Amino acid dipepetide frequency for Polaribacter gangjinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.381AlaAla: 4.381 ± 0.083	0.46AlaCys: 0.46 ± 0.029	3.271AlaAsp: 3.271 ± 0.071	3.616AlaGlu: 3.616 ± 0.071	3.415AlaPhe: 3.415 ± 0.064	3.852AlaGly: 3.852 ± 0.08	0.977AlaHis: 0.977 ± 0.03	6.063AlaIle: 6.063 ± 0.091	5.045AlaLys: 5.045 ± 0.085	5.529AlaLeu: 5.529 ± 0.083	1.376AlaMet: 1.376 ± 0.046	3.688AlaAsn: 3.688 ± 0.075	1.708AlaPro: 1.708 ± 0.049	2.245AlaGln: 2.245 ± 0.046	1.761AlaArg: 1.761 ± 0.047	4.065AlaSer: 4.065 ± 0.072	4.09AlaThr: 4.09 ± 0.085	3.839AlaVal: 3.839 ± 0.075	0.553AlaTrp: 0.553 ± 0.025	2.13AlaTyr: 2.13 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.4CysAla: 0.4 ± 0.023	0.077CysCys: 0.077 ± 0.01	0.379CysAsp: 0.379 ± 0.024	0.446CysGlu: 0.446 ± 0.024	0.42CysPhe: 0.42 ± 0.021	0.559CysGly: 0.559 ± 0.032	0.165CysHis: 0.165 ± 0.016	0.512CysIle: 0.512 ± 0.024	0.491CysLys: 0.491 ± 0.027	0.561CysLeu: 0.561 ± 0.024	0.117CysMet: 0.117 ± 0.012	0.415CysAsn: 0.415 ± 0.023	0.283CysPro: 0.283 ± 0.021	0.191CysGln: 0.191 ± 0.015	0.16CysArg: 0.16 ± 0.012	0.471CysSer: 0.471 ± 0.026	0.391CysThr: 0.391 ± 0.021	0.42CysVal: 0.42 ± 0.022	0.052CysTrp: 0.052 ± 0.007	0.24CysTyr: 0.24 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.732AspAla: 3.732 ± 0.079	0.388AspCys: 0.388 ± 0.02	2.698AspAsp: 2.698 ± 0.064	3.934AspGlu: 3.934 ± 0.082	4.169AspPhe: 4.169 ± 0.08	3.449AspGly: 3.449 ± 0.089	0.649AspHis: 0.649 ± 0.032	4.394AspIle: 4.394 ± 0.082	4.028AspLys: 4.028 ± 0.073	4.81AspLeu: 4.81 ± 0.085	0.947AspMet: 0.947 ± 0.036	2.801AspAsn: 2.801 ± 0.069	1.396AspPro: 1.396 ± 0.046	1.254AspGln: 1.254 ± 0.035	1.536AspArg: 1.536 ± 0.047	2.894AspSer: 2.894 ± 0.063	2.565AspThr: 2.565 ± 0.051	3.525AspVal: 3.525 ± 0.065	0.706AspTrp: 0.706 ± 0.031	2.371AspTyr: 2.371 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.987GluAla: 3.987 ± 0.08	0.281GluCys: 0.281 ± 0.019	3.041GluAsp: 3.041 ± 0.064	4.486GluGlu: 4.486 ± 0.09	3.187GluPhe: 3.187 ± 0.062	3.344GluGly: 3.344 ± 0.071	0.987GluHis: 0.987 ± 0.04	6.625GluIle: 6.625 ± 0.11	7.032GluLys: 7.032 ± 0.114	5.687GluLeu: 5.687 ± 0.098	1.57GluMet: 1.57 ± 0.048	5.779GluAsn: 5.779 ± 0.091	1.387GluPro: 1.387 ± 0.04	2.005GluGln: 2.005 ± 0.045	2.272GluArg: 2.272 ± 0.067	3.153GluSer: 3.153 ± 0.065	3.925GluThr: 3.925 ± 0.066	4.056GluVal: 4.056 ± 0.085	0.551GluTrp: 0.551 ± 0.027	2.14GluTyr: 2.14 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.279PheAla: 3.279 ± 0.063	0.439PheCys: 0.439 ± 0.023	3.714PheAsp: 3.714 ± 0.065	3.692PheGlu: 3.692 ± 0.062	3.266PhePhe: 3.266 ± 0.07	4.06PheGly: 4.06 ± 0.082	0.931PheHis: 0.931 ± 0.038	4.523PheIle: 4.523 ± 0.079	4.037PheLys: 4.037 ± 0.072	5.538PheLeu: 5.538 ± 0.089	1.174PheMet: 1.174 ± 0.036	3.402PheAsn: 3.402 ± 0.078	1.837PhePro: 1.837 ± 0.049	1.991PheGln: 1.991 ± 0.048	1.626PheArg: 1.626 ± 0.048	4.753PheSer: 4.753 ± 0.081	3.444PheThr: 3.444 ± 0.068	3.35PheVal: 3.35 ± 0.061	0.658PheTrp: 0.658 ± 0.029	2.349PheTyr: 2.349 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	3.962GlyAla: 3.962 ± 0.079	0.491GlyCys: 0.491 ± 0.027	2.903GlyAsp: 2.903 ± 0.064	3.327GlyGlu: 3.327 ± 0.063	4.123GlyPhe: 4.123 ± 0.076	4.451GlyGly: 4.451 ± 0.103	0.974GlyHis: 0.974 ± 0.037	5.772GlyIle: 5.772 ± 0.1	5.111GlyLys: 5.111 ± 0.079	5.258GlyLeu: 5.258 ± 0.08	1.504GlyMet: 1.504 ± 0.053	3.874GlyAsn: 3.874 ± 0.082	1.185GlyPro: 1.185 ± 0.036	1.571GlyGln: 1.571 ± 0.044	1.883GlyArg: 1.883 ± 0.059	3.712GlySer: 3.712 ± 0.08	3.883GlyThr: 3.883 ± 0.086	4.061GlyVal: 4.061 ± 0.072	0.703GlyTrp: 0.703 ± 0.03	2.478GlyTyr: 2.478 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.895HisAla: 0.895 ± 0.039	0.166HisCys: 0.166 ± 0.012	0.752HisAsp: 0.752 ± 0.027	0.991HisGlu: 0.991 ± 0.036	1.244HisPhe: 1.244 ± 0.038	0.965HisGly: 0.965 ± 0.037	0.526HisHis: 0.526 ± 0.028	1.398HisIle: 1.398 ± 0.042	1.264HisLys: 1.264 ± 0.045	1.668HisLeu: 1.668 ± 0.047	0.257HisMet: 0.257 ± 0.017	0.877HisAsn: 0.877 ± 0.031	0.939HisPro: 0.939 ± 0.04	0.922HisGln: 0.922 ± 0.036	0.568HisArg: 0.568 ± 0.025	0.998HisSer: 0.998 ± 0.038	0.854HisThr: 0.854 ± 0.031	0.806HisVal: 0.806 ± 0.028	0.196HisTrp: 0.196 ± 0.017	0.759HisTyr: 0.759 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.986IleAla: 5.986 ± 0.095	0.64IleCys: 0.64 ± 0.027	5.287IleAsp: 5.287 ± 0.077	5.885IleGlu: 5.885 ± 0.09	4.469IlePhe: 4.469 ± 0.074	5.141IleGly: 5.141 ± 0.081	1.513IleHis: 1.513 ± 0.047	6.874IleIle: 6.874 ± 0.084	6.48IleLys: 6.48 ± 0.093	7.737IleLeu: 7.737 ± 0.114	1.294IleMet: 1.294 ± 0.039	5.341IleAsn: 5.341 ± 0.099	3.487IlePro: 3.487 ± 0.063	3.094IleGln: 3.094 ± 0.054	2.539IleArg: 2.539 ± 0.05	6.546IleSer: 6.546 ± 0.107	5.171IleThr: 5.171 ± 0.083	5.037IleVal: 5.037 ± 0.072	0.713IleTrp: 0.713 ± 0.03	2.917IleTyr: 2.917 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.743LysAla: 4.743 ± 0.077	0.35LysCys: 0.35 ± 0.017	4.194LysAsp: 4.194 ± 0.07	6.687LysGlu: 6.687 ± 0.106	3.262LysPhe: 3.262 ± 0.075	4.621LysGly: 4.621 ± 0.073	1.304LysHis: 1.304 ± 0.041	7.584LysIle: 7.584 ± 0.11	7.917LysLys: 7.917 ± 0.131	6.714LysLeu: 6.714 ± 0.092	2.222LysMet: 2.222 ± 0.056	7.038LysAsn: 7.038 ± 0.101	2.472LysPro: 2.472 ± 0.061	2.806LysGln: 2.806 ± 0.062	2.71LysArg: 2.71 ± 0.06	5.111LysSer: 5.111 ± 0.085	5.145LysThr: 5.145 ± 0.09	4.741LysVal: 4.741 ± 0.092	0.826LysTrp: 0.826 ± 0.034	3.044LysTyr: 3.044 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.562LeuAla: 5.562 ± 0.097	0.544LeuCys: 0.544 ± 0.023	4.606LeuAsp: 4.606 ± 0.081	6.085LeuGlu: 6.085 ± 0.097	5.281LeuPhe: 5.281 ± 0.096	5.637LeuGly: 5.637 ± 0.082	1.648LeuHis: 1.648 ± 0.043	7.143LeuIle: 7.143 ± 0.128	7.936LeuLys: 7.936 ± 0.106	8.466LeuLeu: 8.466 ± 0.144	1.981LeuMet: 1.981 ± 0.052	5.511LeuAsn: 5.511 ± 0.089	3.302LeuPro: 3.302 ± 0.061	3.772LeuGln: 3.772 ± 0.065	2.843LeuArg: 2.843 ± 0.056	6.417LeuSer: 6.417 ± 0.098	4.779LeuThr: 4.779 ± 0.079	5.28LeuVal: 5.28 ± 0.08	0.742LeuTrp: 0.742 ± 0.03	2.917LeuTyr: 2.917 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.395MetAla: 1.395 ± 0.041	0.112MetCys: 0.112 ± 0.011	1.039MetAsp: 1.039 ± 0.04	1.19MetGlu: 1.19 ± 0.04	0.824MetPhe: 0.824 ± 0.032	1.207MetGly: 1.207 ± 0.037	0.396MetHis: 0.396 ± 0.022	1.771MetIle: 1.771 ± 0.046	2.211MetLys: 2.211 ± 0.053	1.872MetLeu: 1.872 ± 0.05	0.627MetMet: 0.627 ± 0.03	1.377MetAsn: 1.377 ± 0.039	0.822MetPro: 0.822 ± 0.028	0.803MetGln: 0.803 ± 0.034	0.791MetArg: 0.791 ± 0.031	1.328MetSer: 1.328 ± 0.036	1.147MetThr: 1.147 ± 0.036	1.112MetVal: 1.112 ± 0.036	0.149MetTrp: 0.149 ± 0.014	0.695MetTyr: 0.695 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.216AsnAla: 4.216 ± 0.077	0.519AsnCys: 0.519 ± 0.028	3.403AsnAsp: 3.403 ± 0.066	4.05AsnGlu: 4.05 ± 0.081	3.736AsnPhe: 3.736 ± 0.081	4.2AsnGly: 4.2 ± 0.093	1.222AsnHis: 1.222 ± 0.037	5.176AsnIle: 5.176 ± 0.087	4.473AsnLys: 4.473 ± 0.081	5.995AsnLeu: 5.995 ± 0.086	1.22AsnMet: 1.22 ± 0.04	4.427AsnAsn: 4.427 ± 0.104	3.15AsnPro: 3.15 ± 0.076	2.702AsnGln: 2.702 ± 0.066	1.928AsnArg: 1.928 ± 0.044	4.523AsnSer: 4.523 ± 0.083	3.862AsnThr: 3.862 ± 0.091	3.651AsnVal: 3.651 ± 0.07	0.806AsnTrp: 0.806 ± 0.033	2.965AsnTyr: 2.965 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.761ProAla: 1.761 ± 0.055	0.201ProCys: 0.201 ± 0.015	1.656ProAsp: 1.656 ± 0.044	2.525ProGlu: 2.525 ± 0.058	2.07ProPhe: 2.07 ± 0.044	1.654ProGly: 1.654 ± 0.045	0.562ProHis: 0.562 ± 0.029	2.981ProIle: 2.981 ± 0.062	2.722ProLys: 2.722 ± 0.054	2.751ProLeu: 2.751 ± 0.055	0.652ProMet: 0.652 ± 0.029	2.487ProAsn: 2.487 ± 0.058	0.742ProPro: 0.742 ± 0.032	0.998ProGln: 0.998 ± 0.036	0.855ProArg: 0.855 ± 0.035	2.067ProSer: 2.067 ± 0.055	2.172ProThr: 2.172 ± 0.052	1.985ProVal: 1.985 ± 0.051	0.347ProTrp: 0.347 ± 0.022	1.242ProTyr: 1.242 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.748GlnAla: 1.748 ± 0.051	0.176GlnCys: 0.176 ± 0.013	1.518GlnAsp: 1.518 ± 0.038	2.519GlnGlu: 2.519 ± 0.05	2.059GlnPhe: 2.059 ± 0.049	1.722GlnGly: 1.722 ± 0.049	0.619GlnHis: 0.619 ± 0.025	2.979GlnIle: 2.979 ± 0.059	3.673GlnLys: 3.673 ± 0.074	3.67GlnLeu: 3.67 ± 0.078	0.822GlnMet: 0.822 ± 0.03	2.565GlnAsn: 2.565 ± 0.06	1.025GlnPro: 1.025 ± 0.038	1.775GlnGln: 1.775 ± 0.057	1.223GlnArg: 1.223 ± 0.04	1.859GlnSer: 1.859 ± 0.044	1.928GlnThr: 1.928 ± 0.048	1.843GlnVal: 1.843 ± 0.043	0.31GlnTrp: 0.31 ± 0.019	1.241GlnTyr: 1.241 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.897ArgAla: 1.897 ± 0.054	0.157ArgCys: 0.157 ± 0.014	1.51ArgAsp: 1.51 ± 0.05	2.059ArgGlu: 2.059 ± 0.054	2.045ArgPhe: 2.045 ± 0.051	1.708ArgGly: 1.708 ± 0.047	0.515ArgHis: 0.515 ± 0.025	2.766ArgIle: 2.766 ± 0.065	2.7ArgLys: 2.7 ± 0.063	2.708ArgLeu: 2.708 ± 0.057	0.792ArgMet: 0.792 ± 0.036	2.09ArgAsn: 2.09 ± 0.053	0.937ArgPro: 0.937 ± 0.031	0.994ArgGln: 0.994 ± 0.037	1.091ArgArg: 1.091 ± 0.042	1.531ArgSer: 1.531 ± 0.048	1.725ArgThr: 1.725 ± 0.047	1.926ArgVal: 1.926 ± 0.046	0.309ArgTrp: 0.309 ± 0.02	1.255ArgTyr: 1.255 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.517SerAla: 3.517 ± 0.056	0.586SerCys: 0.586 ± 0.028	3.323SerAsp: 3.323 ± 0.063	4.338SerGlu: 4.338 ± 0.072	4.266SerPhe: 4.266 ± 0.079	4.292SerGly: 4.292 ± 0.081	1.031SerHis: 1.031 ± 0.036	5.652SerIle: 5.652 ± 0.1	5.516SerLys: 5.516 ± 0.088	5.992SerLeu: 5.992 ± 0.1	1.277SerMet: 1.277 ± 0.034	4.075SerAsn: 4.075 ± 0.083	1.895SerPro: 1.895 ± 0.05	2.213SerGln: 2.213 ± 0.053	1.872SerArg: 1.872 ± 0.05	4.396SerSer: 4.396 ± 0.083	3.574SerThr: 3.574 ± 0.073	3.836SerVal: 3.836 ± 0.072	0.766SerTrp: 0.766 ± 0.031	2.75SerTyr: 2.75 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.638ThrAla: 3.638 ± 0.076	0.338ThrCys: 0.338 ± 0.023	3.008ThrAsp: 3.008 ± 0.063	3.341ThrGlu: 3.341 ± 0.069	3.414ThrPhe: 3.414 ± 0.062	3.722ThrGly: 3.722 ± 0.069	1.005ThrHis: 1.005 ± 0.035	5.783ThrIle: 5.783 ± 0.09	4.413ThrLys: 4.413 ± 0.085	5.288ThrLeu: 5.288 ± 0.08	0.906ThrMet: 0.906 ± 0.033	3.784ThrAsn: 3.784 ± 0.09	2.372ThrPro: 2.372 ± 0.062	1.886ThrGln: 1.886 ± 0.055	1.507ThrArg: 1.507 ± 0.043	4.042ThrSer: 4.042 ± 0.081	3.69ThrThr: 3.69 ± 0.076	3.655ThrVal: 3.655 ± 0.086	0.583ThrTrp: 0.583 ± 0.027	2.259ThrTyr: 2.259 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.203ValAla: 4.203 ± 0.083	0.456ValCys: 0.456 ± 0.024	3.434ValAsp: 3.434 ± 0.068	3.469ValGlu: 3.469 ± 0.068	3.587ValPhe: 3.587 ± 0.065	3.768ValGly: 3.768 ± 0.082	1.015ValHis: 1.015 ± 0.035	4.844ValIle: 4.844 ± 0.078	4.477ValLys: 4.477 ± 0.081	5.697ValLeu: 5.697 ± 0.083	1.216ValMet: 1.216 ± 0.035	3.531ValAsn: 3.531 ± 0.068	1.919ValPro: 1.919 ± 0.045	1.781ValGln: 1.781 ± 0.044	1.814ValArg: 1.814 ± 0.048	4.428ValSer: 4.428 ± 0.083	3.507ValThr: 3.507 ± 0.088	3.986ValVal: 3.986 ± 0.086	0.579ValTrp: 0.579 ± 0.027	2.077ValTyr: 2.077 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.591TrpAla: 0.591 ± 0.026	0.084TrpCys: 0.084 ± 0.01	0.515TrpAsp: 0.515 ± 0.024	0.649TrpGlu: 0.649 ± 0.026	0.632TrpPhe: 0.632 ± 0.024	0.615TrpGly: 0.615 ± 0.031	0.214TrpHis: 0.214 ± 0.017	0.748TrpIle: 0.748 ± 0.029	0.881TrpLys: 0.881 ± 0.034	0.916TrpLeu: 0.916 ± 0.036	0.339TrpMet: 0.339 ± 0.021	0.735TrpAsn: 0.735 ± 0.034	0.199TrpPro: 0.199 ± 0.017	0.408TrpGln: 0.408 ± 0.024	0.41TrpArg: 0.41 ± 0.019	0.584TrpSer: 0.584 ± 0.031	0.528TrpThr: 0.528 ± 0.026	0.548TrpVal: 0.548 ± 0.024	0.143TrpTrp: 0.143 ± 0.014	0.38TrpTyr: 0.38 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.171TyrAla: 2.171 ± 0.053	0.283TyrCys: 0.283 ± 0.021	1.997TyrAsp: 1.997 ± 0.049	2.205TyrGlu: 2.205 ± 0.06	2.592TyrPhe: 2.592 ± 0.057	2.255TyrGly: 2.255 ± 0.058	0.792TyrHis: 0.792 ± 0.035	2.561TyrIle: 2.561 ± 0.064	3.084TyrLys: 3.084 ± 0.062	3.593TyrLeu: 3.593 ± 0.07	0.574TyrMet: 0.574 ± 0.024	2.427TyrAsn: 2.427 ± 0.058	1.376TyrPro: 1.376 ± 0.038	1.864TyrGln: 1.864 ± 0.047	1.329TyrArg: 1.329 ± 0.039	2.291TyrSer: 2.291 ± 0.056	2.256TyrThr: 2.256 ± 0.065	2.131TyrVal: 2.131 ± 0.043	0.429TyrTrp: 0.429 ± 0.021	1.584TyrTyr: 1.584 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2512 proteins (883914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---