Amino acid dipepetide frequency for Deinococcus marmoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.548AlaAla: 16.548 ± 0.148	0.853AlaCys: 0.853 ± 0.027	6.146AlaAsp: 6.146 ± 0.073	6.786AlaGlu: 6.786 ± 0.084	3.932AlaPhe: 3.932 ± 0.051	11.309AlaGly: 11.309 ± 0.104	2.573AlaHis: 2.573 ± 0.052	3.777AlaIle: 3.777 ± 0.059	2.646AlaLys: 2.646 ± 0.061	15.866AlaLeu: 15.866 ± 0.139	2.225AlaMet: 2.225 ± 0.04	2.315AlaAsn: 2.315 ± 0.041	5.793AlaPro: 5.793 ± 0.076	5.889AlaGln: 5.889 ± 0.081	9.073AlaArg: 9.073 ± 0.091	6.092AlaSer: 6.092 ± 0.057	5.631AlaThr: 5.631 ± 0.08	8.981AlaVal: 8.981 ± 0.094	1.643AlaTrp: 1.643 ± 0.039	2.858AlaTyr: 2.858 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.783CysAla: 0.783 ± 0.025	0.072CysCys: 0.072 ± 0.007	0.328CysAsp: 0.328 ± 0.017	0.298CysGlu: 0.298 ± 0.017	0.158CysPhe: 0.158 ± 0.009	0.74CysGly: 0.74 ± 0.025	0.162CysHis: 0.162 ± 0.012	0.216CysIle: 0.216 ± 0.014	0.137CysLys: 0.137 ± 0.011	0.599CysLeu: 0.599 ± 0.02	0.091CysMet: 0.091 ± 0.008	0.158CysAsn: 0.158 ± 0.011	0.436CysPro: 0.436 ± 0.021	0.204CysGln: 0.204 ± 0.012	0.392CysArg: 0.392 ± 0.018	0.323CysSer: 0.323 ± 0.016	0.37CysThr: 0.37 ± 0.017	0.478CysVal: 0.478 ± 0.017	0.1CysTrp: 0.1 ± 0.007	0.125CysTyr: 0.125 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.877AspAla: 6.877 ± 0.07	0.275AspCys: 0.275 ± 0.014	2.552AspAsp: 2.552 ± 0.044	2.913AspGlu: 2.913 ± 0.052	1.899AspPhe: 1.899 ± 0.036	5.234AspGly: 5.234 ± 0.08	1.181AspHis: 1.181 ± 0.029	2.097AspIle: 2.097 ± 0.044	1.214AspLys: 1.214 ± 0.038	6.395AspLeu: 6.395 ± 0.072	0.996AspMet: 0.996 ± 0.026	1.117AspAsn: 1.117 ± 0.03	3.311AspPro: 3.311 ± 0.051	1.572AspGln: 1.572 ± 0.036	2.962AspArg: 2.962 ± 0.051	2.467AspSer: 2.467 ± 0.044	2.923AspThr: 2.923 ± 0.049	4.166AspVal: 4.166 ± 0.055	0.956AspTrp: 0.956 ± 0.029	1.289AspTyr: 1.289 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.114GluAla: 7.114 ± 0.094	0.274GluCys: 0.274 ± 0.015	2.663GluAsp: 2.663 ± 0.051	2.791GluGlu: 2.791 ± 0.057	1.713GluPhe: 1.713 ± 0.035	4.3GluGly: 4.3 ± 0.062	1.165GluHis: 1.165 ± 0.034	2.341GluIle: 2.341 ± 0.043	1.705GluLys: 1.705 ± 0.042	6.884GluLeu: 6.884 ± 0.084	1.162GluMet: 1.162 ± 0.034	1.401GluAsn: 1.401 ± 0.029	2.062GluPro: 2.062 ± 0.047	2.322GluGln: 2.322 ± 0.042	4.811GluArg: 4.811 ± 0.073	2.261GluSer: 2.261 ± 0.041	3.064GluThr: 3.064 ± 0.047	4.574GluVal: 4.574 ± 0.057	0.791GluTrp: 0.791 ± 0.025	1.325GluTyr: 1.325 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.577PheAla: 3.577 ± 0.055	0.212PheCys: 0.212 ± 0.014	1.873PheAsp: 1.873 ± 0.039	1.762PheGlu: 1.762 ± 0.036	1.123PhePhe: 1.123 ± 0.032	3.211PheGly: 3.211 ± 0.053	0.616PheHis: 0.616 ± 0.021	1.329PheIle: 1.329 ± 0.033	1.024PheLys: 1.024 ± 0.023	3.267PheLeu: 3.267 ± 0.056	0.71PheMet: 0.71 ± 0.023	0.964PheAsn: 0.964 ± 0.029	1.698PhePro: 1.698 ± 0.037	1.179PheGln: 1.179 ± 0.03	1.803PheArg: 1.803 ± 0.036	2.041PheSer: 2.041 ± 0.035	2.144PheThr: 2.144 ± 0.041	2.359PheVal: 2.359 ± 0.036	0.476PheTrp: 0.476 ± 0.022	0.848PheTyr: 0.848 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.409GlyAla: 9.409 ± 0.099	0.585GlyCys: 0.585 ± 0.022	4.361GlyAsp: 4.361 ± 0.067	5.326GlyGlu: 5.326 ± 0.069	3.121GlyPhe: 3.121 ± 0.056	8.759GlyGly: 8.759 ± 0.113	1.934GlyHis: 1.934 ± 0.039	3.72GlyIle: 3.72 ± 0.056	3.411GlyLys: 3.411 ± 0.058	10.372GlyLeu: 10.372 ± 0.104	2.188GlyMet: 2.188 ± 0.046	2.407GlyAsn: 2.407 ± 0.045	3.607GlyPro: 3.607 ± 0.058	4.449GlyGln: 4.449 ± 0.069	5.958GlyArg: 5.958 ± 0.077	4.68GlySer: 4.68 ± 0.068	5.23GlyThr: 5.23 ± 0.071	7.651GlyVal: 7.651 ± 0.084	1.555GlyTrp: 1.555 ± 0.036	2.373GlyTyr: 2.373 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.691HisAla: 2.691 ± 0.046	0.158HisCys: 0.158 ± 0.012	1.184HisAsp: 1.184 ± 0.029	1.088HisGlu: 1.088 ± 0.029	0.737HisPhe: 0.737 ± 0.022	1.891HisGly: 1.891 ± 0.036	0.633HisHis: 0.633 ± 0.021	0.769HisIle: 0.769 ± 0.023	0.372HisLys: 0.372 ± 0.016	2.716HisLeu: 2.716 ± 0.054	0.334HisMet: 0.334 ± 0.017	0.446HisAsn: 0.446 ± 0.019	1.595HisPro: 1.595 ± 0.038	0.657HisGln: 0.657 ± 0.024	1.222HisArg: 1.222 ± 0.035	1.093HisSer: 1.093 ± 0.031	1.145HisThr: 1.145 ± 0.033	1.399HisVal: 1.399 ± 0.036	0.35HisTrp: 0.35 ± 0.016	0.514HisTyr: 0.514 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.314IleAla: 4.314 ± 0.065	0.257IleCys: 0.257 ± 0.013	2.159IleAsp: 2.159 ± 0.041	2.319IleGlu: 2.319 ± 0.047	1.249IlePhe: 1.249 ± 0.032	3.791IleGly: 3.791 ± 0.056	0.869IleHis: 0.869 ± 0.025	1.585IleIle: 1.585 ± 0.038	1.203IleLys: 1.203 ± 0.031	3.787IleLeu: 3.787 ± 0.062	0.708IleMet: 0.708 ± 0.025	1.199IleAsn: 1.199 ± 0.032	2.248IlePro: 2.248 ± 0.042	1.421IleGln: 1.421 ± 0.032	2.467IleArg: 2.467 ± 0.043	2.443IleSer: 2.443 ± 0.049	2.573IleThr: 2.573 ± 0.04	3.021IleVal: 3.021 ± 0.054	0.43IleTrp: 0.43 ± 0.019	0.936IleTyr: 0.936 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.394LysAla: 3.394 ± 0.065	0.112LysCys: 0.112 ± 0.009	1.512LysAsp: 1.512 ± 0.042	1.294LysGlu: 1.294 ± 0.033	0.855LysPhe: 0.855 ± 0.031	2.199LysGly: 2.199 ± 0.044	0.488LysHis: 0.488 ± 0.02	1.237LysIle: 1.237 ± 0.036	1.21LysLys: 1.21 ± 0.039	3.224LysLeu: 3.224 ± 0.054	0.79LysMet: 0.79 ± 0.03	0.973LysAsn: 0.973 ± 0.026	1.679LysPro: 1.679 ± 0.035	0.945LysGln: 0.945 ± 0.027	1.81LysArg: 1.81 ± 0.039	1.441LysSer: 1.441 ± 0.036	1.935LysThr: 1.935 ± 0.04	2.276LysVal: 2.276 ± 0.045	0.365LysTrp: 0.365 ± 0.017	0.779LysTyr: 0.779 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.147LeuAla: 14.147 ± 0.134	0.74LeuCys: 0.74 ± 0.026	6.492LeuAsp: 6.492 ± 0.073	6.645LeuGlu: 6.645 ± 0.074	3.098LeuPhe: 3.098 ± 0.054	10.454LeuGly: 10.454 ± 0.106	2.306LeuHis: 2.306 ± 0.047	4.903LeuIle: 4.903 ± 0.074	3.814LeuLys: 3.814 ± 0.05	12.891LeuLeu: 12.891 ± 0.149	2.247LeuMet: 2.247 ± 0.042	3.617LeuAsn: 3.617 ± 0.052	7.221LeuPro: 7.221 ± 0.084	3.384LeuGln: 3.384 ± 0.054	8.058LeuArg: 8.058 ± 0.092	7.555LeuSer: 7.555 ± 0.084	7.74LeuThr: 7.74 ± 0.081	6.815LeuVal: 6.815 ± 0.073	1.383LeuTrp: 1.383 ± 0.037	2.421LeuTyr: 2.421 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.064MetAla: 2.064 ± 0.04	0.082MetCys: 0.082 ± 0.007	1.003MetAsp: 1.003 ± 0.029	0.876MetGlu: 0.876 ± 0.024	0.542MetPhe: 0.542 ± 0.022	1.691MetGly: 1.691 ± 0.041	0.408MetHis: 0.408 ± 0.017	0.887MetIle: 0.887 ± 0.024	0.815MetLys: 0.815 ± 0.027	2.297MetLeu: 2.297 ± 0.036	0.436MetMet: 0.436 ± 0.018	0.844MetAsn: 0.844 ± 0.024	1.226MetPro: 1.226 ± 0.033	0.8MetGln: 0.8 ± 0.027	1.362MetArg: 1.362 ± 0.032	1.263MetSer: 1.263 ± 0.029	2.042MetThr: 2.042 ± 0.031	1.318MetVal: 1.318 ± 0.033	0.194MetTrp: 0.194 ± 0.011	0.404MetTyr: 0.404 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.424AsnAla: 3.424 ± 0.054	0.165AsnCys: 0.165 ± 0.011	1.229AsnAsp: 1.229 ± 0.03	1.091AsnGlu: 1.091 ± 0.027	0.985AsnPhe: 0.985 ± 0.026	2.246AsnGly: 2.246 ± 0.038	0.506AsnHis: 0.506 ± 0.022	1.188AsnIle: 1.188 ± 0.03	0.697AsnLys: 0.697 ± 0.026	3.091AsnLeu: 3.091 ± 0.047	0.581AsnMet: 0.581 ± 0.023	0.758AsnAsn: 0.758 ± 0.029	2.021AsnPro: 2.021 ± 0.044	0.763AsnGln: 0.763 ± 0.026	1.526AsnArg: 1.526 ± 0.034	1.308AsnSer: 1.308 ± 0.035	1.624AsnThr: 1.624 ± 0.038	2.269AsnVal: 2.269 ± 0.043	0.395AsnTrp: 0.395 ± 0.018	0.731AsnTyr: 0.731 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.885ProAla: 6.885 ± 0.08	0.274ProCys: 0.274 ± 0.016	4.019ProAsp: 4.019 ± 0.064	4.2ProGlu: 4.2 ± 0.054	1.735ProPhe: 1.735 ± 0.033	5.296ProGly: 5.296 ± 0.065	1.276ProHis: 1.276 ± 0.035	1.876ProIle: 1.876 ± 0.043	1.289ProLys: 1.289 ± 0.034	5.959ProLeu: 5.959 ± 0.074	1.13ProMet: 1.13 ± 0.031	1.433ProAsn: 1.433 ± 0.034	3.128ProPro: 3.128 ± 0.065	2.421ProGln: 2.421 ± 0.041	3.061ProArg: 3.061 ± 0.051	2.847ProSer: 2.847 ± 0.046	3.139ProThr: 3.139 ± 0.062	4.335ProVal: 4.335 ± 0.052	0.704ProTrp: 0.704 ± 0.024	1.301ProTyr: 1.301 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.099GlnAla: 5.099 ± 0.073	0.167GlnCys: 0.167 ± 0.01	2.048GlnAsp: 2.048 ± 0.039	2.093GlnGlu: 2.093 ± 0.039	1.13GlnPhe: 1.13 ± 0.029	3.294GlnGly: 3.294 ± 0.054	0.924GlnHis: 0.924 ± 0.03	1.726GlnIle: 1.726 ± 0.035	1.236GlnLys: 1.236 ± 0.032	3.545GlnLeu: 3.545 ± 0.06	0.884GlnMet: 0.884 ± 0.024	1.247GlnAsn: 1.247 ± 0.031	2.538GlnPro: 2.538 ± 0.045	1.758GlnGln: 1.758 ± 0.042	2.585GlnArg: 2.585 ± 0.056	1.998GlnSer: 1.998 ± 0.039	2.852GlnThr: 2.852 ± 0.047	2.96GlnVal: 2.96 ± 0.047	0.48GlnTrp: 0.48 ± 0.019	0.849GlnTyr: 0.849 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.271ArgAla: 8.271 ± 0.096	0.391ArgCys: 0.391 ± 0.017	3.542ArgAsp: 3.542 ± 0.054	4.587ArgGlu: 4.587 ± 0.075	2.193ArgPhe: 2.193 ± 0.044	5.339ArgGly: 5.339 ± 0.066	1.493ArgHis: 1.493 ± 0.03	2.658ArgIle: 2.658 ± 0.045	1.81ArgLys: 1.81 ± 0.041	7.765ArgLeu: 7.765 ± 0.089	1.519ArgMet: 1.519 ± 0.035	1.557ArgAsn: 1.557 ± 0.034	3.69ArgPro: 3.69 ± 0.062	2.902ArgGln: 2.902 ± 0.055	4.892ArgArg: 4.892 ± 0.079	3.223ArgSer: 3.223 ± 0.054	3.685ArgThr: 3.685 ± 0.052	5.612ArgVal: 5.612 ± 0.07	1.059ArgTrp: 1.059 ± 0.03	1.661ArgTyr: 1.661 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.589SerAla: 6.589 ± 0.075	0.349SerCys: 0.349 ± 0.016	2.638SerAsp: 2.638 ± 0.047	2.723SerGlu: 2.723 ± 0.044	1.809SerPhe: 1.809 ± 0.039	6.117SerGly: 6.117 ± 0.078	0.982SerHis: 0.982 ± 0.025	1.942SerIle: 1.942 ± 0.041	1.467SerLys: 1.467 ± 0.039	5.784SerLeu: 5.784 ± 0.071	1.13SerMet: 1.13 ± 0.028	1.392SerAsn: 1.392 ± 0.031	3.114SerPro: 3.114 ± 0.046	1.796SerGln: 1.796 ± 0.042	3.377SerArg: 3.377 ± 0.056	3.067SerSer: 3.067 ± 0.06	2.838SerThr: 2.838 ± 0.047	4.467SerVal: 4.467 ± 0.062	0.669SerTrp: 0.669 ± 0.026	1.223SerTyr: 1.223 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.024ThrAla: 7.024 ± 0.073	0.383ThrCys: 0.383 ± 0.02	2.992ThrAsp: 2.992 ± 0.054	2.691ThrGlu: 2.691 ± 0.054	2.193ThrPhe: 2.193 ± 0.04	5.452ThrGly: 5.452 ± 0.072	1.275ThrHis: 1.275 ± 0.031	1.979ThrIle: 1.979 ± 0.043	1.085ThrLys: 1.085 ± 0.034	8.362ThrLeu: 8.362 ± 0.092	0.911ThrMet: 0.911 ± 0.027	1.309ThrAsn: 1.309 ± 0.034	4.716ThrPro: 4.716 ± 0.064	2.067ThrGln: 2.067 ± 0.042	3.963ThrArg: 3.963 ± 0.061	2.9ThrSer: 2.9 ± 0.057	3.099ThrThr: 3.099 ± 0.061	5.349ThrVal: 5.349 ± 0.074	0.694ThrTrp: 0.694 ± 0.022	1.424ThrTyr: 1.424 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.22ValAla: 8.22 ± 0.092	0.56ValCys: 0.56 ± 0.021	3.596ValAsp: 3.596 ± 0.05	3.543ValGlu: 3.543 ± 0.052	2.481ValPhe: 2.481 ± 0.04	6.285ValGly: 6.285 ± 0.072	1.383ValHis: 1.383 ± 0.034	3.547ValIle: 3.547 ± 0.054	2.322ValLys: 2.322 ± 0.044	8.684ValLeu: 8.684 ± 0.088	1.793ValMet: 1.793 ± 0.034	2.299ValAsn: 2.299 ± 0.044	4.077ValPro: 4.077 ± 0.054	3.281ValGln: 3.281 ± 0.045	5.631ValArg: 5.631 ± 0.064	4.485ValSer: 4.485 ± 0.06	5.38ValThr: 5.38 ± 0.073	5.578ValVal: 5.578 ± 0.077	1.171ValTrp: 1.171 ± 0.035	1.829ValTyr: 1.829 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.498TrpAla: 1.498 ± 0.037	0.105TrpCys: 0.105 ± 0.008	0.706TrpAsp: 0.706 ± 0.024	0.624TrpGlu: 0.624 ± 0.02	0.413TrpPhe: 0.413 ± 0.017	1.083TrpGly: 1.083 ± 0.032	0.341TrpHis: 0.341 ± 0.016	0.489TrpIle: 0.489 ± 0.02	0.486TrpLys: 0.486 ± 0.022	1.708TrpLeu: 1.708 ± 0.043	0.355TrpMet: 0.355 ± 0.017	0.563TrpAsn: 0.563 ± 0.022	0.79TrpPro: 0.79 ± 0.026	0.742TrpGln: 0.742 ± 0.024	1.03TrpArg: 1.03 ± 0.027	0.657TrpSer: 0.657 ± 0.023	0.981TrpThr: 0.981 ± 0.029	0.933TrpVal: 0.933 ± 0.025	0.259TrpTrp: 0.259 ± 0.014	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.004TyrAla: 3.004 ± 0.046	0.158TyrCys: 0.158 ± 0.01	1.351TyrAsp: 1.351 ± 0.034	1.073TyrGlu: 1.073 ± 0.029	0.847TyrPhe: 0.847 ± 0.026	2.405TyrGly: 2.405 ± 0.043	0.478TyrHis: 0.478 ± 0.018	0.714TyrIle: 0.714 ± 0.023	0.576TyrLys: 0.576 ± 0.02	2.735TyrLeu: 2.735 ± 0.044	0.365TyrMet: 0.365 ± 0.014	0.6TyrAsn: 0.6 ± 0.019	1.362TyrPro: 1.362 ± 0.033	0.86TyrGln: 0.86 ± 0.025	1.866TyrArg: 1.866 ± 0.041	1.33TyrSer: 1.33 ± 0.029	1.477TyrThr: 1.477 ± 0.035	1.601TyrVal: 1.601 ± 0.036	0.37TyrTrp: 0.37 ± 0.018	0.612TyrTyr: 0.612 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4906 proteins (1434284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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