Amino acid dipepetide frequency for Smittium megazygosporum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.398AlaAla: 3.398 ± 0.047	0.655AlaCys: 0.655 ± 0.014	2.643AlaAsp: 2.643 ± 0.038	3.089AlaGlu: 3.089 ± 0.035	2.404AlaPhe: 2.404 ± 0.03	2.582AlaGly: 2.582 ± 0.037	0.938AlaHis: 0.938 ± 0.02	3.73AlaIle: 3.73 ± 0.038	3.832AlaLys: 3.832 ± 0.046	5.179AlaLeu: 5.179 ± 0.045	0.981AlaMet: 0.981 ± 0.02	3.011AlaAsn: 3.011 ± 0.035	2.185AlaPro: 2.185 ± 0.032	2.087AlaGln: 2.087 ± 0.029	2.193AlaArg: 2.193 ± 0.033	5.375AlaSer: 5.375 ± 0.045	2.983AlaThr: 2.983 ± 0.051	2.951AlaVal: 2.951 ± 0.04	0.395AlaTrp: 0.395 ± 0.013	1.61AlaTyr: 1.61 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.586CysAla: 0.586 ± 0.013	0.19CysCys: 0.19 ± 0.008	0.627CysAsp: 0.627 ± 0.015	0.581CysGlu: 0.581 ± 0.016	0.68CysPhe: 0.68 ± 0.014	0.73CysGly: 0.73 ± 0.019	0.22CysHis: 0.22 ± 0.008	0.952CysIle: 0.952 ± 0.019	0.808CysLys: 0.808 ± 0.02	1.233CysLeu: 1.233 ± 0.022	0.27CysMet: 0.27 ± 0.01	0.658CysAsn: 0.658 ± 0.021	0.577CysPro: 0.577 ± 0.015	0.353CysGln: 0.353 ± 0.011	0.467CysArg: 0.467 ± 0.013	1.177CysSer: 1.177 ± 0.02	0.699CysThr: 0.699 ± 0.019	0.71CysVal: 0.71 ± 0.016	0.119CysTrp: 0.119 ± 0.006	0.464CysTyr: 0.464 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.497AspAla: 2.497 ± 0.029	0.629AspCys: 0.629 ± 0.015	2.759AspAsp: 2.759 ± 0.035	3.224AspGlu: 3.224 ± 0.037	3.061AspPhe: 3.061 ± 0.036	2.38AspGly: 2.38 ± 0.034	0.999AspHis: 0.999 ± 0.032	4.207AspIle: 4.207 ± 0.044	3.43AspLys: 3.43 ± 0.031	5.478AspLeu: 5.478 ± 0.044	0.97AspMet: 0.97 ± 0.016	3.018AspAsn: 3.018 ± 0.038	2.903AspPro: 2.903 ± 0.031	2.117AspGln: 2.117 ± 0.028	1.873AspArg: 1.873 ± 0.028	6.43AspSer: 6.43 ± 0.062	3.054AspThr: 3.054 ± 0.045	2.66AspVal: 2.66 ± 0.035	0.47AspTrp: 0.47 ± 0.012	2.075AspTyr: 2.075 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	3.076GluAla: 3.076 ± 0.038	0.671GluCys: 0.671 ± 0.02	3.025GluAsp: 3.025 ± 0.038	3.804GluGlu: 3.804 ± 0.051	2.865GluPhe: 2.865 ± 0.031	2.126GluGly: 2.126 ± 0.028	1.137GluHis: 1.137 ± 0.023	4.62GluIle: 4.62 ± 0.043	5.372GluLys: 5.372 ± 0.053	5.618GluLeu: 5.618 ± 0.052	1.282GluMet: 1.282 ± 0.023	4.976GluAsn: 4.976 ± 0.039	2.115GluPro: 2.115 ± 0.031	2.312GluGln: 2.312 ± 0.03	2.366GluArg: 2.366 ± 0.033	5.792GluSer: 5.792 ± 0.05	3.65GluThr: 3.65 ± 0.036	2.549GluVal: 2.549 ± 0.04	0.497GluTrp: 0.497 ± 0.013	2.457GluTyr: 2.457 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	2.413PheAla: 2.413 ± 0.034	0.725PheCys: 0.725 ± 0.017	2.998PheAsp: 2.998 ± 0.035	3.11PheGlu: 3.11 ± 0.034	2.277PhePhe: 2.277 ± 0.034	2.895PheGly: 2.895 ± 0.039	0.829PheHis: 0.829 ± 0.018	3.084PheIle: 3.084 ± 0.036	3.12PheLys: 3.12 ± 0.029	4.319PheLeu: 4.319 ± 0.052	0.896PheMet: 0.896 ± 0.019	2.844PheAsn: 2.844 ± 0.035	1.958PhePro: 1.958 ± 0.028	1.643PheGln: 1.643 ± 0.023	1.768PheArg: 1.768 ± 0.022	5.442PheSer: 5.442 ± 0.051	2.218PheThr: 2.218 ± 0.028	2.794PheVal: 2.794 ± 0.036	0.445PheTrp: 0.445 ± 0.012	1.753PheTyr: 1.753 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	2.703GlyAla: 2.703 ± 0.05	0.663GlyCys: 0.663 ± 0.015	2.329GlyAsp: 2.329 ± 0.03	2.239GlyGlu: 2.239 ± 0.028	2.629GlyPhe: 2.629 ± 0.03	2.826GlyGly: 2.826 ± 0.061	1.038GlyHis: 1.038 ± 0.022	3.807GlyIle: 3.807 ± 0.044	3.426GlyLys: 3.426 ± 0.04	4.389GlyLeu: 4.389 ± 0.041	0.985GlyMet: 0.985 ± 0.021	2.998GlyAsn: 2.998 ± 0.036	1.738GlyPro: 1.738 ± 0.032	1.515GlyGln: 1.515 ± 0.023	1.91GlyArg: 1.91 ± 0.032	5.092GlySer: 5.092 ± 0.064	2.868GlyThr: 2.868 ± 0.058	2.784GlyVal: 2.784 ± 0.036	0.485GlyTrp: 0.485 ± 0.013	2.153GlyTyr: 2.153 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	0.856HisAla: 0.856 ± 0.022	0.244HisCys: 0.244 ± 0.008	0.923HisAsp: 0.923 ± 0.032	0.992HisGlu: 0.992 ± 0.019	0.942HisPhe: 0.942 ± 0.018	0.944HisGly: 0.944 ± 0.019	0.439HisHis: 0.439 ± 0.015	1.32HisIle: 1.32 ± 0.019	1.235HisLys: 1.235 ± 0.021	1.819HisLeu: 1.819 ± 0.028	0.35HisMet: 0.35 ± 0.01	1.118HisAsn: 1.118 ± 0.025	1.131HisPro: 1.131 ± 0.022	0.752HisGln: 0.752 ± 0.018	0.839HisArg: 0.839 ± 0.015	2.059HisSer: 2.059 ± 0.036	0.978HisThr: 0.978 ± 0.017	0.928HisVal: 0.928 ± 0.018	0.171HisTrp: 0.171 ± 0.008	0.639HisTyr: 0.639 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.495IleAla: 3.495 ± 0.036	0.965IleCys: 0.965 ± 0.018	4.076IleAsp: 4.076 ± 0.035	4.36IleGlu: 4.36 ± 0.041	3.204IlePhe: 3.204 ± 0.038	3.153IleGly: 3.153 ± 0.043	1.329IleHis: 1.329 ± 0.024	4.226IleIle: 4.226 ± 0.045	5.009IleLys: 5.009 ± 0.045	6.327IleLeu: 6.327 ± 0.057	1.175IleMet: 1.175 ± 0.021	4.409IleAsn: 4.409 ± 0.043	3.684IlePro: 3.684 ± 0.033	2.725IleGln: 2.725 ± 0.029	2.714IleArg: 2.714 ± 0.034	7.839IleSer: 7.839 ± 0.057	3.196IleThr: 3.196 ± 0.033	3.625IleVal: 3.625 ± 0.038	0.567IleTrp: 0.567 ± 0.013	2.326IleTyr: 2.326 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.957LysAla: 3.957 ± 0.043	0.736LysCys: 0.736 ± 0.017	3.979LysAsp: 3.979 ± 0.032	4.481LysGlu: 4.481 ± 0.048	2.885LysPhe: 2.885 ± 0.031	2.947LysGly: 2.947 ± 0.033	1.54LysHis: 1.54 ± 0.024	5.28LysIle: 5.28 ± 0.045	6.705LysLys: 6.705 ± 0.064	6.871LysLeu: 6.871 ± 0.063	1.397LysMet: 1.397 ± 0.023	5.56LysAsn: 5.56 ± 0.05	3.446LysPro: 3.446 ± 0.039	2.816LysGln: 2.816 ± 0.033	3.352LysArg: 3.352 ± 0.039	7.688LysSer: 7.688 ± 0.065	4.306LysThr: 4.306 ± 0.039	3.713LysVal: 3.713 ± 0.041	0.553LysTrp: 0.553 ± 0.015	2.94LysTyr: 2.94 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	5.251LeuAla: 5.251 ± 0.046	1.224LeuCys: 1.224 ± 0.025	5.704LeuAsp: 5.704 ± 0.056	6.551LeuGlu: 6.551 ± 0.069	4.473LeuPhe: 4.473 ± 0.05	4.766LeuGly: 4.766 ± 0.043	1.612LeuHis: 1.612 ± 0.022	5.415LeuIle: 5.415 ± 0.049	6.979LeuLys: 6.979 ± 0.056	8.891LeuLeu: 8.891 ± 0.102	1.602LeuMet: 1.602 ± 0.022	6.05LeuAsn: 6.05 ± 0.058	4.152LeuPro: 4.152 ± 0.046	3.49LeuGln: 3.49 ± 0.036	3.626LeuArg: 3.626 ± 0.038	9.88LeuSer: 9.88 ± 0.079	4.108LeuThr: 4.108 ± 0.04	5.421LeuVal: 5.421 ± 0.051	0.751LeuTrp: 0.751 ± 0.017	3.159LeuTyr: 3.159 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	1.078MetAla: 1.078 ± 0.022	0.252MetCys: 0.252 ± 0.009	1.128MetAsp: 1.128 ± 0.02	1.127MetGlu: 1.127 ± 0.023	0.953MetPhe: 0.953 ± 0.017	1.018MetGly: 1.018 ± 0.021	0.312MetHis: 0.312 ± 0.009	1.208MetIle: 1.208 ± 0.023	1.268MetLys: 1.268 ± 0.021	1.742MetLeu: 1.742 ± 0.024	0.378MetMet: 0.378 ± 0.011	1.161MetAsn: 1.161 ± 0.022	0.736MetPro: 0.736 ± 0.016	0.598MetGln: 0.598 ± 0.014	0.737MetArg: 0.737 ± 0.018	1.72MetSer: 1.72 ± 0.025	0.902MetThr: 0.902 ± 0.018	1.088MetVal: 1.088 ± 0.022	0.156MetTrp: 0.156 ± 0.007	0.663MetTyr: 0.663 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.036	0.693AsnCys: 0.693 ± 0.014	3.23AsnAsp: 3.23 ± 0.038	3.625AsnGlu: 3.625 ± 0.036	2.908AsnPhe: 2.908 ± 0.035	2.967AsnGly: 2.967 ± 0.041	1.248AsnHis: 1.248 ± 0.024	4.781AsnIle: 4.781 ± 0.039	4.793AsnLys: 4.793 ± 0.045	6.079AsnLeu: 6.079 ± 0.058	1.197AsnMet: 1.197 ± 0.022	4.538AsnAsn: 4.538 ± 0.055	3.681AsnPro: 3.681 ± 0.042	3.066AsnGln: 3.066 ± 0.034	2.456AsnArg: 2.456 ± 0.033	7.976AsnSer: 7.976 ± 0.067	4.176AsnThr: 4.176 ± 0.047	3.048AsnVal: 3.048 ± 0.029	0.467AsnTrp: 0.467 ± 0.013	2.275AsnTyr: 2.275 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.277ProAla: 2.277 ± 0.034	0.383ProCys: 0.383 ± 0.013	2.479ProAsp: 2.479 ± 0.034	3.396ProGlu: 3.396 ± 0.038	2.049ProPhe: 2.049 ± 0.027	2.202ProGly: 2.202 ± 0.034	0.833ProHis: 0.833 ± 0.018	2.969ProIle: 2.969 ± 0.032	3.573ProLys: 3.573 ± 0.045	3.865ProLeu: 3.865 ± 0.036	0.684ProMet: 0.684 ± 0.019	3.282ProAsn: 3.282 ± 0.038	2.462ProPro: 2.462 ± 0.057	1.878ProGln: 1.878 ± 0.036	1.709ProArg: 1.709 ± 0.024	5.198ProSer: 5.198 ± 0.056	2.9ProThr: 2.9 ± 0.045	2.62ProVal: 2.62 ± 0.035	0.313ProTrp: 0.313 ± 0.01	1.387ProTyr: 1.387 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	1.964GlnAla: 1.964 ± 0.03	0.348GlnCys: 0.348 ± 0.013	1.866GlnAsp: 1.866 ± 0.028	2.158GlnGlu: 2.158 ± 0.029	1.51GlnPhe: 1.51 ± 0.024	1.698GlnGly: 1.698 ± 0.029	0.715GlnHis: 0.715 ± 0.019	2.823GlnIle: 2.823 ± 0.03	3.205GlnLys: 3.205 ± 0.036	3.435GlnLeu: 3.435 ± 0.038	0.751GlnMet: 0.751 ± 0.016	3.213GlnAsn: 3.213 ± 0.036	1.721GlnPro: 1.721 ± 0.036	1.688GlnGln: 1.688 ± 0.035	1.617GlnArg: 1.617 ± 0.025	3.685GlnSer: 3.685 ± 0.043	2.45GlnThr: 2.45 ± 0.033	1.909GlnVal: 1.909 ± 0.027	0.261GlnTrp: 0.261 ± 0.009	1.263GlnTyr: 1.263 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	2.238ArgAla: 2.238 ± 0.03	0.483ArgCys: 0.483 ± 0.012	2.066ArgAsp: 2.066 ± 0.027	2.11ArgGlu: 2.11 ± 0.035	2.07ArgPhe: 2.07 ± 0.024	1.889ArgGly: 1.889 ± 0.033	0.845ArgHis: 0.845 ± 0.017	2.866ArgIle: 2.866 ± 0.032	3.203ArgLys: 3.203 ± 0.035	3.719ArgLeu: 3.719 ± 0.034	0.843ArgMet: 0.843 ± 0.018	2.682ArgAsn: 2.682 ± 0.032	1.6ArgPro: 1.6 ± 0.025	1.421ArgGln: 1.421 ± 0.022	1.996ArgArg: 1.996 ± 0.036	3.639ArgSer: 3.639 ± 0.044	2.017ArgThr: 2.017 ± 0.031	2.261ArgVal: 2.261 ± 0.026	0.389ArgTrp: 0.389 ± 0.012	1.502ArgTyr: 1.502 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	5.401SerAla: 5.401 ± 0.046	1.071SerCys: 1.071 ± 0.021	5.91SerAsp: 5.91 ± 0.062	6.648SerGlu: 6.648 ± 0.062	5.03SerPhe: 5.03 ± 0.046	5.444SerGly: 5.444 ± 0.053	1.873SerHis: 1.873 ± 0.026	7.18SerIle: 7.18 ± 0.054	8.698SerLys: 8.698 ± 0.07	9.804SerLeu: 9.804 ± 0.076	1.708SerMet: 1.708 ± 0.022	7.473SerAsn: 7.473 ± 0.074	4.809SerPro: 4.809 ± 0.066	4.317SerGln: 4.317 ± 0.045	4.295SerArg: 4.295 ± 0.043	13.561SerSer: 13.561 ± 0.116	6.409SerThr: 6.409 ± 0.071	5.427SerVal: 5.427 ± 0.047	0.776SerTrp: 0.776 ± 0.019	3.048SerTyr: 3.048 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	2.942ThrAla: 2.942 ± 0.038	0.698ThrCys: 0.698 ± 0.018	2.877ThrAsp: 2.877 ± 0.04	3.338ThrGlu: 3.338 ± 0.036	2.55ThrPhe: 2.55 ± 0.028	2.979ThrGly: 2.979 ± 0.064	1.003ThrHis: 1.003 ± 0.018	3.714ThrIle: 3.714 ± 0.039	3.947ThrLys: 3.947 ± 0.04	4.981ThrLeu: 4.981 ± 0.046	0.917ThrMet: 0.917 ± 0.017	3.469ThrAsn: 3.469 ± 0.034	3.027ThrPro: 3.027 ± 0.052	2.201ThrGln: 2.201 ± 0.036	2.26ThrArg: 2.26 ± 0.031	5.925ThrSer: 5.925 ± 0.054	3.76ThrThr: 3.76 ± 0.089	3.081ThrVal: 3.081 ± 0.04	0.436ThrTrp: 0.436 ± 0.012	1.418ThrTyr: 1.418 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	2.963ValAla: 2.963 ± 0.041	0.83ValCys: 0.83 ± 0.017	3.177ValAsp: 3.177 ± 0.036	3.157ValGlu: 3.157 ± 0.038	2.74ValPhe: 2.74 ± 0.033	2.686ValGly: 2.686 ± 0.033	0.994ValHis: 0.994 ± 0.02	3.216ValIle: 3.216 ± 0.043	3.44ValLys: 3.44 ± 0.042	5.295ValLeu: 5.295 ± 0.049	0.952ValMet: 0.952 ± 0.019	2.946ValAsn: 2.946 ± 0.034	2.674ValPro: 2.674 ± 0.029	1.84ValGln: 1.84 ± 0.023	1.917ValArg: 1.917 ± 0.027	5.835ValSer: 5.835 ± 0.05	2.496ValThr: 2.496 ± 0.036	3.488ValVal: 3.488 ± 0.06	0.478ValTrp: 0.478 ± 0.014	2.051ValTyr: 2.051 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.474TrpAla: 0.474 ± 0.013	0.116TrpCys: 0.116 ± 0.006	0.568TrpAsp: 0.568 ± 0.016	0.49TrpGlu: 0.49 ± 0.013	0.43TrpPhe: 0.43 ± 0.01	0.412TrpGly: 0.412 ± 0.013	0.149TrpHis: 0.149 ± 0.007	0.617TrpIle: 0.617 ± 0.015	0.584TrpLys: 0.584 ± 0.013	0.758TrpLeu: 0.758 ± 0.017	0.196TrpMet: 0.196 ± 0.008	0.549TrpAsn: 0.549 ± 0.013	0.251TrpPro: 0.251 ± 0.009	0.231TrpGln: 0.231 ± 0.009	0.33TrpArg: 0.33 ± 0.011	0.699TrpSer: 0.699 ± 0.016	0.415TrpThr: 0.415 ± 0.012	0.511TrpVal: 0.511 ± 0.014	0.13TrpTrp: 0.13 ± 0.007	0.282TrpTyr: 0.282 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.626TyrAla: 1.626 ± 0.023	0.522TyrCys: 0.522 ± 0.014	1.871TyrAsp: 1.871 ± 0.027	1.828TyrGlu: 1.828 ± 0.026	1.874TyrPhe: 1.874 ± 0.025	1.932TyrGly: 1.932 ± 0.031	0.623TyrHis: 0.623 ± 0.015	2.39TyrIle: 2.39 ± 0.03	2.526TyrLys: 2.526 ± 0.028	3.305TyrLeu: 3.305 ± 0.037	0.692TyrMet: 0.692 ± 0.015	2.278TyrAsn: 2.278 ± 0.031	1.608TyrPro: 1.608 ± 0.025	1.229TyrGln: 1.229 ± 0.019	1.413TyrArg: 1.413 ± 0.023	3.871TyrSer: 3.871 ± 0.043	1.935TyrThr: 1.935 ± 0.029	1.606TyrVal: 1.606 ± 0.024	0.334TyrTrp: 0.334 ± 0.012	1.418TyrTyr: 1.418 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6835 proteins (3127516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---