Amino acid dipepetide frequency for Mesorhizobium phage vB_MloP_Lo5R7ANS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.236AlaAla: 12.236 ± 1.174
0.796AlaCys: 0.796 ± 0.289
6.661AlaAsp: 6.661 ± 0.725
4.851AlaGlu: 4.851 ± 0.793
3.186AlaPhe: 3.186 ± 0.432
8.543AlaGly: 8.543 ± 1.054
1.448AlaHis: 1.448 ± 0.366
5.575AlaIle: 5.575 ± 0.589
6.588AlaLys: 6.588 ± 0.928
7.602AlaLeu: 7.602 ± 0.833
3.692AlaMet: 3.692 ± 0.622
4.634AlaAsn: 4.634 ± 0.735
4.561AlaPro: 4.561 ± 0.745
3.765AlaGln: 3.765 ± 0.643
6.299AlaArg: 6.299 ± 0.783
6.082AlaSer: 6.082 ± 0.775
6.226AlaThr: 6.226 ± 0.854
6.371AlaVal: 6.371 ± 0.539
1.086AlaTrp: 1.086 ± 0.304
3.475AlaTyr: 3.475 ± 0.549
0.0AlaXaa: 0.0 ± 0.0
Cys
0.724CysAla: 0.724 ± 0.22
0.217CysCys: 0.217 ± 0.13
0.507CysAsp: 0.507 ± 0.214
0.652CysGlu: 0.652 ± 0.21
0.796CysPhe: 0.796 ± 0.261
0.652CysGly: 0.652 ± 0.223
0.145CysHis: 0.145 ± 0.154
0.362CysIle: 0.362 ± 0.164
0.217CysLys: 0.217 ± 0.122
0.579CysLeu: 0.579 ± 0.197
0.145CysMet: 0.145 ± 0.111
0.29CysAsn: 0.29 ± 0.173
0.652CysPro: 0.652 ± 0.235
0.145CysGln: 0.145 ± 0.11
0.652CysArg: 0.652 ± 0.187
0.217CysSer: 0.217 ± 0.141
0.072CysThr: 0.072 ± 0.076
0.29CysVal: 0.29 ± 0.146
0.145CysTrp: 0.145 ± 0.102
0.217CysTyr: 0.217 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
7.095AspAla: 7.095 ± 0.558
0.434AspCys: 0.434 ± 0.198
3.33AspAsp: 3.33 ± 0.512
3.186AspGlu: 3.186 ± 0.472
2.534AspPhe: 2.534 ± 0.403
5.72AspGly: 5.72 ± 0.625
1.231AspHis: 1.231 ± 0.333
3.113AspIle: 3.113 ± 0.518
3.765AspLys: 3.765 ± 0.696
5.502AspLeu: 5.502 ± 0.628
1.303AspMet: 1.303 ± 0.239
1.955AspAsn: 1.955 ± 0.297
3.692AspPro: 3.692 ± 0.569
2.389AspGln: 2.389 ± 0.481
4.561AspArg: 4.561 ± 0.518
2.389AspSer: 2.389 ± 0.446
3.186AspThr: 3.186 ± 0.455
3.837AspVal: 3.837 ± 0.55
1.158AspTrp: 1.158 ± 0.219
2.027AspTyr: 2.027 ± 0.42
0.0AspXaa: 0.0 ± 0.0
Glu
6.009GluAla: 6.009 ± 0.7
0.579GluCys: 0.579 ± 0.229
3.041GluAsp: 3.041 ± 0.448
3.475GluGlu: 3.475 ± 0.625
2.244GluPhe: 2.244 ± 0.421
3.692GluGly: 3.692 ± 0.571
1.086GluHis: 1.086 ± 0.346
2.824GluIle: 2.824 ± 0.657
1.955GluLys: 1.955 ± 0.414
5.792GluLeu: 5.792 ± 0.677
1.665GluMet: 1.665 ± 0.356
1.882GluAsn: 1.882 ± 0.304
2.244GluPro: 2.244 ± 0.429
2.244GluGln: 2.244 ± 0.466
3.91GluArg: 3.91 ± 0.505
1.448GluSer: 1.448 ± 0.283
4.272GluThr: 4.272 ± 0.538
4.489GluVal: 4.489 ± 0.675
1.303GluTrp: 1.303 ± 0.351
1.52GluTyr: 1.52 ± 0.295
0.0GluXaa: 0.0 ± 0.0
Phe
3.403PheAla: 3.403 ± 0.487
0.145PheCys: 0.145 ± 0.131
2.896PheAsp: 2.896 ± 0.472
1.882PheGlu: 1.882 ± 0.438
1.303PhePhe: 1.303 ± 0.293
3.765PheGly: 3.765 ± 0.52
0.507PheHis: 0.507 ± 0.176
1.665PheIle: 1.665 ± 0.308
2.244PheLys: 2.244 ± 0.532
3.113PheLeu: 3.113 ± 0.506
1.376PheMet: 1.376 ± 0.347
0.869PheAsn: 0.869 ± 0.184
1.158PhePro: 1.158 ± 0.268
0.724PheGln: 0.724 ± 0.201
2.679PheArg: 2.679 ± 0.442
2.824PheSer: 2.824 ± 0.369
3.62PheThr: 3.62 ± 0.482
2.679PheVal: 2.679 ± 0.434
0.652PheTrp: 0.652 ± 0.189
0.869PheTyr: 0.869 ± 0.233
0.0PheXaa: 0.0 ± 0.0
Gly
8.036GlyAla: 8.036 ± 1.03
0.796GlyCys: 0.796 ± 0.267
5.14GlyAsp: 5.14 ± 0.858
4.561GlyGlu: 4.561 ± 0.717
4.127GlyPhe: 4.127 ± 0.516
6.588GlyGly: 6.588 ± 1.357
1.955GlyHis: 1.955 ± 0.38
4.199GlyIle: 4.199 ± 0.495
4.778GlyLys: 4.778 ± 0.857
7.312GlyLeu: 7.312 ± 0.858
1.376GlyMet: 1.376 ± 0.299
3.765GlyAsn: 3.765 ± 0.576
2.968GlyPro: 2.968 ± 1.01
2.244GlyGln: 2.244 ± 0.466
6.516GlyArg: 6.516 ± 0.709
5.647GlySer: 5.647 ± 0.791
5.068GlyThr: 5.068 ± 0.575
5.575GlyVal: 5.575 ± 0.563
1.665GlyTrp: 1.665 ± 0.352
2.172GlyTyr: 2.172 ± 0.391
0.0GlyXaa: 0.0 ± 0.0
His
1.376HisAla: 1.376 ± 0.245
0.29HisCys: 0.29 ± 0.136
1.231HisAsp: 1.231 ± 0.325
0.796HisGlu: 0.796 ± 0.284
1.158HisPhe: 1.158 ± 0.425
1.158HisGly: 1.158 ± 0.282
0.434HisHis: 0.434 ± 0.159
1.231HisIle: 1.231 ± 0.315
0.941HisLys: 0.941 ± 0.222
1.738HisLeu: 1.738 ± 0.417
0.579HisMet: 0.579 ± 0.249
0.869HisAsn: 0.869 ± 0.351
0.869HisPro: 0.869 ± 0.29
0.507HisGln: 0.507 ± 0.212
0.941HisArg: 0.941 ± 0.274
1.014HisSer: 1.014 ± 0.347
0.941HisThr: 0.941 ± 0.323
1.014HisVal: 1.014 ± 0.298
0.434HisTrp: 0.434 ± 0.225
0.507HisTyr: 0.507 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.792IleAla: 5.792 ± 0.556
0.29IleCys: 0.29 ± 0.201
3.33IleAsp: 3.33 ± 0.389
4.127IleGlu: 4.127 ± 0.519
1.158IlePhe: 1.158 ± 0.272
3.692IleGly: 3.692 ± 0.437
0.941IleHis: 0.941 ± 0.383
2.534IleIle: 2.534 ± 0.419
2.317IleLys: 2.317 ± 0.362
3.475IleLeu: 3.475 ± 0.443
1.231IleMet: 1.231 ± 0.304
2.172IleAsn: 2.172 ± 0.306
2.751IlePro: 2.751 ± 0.373
1.665IleGln: 1.665 ± 0.298
3.765IleArg: 3.765 ± 0.489
2.027IleSer: 2.027 ± 0.41
3.91IleThr: 3.91 ± 0.543
3.692IleVal: 3.692 ± 0.505
0.652IleTrp: 0.652 ± 0.236
1.303IleTyr: 1.303 ± 0.296
0.0IleXaa: 0.0 ± 0.0
Lys
6.878LysAla: 6.878 ± 0.712
0.29LysCys: 0.29 ± 0.149
2.968LysAsp: 2.968 ± 0.394
3.548LysGlu: 3.548 ± 0.576
1.52LysPhe: 1.52 ± 0.329
3.982LysGly: 3.982 ± 0.722
0.869LysHis: 0.869 ± 0.224
1.882LysIle: 1.882 ± 0.367
1.81LysLys: 1.81 ± 0.378
4.416LysLeu: 4.416 ± 0.772
1.014LysMet: 1.014 ± 0.258
1.593LysAsn: 1.593 ± 0.353
3.113LysPro: 3.113 ± 0.575
1.81LysGln: 1.81 ± 0.402
4.634LysArg: 4.634 ± 0.576
2.606LysSer: 2.606 ± 0.381
2.389LysThr: 2.389 ± 0.498
4.489LysVal: 4.489 ± 0.453
1.086LysTrp: 1.086 ± 0.288
1.81LysTyr: 1.81 ± 0.368
0.0LysXaa: 0.0 ± 0.0
Leu
8.326LeuAla: 8.326 ± 0.809
0.145LeuCys: 0.145 ± 0.149
5.792LeuAsp: 5.792 ± 0.626
4.416LeuGlu: 4.416 ± 0.555
3.186LeuPhe: 3.186 ± 0.481
7.819LeuGly: 7.819 ± 1.074
1.231LeuHis: 1.231 ± 0.331
4.923LeuIle: 4.923 ± 0.61
4.344LeuLys: 4.344 ± 0.608
5.792LeuLeu: 5.792 ± 0.769
2.1LeuMet: 2.1 ± 0.426
2.679LeuAsn: 2.679 ± 0.384
4.199LeuPro: 4.199 ± 0.548
3.475LeuGln: 3.475 ± 0.433
5.864LeuArg: 5.864 ± 0.738
5.575LeuSer: 5.575 ± 0.571
4.996LeuThr: 4.996 ± 0.581
5.43LeuVal: 5.43 ± 0.552
1.014LeuTrp: 1.014 ± 0.26
2.172LeuTyr: 2.172 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
3.765MetAla: 3.765 ± 0.41
0.29MetCys: 0.29 ± 0.125
1.448MetAsp: 1.448 ± 0.322
1.376MetGlu: 1.376 ± 0.314
1.303MetPhe: 1.303 ± 0.31
2.027MetGly: 2.027 ± 0.336
0.507MetHis: 0.507 ± 0.227
1.014MetIle: 1.014 ± 0.274
1.448MetLys: 1.448 ± 0.288
1.738MetLeu: 1.738 ± 0.351
0.434MetMet: 0.434 ± 0.172
1.158MetAsn: 1.158 ± 0.26
0.796MetPro: 0.796 ± 0.22
0.869MetGln: 0.869 ± 0.285
1.231MetArg: 1.231 ± 0.273
1.665MetSer: 1.665 ± 0.35
1.738MetThr: 1.738 ± 0.351
1.303MetVal: 1.303 ± 0.325
0.217MetTrp: 0.217 ± 0.149
0.29MetTyr: 0.29 ± 0.173
0.0MetXaa: 0.0 ± 0.0
Asn
3.837AsnAla: 3.837 ± 0.694
0.217AsnCys: 0.217 ± 0.13
1.52AsnAsp: 1.52 ± 0.328
2.244AsnGlu: 2.244 ± 0.341
1.303AsnPhe: 1.303 ± 0.295
5.285AsnGly: 5.285 ± 0.611
0.507AsnHis: 0.507 ± 0.178
1.81AsnIle: 1.81 ± 0.374
1.738AsnLys: 1.738 ± 0.411
2.679AsnLeu: 2.679 ± 0.382
1.231AsnMet: 1.231 ± 0.354
1.303AsnAsn: 1.303 ± 0.375
1.955AsnPro: 1.955 ± 0.451
1.303AsnGln: 1.303 ± 0.32
2.172AsnArg: 2.172 ± 0.463
2.1AsnSer: 2.1 ± 0.402
3.186AsnThr: 3.186 ± 0.447
1.882AsnVal: 1.882 ± 0.327
0.507AsnTrp: 0.507 ± 0.179
1.303AsnTyr: 1.303 ± 0.293
0.0AsnXaa: 0.0 ± 0.0
Pro
4.344ProAla: 4.344 ± 0.738
0.217ProCys: 0.217 ± 0.129
2.896ProAsp: 2.896 ± 0.453
2.679ProGlu: 2.679 ± 0.499
1.81ProPhe: 1.81 ± 0.447
3.765ProGly: 3.765 ± 0.652
0.941ProHis: 0.941 ± 0.254
2.244ProIle: 2.244 ± 0.295
2.679ProLys: 2.679 ± 0.442
2.896ProLeu: 2.896 ± 0.526
1.014ProMet: 1.014 ± 0.256
2.462ProAsn: 2.462 ± 0.365
1.882ProPro: 1.882 ± 0.422
2.172ProGln: 2.172 ± 0.367
2.172ProArg: 2.172 ± 0.387
2.824ProSer: 2.824 ± 0.561
2.027ProThr: 2.027 ± 0.366
4.127ProVal: 4.127 ± 0.451
1.086ProTrp: 1.086 ± 0.257
1.158ProTyr: 1.158 ± 0.349
0.0ProXaa: 0.0 ± 0.0
Gln
3.62GlnAla: 3.62 ± 0.602
0.145GlnCys: 0.145 ± 0.108
2.172GlnAsp: 2.172 ± 0.294
1.448GlnGlu: 1.448 ± 0.299
2.1GlnPhe: 2.1 ± 0.357
2.968GlnGly: 2.968 ± 0.91
0.652GlnHis: 0.652 ± 0.189
1.81GlnIle: 1.81 ± 0.341
1.955GlnLys: 1.955 ± 0.433
3.548GlnLeu: 3.548 ± 0.483
1.158GlnMet: 1.158 ± 0.267
1.81GlnAsn: 1.81 ± 0.307
1.231GlnPro: 1.231 ± 0.323
2.824GlnGln: 2.824 ± 0.746
2.679GlnArg: 2.679 ± 0.475
1.52GlnSer: 1.52 ± 0.356
2.824GlnThr: 2.824 ± 0.485
2.1GlnVal: 2.1 ± 0.396
0.434GlnTrp: 0.434 ± 0.188
1.231GlnTyr: 1.231 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
6.226ArgAla: 6.226 ± 0.654
0.724ArgCys: 0.724 ± 0.223
4.561ArgAsp: 4.561 ± 0.517
2.968ArgGlu: 2.968 ± 0.46
2.679ArgPhe: 2.679 ± 0.427
4.778ArgGly: 4.778 ± 0.618
1.158ArgHis: 1.158 ± 0.31
3.765ArgIle: 3.765 ± 0.448
3.837ArgLys: 3.837 ± 0.467
6.733ArgLeu: 6.733 ± 0.701
1.665ArgMet: 1.665 ± 0.299
2.317ArgAsn: 2.317 ± 0.301
3.186ArgPro: 3.186 ± 0.588
3.186ArgGln: 3.186 ± 0.499
3.33ArgArg: 3.33 ± 0.461
4.416ArgSer: 4.416 ± 0.54
2.824ArgThr: 2.824 ± 0.51
3.837ArgVal: 3.837 ± 0.53
1.158ArgTrp: 1.158 ± 0.294
2.679ArgTyr: 2.679 ± 0.381
0.0ArgXaa: 0.0 ± 0.0
Ser
5.14SerAla: 5.14 ± 0.662
0.579SerCys: 0.579 ± 0.226
3.837SerAsp: 3.837 ± 0.586
2.751SerGlu: 2.751 ± 0.442
2.1SerPhe: 2.1 ± 0.333
5.285SerGly: 5.285 ± 0.787
1.014SerHis: 1.014 ± 0.274
3.041SerIle: 3.041 ± 0.443
3.258SerLys: 3.258 ± 0.481
4.778SerLeu: 4.778 ± 0.435
1.231SerMet: 1.231 ± 0.34
1.448SerAsn: 1.448 ± 0.269
1.882SerPro: 1.882 ± 0.34
1.882SerGln: 1.882 ± 0.334
4.127SerArg: 4.127 ± 0.527
3.982SerSer: 3.982 ± 0.563
3.62SerThr: 3.62 ± 0.687
3.548SerVal: 3.548 ± 0.572
0.796SerTrp: 0.796 ± 0.198
2.534SerTyr: 2.534 ± 0.461
0.0SerXaa: 0.0 ± 0.0
Thr
5.43ThrAla: 5.43 ± 0.629
0.29ThrCys: 0.29 ± 0.141
4.054ThrAsp: 4.054 ± 0.6
3.186ThrGlu: 3.186 ± 0.377
2.027ThrPhe: 2.027 ± 0.371
5.358ThrGly: 5.358 ± 0.794
1.738ThrHis: 1.738 ± 0.443
3.258ThrIle: 3.258 ± 0.529
3.548ThrLys: 3.548 ± 0.452
5.864ThrLeu: 5.864 ± 0.774
0.724ThrMet: 0.724 ± 0.241
2.172ThrAsn: 2.172 ± 0.425
3.982ThrPro: 3.982 ± 0.656
2.244ThrGln: 2.244 ± 0.372
2.824ThrArg: 2.824 ± 0.411
4.127ThrSer: 4.127 ± 0.695
3.765ThrThr: 3.765 ± 0.48
4.127ThrVal: 4.127 ± 0.493
0.579ThrTrp: 0.579 ± 0.168
2.389ThrTyr: 2.389 ± 0.415
0.0ThrXaa: 0.0 ± 0.0
Val
6.95ValAla: 6.95 ± 0.707
0.579ValCys: 0.579 ± 0.19
4.272ValAsp: 4.272 ± 0.612
4.851ValGlu: 4.851 ± 0.644
1.738ValPhe: 1.738 ± 0.359
5.285ValGly: 5.285 ± 0.623
0.579ValHis: 0.579 ± 0.207
3.548ValIle: 3.548 ± 0.566
3.258ValLys: 3.258 ± 0.493
5.575ValLeu: 5.575 ± 0.659
1.593ValMet: 1.593 ± 0.293
2.896ValAsn: 2.896 ± 0.555
2.462ValPro: 2.462 ± 0.395
3.041ValGln: 3.041 ± 0.413
4.272ValArg: 4.272 ± 0.521
3.837ValSer: 3.837 ± 0.57
4.199ValThr: 4.199 ± 0.626
4.634ValVal: 4.634 ± 0.537
1.014ValTrp: 1.014 ± 0.297
1.448ValTyr: 1.448 ± 0.323
0.0ValXaa: 0.0 ± 0.0
Trp
1.593TrpAla: 1.593 ± 0.373
0.29TrpCys: 0.29 ± 0.126
0.941TrpAsp: 0.941 ± 0.225
0.652TrpGlu: 0.652 ± 0.181
0.869TrpPhe: 0.869 ± 0.321
1.014TrpGly: 1.014 ± 0.28
0.362TrpHis: 0.362 ± 0.199
0.579TrpIle: 0.579 ± 0.159
1.014TrpLys: 1.014 ± 0.247
2.1TrpLeu: 2.1 ± 0.462
0.29TrpMet: 0.29 ± 0.129
0.652TrpAsn: 0.652 ± 0.179
0.362TrpPro: 0.362 ± 0.16
0.434TrpGln: 0.434 ± 0.149
1.158TrpArg: 1.158 ± 0.314
0.941TrpSer: 0.941 ± 0.217
1.231TrpThr: 1.231 ± 0.321
0.941TrpVal: 0.941 ± 0.294
0.29TrpTrp: 0.29 ± 0.118
0.145TrpTyr: 0.145 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.896TyrAla: 2.896 ± 0.564
0.362TyrCys: 0.362 ± 0.127
1.882TyrAsp: 1.882 ± 0.39
2.027TyrGlu: 2.027 ± 0.334
1.231TyrPhe: 1.231 ± 0.252
3.113TyrGly: 3.113 ± 0.575
0.724TyrHis: 0.724 ± 0.277
1.448TyrIle: 1.448 ± 0.382
1.014TyrLys: 1.014 ± 0.306
2.244TyrLeu: 2.244 ± 0.391
0.724TyrMet: 0.724 ± 0.173
1.158TyrAsn: 1.158 ± 0.266
1.448TyrPro: 1.448 ± 0.398
1.303TyrGln: 1.303 ± 0.306
2.244TyrArg: 2.244 ± 0.378
1.593TyrSer: 1.593 ± 0.327
1.593TyrThr: 1.593 ± 0.296
1.665TyrVal: 1.665 ± 0.358
0.579TyrTrp: 0.579 ± 0.173
0.652TyrTyr: 0.652 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (13813 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski