLys: 4.693 ± 0.479
8.377AlaLeu: 8.377 ± 0.702
3.149AlaMet: 3.149 ± 0.603
2.971AlaAsn: 2.971 ± 0.404
5.406AlaPro: 5.406 ± 0.528
4.515AlaGln: 4.515 ± 0.765
7.248AlaArg: 7.248 ± 0.756
6.416AlaSer: 6.416 ± 0.943
9.209AlaThr: 9.209 ± 1.051
8.317AlaVal: 8.317 ± 0.84
1.366AlaTrp: 1.366 ± 0.279
2.198AlaTyr: 2.198 ± 0.245
0.0AlaXaa: 0.0 ± 0.0
Cys
1.01CysAla: 1.01 ± 0.297
0.059CysCys: 0.059 ± 0.054
0.535CysAsp: 0.535 ± 0.219
0.475CysGlu: 0.475 ± 0.204
0.178CysPhe: 0.178 ± 0.094
1.069CysGly: 1.069 ± 0.34
0.356CysHis: 0.356 ± 0.192
0.119CysIle: 0.119 ± 0.077
0.416CysLys: 0.416 ± 0.177
0.297CysLeu: 0.297 ± 0.139
0.178CysMet: 0.178 ± 0.11
0.356CysAsn: 0.356 ± 0.177
0.416CysPro: 0.416 ± 0.17
0.178CysGln: 0.178 ± 0.097
0.832CysArg: 0.832 ± 0.244
0.594CysSer: 0.594 ± 0.213
0.178CysThr: 0.178 ± 0.11
0.475CysVal: 0.475 ± 0.176
0.535CysTrp: 0.535 ± 0.2
0.356CysTyr: 0.356 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
7.189AspAla: 7.189 ± 0.923
0.654AspCys: 0.654 ± 0.271
6.06AspAsp: 6.06 ± 0.847
5.347AspGlu: 5.347 ± 0.711
2.02AspPhe: 2.02 ± 0.453
5.288AspGly: 5.288 ± 0.637
2.198AspHis: 2.198 ± 0.37
2.079AspIle: 2.079 ± 0.348
1.723AspLys: 1.723 ± 0.309
7.605AspLeu: 7.605 ± 0.633
1.248AspMet: 1.248 ± 0.34
2.614AspAsn: 2.614 ± 0.363
4.753AspPro: 4.753 ± 0.559
2.376AspGln: 2.376 ± 0.347
4.515AspArg: 4.515 ± 0.616
2.733AspSer: 2.733 ± 0.405
3.862AspThr: 3.862 ± 0.536
4.931AspVal: 4.931 ± 0.544
1.485AspTrp: 1.485 ± 0.306
1.307AspTyr: 1.307 ± 0.275
0.0AspXaa: 0.0 ± 0.0
Glu
7.07GluAla: 7.07 ± 0.934
1.01GluCys: 1.01 ± 0.292
2.971GluAsp: 2.971 ± 0.463
2.792GluGlu: 2.792 ± 0.448
2.317GluPhe: 2.317 ± 0.367
2.792GluGly: 2.792 ± 0.472
1.426GluHis: 1.426 ± 0.324
3.862GluIle: 3.862 ± 0.517
2.079GluLys: 2.079 ± 0.36
5.703GluLeu: 5.703 ± 0.678
0.951GluMet: 0.951 ± 0.253
1.485GluAsn: 1.485 ± 0.353
3.089GluPro: 3.089 ± 0.523
2.614GluGln: 2.614 ± 0.471
5.05GluArg: 5.05 ± 0.685
3.862GluSer: 3.862 ± 0.586
3.683GluThr: 3.683 ± 0.59
4.278GluVal: 4.278 ± 0.398
1.188GluTrp: 1.188 ± 0.216
1.307GluTyr: 1.307 ± 0.265
0.0GluXaa: 0.0 ± 0.0
Phe
2.614PheAla: 2.614 ± 0.468
0.119PheCys: 0.119 ± 0.092
2.376PheAsp: 2.376 ± 0.426
1.901PheGlu: 1.901 ± 0.298
0.535PhePhe: 0.535 ± 0.162
2.614PheGly: 2.614 ± 0.369
0.475PheHis: 0.475 ± 0.21
0.654PheIle: 0.654 ± 0.149
0.951PheLys: 0.951 ± 0.249
1.129PheLeu: 1.129 ± 0.342
0.475PheMet: 0.475 ± 0.147
1.01PheAsn: 1.01 ± 0.253
1.188PhePro: 1.188 ± 0.308
0.475PheGln: 0.475 ± 0.165
1.723PheArg: 1.723 ± 0.41
1.604PheSer: 1.604 ± 0.32
2.02PheThr: 2.02 ± 0.303
1.663PheVal: 1.663 ± 0.381
0.951PheTrp: 0.951 ± 0.224
0.654PheTyr: 0.654 ± 0.188
0.0PheXaa: 0.0 ± 0.0
Gly
7.189GlyAla: 7.189 ± 0.681
0.416GlyCys: 0.416 ± 0.184
5.763GlyAsp: 5.763 ± 0.451
4.396GlyGlu: 4.396 ± 0.53
2.198GlyPhe: 2.198 ± 0.332
8.555GlyGly: 8.555 ± 1.025
1.307GlyHis: 1.307 ± 0.246
3.683GlyIle: 3.683 ± 0.356
3.565GlyLys: 3.565 ± 0.43
6.416GlyLeu: 6.416 ± 0.672
2.02GlyMet: 2.02 ± 0.353
3.149GlyAsn: 3.149 ± 0.396
3.327GlyPro: 3.327 ± 0.488
2.852GlyGln: 2.852 ± 0.432
6.416GlyArg: 6.416 ± 0.565
4.634GlySer: 4.634 ± 0.594
6.773GlyThr: 6.773 ± 1.188
5.941GlyVal: 5.941 ± 0.691
1.545GlyTrp: 1.545 ± 0.346
1.901GlyTyr: 1.901 ± 0.269
0.0GlyXaa: 0.0 ± 0.0
His
2.673HisAla: 2.673 ± 0.399
0.178HisCys: 0.178 ± 0.118
1.248HisAsp: 1.248 ± 0.32
1.307HisGlu: 1.307 ± 0.277
0.475HisPhe: 0.475 ± 0.181
1.485HisGly: 1.485 ± 0.287
0.832HisHis: 0.832 ± 0.254
0.832HisIle: 0.832 ± 0.252
0.535HisLys: 0.535 ± 0.204
1.485HisLeu: 1.485 ± 0.354
0.297HisMet: 0.297 ± 0.129
0.238HisAsn: 0.238 ± 0.131
1.901HisPro: 1.901 ± 0.541
0.891HisGln: 0.891 ± 0.184
2.02HisArg: 2.02 ± 0.488
0.891HisSer: 0.891 ± 0.214
1.901HisThr: 1.901 ± 0.325
1.485HisVal: 1.485 ± 0.273
0.475HisTrp: 0.475 ± 0.153
0.713HisTyr: 0.713 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
5.228IleAla: 5.228 ± 0.511
0.356IleCys: 0.356 ± 0.201
4.456IleAsp: 4.456 ± 0.557
4.099IleGlu: 4.099 ± 0.457
0.416IlePhe: 0.416 ± 0.134
3.446IleGly: 3.446 ± 0.522
0.832IleHis: 0.832 ± 0.183
0.713IleIle: 0.713 ± 0.187
1.307IleLys: 1.307 ± 0.239
2.258IleLeu: 2.258 ± 0.347
0.297IleMet: 0.297 ± 0.102
1.426IleAsn: 1.426 ± 0.266
2.733IlePro: 2.733 ± 0.405
2.02IleGln: 2.02 ± 0.33
3.505IleArg: 3.505 ± 0.458
2.079IleSer: 2.079 ± 0.346
2.495IleThr: 2.495 ± 0.511
3.268IleVal: 3.268 ± 0.485
0.356IleTrp: 0.356 ± 0.136
1.129IleTyr: 1.129 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
4.575LysAla: 4.575 ± 0.747
0.178LysCys: 0.178 ± 0.111
1.069LysAsp: 1.069 ± 0.236
1.842LysGlu: 1.842 ± 0.366
0.891LysPhe: 0.891 ± 0.226
2.436LysGly: 2.436 ± 0.384
0.951LysHis: 0.951 ± 0.195
1.545LysIle: 1.545 ± 0.243
1.248LysLys: 1.248 ± 0.303
3.268LysLeu: 3.268 ± 0.462
0.416LysMet: 0.416 ± 0.153
0.713LysAsn: 0.713 ± 0.201
2.376LysPro: 2.376 ± 0.328
1.129LysGln: 1.129 ± 0.362
2.317LysArg: 2.317 ± 0.412
2.376LysSer: 2.376 ± 0.469
2.258LysThr: 2.258 ± 0.352
2.614LysVal: 2.614 ± 0.298
0.713LysTrp: 0.713 ± 0.238
0.832LysTyr: 0.832 ± 0.185
0.0LysXaa: 0.0 ± 0.0
Leu
10.694LeuAla: 10.694 ± 0.851
0.713LeuCys: 0.713 ± 0.222
6.179LeuAsp: 6.179 ± 0.618
4.396LeuGlu: 4.396 ± 0.532
2.079LeuPhe: 2.079 ± 0.456
5.882LeuGly: 5.882 ± 0.533
1.604LeuHis: 1.604 ± 0.361
3.327LeuIle: 3.327 ± 0.427
2.079LeuLys: 2.079 ± 0.392
5.882LeuLeu: 5.882 ± 0.656
1.426LeuMet: 1.426 ± 0.288
2.555LeuAsn: 2.555 ± 0.309
4.218LeuPro: 4.218 ± 0.485
2.317LeuGln: 2.317 ± 0.362
5.347LeuArg: 5.347 ± 0.567
3.921LeuSer: 3.921 ± 0.478
5.644LeuThr: 5.644 ± 0.693
5.703LeuVal: 5.703 ± 0.735
1.485LeuTrp: 1.485 ± 0.264
1.188LeuTyr: 1.188 ± 0.366
0.0LeuXaa: 0.0 ± 0.0
Met
2.495MetAla: 2.495 ± 0.42
0.356MetCys: 0.356 ± 0.154
0.356MetAsp: 0.356 ± 0.153
0.951MetGlu: 0.951 ± 0.254
0.475MetPhe: 0.475 ± 0.189
1.366MetGly: 1.366 ± 0.364
0.535MetHis: 0.535 ± 0.178
0.594MetIle: 0.594 ± 0.209
0.832MetLys: 0.832 ± 0.242
1.01MetLeu: 1.01 ± 0.275
0.535MetMet: 0.535 ± 0.2
0.713MetAsn: 0.713 ± 0.242
1.307MetPro: 1.307 ± 0.232
0.713MetGln: 0.713 ± 0.172
1.961MetArg: 1.961 ± 0.404
1.485MetSer: 1.485 ± 0.231
2.852MetThr: 2.852 ± 0.408
1.248MetVal: 1.248 ± 0.298
0.416MetTrp: 0.416 ± 0.211
0.238MetTyr: 0.238 ± 0.128
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 0.443
0.238AsnCys: 0.238 ± 0.116
1.901AsnAsp: 1.901 ± 0.322
1.545AsnGlu: 1.545 ± 0.292
0.297AsnPhe: 0.297 ± 0.166
3.208AsnGly: 3.208 ± 0.37
0.772AsnHis: 0.772 ± 0.175
1.188AsnIle: 1.188 ± 0.22
0.891AsnLys: 0.891 ± 0.265
1.723AsnLeu: 1.723 ± 0.347
0.416AsnMet: 0.416 ± 0.165
0.832AsnAsn: 0.832 ± 0.281
2.495AsnPro: 2.495 ± 0.378
1.188AsnGln: 1.188 ± 0.268
2.436AsnArg: 2.436 ± 0.376
1.842AsnSer: 1.842 ± 0.317
2.792AsnThr: 2.792 ± 0.536
1.901AsnVal: 1.901 ± 0.296
0.594AsnTrp: 0.594 ± 0.142
0.475AsnTyr: 0.475 ± 0.164
0.0AsnXaa: 0.0 ± 0.0
Pro
6.416ProAla: 6.416 ± 0.613
0.654ProCys: 0.654 ± 0.183
4.634ProAsp: 4.634 ± 0.741
3.683ProGlu: 3.683 ± 0.602
1.426ProPhe: 1.426 ± 0.315
5.763ProGly: 5.763 ± 0.6
0.772ProHis: 0.772 ± 0.25
1.842ProIle: 1.842 ± 0.28
1.842ProLys: 1.842 ± 0.373
3.089ProLeu: 3.089 ± 0.389
1.545ProMet: 1.545 ± 0.271
2.258ProAsn: 2.258 ± 0.313
3.683ProPro: 3.683 ± 0.741
1.842ProGln: 1.842 ± 0.331
3.802ProArg: 3.802 ± 0.548
3.327ProSer: 3.327 ± 0.458
4.337ProThr: 4.337 ± 0.626
3.386ProVal: 3.386 ± 0.372
1.426ProTrp: 1.426 ± 0.265
1.01ProTyr: 1.01 ± 0.238
0.0ProXaa: 0.0 ± 0.0
Gln
4.456GlnAla: 4.456 ± 0.509
0.238GlnCys: 0.238 ± 0.134
1.248GlnAsp: 1.248 ± 0.288
1.366GlnGlu: 1.366 ± 0.276
0.713GlnPhe: 0.713 ± 0.202
2.555GlnGly: 2.555 ± 0.618
1.188GlnHis: 1.188 ± 0.345
2.198GlnIle: 2.198 ± 0.37
1.188GlnLys: 1.188 ± 0.334
3.921GlnLeu: 3.921 ± 0.515
0.951GlnMet: 0.951 ± 0.225
0.772GlnAsn: 0.772 ± 0.205
1.366GlnPro: 1.366 ± 0.249
2.079GlnGln: 2.079 ± 0.324
3.862GlnArg: 3.862 ± 0.557
1.366GlnSer: 1.366 ± 0.338
1.901GlnThr: 1.901 ± 0.367
2.614GlnVal: 2.614 ± 0.368
1.307GlnTrp: 1.307 ± 0.275
0.654GlnTyr: 0.654 ± 0.205
0.0GlnXaa: 0.0 ± 0.0
Arg
8.496ArgAla: 8.496 ± 0.71
0.594ArgCys: 0.594 ± 0.286
4.931ArgAsp: 4.931 ± 0.546
4.396ArgGlu: 4.396 ± 0.753
1.961ArgPhe: 1.961 ± 0.315
5.525ArgGly: 5.525 ± 0.689
1.485ArgHis: 1.485 ± 0.445
4.099ArgIle: 4.099 ± 0.594
2.733ArgLys: 2.733 ± 0.355
6.535ArgLeu: 6.535 ± 0.642
1.842ArgMet: 1.842 ± 0.353
2.376ArgAsn: 2.376 ± 0.358
4.04ArgPro: 4.04 ± 0.653
2.614ArgGln: 2.614 ± 0.492
6.298ArgArg: 6.298 ± 0.897
3.981ArgSer: 3.981 ± 0.494
5.288ArgThr: 5.288 ± 0.531
5.228ArgVal: 5.228 ± 0.609
1.842ArgTrp: 1.842 ± 0.335
2.02ArgTyr: 2.02 ± 0.368
0.0ArgXaa: 0.0 ± 0.0
Ser
6.832SerAla: 6.832 ± 0.692
0.416SerCys: 0.416 ± 0.164
3.624SerAsp: 3.624 ± 0.514
2.614SerGlu: 2.614 ± 0.39
1.307SerPhe: 1.307 ± 0.266
5.882SerGly: 5.882 ± 0.669
0.951SerHis: 0.951 ± 0.217
2.376SerIle: 2.376 ± 0.442
1.604SerLys: 1.604 ± 0.318
3.921SerLeu: 3.921 ± 0.457
1.663SerMet: 1.663 ± 0.366
1.901SerAsn: 1.901 ± 0.326
2.673SerPro: 2.673 ± 0.455
2.02SerGln: 2.02 ± 0.475
4.159SerArg: 4.159 ± 0.573
3.089SerSer: 3.089 ± 0.515
3.624SerThr: 3.624 ± 0.456
4.099SerVal: 4.099 ± 0.534
1.366SerTrp: 1.366 ± 0.275
1.01SerTyr: 1.01 ± 0.345
0.0SerXaa: 0.0 ± 0.0
Thr
10.753ThrAla: 10.753 ± 1.429
0.356ThrCys: 0.356 ± 0.162
5.585ThrAsp: 5.585 ± 0.618
3.327ThrGlu: 3.327 ± 0.53
1.723ThrPhe: 1.723 ± 0.363
5.941ThrGly: 5.941 ± 0.681
1.366ThrHis: 1.366 ± 0.28
3.743ThrIle: 3.743 ± 0.411
2.376ThrLys: 2.376 ± 0.35
4.931ThrLeu: 4.931 ± 0.581
1.129ThrMet: 1.129 ± 0.239
1.426ThrAsn: 1.426 ± 0.294
4.872ThrPro: 4.872 ± 0.662
1.307ThrGln: 1.307 ± 0.288
5.169ThrArg: 5.169 ± 0.54
4.931ThrSer: 4.931 ± 0.722
6.06ThrThr: 6.06 ± 0.653
6.179ThrVal: 6.179 ± 0.537
1.663ThrTrp: 1.663 ± 0.344
1.069ThrTyr: 1.069 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
7.308ValAla: 7.308 ± 0.82
0.475ValCys: 0.475 ± 0.162
5.941ValAsp: 5.941 ± 0.569
4.515ValGlu: 4.515 ± 0.545
2.02ValPhe: 2.02 ± 0.36
5.05ValGly: 5.05 ± 0.688
1.485ValHis: 1.485 ± 0.283
3.446ValIle: 3.446 ± 0.557
2.079ValLys: 2.079 ± 0.436
5.882ValLeu: 5.882 ± 0.748
1.248ValMet: 1.248 ± 0.231
2.139ValAsn: 2.139 ± 0.433
4.456ValPro: 4.456 ± 0.524
3.268ValGln: 3.268 ± 0.592
5.347ValArg: 5.347 ± 0.59
3.149ValSer: 3.149 ± 0.436
6.119ValThr: 6.119 ± 0.778
4.456ValVal: 4.456 ± 0.469
0.594ValTrp: 0.594 ± 0.207
1.426ValTyr: 1.426 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
1.248TrpAla: 1.248 ± 0.315
0.535TrpCys: 0.535 ± 0.215
0.772TrpAsp: 0.772 ± 0.257
1.248TrpGlu: 1.248 ± 0.355
0.713TrpPhe: 0.713 ± 0.231
1.604TrpGly: 1.604 ± 0.343
0.475TrpHis: 0.475 ± 0.171
0.416TrpIle: 0.416 ± 0.172
0.713TrpLys: 0.713 ± 0.199
1.723TrpLeu: 1.723 ± 0.28
0.416TrpMet: 0.416 ± 0.159
0.654TrpAsn: 0.654 ± 0.198
1.188TrpPro: 1.188 ± 0.289
0.832TrpGln: 0.832 ± 0.276
2.495TrpArg: 2.495 ± 0.43
1.129TrpSer: 1.129 ± 0.226
1.545TrpThr: 1.545 ± 0.306
1.188TrpVal: 1.188 ± 0.311
0.654TrpTrp: 0.654 ± 0.242
0.654TrpTyr: 0.654 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.792TyrAla: 2.792 ± 0.431
0.119TyrCys: 0.119 ± 0.097
1.129TyrAsp: 1.129 ± 0.238
0.713TyrGlu: 0.713 ± 0.232
0.416TyrPhe: 0.416 ± 0.168
2.198TyrGly: 2.198 ± 0.363
0.594TyrHis: 0.594 ± 0.207
0.713TyrIle: 0.713 ± 0.185
0.891TyrLys: 0.891 ± 0.226
1.485TyrLeu: 1.485 ± 0.311
0.178TyrMet: 0.178 ± 0.093
0.356TyrAsn: 0.356 ± 0.136
1.248TyrPro: 1.248 ± 0.297
0.772TyrGln: 0.772 ± 0.2
1.782TyrArg: 1.782 ± 0.3
1.723TyrSer: 1.723 ± 0.305
1.366TyrThr: 1.366 ± 0.244
1.426TyrVal: 1.426 ± 0.25
0.238TyrTrp: 0.238 ± 0.121
0.535TyrTyr: 0.535 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (16833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski