Amino acid dipepetide frequency for Bifidobacterium commune

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.636AlaAla: 10.636 ± 0.211
0.95AlaCys: 0.95 ± 0.05
6.544AlaAsp: 6.544 ± 0.117
5.412AlaGlu: 5.412 ± 0.141
3.261AlaPhe: 3.261 ± 0.096
7.981AlaGly: 7.981 ± 0.142
2.011AlaHis: 2.011 ± 0.062
5.138AlaIle: 5.138 ± 0.125
4.853AlaLys: 4.853 ± 0.116
9.39AlaLeu: 9.39 ± 0.189
2.798AlaMet: 2.798 ± 0.08
3.49AlaAsn: 3.49 ± 0.093
3.74AlaPro: 3.74 ± 0.11
4.477AlaGln: 4.477 ± 0.125
5.383AlaArg: 5.383 ± 0.112
6.494AlaSer: 6.494 ± 0.136
5.288AlaThr: 5.288 ± 0.126
7.816AlaVal: 7.816 ± 0.161
1.109AlaTrp: 1.109 ± 0.046
2.239AlaTyr: 2.239 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.048
0.117CysCys: 0.117 ± 0.016
0.591CysAsp: 0.591 ± 0.039
0.52CysGlu: 0.52 ± 0.036
0.322CysPhe: 0.322 ± 0.026
1.004CysGly: 1.004 ± 0.058
0.233CysHis: 0.233 ± 0.023
0.504CysIle: 0.504 ± 0.034
0.337CysLys: 0.337 ± 0.026
0.739CysLeu: 0.739 ± 0.047
0.22CysMet: 0.22 ± 0.021
0.283CysAsn: 0.283 ± 0.023
0.509CysPro: 0.509 ± 0.033
0.259CysGln: 0.259 ± 0.023
0.459CysArg: 0.459 ± 0.03
0.615CysSer: 0.615 ± 0.035
0.565CysThr: 0.565 ± 0.039
0.761CysVal: 0.761 ± 0.044
0.1CysTrp: 0.1 ± 0.013
0.226CysTyr: 0.226 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
6.518AspAla: 6.518 ± 0.131
0.581AspCys: 0.581 ± 0.035
4.483AspAsp: 4.483 ± 0.119
5.196AspGlu: 5.196 ± 0.118
2.448AspPhe: 2.448 ± 0.075
5.692AspGly: 5.692 ± 0.119
1.341AspHis: 1.341 ± 0.05
3.629AspIle: 3.629 ± 0.09
2.713AspLys: 2.713 ± 0.082
5.198AspLeu: 5.198 ± 0.125
1.694AspMet: 1.694 ± 0.061
2.087AspAsn: 2.087 ± 0.066
3.259AspPro: 3.259 ± 0.091
2.094AspGln: 2.094 ± 0.065
3.27AspArg: 3.27 ± 0.093
4.118AspSer: 4.118 ± 0.103
3.607AspThr: 3.607 ± 0.108
5.116AspVal: 5.116 ± 0.115
0.885AspTrp: 0.885 ± 0.049
1.742AspTyr: 1.742 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.896GluAla: 5.896 ± 0.141
0.478GluCys: 0.478 ± 0.043
3.326GluAsp: 3.326 ± 0.086
3.474GluGlu: 3.474 ± 0.106
1.687GluPhe: 1.687 ± 0.065
4.033GluGly: 4.033 ± 0.107
1.696GluHis: 1.696 ± 0.063
3.168GluIle: 3.168 ± 0.094
2.596GluLys: 2.596 ± 0.087
5.277GluLeu: 5.277 ± 0.122
1.607GluMet: 1.607 ± 0.058
2.324GluAsn: 2.324 ± 0.073
2.498GluPro: 2.498 ± 0.088
2.868GluGln: 2.868 ± 0.088
3.898GluArg: 3.898 ± 0.097
3.607GluSer: 3.607 ± 0.096
3.422GluThr: 3.422 ± 0.085
4.064GluVal: 4.064 ± 0.106
0.644GluTrp: 0.644 ± 0.044
1.555GluTyr: 1.555 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.583PheAla: 3.583 ± 0.092
0.38PheCys: 0.38 ± 0.031
2.642PheAsp: 2.642 ± 0.082
1.965PheGlu: 1.965 ± 0.075
1.168PhePhe: 1.168 ± 0.063
3.211PheGly: 3.211 ± 0.087
0.667PheHis: 0.667 ± 0.038
1.807PheIle: 1.807 ± 0.07
1.32PheLys: 1.32 ± 0.053
2.544PheLeu: 2.544 ± 0.091
0.824PheMet: 0.824 ± 0.041
1.407PheAsn: 1.407 ± 0.055
1.272PhePro: 1.272 ± 0.052
0.826PheGln: 0.826 ± 0.046
1.548PheArg: 1.548 ± 0.06
2.42PheSer: 2.42 ± 0.074
2.113PheThr: 2.113 ± 0.066
2.82PheVal: 2.82 ± 0.075
0.426PheTrp: 0.426 ± 0.033
0.822PheTyr: 0.822 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
6.816GlyAla: 6.816 ± 0.129
0.798GlyCys: 0.798 ± 0.043
4.622GlyAsp: 4.622 ± 0.105
4.524GlyGlu: 4.524 ± 0.109
3.216GlyPhe: 3.216 ± 0.076
6.053GlyGly: 6.053 ± 0.157
1.859GlyHis: 1.859 ± 0.06
4.753GlyIle: 4.753 ± 0.117
4.335GlyLys: 4.335 ± 0.103
6.718GlyLeu: 6.718 ± 0.138
2.183GlyMet: 2.183 ± 0.068
3.205GlyAsn: 3.205 ± 0.094
2.781GlyPro: 2.781 ± 0.074
2.898GlyGln: 2.898 ± 0.092
4.372GlyArg: 4.372 ± 0.104
5.883GlySer: 5.883 ± 0.14
4.946GlyThr: 4.946 ± 0.127
6.205GlyVal: 6.205 ± 0.108
1.148GlyTrp: 1.148 ± 0.057
2.416GlyTyr: 2.416 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
1.892HisAla: 1.892 ± 0.063
0.211HisCys: 0.211 ± 0.022
1.591HisAsp: 1.591 ± 0.055
1.37HisGlu: 1.37 ± 0.059
0.691HisPhe: 0.691 ± 0.041
1.881HisGly: 1.881 ± 0.07
0.589HisHis: 0.589 ± 0.037
1.313HisIle: 1.313 ± 0.06
0.75HisLys: 0.75 ± 0.041
1.702HisLeu: 1.702 ± 0.071
0.502HisMet: 0.502 ± 0.037
0.837HisAsn: 0.837 ± 0.043
1.268HisPro: 1.268 ± 0.054
0.759HisGln: 0.759 ± 0.038
1.461HisArg: 1.461 ± 0.058
1.361HisSer: 1.361 ± 0.057
1.272HisThr: 1.272 ± 0.049
1.718HisVal: 1.718 ± 0.054
0.309HisTrp: 0.309 ± 0.026
0.65HisTyr: 0.65 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.238IleAla: 6.238 ± 0.144
0.681IleCys: 0.681 ± 0.04
4.311IleAsp: 4.311 ± 0.1
3.398IleGlu: 3.398 ± 0.101
1.737IlePhe: 1.737 ± 0.08
4.609IleGly: 4.609 ± 0.114
1.009IleHis: 1.009 ± 0.048
3.098IleIle: 3.098 ± 0.1
2.063IleLys: 2.063 ± 0.078
4.0IleLeu: 4.0 ± 0.101
1.159IleMet: 1.159 ± 0.048
2.085IleAsn: 2.085 ± 0.074
2.659IlePro: 2.659 ± 0.08
1.448IleGln: 1.448 ± 0.057
2.763IleArg: 2.763 ± 0.081
3.944IleSer: 3.944 ± 0.094
3.146IleThr: 3.146 ± 0.092
4.772IleVal: 4.772 ± 0.107
0.609IleTrp: 0.609 ± 0.039
1.294IleTyr: 1.294 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.859LysAla: 4.859 ± 0.133
0.2LysCys: 0.2 ± 0.022
2.757LysAsp: 2.757 ± 0.089
2.42LysGlu: 2.42 ± 0.087
1.07LysPhe: 1.07 ± 0.051
3.098LysGly: 3.098 ± 0.083
0.97LysHis: 0.97 ± 0.044
2.2LysIle: 2.2 ± 0.076
2.311LysLys: 2.311 ± 0.084
3.661LysLeu: 3.661 ± 0.089
1.098LysMet: 1.098 ± 0.047
1.789LysAsn: 1.789 ± 0.069
2.466LysPro: 2.466 ± 0.077
1.802LysGln: 1.802 ± 0.071
2.763LysArg: 2.763 ± 0.079
2.866LysSer: 2.866 ± 0.089
3.053LysThr: 3.053 ± 0.1
3.285LysVal: 3.285 ± 0.087
0.507LysTrp: 0.507 ± 0.032
1.141LysTyr: 1.141 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
8.871LeuAla: 8.871 ± 0.146
0.863LeuCys: 0.863 ± 0.045
5.849LeuAsp: 5.849 ± 0.131
4.629LeuGlu: 4.629 ± 0.12
2.853LeuPhe: 2.853 ± 0.098
6.944LeuGly: 6.944 ± 0.148
1.848LeuHis: 1.848 ± 0.064
4.868LeuIle: 4.868 ± 0.126
3.922LeuLys: 3.922 ± 0.091
7.57LeuLeu: 7.57 ± 0.174
2.179LeuMet: 2.179 ± 0.071
3.279LeuAsn: 3.279 ± 0.097
4.253LeuPro: 4.253 ± 0.113
2.724LeuGln: 2.724 ± 0.08
4.909LeuArg: 4.909 ± 0.108
6.107LeuSer: 6.107 ± 0.113
5.429LeuThr: 5.429 ± 0.11
6.42LeuVal: 6.42 ± 0.14
0.898LeuTrp: 0.898 ± 0.047
1.898LeuTyr: 1.898 ± 0.062
0.002LeuXaa: 0.002 ± 0.002
Met
2.6MetAla: 2.6 ± 0.08
0.237MetCys: 0.237 ± 0.023
1.439MetAsp: 1.439 ± 0.053
1.17MetGlu: 1.17 ± 0.053
0.968MetPhe: 0.968 ± 0.053
1.874MetGly: 1.874 ± 0.071
0.583MetHis: 0.583 ± 0.035
1.213MetIle: 1.213 ± 0.057
1.122MetLys: 1.122 ± 0.05
2.572MetLeu: 2.572 ± 0.078
0.696MetMet: 0.696 ± 0.04
1.094MetAsn: 1.094 ± 0.045
1.411MetPro: 1.411 ± 0.045
0.828MetGln: 0.828 ± 0.044
1.585MetArg: 1.585 ± 0.058
1.933MetSer: 1.933 ± 0.07
1.809MetThr: 1.809 ± 0.062
1.926MetVal: 1.926 ± 0.071
0.254MetTrp: 0.254 ± 0.024
0.533MetTyr: 0.533 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.822AsnAla: 3.822 ± 0.094
0.272AsnCys: 0.272 ± 0.026
2.624AsnAsp: 2.624 ± 0.08
2.324AsnGlu: 2.324 ± 0.069
1.081AsnPhe: 1.081 ± 0.048
3.62AsnGly: 3.62 ± 0.093
0.759AsnHis: 0.759 ± 0.04
1.948AsnIle: 1.948 ± 0.062
1.628AsnLys: 1.628 ± 0.068
2.961AsnLeu: 2.961 ± 0.084
0.928AsnMet: 0.928 ± 0.045
1.5AsnAsn: 1.5 ± 0.069
2.302AsnPro: 2.302 ± 0.074
1.309AsnGln: 1.309 ± 0.056
2.155AsnArg: 2.155 ± 0.066
2.109AsnSer: 2.109 ± 0.07
2.255AsnThr: 2.255 ± 0.084
2.833AsnVal: 2.833 ± 0.075
0.428AsnTrp: 0.428 ± 0.033
0.841AsnTyr: 0.841 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.19ProAla: 4.19 ± 0.104
0.337ProCys: 0.337 ± 0.029
3.153ProAsp: 3.153 ± 0.083
3.368ProGlu: 3.368 ± 0.092
1.557ProPhe: 1.557 ± 0.064
3.326ProGly: 3.326 ± 0.095
1.0ProHis: 1.0 ± 0.05
2.435ProIle: 2.435 ± 0.071
2.155ProLys: 2.155 ± 0.072
3.663ProLeu: 3.663 ± 0.089
1.072ProMet: 1.072 ± 0.055
1.752ProAsn: 1.752 ± 0.063
1.228ProPro: 1.228 ± 0.063
1.905ProGln: 1.905 ± 0.073
2.098ProArg: 2.098 ± 0.067
3.298ProSer: 3.298 ± 0.116
2.803ProThr: 2.803 ± 0.093
3.798ProVal: 3.798 ± 0.111
0.637ProTrp: 0.637 ± 0.04
1.326ProTyr: 1.326 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.881GlnAla: 3.881 ± 0.108
0.278GlnCys: 0.278 ± 0.025
1.813GlnAsp: 1.813 ± 0.07
1.863GlnGlu: 1.863 ± 0.066
1.141GlnPhe: 1.141 ± 0.049
2.652GlnGly: 2.652 ± 0.08
0.898GlnHis: 0.898 ± 0.044
2.205GlnIle: 2.205 ± 0.079
1.437GlnLys: 1.437 ± 0.065
3.303GlnLeu: 3.303 ± 0.107
1.081GlnMet: 1.081 ± 0.049
1.341GlnAsn: 1.341 ± 0.062
1.687GlnPro: 1.687 ± 0.067
1.944GlnGln: 1.944 ± 0.078
2.518GlnArg: 2.518 ± 0.076
2.474GlnSer: 2.474 ± 0.075
2.113GlnThr: 2.113 ± 0.071
2.761GlnVal: 2.761 ± 0.073
0.57GlnTrp: 0.57 ± 0.04
1.102GlnTyr: 1.102 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
4.644ArgAla: 4.644 ± 0.122
0.539ArgCys: 0.539 ± 0.037
3.622ArgAsp: 3.622 ± 0.099
3.544ArgGlu: 3.544 ± 0.096
2.226ArgPhe: 2.226 ± 0.068
3.609ArgGly: 3.609 ± 0.105
1.494ArgHis: 1.494 ± 0.064
3.318ArgIle: 3.318 ± 0.076
2.744ArgLys: 2.744 ± 0.072
5.131ArgLeu: 5.131 ± 0.123
1.585ArgMet: 1.585 ± 0.056
2.226ArgAsn: 2.226 ± 0.082
2.398ArgPro: 2.398 ± 0.065
2.424ArgGln: 2.424 ± 0.077
4.227ArgArg: 4.227 ± 0.132
3.566ArgSer: 3.566 ± 0.104
3.231ArgThr: 3.231 ± 0.092
4.046ArgVal: 4.046 ± 0.085
0.739ArgTrp: 0.739 ± 0.041
1.689ArgTyr: 1.689 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
6.579SerAla: 6.579 ± 0.144
0.665SerCys: 0.665 ± 0.041
4.446SerAsp: 4.446 ± 0.103
3.668SerGlu: 3.668 ± 0.105
2.179SerPhe: 2.179 ± 0.071
6.138SerGly: 6.138 ± 0.122
1.509SerHis: 1.509 ± 0.057
3.637SerIle: 3.637 ± 0.087
3.094SerLys: 3.094 ± 0.092
5.855SerLeu: 5.855 ± 0.114
1.748SerMet: 1.748 ± 0.059
2.694SerAsn: 2.694 ± 0.083
2.659SerPro: 2.659 ± 0.077
2.596SerGln: 2.596 ± 0.067
3.84SerArg: 3.84 ± 0.097
4.931SerSer: 4.931 ± 0.138
4.024SerThr: 4.024 ± 0.103
5.307SerVal: 5.307 ± 0.114
0.839SerTrp: 0.839 ± 0.038
1.663SerTyr: 1.663 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
5.742ThrAla: 5.742 ± 0.138
0.526ThrCys: 0.526 ± 0.034
3.903ThrAsp: 3.903 ± 0.101
2.844ThrGlu: 2.844 ± 0.085
2.024ThrPhe: 2.024 ± 0.08
5.118ThrGly: 5.118 ± 0.102
1.231ThrHis: 1.231 ± 0.058
3.381ThrIle: 3.381 ± 0.09
2.335ThrLys: 2.335 ± 0.084
5.538ThrLeu: 5.538 ± 0.141
1.47ThrMet: 1.47 ± 0.067
2.189ThrAsn: 2.189 ± 0.073
3.255ThrPro: 3.255 ± 0.108
2.131ThrGln: 2.131 ± 0.072
2.85ThrArg: 2.85 ± 0.075
4.037ThrSer: 4.037 ± 0.114
3.703ThrThr: 3.703 ± 0.111
5.142ThrVal: 5.142 ± 0.125
0.765ThrTrp: 0.765 ± 0.045
1.452ThrTyr: 1.452 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
7.779ValAla: 7.779 ± 0.165
0.865ValCys: 0.865 ± 0.044
5.457ValAsp: 5.457 ± 0.141
4.507ValGlu: 4.507 ± 0.118
2.711ValPhe: 2.711 ± 0.079
5.575ValGly: 5.575 ± 0.126
1.622ValHis: 1.622 ± 0.06
4.429ValIle: 4.429 ± 0.109
3.157ValLys: 3.157 ± 0.082
7.12ValLeu: 7.12 ± 0.131
2.046ValMet: 2.046 ± 0.071
2.694ValAsn: 2.694 ± 0.083
3.729ValPro: 3.729 ± 0.096
2.329ValGln: 2.329 ± 0.087
4.381ValArg: 4.381 ± 0.095
5.803ValSer: 5.803 ± 0.118
4.79ValThr: 4.79 ± 0.107
6.873ValVal: 6.873 ± 0.157
0.852ValTrp: 0.852 ± 0.044
1.755ValTyr: 1.755 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.965TrpAla: 0.965 ± 0.045
0.126TrpCys: 0.126 ± 0.018
0.698TrpAsp: 0.698 ± 0.041
0.435TrpGlu: 0.435 ± 0.034
0.509TrpPhe: 0.509 ± 0.039
0.872TrpGly: 0.872 ± 0.051
0.27TrpHis: 0.27 ± 0.027
0.713TrpIle: 0.713 ± 0.04
0.561TrpLys: 0.561 ± 0.038
1.272TrpLeu: 1.272 ± 0.058
0.378TrpMet: 0.378 ± 0.029
0.526TrpAsn: 0.526 ± 0.033
0.546TrpPro: 0.546 ± 0.037
0.561TrpGln: 0.561 ± 0.037
0.835TrpArg: 0.835 ± 0.044
0.867TrpSer: 0.867 ± 0.05
0.667TrpThr: 0.667 ± 0.04
0.863TrpVal: 0.863 ± 0.041
0.215TrpTrp: 0.215 ± 0.02
0.372TrpTyr: 0.372 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.483TyrAla: 2.483 ± 0.076
0.274TyrCys: 0.274 ± 0.026
1.798TyrAsp: 1.798 ± 0.072
1.487TyrGlu: 1.487 ± 0.063
0.918TyrPhe: 0.918 ± 0.046
2.439TyrGly: 2.439 ± 0.07
0.539TyrHis: 0.539 ± 0.033
1.268TyrIle: 1.268 ± 0.048
0.883TyrLys: 0.883 ± 0.051
2.098TyrLeu: 2.098 ± 0.071
0.578TyrMet: 0.578 ± 0.037
0.898TyrAsn: 0.898 ± 0.051
1.183TyrPro: 1.183 ± 0.054
0.883TyrGln: 0.883 ± 0.042
1.685TyrArg: 1.685 ± 0.062
1.639TyrSer: 1.639 ± 0.068
1.4TyrThr: 1.4 ± 0.06
1.946TyrVal: 1.946 ± 0.062
0.317TyrTrp: 0.317 ± 0.027
0.678TyrTyr: 0.678 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.002XaaArg: 0.002 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.004
Statistics based on 1238 proteins (459946 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski