Amino acid dipepetide frequency for Streptococcus phage Javan146

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.635AlaAla: 3.635 ± 0.628
0.553AlaCys: 0.553 ± 0.199
4.03AlaAsp: 4.03 ± 0.653
6.796AlaGlu: 6.796 ± 0.647
2.766AlaPhe: 2.766 ± 0.485
5.531AlaGly: 5.531 ± 1.144
0.869AlaHis: 0.869 ± 0.271
5.294AlaIle: 5.294 ± 0.922
6.006AlaLys: 6.006 ± 0.761
5.689AlaLeu: 5.689 ± 1.306
1.738AlaMet: 1.738 ± 0.354
3.398AlaAsn: 3.398 ± 0.51
1.264AlaPro: 1.264 ± 0.365
2.292AlaGln: 2.292 ± 0.393
2.766AlaArg: 2.766 ± 0.356
2.924AlaSer: 2.924 ± 0.549
4.504AlaThr: 4.504 ± 0.642
5.373AlaVal: 5.373 ± 0.797
1.106AlaTrp: 1.106 ± 0.589
2.292AlaTyr: 2.292 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
0.237CysAla: 0.237 ± 0.142
0.0CysCys: 0.0 ± 0.0
0.395CysAsp: 0.395 ± 0.149
0.553CysGlu: 0.553 ± 0.192
0.079CysPhe: 0.079 ± 0.074
0.395CysGly: 0.395 ± 0.205
0.0CysHis: 0.0 ± 0.0
0.158CysIle: 0.158 ± 0.112
0.474CysLys: 0.474 ± 0.213
0.553CysLeu: 0.553 ± 0.21
0.0CysMet: 0.0 ± 0.0
0.316CysAsn: 0.316 ± 0.146
0.079CysPro: 0.079 ± 0.081
0.316CysGln: 0.316 ± 0.145
0.0CysArg: 0.0 ± 0.0
0.316CysSer: 0.316 ± 0.152
0.079CysThr: 0.079 ± 0.069
0.395CysVal: 0.395 ± 0.175
0.0CysTrp: 0.0 ± 0.0
0.079CysTyr: 0.079 ± 0.071
0.0CysXaa: 0.0 ± 0.0
Asp
4.583AspAla: 4.583 ± 0.598
0.474AspCys: 0.474 ± 0.181
3.714AspAsp: 3.714 ± 0.648
5.057AspGlu: 5.057 ± 0.732
3.556AspPhe: 3.556 ± 0.471
5.61AspGly: 5.61 ± 0.767
0.553AspHis: 0.553 ± 0.21
5.057AspIle: 5.057 ± 0.678
5.847AspLys: 5.847 ± 0.878
6.164AspLeu: 6.164 ± 0.789
1.106AspMet: 1.106 ± 0.397
3.398AspAsn: 3.398 ± 0.546
1.58AspPro: 1.58 ± 0.336
0.869AspGln: 0.869 ± 0.262
2.371AspArg: 2.371 ± 0.411
4.03AspSer: 4.03 ± 0.547
3.714AspThr: 3.714 ± 0.48
3.477AspVal: 3.477 ± 0.48
1.027AspTrp: 1.027 ± 0.283
3.398AspTyr: 3.398 ± 0.484
0.0AspXaa: 0.0 ± 0.0
Glu
5.927GluAla: 5.927 ± 0.676
0.079GluCys: 0.079 ± 0.083
3.319GluAsp: 3.319 ± 0.605
5.215GluGlu: 5.215 ± 0.824
3.082GluPhe: 3.082 ± 0.398
3.872GluGly: 3.872 ± 0.502
1.185GluHis: 1.185 ± 0.267
6.164GluIle: 6.164 ± 0.594
7.191GluLys: 7.191 ± 0.962
9.324GluLeu: 9.324 ± 1.037
2.608GluMet: 2.608 ± 0.375
3.951GluAsn: 3.951 ± 0.787
2.055GluPro: 2.055 ± 0.468
3.556GluGln: 3.556 ± 0.496
2.766GluArg: 2.766 ± 0.657
2.687GluSer: 2.687 ± 0.542
4.03GluThr: 4.03 ± 0.465
5.452GluVal: 5.452 ± 0.714
0.869GluTrp: 0.869 ± 0.313
2.924GluTyr: 2.924 ± 0.542
0.0GluXaa: 0.0 ± 0.0
Phe
2.371PheAla: 2.371 ± 0.396
0.237PheCys: 0.237 ± 0.115
2.845PheAsp: 2.845 ± 0.54
3.398PheGlu: 3.398 ± 0.547
1.738PhePhe: 1.738 ± 0.377
2.213PheGly: 2.213 ± 0.373
0.632PheHis: 0.632 ± 0.219
2.687PheIle: 2.687 ± 0.514
3.477PheLys: 3.477 ± 0.562
3.003PheLeu: 3.003 ± 0.599
0.948PheMet: 0.948 ± 0.283
1.976PheAsn: 1.976 ± 0.345
1.264PhePro: 1.264 ± 0.25
1.185PheGln: 1.185 ± 0.342
1.659PheArg: 1.659 ± 0.283
2.608PheSer: 2.608 ± 0.594
2.371PheThr: 2.371 ± 0.317
2.213PheVal: 2.213 ± 0.346
0.316PheTrp: 0.316 ± 0.201
1.896PheTyr: 1.896 ± 0.415
0.0PheXaa: 0.0 ± 0.0
Gly
4.346GlyAla: 4.346 ± 0.677
0.316GlyCys: 0.316 ± 0.151
4.109GlyAsp: 4.109 ± 0.735
4.109GlyGlu: 4.109 ± 0.656
3.398GlyPhe: 3.398 ± 0.517
3.872GlyGly: 3.872 ± 0.601
1.106GlyHis: 1.106 ± 0.277
4.662GlyIle: 4.662 ± 0.889
5.057GlyLys: 5.057 ± 0.565
4.899GlyLeu: 4.899 ± 0.747
1.896GlyMet: 1.896 ± 0.365
3.635GlyAsn: 3.635 ± 0.407
1.976GlyPro: 1.976 ± 1.4
2.45GlyGln: 2.45 ± 0.499
1.976GlyArg: 1.976 ± 0.459
2.45GlySer: 2.45 ± 0.483
3.003GlyThr: 3.003 ± 0.572
4.346GlyVal: 4.346 ± 0.551
1.106GlyTrp: 1.106 ± 0.285
2.608GlyTyr: 2.608 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
0.869HisAla: 0.869 ± 0.287
0.079HisCys: 0.079 ± 0.082
0.553HisAsp: 0.553 ± 0.203
1.501HisGlu: 1.501 ± 0.392
0.237HisPhe: 0.237 ± 0.153
0.79HisGly: 0.79 ± 0.228
0.237HisHis: 0.237 ± 0.139
1.264HisIle: 1.264 ± 0.372
0.553HisLys: 0.553 ± 0.167
0.869HisLeu: 0.869 ± 0.294
0.158HisMet: 0.158 ± 0.117
1.343HisAsn: 1.343 ± 0.293
0.395HisPro: 0.395 ± 0.185
0.632HisGln: 0.632 ± 0.237
0.553HisArg: 0.553 ± 0.172
0.948HisSer: 0.948 ± 0.378
1.185HisThr: 1.185 ± 0.299
0.474HisVal: 0.474 ± 0.232
0.0HisTrp: 0.0 ± 0.0
0.474HisTyr: 0.474 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
4.583IleAla: 4.583 ± 0.564
0.395IleCys: 0.395 ± 0.17
5.927IleAsp: 5.927 ± 0.907
6.48IleGlu: 6.48 ± 0.977
1.976IlePhe: 1.976 ± 0.357
3.319IleGly: 3.319 ± 0.546
0.711IleHis: 0.711 ± 0.234
4.741IleIle: 4.741 ± 0.633
8.692IleLys: 8.692 ± 1.257
4.82IleLeu: 4.82 ± 0.611
1.106IleMet: 1.106 ± 0.329
4.03IleAsn: 4.03 ± 0.566
1.976IlePro: 1.976 ± 0.404
2.292IleGln: 2.292 ± 0.322
2.45IleArg: 2.45 ± 0.495
4.662IleSer: 4.662 ± 0.65
6.006IleThr: 6.006 ± 0.657
4.109IleVal: 4.109 ± 0.621
1.106IleTrp: 1.106 ± 0.456
2.687IleTyr: 2.687 ± 0.485
0.0IleXaa: 0.0 ± 0.0
Lys
6.638LysAla: 6.638 ± 0.905
0.474LysCys: 0.474 ± 0.178
6.085LysAsp: 6.085 ± 0.745
6.243LysGlu: 6.243 ± 0.866
2.687LysPhe: 2.687 ± 0.536
4.899LysGly: 4.899 ± 0.932
1.264LysHis: 1.264 ± 0.309
8.06LysIle: 8.06 ± 0.827
8.139LysLys: 8.139 ± 0.971
7.665LysLeu: 7.665 ± 0.706
3.319LysMet: 3.319 ± 0.516
7.349LysAsn: 7.349 ± 0.726
2.529LysPro: 2.529 ± 0.427
3.951LysGln: 3.951 ± 0.626
3.003LysArg: 3.003 ± 0.568
5.057LysSer: 5.057 ± 0.676
5.531LysThr: 5.531 ± 0.554
5.136LysVal: 5.136 ± 0.767
1.106LysTrp: 1.106 ± 0.271
3.951LysTyr: 3.951 ± 0.662
0.0LysXaa: 0.0 ± 0.0
Leu
5.294LeuAla: 5.294 ± 0.945
0.237LeuCys: 0.237 ± 0.116
7.033LeuAsp: 7.033 ± 0.87
6.164LeuGlu: 6.164 ± 0.8
1.976LeuPhe: 1.976 ± 0.427
5.294LeuGly: 5.294 ± 0.769
1.264LeuHis: 1.264 ± 0.351
5.452LeuIle: 5.452 ± 0.596
9.008LeuLys: 9.008 ± 0.838
6.796LeuLeu: 6.796 ± 0.769
1.343LeuMet: 1.343 ± 0.347
5.768LeuAsn: 5.768 ± 0.582
2.687LeuPro: 2.687 ± 0.442
2.845LeuGln: 2.845 ± 0.558
2.924LeuArg: 2.924 ± 0.477
6.401LeuSer: 6.401 ± 0.754
6.48LeuThr: 6.48 ± 0.715
4.741LeuVal: 4.741 ± 0.52
0.711LeuTrp: 0.711 ± 0.333
2.924LeuTyr: 2.924 ± 0.529
0.0LeuXaa: 0.0 ± 0.0
Met
2.292MetAla: 2.292 ± 0.522
0.079MetCys: 0.079 ± 0.071
1.185MetAsp: 1.185 ± 0.281
1.343MetGlu: 1.343 ± 0.349
1.185MetPhe: 1.185 ± 0.267
0.79MetGly: 0.79 ± 0.259
0.237MetHis: 0.237 ± 0.142
1.422MetIle: 1.422 ± 0.326
1.501MetLys: 1.501 ± 0.386
1.58MetLeu: 1.58 ± 0.313
0.711MetMet: 0.711 ± 0.23
1.659MetAsn: 1.659 ± 0.31
0.711MetPro: 0.711 ± 0.217
1.185MetGln: 1.185 ± 0.272
1.185MetArg: 1.185 ± 0.31
1.343MetSer: 1.343 ± 0.417
1.58MetThr: 1.58 ± 0.406
1.027MetVal: 1.027 ± 0.299
0.237MetTrp: 0.237 ± 0.171
0.79MetTyr: 0.79 ± 0.291
0.0MetXaa: 0.0 ± 0.0
Asn
5.689AsnAla: 5.689 ± 0.931
0.316AsnCys: 0.316 ± 0.145
2.529AsnAsp: 2.529 ± 0.529
3.24AsnGlu: 3.24 ± 0.529
2.213AsnPhe: 2.213 ± 0.393
4.267AsnGly: 4.267 ± 0.614
0.79AsnHis: 0.79 ± 0.288
4.504AsnIle: 4.504 ± 0.501
4.978AsnLys: 4.978 ± 0.549
5.452AsnLeu: 5.452 ± 0.621
1.264AsnMet: 1.264 ± 0.318
3.398AsnAsn: 3.398 ± 0.542
2.529AsnPro: 2.529 ± 0.424
2.845AsnGln: 2.845 ± 0.544
2.924AsnArg: 2.924 ± 0.512
3.477AsnSer: 3.477 ± 0.671
2.924AsnThr: 2.924 ± 0.506
2.45AsnVal: 2.45 ± 0.389
1.264AsnTrp: 1.264 ± 0.303
3.003AsnTyr: 3.003 ± 0.603
0.0AsnXaa: 0.0 ± 0.0
Pro
1.027ProAla: 1.027 ± 0.272
0.0ProCys: 0.0 ± 0.0
2.213ProAsp: 2.213 ± 0.507
2.134ProGlu: 2.134 ± 0.408
0.948ProPhe: 0.948 ± 0.261
0.948ProGly: 0.948 ± 0.26
0.474ProHis: 0.474 ± 0.203
1.58ProIle: 1.58 ± 0.367
2.608ProLys: 2.608 ± 0.691
1.896ProLeu: 1.896 ± 0.381
0.395ProMet: 0.395 ± 0.174
2.45ProAsn: 2.45 ± 0.406
1.185ProPro: 1.185 ± 0.401
1.501ProGln: 1.501 ± 0.353
2.134ProArg: 2.134 ± 0.389
2.213ProSer: 2.213 ± 0.463
1.106ProThr: 1.106 ± 0.286
1.976ProVal: 1.976 ± 0.406
0.079ProTrp: 0.079 ± 0.08
1.185ProTyr: 1.185 ± 0.308
0.0ProXaa: 0.0 ± 0.0
Gln
3.398GlnAla: 3.398 ± 0.46
0.237GlnCys: 0.237 ± 0.131
2.687GlnAsp: 2.687 ± 0.39
2.687GlnGlu: 2.687 ± 0.45
1.264GlnPhe: 1.264 ± 0.3
2.924GlnGly: 2.924 ± 0.618
0.553GlnHis: 0.553 ± 0.187
2.529GlnIle: 2.529 ± 0.477
3.398GlnLys: 3.398 ± 0.44
3.793GlnLeu: 3.793 ± 0.52
0.869GlnMet: 0.869 ± 0.271
1.58GlnAsn: 1.58 ± 0.352
0.474GlnPro: 0.474 ± 0.213
2.213GlnGln: 2.213 ± 0.449
1.264GlnArg: 1.264 ± 0.285
3.714GlnSer: 3.714 ± 0.535
2.292GlnThr: 2.292 ± 0.54
2.45GlnVal: 2.45 ± 0.458
0.158GlnTrp: 0.158 ± 0.096
1.106GlnTyr: 1.106 ± 0.288
0.0GlnXaa: 0.0 ± 0.0
Arg
1.976ArgAla: 1.976 ± 0.316
0.0ArgCys: 0.0 ± 0.0
2.213ArgAsp: 2.213 ± 0.471
2.45ArgGlu: 2.45 ± 0.525
1.501ArgPhe: 1.501 ± 0.34
2.055ArgGly: 2.055 ± 0.673
0.711ArgHis: 0.711 ± 0.276
2.608ArgIle: 2.608 ± 0.512
3.477ArgLys: 3.477 ± 0.484
4.346ArgLeu: 4.346 ± 0.697
1.027ArgMet: 1.027 ± 0.269
2.371ArgAsn: 2.371 ± 0.422
1.501ArgPro: 1.501 ± 0.354
1.58ArgGln: 1.58 ± 0.326
2.134ArgArg: 2.134 ± 0.336
1.738ArgSer: 1.738 ± 0.365
1.58ArgThr: 1.58 ± 0.309
3.003ArgVal: 3.003 ± 0.496
0.316ArgTrp: 0.316 ± 0.162
2.292ArgTyr: 2.292 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
4.425SerAla: 4.425 ± 0.614
0.237SerCys: 0.237 ± 0.14
3.872SerAsp: 3.872 ± 0.631
4.425SerGlu: 4.425 ± 0.562
2.924SerPhe: 2.924 ± 0.651
3.793SerGly: 3.793 ± 0.884
0.395SerHis: 0.395 ± 0.148
3.082SerIle: 3.082 ± 0.462
4.741SerLys: 4.741 ± 0.604
4.109SerLeu: 4.109 ± 0.721
1.422SerMet: 1.422 ± 0.403
4.583SerAsn: 4.583 ± 0.714
1.264SerPro: 1.264 ± 0.339
2.845SerGln: 2.845 ± 0.47
2.45SerArg: 2.45 ± 0.426
2.213SerSer: 2.213 ± 0.472
2.608SerThr: 2.608 ± 0.399
4.662SerVal: 4.662 ± 0.705
0.553SerTrp: 0.553 ± 0.173
2.213SerTyr: 2.213 ± 0.425
0.0SerXaa: 0.0 ± 0.0
Thr
4.741ThrAla: 4.741 ± 1.278
0.079ThrCys: 0.079 ± 0.065
3.872ThrAsp: 3.872 ± 0.559
4.425ThrGlu: 4.425 ± 0.649
2.608ThrPhe: 2.608 ± 0.492
4.899ThrGly: 4.899 ± 0.89
0.632ThrHis: 0.632 ± 0.194
4.03ThrIle: 4.03 ± 0.614
6.638ThrLys: 6.638 ± 1.035
5.768ThrLeu: 5.768 ± 0.748
0.474ThrMet: 0.474 ± 0.151
2.766ThrAsn: 2.766 ± 0.428
1.501ThrPro: 1.501 ± 0.323
1.896ThrGln: 1.896 ± 0.354
1.264ThrArg: 1.264 ± 0.304
3.003ThrSer: 3.003 ± 0.448
4.109ThrThr: 4.109 ± 0.661
3.714ThrVal: 3.714 ± 0.528
0.869ThrTrp: 0.869 ± 0.314
2.687ThrTyr: 2.687 ± 0.519
0.0ThrXaa: 0.0 ± 0.0
Val
4.109ValAla: 4.109 ± 0.709
0.395ValCys: 0.395 ± 0.16
4.741ValAsp: 4.741 ± 0.595
5.689ValGlu: 5.689 ± 0.76
2.687ValPhe: 2.687 ± 0.447
2.45ValGly: 2.45 ± 0.5
0.316ValHis: 0.316 ± 0.147
4.504ValIle: 4.504 ± 0.674
6.164ValLys: 6.164 ± 0.657
4.346ValLeu: 4.346 ± 0.555
0.79ValMet: 0.79 ± 0.245
2.45ValAsn: 2.45 ± 0.468
1.58ValPro: 1.58 ± 0.421
2.371ValGln: 2.371 ± 0.371
2.845ValArg: 2.845 ± 0.469
4.583ValSer: 4.583 ± 0.506
4.504ValThr: 4.504 ± 0.638
4.899ValVal: 4.899 ± 0.583
1.264ValTrp: 1.264 ± 0.422
1.976ValTyr: 1.976 ± 0.456
0.0ValXaa: 0.0 ± 0.0
Trp
0.79TrpAla: 0.79 ± 0.282
0.0TrpCys: 0.0 ± 0.0
0.553TrpAsp: 0.553 ± 0.23
1.501TrpGlu: 1.501 ± 0.718
0.474TrpPhe: 0.474 ± 0.156
0.79TrpGly: 0.79 ± 0.218
0.237TrpHis: 0.237 ± 0.124
1.185TrpIle: 1.185 ± 0.354
1.106TrpLys: 1.106 ± 0.259
1.106TrpLeu: 1.106 ± 0.333
0.237TrpMet: 0.237 ± 0.126
1.106TrpAsn: 1.106 ± 0.408
0.0TrpPro: 0.0 ± 0.0
0.474TrpGln: 0.474 ± 0.187
0.632TrpArg: 0.632 ± 0.253
0.632TrpSer: 0.632 ± 0.205
0.553TrpThr: 0.553 ± 0.198
0.79TrpVal: 0.79 ± 0.304
0.079TrpTrp: 0.079 ± 0.083
0.316TrpTyr: 0.316 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.896TyrAla: 1.896 ± 0.469
0.237TyrCys: 0.237 ± 0.139
3.793TyrAsp: 3.793 ± 0.488
2.845TyrGlu: 2.845 ± 0.478
1.738TyrPhe: 1.738 ± 0.481
2.608TyrGly: 2.608 ± 0.455
0.948TyrHis: 0.948 ± 0.271
3.082TyrIle: 3.082 ± 0.479
4.03TyrLys: 4.03 ± 0.723
3.161TyrLeu: 3.161 ± 0.542
0.553TyrMet: 0.553 ± 0.177
2.529TyrAsn: 2.529 ± 0.501
1.501TyrPro: 1.501 ± 0.425
2.292TyrGln: 2.292 ± 0.525
1.58TyrArg: 1.58 ± 0.319
1.817TyrSer: 1.817 ± 0.429
1.817TyrThr: 1.817 ± 0.369
1.976TyrVal: 1.976 ± 0.472
0.395TyrTrp: 0.395 ± 0.173
1.501TyrTyr: 1.501 ± 0.495
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (12656 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski