Amino acid dipepetide frequency for Burkholderia pseudomallei (strain K96243)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.909AlaAla: 22.909 ± 0.262	1.646AlaCys: 1.646 ± 0.035	7.58AlaAsp: 7.58 ± 0.081	5.988AlaGlu: 5.988 ± 0.064	4.788AlaPhe: 4.788 ± 0.062	11.725AlaGly: 11.725 ± 0.105	3.654AlaHis: 3.654 ± 0.049	5.786AlaIle: 5.786 ± 0.055	3.677AlaLys: 3.677 ± 0.059	16.736AlaLeu: 16.736 ± 0.146	3.213AlaMet: 3.213 ± 0.046	3.436AlaAsn: 3.436 ± 0.062	7.827AlaPro: 7.827 ± 0.117	5.627AlaGln: 5.627 ± 0.061	12.213AlaArg: 12.213 ± 0.13	8.29AlaSer: 8.29 ± 0.101	6.464AlaThr: 6.464 ± 0.073	8.614AlaVal: 8.614 ± 0.085	1.944AlaTrp: 1.944 ± 0.034	2.991AlaTyr: 2.991 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.592CysAla: 1.592 ± 0.03	0.112CysCys: 0.112 ± 0.008	0.598CysAsp: 0.598 ± 0.018	0.466CysGlu: 0.466 ± 0.016	0.326CysPhe: 0.326 ± 0.012	1.09CysGly: 1.09 ± 0.026	0.246CysHis: 0.246 ± 0.013	0.372CysIle: 0.372 ± 0.014	0.169CysLys: 0.169 ± 0.01	0.737CysLeu: 0.737 ± 0.019	0.199CysMet: 0.199 ± 0.009	0.215CysAsn: 0.215 ± 0.01	0.462CysPro: 0.462 ± 0.016	0.196CysGln: 0.196 ± 0.01	0.724CysArg: 0.724 ± 0.019	0.467CysSer: 0.467 ± 0.016	0.454CysThr: 0.454 ± 0.015	0.863CysVal: 0.863 ± 0.025	0.134CysTrp: 0.134 ± 0.008	0.231CysTyr: 0.231 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.606AspAla: 10.606 ± 0.124	0.473AspCys: 0.473 ± 0.017	3.634AspAsp: 3.634 ± 0.052	3.536AspGlu: 3.536 ± 0.05	1.857AspPhe: 1.857 ± 0.025	5.199AspGly: 5.199 ± 0.064	1.101AspHis: 1.101 ± 0.028	2.317AspIle: 2.317 ± 0.041	1.381AspLys: 1.381 ± 0.032	4.793AspLeu: 4.793 ± 0.051	1.089AspMet: 1.089 ± 0.025	1.07AspAsn: 1.07 ± 0.023	3.04AspPro: 3.04 ± 0.044	1.244AspGln: 1.244 ± 0.025	3.401AspArg: 3.401 ± 0.04	2.273AspSer: 2.273 ± 0.04	2.792AspThr: 2.792 ± 0.046	4.605AspVal: 4.605 ± 0.05	0.972AspTrp: 0.972 ± 0.026	1.581AspTyr: 1.581 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.015GluAla: 6.015 ± 0.078	0.433GluCys: 0.433 ± 0.016	1.766GluAsp: 1.766 ± 0.031	1.769GluGlu: 1.769 ± 0.038	1.657GluPhe: 1.657 ± 0.033	2.925GluGly: 2.925 ± 0.044	1.491GluHis: 1.491 ± 0.027	2.687GluIle: 2.687 ± 0.044	1.49GluLys: 1.49 ± 0.032	5.273GluLeu: 5.273 ± 0.065	1.058GluMet: 1.058 ± 0.025	1.239GluAsn: 1.239 ± 0.025	2.785GluPro: 2.785 ± 0.047	2.115GluGln: 2.115 ± 0.041	5.769GluArg: 5.769 ± 0.068	2.167GluSer: 2.167 ± 0.038	2.602GluThr: 2.602 ± 0.034	2.831GluVal: 2.831 ± 0.045	0.697GluTrp: 0.697 ± 0.021	1.135GluTyr: 1.135 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	5.228PheAla: 5.228 ± 0.061	0.418PheCys: 0.418 ± 0.015	2.924PheAsp: 2.924 ± 0.044	1.967PheGlu: 1.967 ± 0.033	1.414PhePhe: 1.414 ± 0.03	3.632PheGly: 3.632 ± 0.046	0.727PheHis: 0.727 ± 0.018	1.313PheIle: 1.313 ± 0.027	0.869PheLys: 0.869 ± 0.024	2.644PheLeu: 2.644 ± 0.046	0.675PheMet: 0.675 ± 0.02	0.985PheAsn: 0.985 ± 0.023	1.476PhePro: 1.476 ± 0.028	0.875PheGln: 0.875 ± 0.021	2.026PheArg: 2.026 ± 0.033	2.093PheSer: 2.093 ± 0.04	1.732PheThr: 1.732 ± 0.034	3.371PheVal: 3.371 ± 0.044	0.492PheTrp: 0.492 ± 0.019	0.903PheTyr: 0.903 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.84GlyAla: 11.84 ± 0.124	0.9GlyCys: 0.9 ± 0.025	4.448GlyAsp: 4.448 ± 0.048	4.46GlyGlu: 4.46 ± 0.056	3.307GlyPhe: 3.307 ± 0.048	7.505GlyGly: 7.505 ± 0.11	1.77GlyHis: 1.77 ± 0.033	3.939GlyIle: 3.939 ± 0.059	2.751GlyLys: 2.751 ± 0.043	7.657GlyLeu: 7.657 ± 0.089	2.055GlyMet: 2.055 ± 0.031	2.145GlyAsn: 2.145 ± 0.05	3.004GlyPro: 3.004 ± 0.034	2.342GlyGln: 2.342 ± 0.041	5.95GlyArg: 5.95 ± 0.067	4.146GlySer: 4.146 ± 0.066	4.289GlyThr: 4.289 ± 0.074	6.859GlyVal: 6.859 ± 0.067	1.418GlyTrp: 1.418 ± 0.027	2.488GlyTyr: 2.488 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.886HisAla: 3.886 ± 0.052	0.27HisCys: 0.27 ± 0.012	1.387HisAsp: 1.387 ± 0.028	1.126HisGlu: 1.126 ± 0.025	0.88HisPhe: 0.88 ± 0.024	2.282HisGly: 2.282 ± 0.04	0.607HisHis: 0.607 ± 0.02	0.75HisIle: 0.75 ± 0.02	0.431HisLys: 0.431 ± 0.016	2.076HisLeu: 2.076 ± 0.036	0.418HisMet: 0.418 ± 0.016	0.453HisAsn: 0.453 ± 0.017	1.535HisPro: 1.535 ± 0.03	0.57HisGln: 0.57 ± 0.017	1.736HisArg: 1.736 ± 0.03	0.973HisSer: 0.973 ± 0.023	1.065HisThr: 1.065 ± 0.021	1.828HisVal: 1.828 ± 0.033	0.395HisTrp: 0.395 ± 0.014	0.669HisTyr: 0.669 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.35IleAla: 7.35 ± 0.064	0.373IleCys: 0.373 ± 0.014	3.597IleAsp: 3.597 ± 0.043	3.015IleGlu: 3.015 ± 0.041	1.206IlePhe: 1.206 ± 0.028	4.7IleGly: 4.7 ± 0.054	0.853IleHis: 0.853 ± 0.022	1.149IleIle: 1.149 ± 0.029	1.104IleLys: 1.104 ± 0.029	2.826IleLeu: 2.826 ± 0.044	0.587IleMet: 0.587 ± 0.018	1.112IleAsn: 1.112 ± 0.027	1.798IlePro: 1.798 ± 0.038	1.053IleGln: 1.053 ± 0.027	2.735IleArg: 2.735 ± 0.038	1.957IleSer: 1.957 ± 0.034	1.927IleThr: 1.927 ± 0.036	4.395IleVal: 4.395 ± 0.054	0.448IleTrp: 0.448 ± 0.017	0.901IleTyr: 0.901 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.161LysAla: 3.161 ± 0.052	0.152LysCys: 0.152 ± 0.008	1.225LysAsp: 1.225 ± 0.026	1.147LysGlu: 1.147 ± 0.033	0.783LysPhe: 0.783 ± 0.027	1.832LysGly: 1.832 ± 0.036	0.643LysHis: 0.643 ± 0.019	1.407LysIle: 1.407 ± 0.032	1.036LysLys: 1.036 ± 0.034	3.069LysLeu: 3.069 ± 0.051	0.692LysMet: 0.692 ± 0.022	0.737LysAsn: 0.737 ± 0.024	1.827LysPro: 1.827 ± 0.032	1.071LysGln: 1.071 ± 0.028	2.423LysArg: 2.423 ± 0.043	1.462LysSer: 1.462 ± 0.033	1.684LysThr: 1.684 ± 0.031	1.899LysVal: 1.899 ± 0.036	0.321LysTrp: 0.321 ± 0.013	0.631LysTyr: 0.631 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.69LeuAla: 15.69 ± 0.139	0.958LeuCys: 0.958 ± 0.024	6.464LeuAsp: 6.464 ± 0.064	4.614LeuGlu: 4.614 ± 0.048	3.546LeuPhe: 3.546 ± 0.042	8.067LeuGly: 8.067 ± 0.072	2.176LeuHis: 2.176 ± 0.033	4.021LeuIle: 4.021 ± 0.054	3.02LeuLys: 3.02 ± 0.045	9.421LeuLeu: 9.421 ± 0.097	2.024LeuMet: 2.024 ± 0.034	2.572LeuAsn: 2.572 ± 0.04	5.879LeuPro: 5.879 ± 0.055	2.844LeuGln: 2.844 ± 0.047	7.494LeuArg: 7.494 ± 0.08	6.109LeuSer: 6.109 ± 0.156	5.047LeuThr: 5.047 ± 0.061	7.551LeuVal: 7.551 ± 0.07	1.122LeuTrp: 1.122 ± 0.025	2.226LeuTyr: 2.226 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.11MetAla: 2.11 ± 0.037	0.166MetCys: 0.166 ± 0.009	0.791MetAsp: 0.791 ± 0.017	0.727MetGlu: 0.727 ± 0.02	0.703MetPhe: 0.703 ± 0.019	1.303MetGly: 1.303 ± 0.029	0.526MetHis: 0.526 ± 0.017	1.019MetIle: 1.019 ± 0.026	0.913MetLys: 0.913 ± 0.024	2.531MetLeu: 2.531 ± 0.04	0.546MetMet: 0.546 ± 0.016	0.828MetAsn: 0.828 ± 0.022	1.461MetPro: 1.461 ± 0.028	0.864MetGln: 0.864 ± 0.022	1.91MetArg: 1.91 ± 0.028	1.655MetSer: 1.655 ± 0.029	1.521MetThr: 1.521 ± 0.026	1.228MetVal: 1.228 ± 0.028	0.205MetTrp: 0.205 ± 0.01	0.375MetTyr: 0.375 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.602AsnAla: 3.602 ± 0.056	0.231AsnCys: 0.231 ± 0.011	1.368AsnAsp: 1.368 ± 0.026	1.127AsnGlu: 1.127 ± 0.026	0.88AsnPhe: 0.88 ± 0.022	2.515AsnGly: 2.515 ± 0.046	0.507AsnHis: 0.507 ± 0.017	0.936AsnIle: 0.936 ± 0.023	0.55AsnLys: 0.55 ± 0.02	2.502AsnLeu: 2.502 ± 0.044	0.477AsnMet: 0.477 ± 0.016	0.715AsnAsn: 0.715 ± 0.028	1.689AsnPro: 1.689 ± 0.035	0.793AsnGln: 0.793 ± 0.026	1.818AsnArg: 1.818 ± 0.033	1.227AsnSer: 1.227 ± 0.062	1.3AsnThr: 1.3 ± 0.031	2.192AsnVal: 2.192 ± 0.038	0.387AsnTrp: 0.387 ± 0.015	0.693AsnTyr: 0.693 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.031ProAla: 8.031 ± 0.107	0.396ProCys: 0.396 ± 0.017	3.504ProAsp: 3.504 ± 0.044	2.667ProGlu: 2.667 ± 0.041	1.986ProPhe: 1.986 ± 0.035	4.426ProGly: 4.426 ± 0.056	1.327ProHis: 1.327 ± 0.026	2.065ProIle: 2.065 ± 0.03	1.332ProLys: 1.332 ± 0.026	5.374ProLeu: 5.374 ± 0.067	1.026ProMet: 1.026 ± 0.021	1.475ProAsn: 1.475 ± 0.033	2.907ProPro: 2.907 ± 0.053	1.718ProGln: 1.718 ± 0.03	3.585ProArg: 3.585 ± 0.053	2.961ProSer: 2.961 ± 0.044	2.504ProThr: 2.504 ± 0.051	4.097ProVal: 4.097 ± 0.046	0.669ProTrp: 0.669 ± 0.018	1.25ProTyr: 1.25 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.422GlnAla: 4.422 ± 0.063	0.272GlnCys: 0.272 ± 0.011	1.22GlnAsp: 1.22 ± 0.029	1.09GlnGlu: 1.09 ± 0.029	1.121GlnPhe: 1.121 ± 0.026	2.162GlnGly: 2.162 ± 0.039	0.792GlnHis: 0.792 ± 0.02	1.732GlnIle: 1.732 ± 0.031	0.893GlnLys: 0.893 ± 0.024	3.394GlnLeu: 3.394 ± 0.046	0.857GlnMet: 0.857 ± 0.023	0.783GlnAsn: 0.783 ± 0.02	1.962GlnPro: 1.962 ± 0.033	1.573GlnGln: 1.573 ± 0.04	2.754GlnArg: 2.754 ± 0.044	1.673GlnSer: 1.673 ± 0.028	1.833GlnThr: 1.833 ± 0.032	2.143GlnVal: 2.143 ± 0.038	0.526GlnTrp: 0.526 ± 0.016	0.859GlnTyr: 0.859 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	11.19ArgAla: 11.19 ± 0.11	0.722ArgCys: 0.722 ± 0.019	4.677ArgAsp: 4.677 ± 0.053	4.404ArgGlu: 4.404 ± 0.062	3.222ArgPhe: 3.222 ± 0.044	5.399ArgGly: 5.399 ± 0.06	2.19ArgHis: 2.19 ± 0.035	3.897ArgIle: 3.897 ± 0.043	1.88ArgLys: 1.88 ± 0.036	7.79ArgLeu: 7.79 ± 0.08	1.896ArgMet: 1.896 ± 0.028	1.813ArgAsn: 1.813 ± 0.033	3.427ArgPro: 3.427 ± 0.04	2.421ArgGln: 2.421 ± 0.039	6.72ArgArg: 6.72 ± 0.081	3.253ArgSer: 3.253 ± 0.039	3.623ArgThr: 3.623 ± 0.052	5.768ArgVal: 5.768 ± 0.064	1.168ArgTrp: 1.168 ± 0.023	2.229ArgTyr: 2.229 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.065SerAla: 7.065 ± 0.084	0.45SerCys: 0.45 ± 0.016	2.581SerAsp: 2.581 ± 0.039	2.192SerGlu: 2.192 ± 0.037	2.006SerPhe: 2.006 ± 0.04	5.208SerGly: 5.208 ± 0.079	1.162SerHis: 1.162 ± 0.021	2.572SerIle: 2.572 ± 0.04	1.334SerLys: 1.334 ± 0.031	5.506SerLeu: 5.506 ± 0.103	1.182SerMet: 1.182 ± 0.028	1.52SerAsn: 1.52 ± 0.037	2.853SerPro: 2.853 ± 0.039	1.5SerGln: 1.5 ± 0.03	3.686SerArg: 3.686 ± 0.044	3.092SerSer: 3.092 ± 0.092	3.247SerThr: 3.247 ± 0.21	3.977SerVal: 3.977 ± 0.05	0.66SerTrp: 0.66 ± 0.02	1.26SerTyr: 1.26 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.674ThrAla: 5.674 ± 0.072	0.419ThrCys: 0.419 ± 0.016	2.525ThrAsp: 2.525 ± 0.038	1.975ThrGlu: 1.975 ± 0.034	1.905ThrPhe: 1.905 ± 0.037	4.703ThrGly: 4.703 ± 0.086	1.209ThrHis: 1.209 ± 0.026	2.451ThrIle: 2.451 ± 0.042	1.177ThrLys: 1.177 ± 0.025	6.314ThrLeu: 6.314 ± 0.064	1.088ThrMet: 1.088 ± 0.024	1.385ThrAsn: 1.385 ± 0.053	3.37ThrPro: 3.37 ± 0.058	1.748ThrGln: 1.748 ± 0.04	3.451ThrArg: 3.451 ± 0.041	2.993ThrSer: 2.993 ± 0.12	2.667ThrThr: 2.667 ± 0.057	3.971ThrVal: 3.971 ± 0.049	0.593ThrTrp: 0.593 ± 0.018	1.236ThrTyr: 1.236 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.294ValAla: 10.294 ± 0.093	0.846ValCys: 0.846 ± 0.024	4.632ValAsp: 4.632 ± 0.049	3.995ValGlu: 3.995 ± 0.053	2.626ValPhe: 2.626 ± 0.042	5.6ValGly: 5.6 ± 0.061	1.464ValHis: 1.464 ± 0.028	3.256ValIle: 3.256 ± 0.048	2.251ValLys: 2.251 ± 0.04	7.579ValLeu: 7.579 ± 0.074	1.56ValMet: 1.56 ± 0.034	1.993ValAsn: 1.993 ± 0.037	4.008ValPro: 4.008 ± 0.048	2.126ValGln: 2.126 ± 0.039	5.573ValArg: 5.573 ± 0.063	4.356ValSer: 4.356 ± 0.053	4.208ValThr: 4.208 ± 0.052	5.898ValVal: 5.898 ± 0.065	0.934ValTrp: 0.934 ± 0.024	1.729ValTyr: 1.729 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.316TrpAla: 1.316 ± 0.026	0.149TrpCys: 0.149 ± 0.009	0.581TrpAsp: 0.581 ± 0.017	0.462TrpGlu: 0.462 ± 0.016	0.548TrpPhe: 0.548 ± 0.019	0.868TrpGly: 0.868 ± 0.021	0.371TrpHis: 0.371 ± 0.013	0.682TrpIle: 0.682 ± 0.021	0.388TrpLys: 0.388 ± 0.014	2.039TrpLeu: 2.039 ± 0.04	0.314TrpMet: 0.314 ± 0.013	0.433TrpAsn: 0.433 ± 0.014	0.717TrpPro: 0.717 ± 0.022	0.577TrpGln: 0.577 ± 0.018	1.479TrpArg: 1.479 ± 0.033	0.755TrpSer: 0.755 ± 0.022	0.67TrpThr: 0.67 ± 0.02	0.824TrpVal: 0.824 ± 0.022	0.204TrpTrp: 0.204 ± 0.012	0.321TrpTyr: 0.321 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.129TyrAla: 3.129 ± 0.042	0.269TyrCys: 0.269 ± 0.012	1.46TyrAsp: 1.46 ± 0.03	1.177TyrGlu: 1.177 ± 0.025	1.005TyrPhe: 1.005 ± 0.027	2.129TyrGly: 2.129 ± 0.039	0.52TyrHis: 0.52 ± 0.016	0.737TyrIle: 0.737 ± 0.024	0.556TyrLys: 0.556 ± 0.019	2.584TyrLeu: 2.584 ± 0.039	0.423TyrMet: 0.423 ± 0.017	0.603TyrAsn: 0.603 ± 0.018	1.276TyrPro: 1.276 ± 0.025	0.807TyrGln: 0.807 ± 0.023	2.239TyrArg: 2.239 ± 0.037	1.149TyrSer: 1.149 ± 0.026	1.225TyrThr: 1.225 ± 0.029	2.011TyrVal: 2.011 ± 0.035	0.41TyrTrp: 0.41 ± 0.016	0.688TyrTyr: 0.688 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5717 proteins (1988316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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